Journal of interdisciplinary histopathology最新文献

{"title":"On The Use of Human Tissues in Research and Practice","authors":"Sergei V. Jargin","doi":"10.5455/JIHP.20160607021524","DOIUrl":"https://doi.org/10.5455/JIHP.20160607021524","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"29 1","pages":"46-47"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary mesenteric carcinoid tumor","authors":"Swati Aggarwal, Shubham Agarwal, D. Ramrakhiani","doi":"10.5455/JIHP.20160116101011","DOIUrl":"https://doi.org/10.5455/JIHP.20160116101011","url":null,"abstract":"Mesenteric tumors are uncommon lesions. Primary mesenteric carcinoid is a rare entity with only a few reported cases. Therefore, a thorough examination of the resected bowel is necessary to rule out the presence of possible primary tumor in the adjacent bowel loop. We present a case of primary mesenteric carcinoid.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"21 1","pages":"23-25"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiotherapy-Induced Ovarian Sarcoma Following the Treatment of Cervical Cancer: Exceptional Case Report and Review of the Literature -","authors":"M. Ayadi, O. E. A. Hadj, I. Zemni, H. Bouzaiene, J. B. Hassouna, A. Gamoudi, K. Rahal","doi":"10.5455/JIHP.20160603121249","DOIUrl":"https://doi.org/10.5455/JIHP.20160603121249","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"107-109"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmablastic Lymphoma: A Report of 2 Cases with Review of Literature. -","authors":"G. Vasudevan, B. Singh, Arijit Bishnu, A. Kulshreshta","doi":"10.5455/jihp.20160629113215","DOIUrl":"https://doi.org/10.5455/jihp.20160629113215","url":null,"abstract":"Plasmablastic lymphoma (PBL) is an aggressive subtype of Non-Hodgkin Lymphoma (NHL) initially described in extra-nodal sites in an immunocompromised and later in immune-competent patients. PBL remains a diagnostic challenge due to morphological overlap with various other entities and also due to similarities on immunohistochemistry with plasma cell myeloma. In-spite of therapeutic advances, PBL remains an aggressive disease with high fatality rate. We describe 2 cases of this uncommon neoplasm; both in immunocompromised patients.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue -","authors":"J. Menczer, L. Schreiber, E. Berger, T. Levy","doi":"10.5455/JIHP.20150923115314","DOIUrl":"https://doi.org/10.5455/JIHP.20150923115314","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Epithelioid Angiosarcoma of the Adrenal Gland: Report of a Case and Review of the Literature -","authors":"M. Ayadi, Nadia Boujelben, R. Doghri, Mouna Rezgani, I. Abbès, M. Driss, R. Chargui, K. Mrad, K. Rahal","doi":"10.5455/JIHP.20160607021215","DOIUrl":"https://doi.org/10.5455/JIHP.20160607021215","url":null,"abstract":"Primary mesenchymal neoplasms of the adrenal gland are extremely rare. The most common primary sarcoma is adrenal angiosarcoma. We report the case of a 51-year-old patient who presented with left flank pain. After ultrasound investigations, the patient underwent surgical removal of an adrenal tumor. The gross adrenal specimen showed extensive cystic changes with old hemorrhage and necrosis. Histologically, irregular branching vascular channels were seen intermixed with solid areas of epithelioid cells. Immunohistochemical staining of tumor cells was positive with antibodies to cytokeratin and CD31. After a 12 months follow-up, the patient is still well with no sign of a relapse. Because of the epithelioid appearance and frequent expression of epithelial immunohistochemical markers, primary epithelioid angiosarcoma of the adrenal gland can be confounded with adrenal carcinomatous metastases. We report our findings with a brief literature review and discussion of differential diagnosis.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"14 1","pages":"67-69"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of BerEp4 and Cytokeratin 19 Expressions in Epithelial Tumors of Kidney and Renal Pelvis","authors":"A. Ozcan, I. Yavan, Melih Kılınç, S. Uğuz, Ş. Ozaydin","doi":"10.5455/JIHP.20160926120648","DOIUrl":"https://doi.org/10.5455/JIHP.20160926120648","url":null,"abstract":"Objective: The differential diagnosis in the epithelial tumors of kidney and renal pelvis can be problematic due to their overlapping morphologic features. This is much more complicated in some conditions, such as renal oncocytoma (RO) vs chromophobe renal cell carcinoma (ChRCC) and renal cell carcinoma (RCC) vs urothelial carcinoma of renal pelvis (UC-RP). The purpose of this study was to assess potential contributions of BerEP4 and cytokeratin 19 (CK19) expressions in the differential diagnosis of these challenging cases. Methods: A total 57 cases consisted of 11 chromophobe (ChRCC), 18 clear cell (CCRCC), 12 papillary (PRCC), and 2 unclassified RCCs, 1 multilocular cystic renal cell neoplasm (MCRCN) with low malignant potential, 7 UC-RP, and 6 renal oncocytomas (RO) were stained against BerEp4 and CK19 antibodies using automated immunostainer. Results: All ROs demonstrated membranous BerEP4 expression, but no CK19 expression. Unlike ROs, most ChRCCs exhibited diffuse and strong CK19 expression, but no or focal and weak BerEP4 expression. This distinctive opposite expression pattern was highlighted in hybrid oncocytic chromophobe tumor (HOCT). CCRCCs showed highly variable expression patterns for both markers. PRCC type 1 tumors demonstrated diffuse and strong BerEp4 and CK19 expressions. PRCC type 2 exhibited BerEP4 and CK19 expressions, but their expressions were focal and weaker than for PRCC type 1. MCRCN demonstrated diffuse and strong BerEP4 expression, but no expression for CK19 unlike cystic CCRCC, which is strongly positive for both markers. Epithelioid cells in unclassified RCC showed strong CK19 and weak BerEP4 expression, whereas spindle cells in the tumor did not express CK19 and BerEp4 or exhibited scattered and weak expressions. UC-RP showed diffuse and strong CK19 expression, but no or scattered BerEP4expression was seen in the tumor. We also evaluated CK19 and BerEP4 expression in non-neoplastic adjacent kidney and renal pelvis. Conclusion: This study revealed that 1) BerEP4 and CK19 exhibit variable and distinctive immunoprofiles in epithelial tumors of kidney and renal pelvis, 2) an immunoprofile of BerEP4 (+)/CK19 (-) favors RO in contrast to an opposite profile for ChRCC, 3) The heterogeneous expressions of BerEP4 and CK19 in low grade RCC with eosinophilic cytoplasm favors HOCT, 4) PRCC type 1 strongly express both biomarkers, and 5) although RCC subtypes express CK19 in a variable proportion and intensity, diffuse and strong CK19 expression favors UC-RP.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirenomelia – Mermaid Syndrome with Oesophageal Atresia: A Rare Case Report -","authors":"V. Raja, Vidyavathi Kannar, C. S. B. R. Prasad","doi":"10.5455/JIHP.20150711023253","DOIUrl":"https://doi.org/10.5455/JIHP.20150711023253","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"113-116"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update) -","authors":"A. Ozcan","doi":"10.5455/jihp.20150930030440","DOIUrl":"https://doi.org/10.5455/jihp.20150930030440","url":null,"abstract":"Renal cell carcinoma (RCC) is the third most common cancer of the genitourinary tract and accounts for approximately 2-3% of all cancer deaths. The recent classification of renal tumors, The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia, has been proposed new distinct epithelial tumors and provisional new entities. Although most renal tumors are morphologically diagnosed, they need to use a panel of immunomarkers due to their overlapping morphologic features in some cases such as benign mimickers and newly emerged tumor types. Overlapping morphologic features are especially complicated in small biopsies and in distinguishing metastatic RCCs from other tumors. Immunohistochemistry is still more useful in renal tumors than non-renal tumors. A wide panel has been performed in the differential diagnosis of renal tumors. If immunohistochemical results are conflict or unconvincing, a diagnosis of unclassified RCC is appropriate. For accurate diagnosis of RCC, it should be careful in performing immunohistochemistry on needle biopsy due to variable expressions of immunomarkers originated from heterogeneity in RCCs. Morphology is still gold standard, but immunohistochemistry should be kept in mind as a useful and supportive diagnostic tool upon morphological features of renal tumors as always.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"32 1","pages":"81-101"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat","authors":"N. El-sherif, N. Issa","doi":"10.5455/JIHP.20150213020636","DOIUrl":"https://doi.org/10.5455/JIHP.20150213020636","url":null,"abstract":"Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. \u0000Materials and Methods: 25 animals were divided into three groups: Group I (Control group), Group II (NA treated group) received NA at a dose of 200 mg/kg/day dissolved in 5 ml/kg corn oil orally by gastric tube, Group III (protected group) received rosemary extract (10 ml/kg/day) followed after 60 min by NA at the same previous dose orally by gastric tube. The experiment lasted 30 days. The following parameters were studied: Biochemical assessment of renal function, histological, immunohistochemical, morphometric studies and statistical analysis of the results. \u0000Results: NA treatment resulted in a highly significant increase in the mean values of serum urea and creatinine. NA induced histological changes in the form of glomerular congestion. Some glomeruli demonstrated marked mesangial expansion and hence that Bowman’s spaces were almost completely obliterated. Shrinkage of renal glomeruli with widening of Bowman’s spaces could also be seen. Focal tubular dilatation with appearance of casts inside the tubules was observed. Congested peritubular blood vessels and interstitial hemorrhage were also seen. The medullary region demonstrated vascular congestion and fibrosis. Focal cellular infiltration was presented in the interstitium. The renal cortex of NA treated rats showed a noticeable down regulation in alkaline phosphatase positive immunoreactive cells in some proximal convoluted tubules. NA induced up regulation of positive immunoreaction for inducible nitric oxide synthase in the proximal and distal convoluted tubules as well as in the collecting tubules. All previous results were significantly reversed in the protected group compared with NA treated group. \u0000Conclusions: It is concluded that NA has a harmful effect on rat kidney. Rosemary extract had a protective role against renal injury induced by NA and this effect may be attributed to its antioxidant and anti-inflammatory activity.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}