Pub Date : 2017-01-01DOI: 10.5455/jihp.20170608045131
S. El-Gendi, I. Talaat, G. Abu-Sheasha
{"title":"Molecular Subtypes and Conventional Prognosticators for Prediction of Recurrence in a Cohort of Primary Breast Carcinoma. A Classification and Regression Trees-guided (CART-guided) Algorithm.","authors":"S. El-Gendi, I. Talaat, G. Abu-Sheasha","doi":"10.5455/jihp.20170608045131","DOIUrl":"https://doi.org/10.5455/jihp.20170608045131","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JIHP.20161231122658
N. Abdessayed, Ahlem Bdioui, Nozha Mhamdi, Marwa Guerfela, M. Mokni
{"title":"Desmoplastic Fibroma of the Bone: Report of an Unusual Location with Literature Review","authors":"N. Abdessayed, Ahlem Bdioui, Nozha Mhamdi, Marwa Guerfela, M. Mokni","doi":"10.5455/JIHP.20161231122658","DOIUrl":"https://doi.org/10.5455/JIHP.20161231122658","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JIHP.20170117112901
A. Moyer, J. Ro, L. Truong, D. Liang, Wade R. Rosenberg, M. Amrikachi
{"title":"Spindled Signet Ring Cell-Like Gastrointestinal Stromal Tumor: A Case Report","authors":"A. Moyer, J. Ro, L. Truong, D. Liang, Wade R. Rosenberg, M. Amrikachi","doi":"10.5455/JIHP.20170117112901","DOIUrl":"https://doi.org/10.5455/JIHP.20170117112901","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JIHP.20170726091652
Hayam E. Rashed, Aziza E. Abdelrahman, Wael Elmesallamy, A. Obaya
Objective: Intracranial extraskeletal myxoid chondrosarcoma is a rare tumor; up to date, only ten cases have been reported. Case report: We present a case report of a 65-year-old female admitted for right side hemiplegia of gradual onset and progressive course over three weeks. Magnetic resonance imaging (MRI) revealed left intra-axial parieto-occipital space occupying lesion, hypodense with ring enhancement surrounded by diffuse edema. The patient underwent subtotal resection of the mass using sonar guided craniotomy. The histopathological and immunohistochemical evaluation confirmed a diagnosis of extraskeletal myxoid chondrosarcoma. One month after initial discharge, the patient underwent radiotherapy. A follow-up examination 6 months after surgery revealed that the patient was deteriorated and died. Conclusion: intracranial extraskeletal myxoid chondrosarcoma is a rare malignant cartilaginous tumor. Pathological diagnosis is the gold standard and radical excision is the standard treatment
{"title":"Primary Intracranial Myxoid Chondrosarcoma: A case report","authors":"Hayam E. Rashed, Aziza E. Abdelrahman, Wael Elmesallamy, A. Obaya","doi":"10.5455/JIHP.20170726091652","DOIUrl":"https://doi.org/10.5455/JIHP.20170726091652","url":null,"abstract":"Objective: Intracranial extraskeletal myxoid chondrosarcoma is a rare tumor; up to date, only ten cases have been reported. Case report: We present a case report of a 65-year-old female admitted for right side hemiplegia of gradual onset and progressive course over three weeks. Magnetic resonance imaging (MRI) revealed left intra-axial parieto-occipital space occupying lesion, hypodense with ring enhancement surrounded by diffuse edema. The patient underwent subtotal resection of the mass using sonar guided craniotomy. The histopathological and immunohistochemical evaluation confirmed a diagnosis of extraskeletal myxoid chondrosarcoma. One month after initial discharge, the patient underwent radiotherapy. A follow-up examination 6 months after surgery revealed that the patient was deteriorated and died. Conclusion: intracranial extraskeletal myxoid chondrosarcoma is a rare malignant cartilaginous tumor. Pathological diagnosis is the gold standard and radical excision is the standard treatment","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"5 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JIHP.20170326021845
M. Zamecnik, Karol Macuch
An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.
{"title":"Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia","authors":"M. Zamecnik, Karol Macuch","doi":"10.5455/JIHP.20170326021845","DOIUrl":"https://doi.org/10.5455/JIHP.20170326021845","url":null,"abstract":"An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/jihp.20170331011238
S. El-Gendi, I. Talaat, G. Abu-Sheasha
Objective: Breast cancer aggressiveness is related to tumor cell proliferation. Despite this, the Ki-67 index is not recommended for routine use in newly diagnosed breast carcinomas. Material and Methods: A total of 164 invasive breast carcinomas were stratified into the intrinsic molecular subtypes based on estrogen receptor, progesterone receptor (PR), HER2, and Ki-67 immunostaining. We studied the distribution of Ki-67 among the molecular subtypes and correlated it with clinicopathologic parameters. Furthermore, the change in the Ki-67 index with tumor size, grade and lymph node (LN) status among the molecular subtypes was examined. Results: As a continuous variable, the median Ki-67 did not show significant differences with the clinicopathological variables. At a cutoff ≥14%, it correlated significantly with the mitotic index. At a cutoff ≥20%, it additionally correlated with the PR status. The median Ki-67 level varied significantly between luminal A and all other molecular subtypes. The median Ki-67 level in T1/T2 tumors compared to T3/T4 tumors was slightly higher in luminal B HER2+, slightly lower in HER2 enriched, and nearly similar among luminal A, triple negative and luminal B HER2-subtypes, yet without statistical significance. The median Ki-67 was lower in G1/G2 compared to G3 tumors in all-except luminal B HER2-positive subtype but without statistical significance. The Ki-67 distribution change between N0/N1 and N2/N3 cases among the molecular subtypes was significant. Conclusions: The impact of Ki-67 as a proliferation marker on the biological behavior of breast carcinomas is context dependent, and its clinical utility increases when interpreted in combination with other prognostic markers in the context of the molecular subtypes. Further studies, on larger sample sizes are recommended to unravel how the molecular types can affect the relation between Ki-67 and clinicopathological characteristics, particularly the LN status.
{"title":"Comprehensive Analysis of the Association of Clinically Relevant Values of Ki-67 Labeling Index with Clinicopathologic and Immunohistochemical Criteria in Female Invasive Breast Carcinoma","authors":"S. El-Gendi, I. Talaat, G. Abu-Sheasha","doi":"10.5455/jihp.20170331011238","DOIUrl":"https://doi.org/10.5455/jihp.20170331011238","url":null,"abstract":"Objective: Breast cancer aggressiveness is related to tumor cell proliferation. Despite this, the Ki-67 index is not recommended for routine use in newly diagnosed breast carcinomas. Material and Methods: A total of 164 invasive breast carcinomas were stratified into the intrinsic molecular subtypes based on estrogen receptor, progesterone receptor (PR), HER2, and Ki-67 immunostaining. We studied the distribution of Ki-67 among the molecular subtypes and correlated it with clinicopathologic parameters. Furthermore, the change in the Ki-67 index with tumor size, grade and lymph node (LN) status among the molecular subtypes was examined. Results: As a continuous variable, the median Ki-67 did not show significant differences with the clinicopathological variables. At a cutoff ≥14%, it correlated significantly with the mitotic index. At a cutoff ≥20%, it additionally correlated with the PR status. The median Ki-67 level varied significantly between luminal A and all other molecular subtypes. The median Ki-67 level in T1/T2 tumors compared to T3/T4 tumors was slightly higher in luminal B HER2+, slightly lower in HER2 enriched, and nearly similar among luminal A, triple negative and luminal B HER2-subtypes, yet without statistical significance. The median Ki-67 was lower in G1/G2 compared to G3 tumors in all-except luminal B HER2-positive subtype but without statistical significance. The Ki-67 distribution change between N0/N1 and N2/N3 cases among the molecular subtypes was significant. Conclusions: The impact of Ki-67 as a proliferation marker on the biological behavior of breast carcinomas is context dependent, and its clinical utility increases when interpreted in combination with other prognostic markers in the context of the molecular subtypes. Further studies, on larger sample sizes are recommended to unravel how the molecular types can affect the relation between Ki-67 and clinicopathological characteristics, particularly the LN status.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"6 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-29DOI: 10.5455/jihp.20160623053540
Christopher S. Hong, W. Ho, Martin G. Piazza, A. Ray‐Chaudhury, Z. Zhuang, John D Heiss
Objective The normal blood–brain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. Materials and Methods Utilizing specimens from cases of pilocytic astrocytoma (n = 5), medulloblastoma (n = 5), and low-grade diffuse astrocytoma (n = 1), immunofluorescence were performed using primary antibodies against CD31, glial fibrillary acidic protein (GFAP), and aquaporin 4 (AQ4). Clinical, magnetic resonance imaging, operative, and histopathological findings were analyzed. Results Strongly-enhancing areas of medulloblastoma exhibited complete BBB breakdown with sparse GFAP and AQ4 staining around CD31-positive vessels. Moderately enhancing regions of pilocytic astrocytomas exhibited regions of intact BBB and vasculature surrounded by dense GFAP staining but reduced and disorganized AQ4 staining, suggesting tumor cells could not fulfill physiological BBB support. Non-enhancing low-grade diffuse astrocytoma demonstrated intact BBB with intense peri-microvasculature GFAP and AQ4 staining. AQ4 stained so strongly that AQ4 visualization alone delineated CD31-positive vessels. Conclusion Taken together, BBB breakdown in pediatric tumors corresponds to a loss of normal endothelial cell-astrocyte foot process relationships. Further development of pharmaceutical agents capitalizing on this disrupted BBB is warranted in medulloblastoma and pilocytic astrocytoma. However, BBB integrity remains a challenge in treating low-grade diffuse astrocytoma before progression toward secondary glioblastoma.
{"title":"Characterization of the blood brain barrier in pediatric central nervous system neoplasms","authors":"Christopher S. Hong, W. Ho, Martin G. Piazza, A. Ray‐Chaudhury, Z. Zhuang, John D Heiss","doi":"10.5455/jihp.20160623053540","DOIUrl":"https://doi.org/10.5455/jihp.20160623053540","url":null,"abstract":"Objective The normal blood–brain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. Materials and Methods Utilizing specimens from cases of pilocytic astrocytoma (n = 5), medulloblastoma (n = 5), and low-grade diffuse astrocytoma (n = 1), immunofluorescence were performed using primary antibodies against CD31, glial fibrillary acidic protein (GFAP), and aquaporin 4 (AQ4). Clinical, magnetic resonance imaging, operative, and histopathological findings were analyzed. Results Strongly-enhancing areas of medulloblastoma exhibited complete BBB breakdown with sparse GFAP and AQ4 staining around CD31-positive vessels. Moderately enhancing regions of pilocytic astrocytomas exhibited regions of intact BBB and vasculature surrounded by dense GFAP staining but reduced and disorganized AQ4 staining, suggesting tumor cells could not fulfill physiological BBB support. Non-enhancing low-grade diffuse astrocytoma demonstrated intact BBB with intense peri-microvasculature GFAP and AQ4 staining. AQ4 stained so strongly that AQ4 visualization alone delineated CD31-positive vessels. Conclusion Taken together, BBB breakdown in pediatric tumors corresponds to a loss of normal endothelial cell-astrocyte foot process relationships. Further development of pharmaceutical agents capitalizing on this disrupted BBB is warranted in medulloblastoma and pilocytic astrocytoma. However, BBB integrity remains a challenge in treating low-grade diffuse astrocytoma before progression toward secondary glioblastoma.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"29 - 33"},"PeriodicalIF":0.0,"publicationDate":"2016-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160823075851
M. Zamecnik
An unusual case of epithelioid hemangioendothelioma (EHE) with immunohistochemical positivity for cytokeratin (CK), alpha-smooth muscle actin, and calponin (CALP) is presented. The lesion occurred in a 43-year-old man in the right frontal region, with clinical suspicion for an epidermoid cyst. It was excised completely. Grossly, an 8 mm nodule was well circumscribed, soft, and it had gray cut surface. Histologically, typical features of EHE were seen, such angiocentric localization, epithelioid cytomorphology with mild atypia, myxohyaline stromal matrix, a few slit-like vascular channels, and isolated vacuolated cells. In addition, the stroma contained numerous spindle cells resembling myoblasts or myofibroblasts. They showed, besides scattered positivity for vascular markers, focal positivity for CALP and diffuse strong expression of alpha-smooth muscle actin and pancytokeratin AE1/AE3. This observation of numerous actin+/CK+cells is unusual. The lesion resembled other CK-positive vascular tumors and actin-positive myofibroblastic lesions, all of which has to be considered in differential diagnosis.
{"title":"Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like Cells: Report of a Case -","authors":"M. Zamecnik","doi":"10.5455/JIHP.20160823075851","DOIUrl":"https://doi.org/10.5455/JIHP.20160823075851","url":null,"abstract":"An unusual case of epithelioid hemangioendothelioma (EHE) with immunohistochemical positivity for cytokeratin (CK), alpha-smooth muscle actin, and calponin (CALP) is presented. The lesion occurred in a 43-year-old man in the right frontal region, with clinical suspicion for an epidermoid cyst. It was excised completely. Grossly, an 8 mm nodule was well circumscribed, soft, and it had gray cut surface. Histologically, typical features of EHE were seen, such angiocentric localization, epithelioid cytomorphology with mild atypia, myxohyaline stromal matrix, a few slit-like vascular channels, and isolated vacuolated cells. In addition, the stroma contained numerous spindle cells resembling myoblasts or myofibroblasts. They showed, besides scattered positivity for vascular markers, focal positivity for CALP and diffuse strong expression of alpha-smooth muscle actin and pancytokeratin AE1/AE3. This observation of numerous actin+/CK+cells is unusual. The lesion resembled other CK-positive vascular tumors and actin-positive myofibroblastic lesions, all of which has to be considered in differential diagnosis.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160607014218
B. Kurt, S. Taşdemir, E. Çelik, K. Inan
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disease with complex clinical features. It has been sub-classified as: (1) Dermatomyositis, (2) Polymyositis, and (3) Inclusion body myositis (IBM). Nowadays, there are some studies in literature suggest necrotizing autoimmune myopathy and immune-mediated necrotizing myopathy should also be added to this group of disease. There is a debate in the diagnosis of IIMs and up until now, about 12 criteria systems have been proposed. Some of the criteria systems have been used widely such as Griggs et al.’s proposal for IBM. Clinical findings, autoantibodies, enzymes, electrophysiological, and muscle biopsy findings are diagnostic tools. Because of diseases’ complexity, none of the findings are diagnostic alone. In this study, we discussed the diagnostic criteria of IMMs and described detailed morphological features.
{"title":"Idiopathic Inflammatory Myopathies: An update -","authors":"B. Kurt, S. Taşdemir, E. Çelik, K. Inan","doi":"10.5455/JIHP.20160607014218","DOIUrl":"https://doi.org/10.5455/JIHP.20160607014218","url":null,"abstract":"Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disease with complex clinical features. It has been sub-classified as: (1) Dermatomyositis, (2) Polymyositis, and (3) Inclusion body myositis (IBM). Nowadays, there are some studies in literature suggest necrotizing autoimmune myopathy and immune-mediated necrotizing myopathy should also be added to this group of disease. There is a debate in the diagnosis of IIMs and up until now, about 12 criteria systems have been proposed. Some of the criteria systems have been used widely such as Griggs et al.’s proposal for IBM. Clinical findings, autoantibodies, enzymes, electrophysiological, and muscle biopsy findings are diagnostic tools. Because of diseases’ complexity, none of the findings are diagnostic alone. In this study, we discussed the diagnostic criteria of IMMs and described detailed morphological features.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JIHP.20160321010001
F. Onyije, V. C. Zenebo, J. K. Bankole, K. Digban, G. Avwioro
Background: The use of Carica papaya leaves for medicines and food in our rural areas is rampant, this is due to its availability and testimonies of its efficacy. Objective: This study was aimed at investigating the activities of C. papaya on the histo-architecture of some organs. Materials and Methods: About 20 Wistar rats were randomly divided into 4 groups of 5 each and received tap water, 2.5, 5, and 7.5 g/kg of ethanolic extract of C. papaya PO once a day for 14 days after which biochemical analyses was performed on the blood samples. The tissues were examined histologically. Results: Albumin was significantly increased (37.6 ± 2.70) in Group B (5 mg/kg) when compared with the control (32.4 ± 2.30). AST decreased significantly in all the treatment groups (68 ± 1.58, 87.4 ± 403, and 89 ± 1.58) when compared with the control (93.6 ± 1.14). ALT decreased in all groups but was significant in Group C (7.5 mg/kg) 22.8 ± 2.16 when compared with the control (30 ± 2.12). Urea decreased significantly in all the groups (3.34 ± 0.11, 3.78 ± 0.50, and 3.36 ± 0.28), creatinine decreased significantly in Group B (35.4 ± 2.79) when compared to their controls (4.52 ± 0.37 and 50.8 ± 6.37), respectively. Na+ and K+ significantly decreased in Groups C and B, respectively; there was no significant difference in other groups and electrolytes. There was increased level of both packed cell volume and hemoglobin significantly. Histologically, there were no tissue alterations in all the treatment groups. Conclusion: Complementary and alternative medicine is fast gaining popularity; this necessitates swift research on various dose ranges.
{"title":"Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following Administration ofLow Dose of Carica Papaya Leaf","authors":"F. Onyije, V. C. Zenebo, J. K. Bankole, K. Digban, G. Avwioro","doi":"10.5455/JIHP.20160321010001","DOIUrl":"https://doi.org/10.5455/JIHP.20160321010001","url":null,"abstract":"Background: The use of Carica papaya leaves for medicines and food in our rural areas is rampant, this is due to its availability and testimonies of its efficacy. Objective: This study was aimed at investigating the activities of C. papaya on the histo-architecture of some organs. Materials and Methods: About 20 Wistar rats were randomly divided into 4 groups of 5 each and received tap water, 2.5, 5, and 7.5 g/kg of ethanolic extract of C. papaya PO once a day for 14 days after which biochemical analyses was performed on the blood samples. The tissues were examined histologically. Results: Albumin was significantly increased (37.6 ± 2.70) in Group B (5 mg/kg) when compared with the control (32.4 ± 2.30). AST decreased significantly in all the treatment groups (68 ± 1.58, 87.4 ± 403, and 89 ± 1.58) when compared with the control (93.6 ± 1.14). ALT decreased in all groups but was significant in Group C (7.5 mg/kg) 22.8 ± 2.16 when compared with the control (30 ± 2.12). Urea decreased significantly in all the groups (3.34 ± 0.11, 3.78 ± 0.50, and 3.36 ± 0.28), creatinine decreased significantly in Group B (35.4 ± 2.79) when compared to their controls (4.52 ± 0.37 and 50.8 ± 6.37), respectively. Na+ and K+ significantly decreased in Groups C and B, respectively; there was no significant difference in other groups and electrolytes. There was increased level of both packed cell volume and hemoglobin significantly. Histologically, there were no tissue alterations in all the treatment groups. Conclusion: Complementary and alternative medicine is fast gaining popularity; this necessitates swift research on various dose ranges.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"4 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：