Pub Date : 2014-01-01DOI: 10.5455/JIHP.20140612073245
G. Vasudevan, A. Shivamurthy
Low grade fibromyxoid sarcoma (LGFMS) is an indolent, rare soft tissue tumor having potential of late metastasis, but high local recurrence rate despite its low grade histologic findings. The morphologic diagnosis may be challenging, owing to its typically low cellularity, abundant collagen, and relatively bland cytology. We present here a rare case report of a mesenteric mass in an elderly male. The mass was excised. On microscopy, the tumor was composed of sweeping fascicles of spindle cells, which were positive for vimentin and negative for CD117, CD34, smooth muscle antigen and S-100. Herein we report a rare, under recognized case of LGFMS arising in the mesentery.
{"title":"Low Grade Fibromyxoid Sarcoma of the Mesentery, an Under Recognised Entity: A Case Report -","authors":"G. Vasudevan, A. Shivamurthy","doi":"10.5455/JIHP.20140612073245","DOIUrl":"https://doi.org/10.5455/JIHP.20140612073245","url":null,"abstract":"Low grade fibromyxoid sarcoma (LGFMS) is an indolent, rare soft tissue tumor having potential of late metastasis, but high local recurrence rate despite its low grade histologic findings. The morphologic diagnosis may be challenging, owing to its typically low cellularity, abundant collagen, and relatively bland cytology. We present here a rare case report of a mesenteric mass in an elderly male. The mass was excised. On microscopy, the tumor was composed of sweeping fascicles of spindle cells, which were positive for vimentin and negative for CD117, CD34, smooth muscle antigen and S-100. Herein we report a rare, under recognized case of LGFMS arising in the mesentery.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"228-231"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/JIHP.20130219073819
M. Mathew, B. Nayal, Raghunath Narayanan Unni, C. Balachandran
Papuloerythroderma of Ofuji (PEO) is an uncommon skin condition characterized by generalized itchy papular eruptions involving the entire body surface, sparing the major skin folds in the body along with peripheral eosinophilia often asssociated with an malignancy, infection or drug therapy. It usually affects the elderly and very few cases have been reported in young adults. We report a 31 year old male with PEO in the absence of an underlying inciting factor.
{"title":"Papuloerythroderma of Ofuji in a young adult","authors":"M. Mathew, B. Nayal, Raghunath Narayanan Unni, C. Balachandran","doi":"10.5455/JIHP.20130219073819","DOIUrl":"https://doi.org/10.5455/JIHP.20130219073819","url":null,"abstract":"Papuloerythroderma of Ofuji (PEO) is an uncommon skin condition characterized by generalized itchy papular eruptions involving the entire body surface, sparing the major skin folds in the body along with peripheral eosinophilia often asssociated with an malignancy, infection or drug therapy. It usually affects the elderly and very few cases have been reported in young adults. We report a 31 year old male with PEO in the absence of an underlying inciting factor.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"38-40"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/JIHP.20140312060341
A. Ozcan, N. Yigit, O. Onguru, Bilal Fırat Alp, Ş. Ozaydin
Objective: The differential diagnosis of renal tumors can be problematic due to overlapping morphologic features. The purpose of this study was to assess the potential contribution of survivin expression in the differential diagnosis and determination of therapy modalities of these tumors. Methods: This study consisted of 15 chromophobe (ChRCC), 15 clear cell (CCRCC) and 9 papillary (PRCC) renal cell carcinomas, and 13 oncocytomas. Sections were stained against survivin antibody. Results: PRCCs and CCRCCs showed diffuse and strong survivin expression. Survivin expression was strikingly prominent in type1 PRCCs and cystic CCRCCs. In CCRCCs, survivin expression was more pronounced in low grade areas than high grade and sarcomatoid areas. In ChRCC, survivin expression was more limited and weaker than that of oncocytomas and other malignant renal tumors. In non-neoplastic renal tissue, survivin expression was more pronounced in podocytes and atrophic tubules than other nephron parts. Conclusions: Our results suggested that survivin may helpful in the differential diagnosis of renal tumors despite limited number of our cases. Experimental studies have revealed that inhibition of survivin induces apoptosis and enhance radiosensitivity of RCC cells. Taken together, to be known the proportion of survivin expression in subtypes of renal tumors may contribute to determine new therapeutic strategies for RCCs. This needs to be proven in more wide series.
{"title":"Survivin Expression in Renal Epithelial Tumors: It’s Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors -","authors":"A. Ozcan, N. Yigit, O. Onguru, Bilal Fırat Alp, Ş. Ozaydin","doi":"10.5455/JIHP.20140312060341","DOIUrl":"https://doi.org/10.5455/JIHP.20140312060341","url":null,"abstract":"Objective: The differential diagnosis of renal tumors can be problematic due to overlapping morphologic features. The purpose of this study was to assess the potential contribution of survivin expression in the differential diagnosis and determination of therapy modalities of these tumors. Methods: This study consisted of 15 chromophobe (ChRCC), 15 clear cell (CCRCC) and 9 papillary (PRCC) renal cell carcinomas, and 13 oncocytomas. Sections were stained against survivin antibody. Results: PRCCs and CCRCCs showed diffuse and strong survivin expression. Survivin expression was strikingly prominent in type1 PRCCs and cystic CCRCCs. In CCRCCs, survivin expression was more pronounced in low grade areas than high grade and sarcomatoid areas. In ChRCC, survivin expression was more limited and weaker than that of oncocytomas and other malignant renal tumors. In non-neoplastic renal tissue, survivin expression was more pronounced in podocytes and atrophic tubules than other nephron parts. Conclusions: Our results suggested that survivin may helpful in the differential diagnosis of renal tumors despite limited number of our cases. Experimental studies have revealed that inhibition of survivin induces apoptosis and enhance radiosensitivity of RCC cells. Taken together, to be known the proportion of survivin expression in subtypes of renal tumors may contribute to determine new therapeutic strategies for RCCs. This needs to be proven in more wide series.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/jihp.20140528113359
Nandeesh Bn, K. Das
Solid-pseudopapillary neoplasm of the pancreas (SPPNP) is a primary epithelial neoplasm of the exocrine pancreas with borderline malignant potential. The unusual features included the ‘giant’ size and the absence of metastases/ capsular or vascular invasion despite the large size and predominantly solid nature. At two years following complete excision, she is asymptomatic and the imaging shows no recurrence/metastases.
{"title":"Giant Solid-Pseudopapillary Neoplasm of the Pancreas in a Child","authors":"Nandeesh Bn, K. Das","doi":"10.5455/jihp.20140528113359","DOIUrl":"https://doi.org/10.5455/jihp.20140528113359","url":null,"abstract":"Solid-pseudopapillary neoplasm of the pancreas (SPPNP) is a primary epithelial neoplasm of the exocrine pancreas with borderline malignant potential. The unusual features included the ‘giant’ size and the absence of metastases/ capsular or vascular invasion despite the large size and predominantly solid nature. At two years following complete excision, she is asymptomatic and the imaging shows no recurrence/metastases.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"167-172"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The mast cell remains an enigmatic cell, found resident in tissues throughout the body particularly in association with structures such as blood vessels and nerves. Various inflammatory disorders of the intestines, joints and lungs appear to be associated with an increase in mast cell numbers. The study was conducted on vermiform appendix. The present study was undertaken (1) to compare the mast cell and eosinophil counts in various layers of the appendix in various histopathological groups, and (2) to establish the relationship between the numbers of eosinophils and mast cells in the inflamed appendix. Materials and Methods: The material for study consisted of appendix specimens received for histopathological examination in the Department of pathology. A 5 year study was conducted, 3 years retrospective and 2 years prospective. Results: Out of 777 cases studied the incidence of appendicitis is high, in the first and second decades of life and slightly higher in females. Recurrent appendicitis was more common when compared to other inflamed appendices. Conclusions: Eosinophil counts in all the layers were very high in acute eosinophilic appendicitis compared to normal appendices. A higher mast cell count was seen in acute eosinophilic appendicitis and recurrent appendicitis. No correlation was found between mast cell and eosinophilic density. Our observations support the allergic theory of appendicitis rather than the obstructive theory.
{"title":"The Significance of Mast Cells and Eosinophils Counts in Surgically Resected Appendix","authors":"Ashwini Kolur, Ashok M. Patil, Vaibhav Agarwal, Saeed Yendigiri, Bb Sajjanar","doi":"10.5455/JIHP.20140512102819","DOIUrl":"https://doi.org/10.5455/JIHP.20140512102819","url":null,"abstract":"Objectives: The mast cell remains an enigmatic cell, found resident in tissues throughout the body particularly in association with structures such as blood vessels and nerves. Various inflammatory disorders of the intestines, joints and lungs appear to be associated with an increase in mast cell numbers. The study was conducted on vermiform appendix. The present study was undertaken (1) to compare the mast cell and eosinophil counts in various layers of the appendix in various histopathological groups, and (2) to establish the relationship between the numbers of eosinophils and mast cells in the inflamed appendix. Materials and Methods: The material for study consisted of appendix specimens received for histopathological examination in the Department of pathology. A 5 year study was conducted, 3 years retrospective and 2 years prospective. Results: Out of 777 cases studied the incidence of appendicitis is high, in the first and second decades of life and slightly higher in females. Recurrent appendicitis was more common when compared to other inflamed appendices. Conclusions: Eosinophil counts in all the layers were very high in acute eosinophilic appendicitis compared to normal appendices. A higher mast cell count was seen in acute eosinophilic appendicitis and recurrent appendicitis. No correlation was found between mast cell and eosinophilic density. Our observations support the allergic theory of appendicitis rather than the obstructive theory.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"150-153"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/JIHP.20131202062446
B. Bommanahalli, S. P., L. Patil
ABSTRACT A 55-year-old female presented with ulcerated swelling over the scalp. Clinically, the case was diagnosed as adnexal tumor of skin. Fine needle aspiration cytology (FNAC) from the lesion showed characteristic micro-follicles with typical nuclear features of papillary thyroid carcinoma. Later, diligent clinical examination revealed a small thyroid nodule and FNAC from the same, showed similar cytomorphological features, indicating possibility of follicular variant of papillary thyroid carcinoma. Biopsy of the scalp swelling and thyroid nodule confirmed the same. Identification of typical nuclear features in cytology helps in differentiating follicular variant papillary carcinoma from follicular neoplasms and, predominant presence of microfollicles favour follicular variant of papillary thyroid carcinoma (FVPTC). Spread through lymphatic route is common in papillary thyroid carcinoma but haematogenous dissemination leading to cutaneous metastases is rare. A solitary cutaneous lesion may be the first evidence of disseminated malignancy in a patient with occult papillary thyroid carcinoma. KEY WORDS: Follicular variant; Papillary thyroid carcinoma; Fine Needle Aspiration Cytology; Adnexal tumor
{"title":"Metastasis of Follicular Variant of Papillary Thyroid Carcinoma to Scalp, Masquerading As Adnexal Tumor: A Rare Presentation","authors":"B. Bommanahalli, S. P., L. Patil","doi":"10.5455/JIHP.20131202062446","DOIUrl":"https://doi.org/10.5455/JIHP.20131202062446","url":null,"abstract":"ABSTRACT A 55-year-old female presented with ulcerated swelling over the scalp. Clinically, the case was diagnosed as adnexal tumor of skin. Fine needle aspiration cytology (FNAC) from the lesion showed characteristic micro-follicles with typical nuclear features of papillary thyroid carcinoma. Later, diligent clinical examination revealed a small thyroid nodule and FNAC from the same, showed similar cytomorphological features, indicating possibility of follicular variant of papillary thyroid carcinoma. Biopsy of the scalp swelling and thyroid nodule confirmed the same. Identification of typical nuclear features in cytology helps in differentiating follicular variant papillary carcinoma from follicular neoplasms and, predominant presence of microfollicles favour follicular variant of papillary thyroid carcinoma (FVPTC). Spread through lymphatic route is common in papillary thyroid carcinoma but haematogenous dissemination leading to cutaneous metastases is rare. A solitary cutaneous lesion may be the first evidence of disseminated malignancy in a patient with occult papillary thyroid carcinoma. KEY WORDS: Follicular variant; Papillary thyroid carcinoma; Fine Needle Aspiration Cytology; Adnexal tumor","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"46 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/JIHP.20140305101625
S. Savvidou, A. Gagalis, I. Efstratiou, A. Kalambakas
The indisputable hepatotoxicity of anabolic androgen steroids has already been well substantiated in the literature, eventhough the exact pathophysiologic mechanisms are still being elucidated. Androgen-induced liver injury presents primarily with acute intrahepatic cholestasis accompanied by markedly elevated cholestatic enzymes and diverse levels of aminotransferases. A case report of a young male with remarkable jaundice due to acute anabolic androgeninduced cholestasis is presented. Interestingly, γ-glutamyl transpeptidase remained normal throughout the patient’s diagnostic workup. Histopathology was indicative of pure, “bland” intrahepatic cholestasis with minimal inflammation but significant fibrosis. The patient was successfully treated with ursodeoxycholic acid and glucocorticosteroids. The significance of normal γ-glutamyl transpeptidase along with the histopathological findings and the possible pathophysiological mechanisms are finally discussed.
{"title":"Anabolic Androgen-induced Intrahepatic Cholestasis Presented With Normal γ-Glutamyl-Transpeptidase","authors":"S. Savvidou, A. Gagalis, I. Efstratiou, A. Kalambakas","doi":"10.5455/JIHP.20140305101625","DOIUrl":"https://doi.org/10.5455/JIHP.20140305101625","url":null,"abstract":"The indisputable hepatotoxicity of anabolic androgen steroids has already been well substantiated in the literature, eventhough the exact pathophysiologic mechanisms are still being elucidated. Androgen-induced liver injury presents primarily with acute intrahepatic cholestasis accompanied by markedly elevated cholestatic enzymes and diverse levels of aminotransferases. A case report of a young male with remarkable jaundice due to acute anabolic androgeninduced cholestasis is presented. Interestingly, γ-glutamyl transpeptidase remained normal throughout the patient’s diagnostic workup. Histopathology was indicative of pure, “bland” intrahepatic cholestasis with minimal inflammation but significant fibrosis. The patient was successfully treated with ursodeoxycholic acid and glucocorticosteroids. The significance of normal γ-glutamyl transpeptidase along with the histopathological findings and the possible pathophysiological mechanisms are finally discussed.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"53 1","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/JIHP.20140130125547
H. Hashish
{"title":"Histopathologic Effect of Prenatal Topiramate Exposure on Rat Cerebral Cortex and Hippocampus","authors":"H. Hashish","doi":"10.5455/JIHP.20140130125547","DOIUrl":"https://doi.org/10.5455/JIHP.20140130125547","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5455/JIHP.20140130125547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/JIHP.20140225013612
S. Krishnamurthy, Kavita Gu, S. Ali, Nagaraj Parvatappa
Congenital melanocytic nevi are defined as benign nevomelanocytic proliferation present at birth. They are rare lesions and occur in approximately 1% of new-borns and are usually classified according to their size. We report a case of 32 year old female who presented with a giant cerebriform lesion of the scalp which was present since birth. Diagnosis of Giant congenital melanocytic nevi was made on the basis of definite histological criteria. Wide excision of the lesion was done with split skin graft. This case is unique due to the fact that this young female lived with this disfiguring lesion for 3 decades and never consulted any physician for cosmetic purpose and fortunately the lesion never turned malignant.
{"title":"Giant Congenital Cerebriform Melanocytic Nevus of the Scalp in Adult","authors":"S. Krishnamurthy, Kavita Gu, S. Ali, Nagaraj Parvatappa","doi":"10.5455/JIHP.20140225013612","DOIUrl":"https://doi.org/10.5455/JIHP.20140225013612","url":null,"abstract":"Congenital melanocytic nevi are defined as benign nevomelanocytic proliferation present at birth. They are rare lesions and occur in approximately 1% of new-borns and are usually classified according to their size. We report a case of 32 year old female who presented with a giant cerebriform lesion of the scalp which was present since birth. Diagnosis of Giant congenital melanocytic nevi was made on the basis of definite histological criteria. Wide excision of the lesion was done with split skin graft. This case is unique due to the fact that this young female lived with this disfiguring lesion for 3 decades and never consulted any physician for cosmetic purpose and fortunately the lesion never turned malignant.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"108-111"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.5455/jihp.20130528053607
F. Limaiem, F. Gargouri, I. Haddad, S. Bouraoui, A. Lahmar, S. Mzabi-Regaya
Biliary hamartomas or von Meyenburg complexes are uncommon benign biliary malformations, which are considered as part of the spectrum of fibrocystic diseases of the liver due to ductal plate malformation. Development of intrahepatic cholangiocarcinoma is well described in these complexes. However, only 10 cases of hepatocellular carcinoma arising in association with von Meyenburg complexes have been described in the English-language literature to date. In this paper, the authors report a peculiar case of hepatocellular carcinoma occurring on a background of von-Meyenburg's complexes and solitary unilocular bile duct cyst. It is not clear whether development of hepatocellular carcinomas is an epiphenomenon unrelated to the precursor lesion or biliary hamartomas may progress to liver cancers. Further studies are mandatory so as to elucidate and consolidate this very rare association.
{"title":"A Rare Association of Multiple Hepatic Lesions: Case Report and Literature Review -","authors":"F. Limaiem, F. Gargouri, I. Haddad, S. Bouraoui, A. Lahmar, S. Mzabi-Regaya","doi":"10.5455/jihp.20130528053607","DOIUrl":"https://doi.org/10.5455/jihp.20130528053607","url":null,"abstract":"Biliary hamartomas or von Meyenburg complexes are uncommon benign biliary malformations, which are considered as part of the spectrum of fibrocystic diseases of the liver due to ductal plate malformation. Development of intrahepatic cholangiocarcinoma is well described in these complexes. However, only 10 cases of hepatocellular carcinoma arising in association with von Meyenburg complexes have been described in the English-language literature to date. In this paper, the authors report a peculiar case of hepatocellular carcinoma occurring on a background of von-Meyenburg's complexes and solitary unilocular bile duct cyst. It is not clear whether development of hepatocellular carcinomas is an epiphenomenon unrelated to the precursor lesion or biliary hamartomas may progress to liver cancers. Further studies are mandatory so as to elucidate and consolidate this very rare association.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"2 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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