Pub Date : 2026-02-11DOI: 10.1186/s12876-026-04604-z
Xianshang Zhu, Zengrui Wang, Xia Yang, Zong Ning
{"title":"Diagnostic performance of TyG-related indices for MAFLD screening in older adults at moderate altitude: TyG-BMI showed the highest discriminatory ability.","authors":"Xianshang Zhu, Zengrui Wang, Xia Yang, Zong Ning","doi":"10.1186/s12876-026-04604-z","DOIUrl":"10.1186/s12876-026-04604-z","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Direct bilirubin was superior to total bilirubin in predicting the long-term outcomes of patients with primary biliary cholangitis.","authors":"Sha Chen, Buer Li, Shuxiang Li, Tingting Lv, Qin Xiao, Hong Ma, Yu Wang, Xinyan Zhao, Xiaojuan Ou, Yuanyuan Kong, Hong You, Jidong Jia, Weijia Duan","doi":"10.1186/s12876-026-04667-y","DOIUrl":"10.1186/s12876-026-04667-y","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1186/s12876-025-04398-6
Iman Elahi Vahed, Amir Mohammad Rishialiabad, Fatemeh Moeinaddini, Amir Hosein Shabani, Asal Kazemzadeh, Mojtaba Esmaeeli, Mostafa Neshat Ghalibaf, Mahdiyeh Nozad Varjovi, Maryam Shirmohamadi, Mohaddese Heydari, Parsa Tavassoli Naini, Mohammadsadegh Jafari, Alireza Gholami, Hossein Soltaninejad, Mohammad Rahmanian
Background: The evidence considering the potential protective impact of statins on the mortality rate caused by colorectal cancer (CRC) is controversial. This study aimed to systematically assess the effect of statins on the survival rate of CRC patients.
Methods: A comprehensive search was conducted in Scopus, PubMed, and Web of Science to assess the relationship between statin consumption and cancer-specific mortality (CSM), all-cause mortality (ACM), disease-free survival (DFS), and recurrence-free survival (RFS). Subgroup analyses were performed to assess data stratified by country, study design, disease stage, time to use, CRC, and treatment type due to high heterogeneity.
Results: Thirty-two studies were included; the data of 24 articles composed the meta-analysis. Statins improved prognosis of CRC, particularly in lower ACM (HR: 0.80; 95% CI: 0.74-0.87) with I²=90%, P-value < 0.01, and lower CSM (HR: 0.74; 95% CI: 0.67-0.82) with I²=88%, P-value < 0.01 when compared to non-users. Both pre- and post-diagnostic statin use were linked to lower ACM and CSM, though high heterogeneity was observed across studies. However, the results for statin use on RFS indicated an HR of 1.01 with 95% CI of 0.94 to 1.09 (I² = 0% and P-value = 0.93). Additionally, for DFS, the HR was 0.93 (95% CI: 0.85-1.01) with I² = 47%, suggesting no meaningful effect of statin use on DFS. No significant publication bias was found.
Conclusion: Statin use was associated with a reduction in ACM and CSM in CRC patients. However, the variances in RFS and DFS were not statistically significant. However, these findings should be interpreted cautiously due to substantial heterogeneity among some included studies.
背景：考虑他汀类药物对结直肠癌（CRC）死亡率的潜在保护作用的证据是有争议的。本研究旨在系统评价他汀类药物对结直肠癌患者生存率的影响。方法：在Scopus、PubMed和Web of Science中进行综合检索，评估他汀类药物消费与癌症特异性死亡率（CSM）、全因死亡率（ACM）、无病生存期（DFS）和无复发生存期（RFS）之间的关系。进行亚组分析以评估按国家、研究设计、疾病分期、使用时间、结直肠癌和治疗类型分层的数据，因为这些数据具有高度异质性。结果：纳入32项研究；meta分析的数据来自24篇文章。他汀类药物改善CRC预后，特别是在低ACM (HR: 0.80; 95% CI: 0.74-0.87), I²=90%，p值结论：他汀类药物的使用与CRC患者ACM和CSM的减少有关。然而，RFS和DFS的差异无统计学意义。然而，这些发现应谨慎解释，因为在一些纳入的研究中存在很大的异质性。
{"title":"The impact of statin use on colorectal cancer prognosis: a systematic review and meta-analysis.","authors":"Iman Elahi Vahed, Amir Mohammad Rishialiabad, Fatemeh Moeinaddini, Amir Hosein Shabani, Asal Kazemzadeh, Mojtaba Esmaeeli, Mostafa Neshat Ghalibaf, Mahdiyeh Nozad Varjovi, Maryam Shirmohamadi, Mohaddese Heydari, Parsa Tavassoli Naini, Mohammadsadegh Jafari, Alireza Gholami, Hossein Soltaninejad, Mohammad Rahmanian","doi":"10.1186/s12876-025-04398-6","DOIUrl":"https://doi.org/10.1186/s12876-025-04398-6","url":null,"abstract":"<p><strong>Background: </strong>The evidence considering the potential protective impact of statins on the mortality rate caused by colorectal cancer (CRC) is controversial. This study aimed to systematically assess the effect of statins on the survival rate of CRC patients.</p><p><strong>Methods: </strong>A comprehensive search was conducted in Scopus, PubMed, and Web of Science to assess the relationship between statin consumption and cancer-specific mortality (CSM), all-cause mortality (ACM), disease-free survival (DFS), and recurrence-free survival (RFS). Subgroup analyses were performed to assess data stratified by country, study design, disease stage, time to use, CRC, and treatment type due to high heterogeneity.</p><p><strong>Results: </strong>Thirty-two studies were included; the data of 24 articles composed the meta-analysis. Statins improved prognosis of CRC, particularly in lower ACM (HR: 0.80; 95% CI: 0.74-0.87) with I²=90%, P-value < 0.01, and lower CSM (HR: 0.74; 95% CI: 0.67-0.82) with I²=88%, P-value < 0.01 when compared to non-users. Both pre- and post-diagnostic statin use were linked to lower ACM and CSM, though high heterogeneity was observed across studies. However, the results for statin use on RFS indicated an HR of 1.01 with 95% CI of 0.94 to 1.09 (I² = 0% and P-value = 0.93). Additionally, for DFS, the HR was 0.93 (95% CI: 0.85-1.01) with I² = 47%, suggesting no meaningful effect of statin use on DFS. No significant publication bias was found.</p><p><strong>Conclusion: </strong>Statin use was associated with a reduction in ACM and CSM in CRC patients. However, the variances in RFS and DFS were not statistically significant. However, these findings should be interpreted cautiously due to substantial heterogeneity among some included studies.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut microbiota dysbiosis and hepatic inflammation in morphine dependence and withdrawal: insights from a rat model.","authors":"Shirin Yousefi, Mahsa Sadeghi-Adl, Samira Tarashi, Seyed Davar Siadat","doi":"10.1186/s12876-026-04669-w","DOIUrl":"10.1186/s12876-026-04669-w","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1186/s12876-026-04661-4
Min Liu, Yajing Sun, Shoufeng Wang, Zhongmin Jiang
{"title":"Primary small intestine angiofibroma of soft tissue (AFST) with intussusception: an extremely rare case report and review of literature.","authors":"Min Liu, Yajing Sun, Shoufeng Wang, Zhongmin Jiang","doi":"10.1186/s12876-026-04661-4","DOIUrl":"10.1186/s12876-026-04661-4","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1186/s12876-025-04250-x
Liping Wu, Min You, Jie Cheng, Xiang Wang, Yayu Wang, Ting Wang, Dajin Li, Manman Chen, Zixuan Ye, MengMeng Zhou, PanPan Ding
{"title":"A meta-analysis of the safety and efficacy of 2 L versus 3 L polyethylene glycol in bowel preparation for colonoscopy.","authors":"Liping Wu, Min You, Jie Cheng, Xiang Wang, Yayu Wang, Ting Wang, Dajin Li, Manman Chen, Zixuan Ye, MengMeng Zhou, PanPan Ding","doi":"10.1186/s12876-025-04250-x","DOIUrl":"10.1186/s12876-025-04250-x","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"26 1","pages":"103"},"PeriodicalIF":2.5,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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