Pub Date : 2016-01-01DOI: 10.5455/jihp.20160531122129
O. E. Amine, Leila Bouhaja, I. Chaar, A. Goucha, A. May, A. Gammoudi
{"title":"Pleomorphic Lobular Carcinoma of the Breast: Clinicopathological Analysis of a Distinctive and Rare Variant of Lobular Carcinoma","authors":"O. E. Amine, Leila Bouhaja, I. Chaar, A. Goucha, A. May, A. Gammoudi","doi":"10.5455/jihp.20160531122129","DOIUrl":"https://doi.org/10.5455/jihp.20160531122129","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"104-106"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160706103059
Lucas Giglio Colli, M. C. Santos, Jéssica Tambor, I. C. C. Camargo
{"title":"The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats -","authors":"Lucas Giglio Colli, M. C. Santos, Jéssica Tambor, I. C. C. Camargo","doi":"10.5455/JIHP.20160706103059","DOIUrl":"https://doi.org/10.5455/JIHP.20160706103059","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160420021353
Aziza E. Abdelrahman, H. Abdel-aziz, Abdelmonem Awad Hegazy, A. Mohamed
Background: Identification of the cellular origin of astrocytic gliomas is a step for improving the treatment strategies. Tumor stem cells have been detected in different neoplasms and have a major role in tumor initiation, progression and therapy resistance. Objective: The study aimed to investigate the expression of nestin and survivin in different grades of astrocytic glioma as well as evaluation of their prognostic role in relation to other prognostic parameters. Methods: Immunohistochemical expressions of nestin and survivin were evaluated in 40 paraffin blocks of different grades of astrocytic glioma and correlated with other prognostic parameters. The obtained data were statistically analyzed. Results: The cases included 10 low grade, 12 anaplastic and 18 glioblastoma multiforme. There was a significant correlation between each of nestin and survivin with the histological grade of astrocytoma and tumor size (p < 0.001). Nestin was strongly correlated to survivin index (p < 0.001). The univariate analysis showed that high histological grade, high nestin score and high survivin index were significantly correlated with overall survival. Multivariate analysis for all investigated cases proved the independent prognostic significance of the nestin expression (p = 0.011). Conclusion: Nestin and survivin are adverse prognostic markers for astrocytic glioma that increase significantly with tumor progression and associated with poor overall survival. Therefore, nestin and survivin could be used to predict high risk group of astrocytoma with unfavorable outcome.
{"title":"Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma","authors":"Aziza E. Abdelrahman, H. Abdel-aziz, Abdelmonem Awad Hegazy, A. Mohamed","doi":"10.5455/JIHP.20160420021353","DOIUrl":"https://doi.org/10.5455/JIHP.20160420021353","url":null,"abstract":"Background: Identification of the cellular origin of astrocytic gliomas is a step for improving the treatment strategies. Tumor stem cells have been detected in different neoplasms and have a major role in tumor initiation, progression and therapy resistance. Objective: The study aimed to investigate the expression of nestin and survivin in different grades of astrocytic glioma as well as evaluation of their prognostic role in relation to other prognostic parameters. Methods: Immunohistochemical expressions of nestin and survivin were evaluated in 40 paraffin blocks of different grades of astrocytic glioma and correlated with other prognostic parameters. The obtained data were statistically analyzed. Results: The cases included 10 low grade, 12 anaplastic and 18 glioblastoma multiforme. There was a significant correlation between each of nestin and survivin with the histological grade of astrocytoma and tumor size (p < 0.001). Nestin was strongly correlated to survivin index (p < 0.001). The univariate analysis showed that high histological grade, high nestin score and high survivin index were significantly correlated with overall survival. Multivariate analysis for all investigated cases proved the independent prognostic significance of the nestin expression (p = 0.011). Conclusion: Nestin and survivin are adverse prognostic markers for astrocytic glioma that increase significantly with tumor progression and associated with poor overall survival. Therefore, nestin and survivin could be used to predict high risk group of astrocytoma with unfavorable outcome.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/jihp.20160823075838
V. Bartoš, Milada Kullová
{"title":"Immunohistochemical Expression of P53 Protein in Cutaneous Basal Cell Carcinoma: A Clinicopathological Study of 66 Cases -","authors":"V. Bartoš, Milada Kullová","doi":"10.5455/jihp.20160823075838","DOIUrl":"https://doi.org/10.5455/jihp.20160823075838","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20151125081952
K. Patrick-Iwuanyanwu, N. A. Udowelle, C. Okereke
Background: Permethrin is widely used as a pesticide in agriculture, homes, gardens, and for treatment of ectoparasites such as fleas, lice, and scabies on human and animals. The aim of the present study was to evaluate the testicular toxicity and sperm quality of adult male Wistar albino rats exposed to Solignum® (SOL), a commercial permethrin-containing wood preservative. Materials and Methods: A total number of 32 adult male Wistar albino rats were divided into four groups of eight rats per group. SOL mixed with olive oil (1:1) was orally administered to rats daily at concentrations of 100, 200, and 400 mg/kg for 28 days while the control received 1 ml of olive oil only. At the end of this study, animals were sacrificed and testes excised, weighed, and processed for histological examination. Results: Rats treated with SOL showed a significant (P ≤ 0.05) decrease in body weight ranging from 127.30 ± 5.95 to 84.50 ± 15.37 g as compared with control group (138.50 ± 6.7 g). Absolute testicular weight, relative testicular weight, and epididymis together with testes decreased significantly (P ≤ 0.05) in treated rats ranging from 0.63 ± 0.44 to 0.22 ± 0.18; 0.49 ± 7.39 to 0.26 ± 1.17, and 1.07 ± 0.75 to 0.37 ± 0.19, respectively, when compared with control groups (0.89 ± 0.27; 0.64 ± 4.00; and 1.40 ± 0.35) for absolute testicular weight, relative testicular weight, and epididymis together with testes, respectively after 28 days. However, there was a significant (P ≤ 0.05) decrease in sperm count, sperm motility, sperm morphology, and sperm viability, whereas sperm debris increased significantly (P ≤ 0.05) in a dose-dependent manner when compared with control group. Furthermore, histological examination of the testes indicated that rats exposed to SOL were characterized by significant degenerative changes when compared with control group. Conclusion: Therefore, exposure to SOL may inhibit spermatogenesis, impair fertility, and generally, have toxicological concerns in the male reproductive system.
{"title":"Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats -","authors":"K. Patrick-Iwuanyanwu, N. A. Udowelle, C. Okereke","doi":"10.5455/JIHP.20151125081952","DOIUrl":"https://doi.org/10.5455/JIHP.20151125081952","url":null,"abstract":"Background: Permethrin is widely used as a pesticide in agriculture, homes, gardens, and for treatment of ectoparasites such as fleas, lice, and scabies on human and animals. The aim of the present study was to evaluate the testicular toxicity and sperm quality of adult male Wistar albino rats exposed to Solignum® (SOL), a commercial permethrin-containing wood preservative. Materials and Methods: A total number of 32 adult male Wistar albino rats were divided into four groups of eight rats per group. SOL mixed with olive oil (1:1) was orally administered to rats daily at concentrations of 100, 200, and 400 mg/kg for 28 days while the control received 1 ml of olive oil only. At the end of this study, animals were sacrificed and testes excised, weighed, and processed for histological examination. Results: Rats treated with SOL showed a significant (P ≤ 0.05) decrease in body weight ranging from 127.30 ± 5.95 to 84.50 ± 15.37 g as compared with control group (138.50 ± 6.7 g). Absolute testicular weight, relative testicular weight, and epididymis together with testes decreased significantly (P ≤ 0.05) in treated rats ranging from 0.63 ± 0.44 to 0.22 ± 0.18; 0.49 ± 7.39 to 0.26 ± 1.17, and 1.07 ± 0.75 to 0.37 ± 0.19, respectively, when compared with control groups (0.89 ± 0.27; 0.64 ± 4.00; and 1.40 ± 0.35) for absolute testicular weight, relative testicular weight, and epididymis together with testes, respectively after 28 days. However, there was a significant (P ≤ 0.05) decrease in sperm count, sperm motility, sperm morphology, and sperm viability, whereas sperm debris increased significantly (P ≤ 0.05) in a dose-dependent manner when compared with control group. Furthermore, histological examination of the testes indicated that rats exposed to SOL were characterized by significant degenerative changes when compared with control group. Conclusion: Therefore, exposure to SOL may inhibit spermatogenesis, impair fertility, and generally, have toxicological concerns in the male reproductive system.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"13-16"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20151220033246
S. Ravindran, J. Pailoor, Poh Bee Hoon
A 47-year-old, single, Chinese woman presented with pain on the 1st day of menses for more than 30 years. Her dysmenorrhea worsened over years and underwent a total abdominal hysterectomy and bilateral salpingooophorectomy. The myometrium showed trabeculated appearance, and there were adhesions between ovaries and fallopian tubes. A pale solid brownish mass measuring 1.5 cm × 1 cm × 0.6 cm with fibrous whitish cut surfaces was present on the lateral wall of the uterus in the lower uterine segment. Histologically, adenomyosis and left ovarian endometriosis were confirmed. The lateral uterine wall nodule showed a tubular structure lined by ciliated pseudostratified columnar epithelium. Smooth muscle bundles were found around the entire tubular structure. Lobules of salivary type glands containing both serous and mucous cells are present. The pathological diagnosis of heterotopic respiratory mucosa (HRM) was made. To our knowledge, this is the first reported case of HRM of the uterine corpus.
47岁，单身，中国女性，月经第一天疼痛30多年。她的痛经多年来恶化，并接受了全腹子宫切除术和双侧输卵管卵巢切除术。子宫肌层呈小梁状，卵巢与输卵管间有粘连。子宫下段子宫侧壁可见一淡色实心褐色肿块，大小为1.5 cm × 1 cm × 0.6 cm，呈纤维状白色切面。组织学上证实为子宫腺肌症和左卵巢子宫内膜异位症。子宫侧壁结节呈管状结构，衬有纤毛假层状柱状上皮。整个管状结构周围可见平滑肌束。唾液腺的小叶包含浆液细胞和黏液细胞。对异位呼吸道黏膜(HRM)进行病理诊断。据我们所知，这是第一例报告的子宫体HRM。
{"title":"Heterotopic respiratory mucosa of the uterine corpus","authors":"S. Ravindran, J. Pailoor, Poh Bee Hoon","doi":"10.5455/JIHP.20151220033246","DOIUrl":"https://doi.org/10.5455/JIHP.20151220033246","url":null,"abstract":"A 47-year-old, single, Chinese woman presented with pain on the 1st day of menses for more than 30 years. Her dysmenorrhea worsened over years and underwent a total abdominal hysterectomy and bilateral salpingooophorectomy. The myometrium showed trabeculated appearance, and there were adhesions between ovaries and fallopian tubes. A pale solid brownish mass measuring 1.5 cm × 1 cm × 0.6 cm with fibrous whitish cut surfaces was present on the lateral wall of the uterus in the lower uterine segment. Histologically, adenomyosis and left ovarian endometriosis were confirmed. The lateral uterine wall nodule showed a tubular structure lined by ciliated pseudostratified columnar epithelium. Smooth muscle bundles were found around the entire tubular structure. Lobules of salivary type glands containing both serous and mucous cells are present. The pathological diagnosis of heterotopic respiratory mucosa (HRM) was made. To our knowledge, this is the first reported case of HRM of the uterine corpus.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"26-28"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/jihp.20160412114319
S. Ravindran, P. Rajadurai, J. Daniel, Y. C. Har
{"title":"Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic Type","authors":"S. Ravindran, P. Rajadurai, J. Daniel, Y. C. Har","doi":"10.5455/jihp.20160412114319","DOIUrl":"https://doi.org/10.5455/jihp.20160412114319","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160618041629
C. Imafidon, Olatoye Taiwo Risikat, B. F. Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
Background: Cadmium (Cd) is a toxic heavy metal of both environmental and occupational concerns. The health impact of ethno-botanical approaches in attempts to ameliorate its deleterious effects in biological systems should be an area of scientific interest since established therapies are often burdened with undesirable side effects. Aim: To determine the effects of polyphenol-rich extract of the leaf of Vernonia amygdalina (PEVA) on Cd-induced testicular toxicity, oxidative stress, and histopathology in Wistar rats. Materials and Methods: A total of twenty five (25) male Wistar rats were divided into five groups as follows: Group 1 (Control) received distilled water (0.2 ml/100 g i.p.) for 5 consecutive days and thereafter left untreated for 28 days. Group 2 received Cd alone at 5 mg/kg (i.p.) for 5 consecutive days. Group 3 was pre-treated with Cd as Group 2 and thereafter left untreated for a period of 28 days, whereas Groups 4 and 5 were pre-treated with Cd as Group 2 and thereafter received PEVA (orally) at two dose levels (200 and 400 mg/kg, respectively) for 28 days. Results: Cd administration induced reproductive toxicity as evidenced by lowered level of follicle stimulating hormone, luteinizing hormone, and testosterone (P < 0.05); perturbation of sperm characterization (P < 0.05); deleterious disruptions of the antioxidant system as evidenced by lowered levels of reduced glutathione and superoxide dismutase as well as elevation in thiobarbituric acid reactive substances level (P < 0.05); decrease in relative testicular weight (P < 0.05); and severe disseminated necrosis of the seminiferous tubules with terminally undifferentiated/necrotic cells as revealed by the histopathological examination. These conditions were sustained following administration of the two dose levels of PEVA. Conclusion: PEVA administration is not a suitable therapeutic choice for fertility enhancement in male Wistar rat model of Cd-induced decline in reproductive function.
{"title":"Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf -","authors":"C. Imafidon, Olatoye Taiwo Risikat, B. F. Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke","doi":"10.5455/JIHP.20160618041629","DOIUrl":"https://doi.org/10.5455/JIHP.20160618041629","url":null,"abstract":"Background: Cadmium (Cd) is a toxic heavy metal of both environmental and occupational concerns. The health impact of ethno-botanical approaches in attempts to ameliorate its deleterious effects in biological systems should be an area of scientific interest since established therapies are often burdened with undesirable side effects. Aim: To determine the effects of polyphenol-rich extract of the leaf of Vernonia amygdalina (PEVA) on Cd-induced testicular toxicity, oxidative stress, and histopathology in Wistar rats. Materials and Methods: A total of twenty five (25) male Wistar rats were divided into five groups as follows: Group 1 (Control) received distilled water (0.2 ml/100 g i.p.) for 5 consecutive days and thereafter left untreated for 28 days. Group 2 received Cd alone at 5 mg/kg (i.p.) for 5 consecutive days. Group 3 was pre-treated with Cd as Group 2 and thereafter left untreated for a period of 28 days, whereas Groups 4 and 5 were pre-treated with Cd as Group 2 and thereafter received PEVA (orally) at two dose levels (200 and 400 mg/kg, respectively) for 28 days. Results: Cd administration induced reproductive toxicity as evidenced by lowered level of follicle stimulating hormone, luteinizing hormone, and testosterone (P < 0.05); perturbation of sperm characterization (P < 0.05); deleterious disruptions of the antioxidant system as evidenced by lowered levels of reduced glutathione and superoxide dismutase as well as elevation in thiobarbituric acid reactive substances level (P < 0.05); decrease in relative testicular weight (P < 0.05); and severe disseminated necrosis of the seminiferous tubules with terminally undifferentiated/necrotic cells as revealed by the histopathological examination. These conditions were sustained following administration of the two dose levels of PEVA. Conclusion: PEVA administration is not a suitable therapeutic choice for fertility enhancement in male Wistar rat model of Cd-induced decline in reproductive function.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/jihp.20160517083824
G. Vasudevan, P. Prabhakar, Shephali Sharma
Cytomegalovirus infection of the female genital tract is a rare entity. We present a case of 70 year old woman who came with recurrent pyometra, but was otherwise in good health. Hysterectomy was done and the endometrium showed occasional stromal cells with karyomegaly and intranuclear eosinophilic inclusions consistent with cytomegaloviral infection and dense lymphoplasmacytic infiltrate. This was an incidental finding in an otherwise immunocompetent nonpregnant woman, hence being reported for its rarity and uncommon presentation. Keywords: cytomegalovirus, inclusions, endometrium.
{"title":"CMV endometritis in a non- immunosuppressed patient presenting as recurrent pyometra- A case report -","authors":"G. Vasudevan, P. Prabhakar, Shephali Sharma","doi":"10.5455/jihp.20160517083824","DOIUrl":"https://doi.org/10.5455/jihp.20160517083824","url":null,"abstract":"Cytomegalovirus infection of the female genital tract is a rare entity. We present a case of 70 year old woman who came with recurrent pyometra, but was otherwise in good health. Hysterectomy was done and the endometrium showed occasional stromal cells with karyomegaly and intranuclear eosinophilic inclusions consistent with cytomegaloviral infection and dense lymphoplasmacytic infiltrate. This was an incidental finding in an otherwise immunocompetent nonpregnant woman, hence being reported for its rarity and uncommon presentation. Keywords: cytomegalovirus, inclusions, endometrium.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"52-53"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160328113716
M. Shomaf, A. Yousef, J. Masad, Murad Sahawneh, A. Halawa
Objective: C-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types as gastrointestinal stromal tumor, malignant melanoma, breast and lung cancer, sarcoma and mastocytosis. C-kit expression in malignant tumors can be a factor that might affect the prognosis and its expression in different tumors was studied in respect of its correlation with the outcome. Imatinib or sunitinib therapy of KIT-positive tumors is an example of a targeted cancer therapy requiring immunohistochemical tumor analysis to identify patients that would benefit from this kind of therapy. This study is done on patients with breast cancer to find out the frequency of c-kit expression and to find out if it has any effect on the outcome of the patients and to compare the results with that of other ethnicities. Materials and Methods: Paraffin-embedded tumor tissues from 81 patients with breast invasive ductal carcinoma were analyzed immunohistochemically for c-kit expression and correlated to the survival of the patients after initial diagnosis using the follow-up data. Results: The mean age of the patients was 52.8 years. The median follow-up period was 22 months (range 1-37 months). C-kit immunopositivity was found in 37 cases (46%). Expression of c-kit was found in tumor samples with varying intensities and infrequently. Conclusion: There was no significant correlation between c-kit expression and prognosis.
{"title":"C-kit (CD117) Expression Is Not Valuable to Predict Prognosis in Invasive Ductal Carcinoma of Breast -","authors":"M. Shomaf, A. Yousef, J. Masad, Murad Sahawneh, A. Halawa","doi":"10.5455/JIHP.20160328113716","DOIUrl":"https://doi.org/10.5455/JIHP.20160328113716","url":null,"abstract":"Objective: C-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types as gastrointestinal stromal tumor, malignant melanoma, breast and lung cancer, sarcoma and mastocytosis. C-kit expression in malignant tumors can be a factor that might affect the prognosis and its expression in different tumors was studied in respect of its correlation with the outcome. Imatinib or sunitinib therapy of KIT-positive tumors is an example of a targeted cancer therapy requiring immunohistochemical tumor analysis to identify patients that would benefit from this kind of therapy. This study is done on patients with breast cancer to find out the frequency of c-kit expression and to find out if it has any effect on the outcome of the patients and to compare the results with that of other ethnicities. Materials and Methods: Paraffin-embedded tumor tissues from 81 patients with breast invasive ductal carcinoma were analyzed immunohistochemically for c-kit expression and correlated to the survival of the patients after initial diagnosis using the follow-up data. Results: The mean age of the patients was 52.8 years. The median follow-up period was 22 months (range 1-37 months). C-kit immunopositivity was found in 37 cases (46%). Expression of c-kit was found in tumor samples with varying intensities and infrequently. Conclusion: There was no significant correlation between c-kit expression and prognosis.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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