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Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients CA125在子宫浆液性癌组织及血清中的表达
Pub Date : 2015-01-01 DOI: 10.5455/jihp.20150713121418
J. Menczer, L. Schreiber, E. Berger, T. Levy
Uterine serous carcinoma (USC) represents only about 10% of endometrial cancer cases. It is an aggressive tumor with a poor prognosis that is diagnosed in advanced stages in about 40% of the cases and it accounts for a disproportionate number of uterine cancer-related deaths. Even in apparent clinical early stage disease, USC is found to have unfavorable pathological prognostic factors such as lymphovascular space invasion, lymph node involvement, and microscopic intraperitoneal spread [1,2].
子宫浆液性癌(USC)仅占子宫内膜癌病例的10%左右。它是一种侵袭性肿瘤,预后差,约40%的病例在晚期被诊断出来,它占子宫癌相关死亡人数的比例不成比例。即使在明显的临床早期疾病中,USC也被发现有不利的病理预后因素,如淋巴血管间隙侵犯、淋巴结累及和显微镜下的腹腔内扩散[1,2]。
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引用次数: 0
Large Multiloculated Splenic Mesothelial Cyst: A Rare Case Report 大脾多室间皮囊肿1例报告
Pub Date : 2015-01-01 DOI: 10.5455/JIHP.20151130122548
Roumina Hasan, Anuradha Rao, Sandeep Kumar, S. Gopal, N. Jain
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引用次数: 0
A Comparative Study of Oral Hamartoma and Choristoma 口腔错构瘤与绒毛瘤的比较研究
Pub Date : 2014-12-01 DOI: 10.5455/JIHP.20151020122441
I. Kaplan, I. Allon, B. Shlomi, V. Raiser, D. Allon
Aim: To compare the clinical and microscopic characteristics of hamartoma and choristoma of the oral mucosa and jaws and discuss the challenges in diagnosis. Materials and Methods: Analysis of patients diagnosed between 2000 and 2012, and literature review of the same years. A sub-classification into “single tissue” or “mixed-tissue” types was applied for all the diagnoses according to the histopathological description. Results: A total of 61 new cases of hamartoma or choristoma were retrieved, the majority were hamartoma. The literature analysis yielded 155 cases, of which 44.5% were choristoma. The majority of hamartoma were mixed. Among these, neurovascular hamartoma was the most prevalent type (36.7%). Of the choristoma, 59.4% were single tissue, with respiratory, gastric and cartilaginous being the most prevalent single tissue types. The tongue was the most frequent location of both groups. Conclusion: Differentiating choristoma from hamartoma depends to a great extent on the recognition of the normal tissues expected at every individual location.
目的:比较口腔黏膜和颌骨错构瘤与脉络膜瘤的临床及显微特征,探讨其诊断难点。材料与方法:对2000 - 2012年诊断的患者进行分析,并对同年的文献进行复习。根据组织病理学描述,将所有诊断分为“单一组织”或“混合组织”类型。结果:共检出错构瘤或脉络膜瘤61例,以错构瘤居多。文献分析155例,其中绒毛瘤占44.5%。多数错构瘤为混合性。其中以神经血管错构瘤最常见(36.7%)。其中,单一组织占59.4%,呼吸道、胃和软骨是最常见的单一组织类型。舌头是两组中最常见的部位。结论:鉴别浆膜瘤和错构瘤在很大程度上取决于对每个部位正常组织的识别。
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引用次数: 8
Isolated Juvenile Xanthogranuloma in Thoracic Spine: Intraoperative Cytological Diagnosis of a Rare Presentation 胸椎孤立幼年黄色肉芽肿:术中细胞学诊断的罕见表现
Pub Date : 2014-06-01 DOI: 10.5455/JIHP.20140601071010
Shashi Singhvi, S. Bhargava
Juvenile Xanthogranulomas (JXG) are benign proliferative disorders of non-Langerhans histiocytes, which present in children as multiple, self-limited, cutaneous lesions. The extracutaneous manifestations of JXG are uncommon, and isolated JXG involving the spinal column is extremely rare. We report here a case of isolated juvenile xanthogranuloma in thoracic spine correctly diagnosed intraoperatively on crush smear cytology and later confirmed by histopathological and immunohistochemical studies. This case report draws attention to the fact that isolated xanthogranuloma should be considered among possible diagnoses of spinal tumor in children. Also, since the long term survival depends on complete surgical resection, a correct intraoperative diagnosis is extremely important for optimal management and prognosis of the patient.
幼年型黄色肉芽肿(JXG)是一种非朗格汉斯组织细胞的良性增殖性疾病,在儿童中表现为多发性、自限性皮肤病变。JXG的皮外表现并不常见,而累及脊柱的孤立性JXG极为罕见。我们在此报告一例胸椎孤立的幼年黄色肉芽肿,术中经碾压涂片细胞学正确诊断,后经组织病理学和免疫组织化学研究证实。本病例报告提请注意,孤立的黄色肉芽肿应考虑在可能的诊断脊柱肿瘤的儿童。此外,由于长期生存依赖于完全的手术切除,正确的术中诊断对于患者的最佳管理和预后至关重要。
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引用次数: 0
False Immunohistochemical Results for Herpesviridae and Other Clusters of Differentiation Due To Biotin Intranuclear Inclusions in the Gestational Endometrium 妊娠子宫内膜内生物素核内包涵体导致疱疹病毒和其他簇状分化的假免疫组织化学结果
Pub Date : 2014-01-01 DOI: 10.5455/JIHP.20130905124106
F. Rivasi, L. Roncati, G. Barbolini, E. Petrella, R. Boldorini
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引用次数: 0
Warfarin Related Nephropathy and Beyond. What Renal Pathologists Need To Suspect in A Kidney Biopsy. 华法林相关肾病及其他。肾脏病理学家在肾活检中需要怀疑什么。
Pub Date : 2014-01-01 DOI: 10.5455/JIHP.20140725053203
S. Brodsky, A. Satoskar, T. Nadasdy
We have recently described a new clinical syndrome in patients receiving warfarin for anticoagulation. First, we identified that warfarin therapy can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients. This syndrome has been named warfarin-related nephropathy (WRN), and patients with chronic kidney disease (CKD) appear to be particularly susceptible. We defined WRN as an acute increase in INR to greater than 3.0, followed by evidence of AKI (defined as a sustained increase in serum creatinine of greater than or equal to 0.3 mg/dl) within a week of the INR increase. We believe that anticoagulant-related kidney injury should be suspected in a patient on an anticoagulation therapy, if there is a disproportion between the number of RBC tubular casts, ATN and the degree of an underlying kidney lesion (such as glomerular immune complex depositions, GBM thickness abnormalities etc) in kidney biopsy. Detailed evaluation of coagulation data and medications is recommended for all patients with RBC casts and AKI.
我们最近在接受华法林抗凝治疗的患者中描述了一种新的临床综合征。首先,我们发现华法林治疗可导致急性肾损伤(AKI),在一些患者中引起肾小球出血和红细胞(RBC)铸型引起肾小管阻塞。这种综合征被命名为华法林相关性肾病(WRN),慢性肾脏疾病(CKD)患者似乎特别容易受到影响。我们将WRN定义为INR急性升高至大于3.0,随后在INR升高一周内出现AKI(定义为血清肌酐持续升高大于或等于0.3 mg/dl)。我们认为,在接受抗凝治疗的患者中,如果在肾活检中RBC小管铸型、ATN的数量与潜在肾脏病变程度(如肾小球免疫复合物沉积、GBM厚度异常等)之间存在不比例,则应怀疑抗凝相关肾损伤。建议所有RBC铸型和AKI患者对凝血数据和药物进行详细评估。
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引用次数: 0
Extraovarian Primary Peritoneal Carcinoma: A Clinicopathological Gray Zone - 卵巢外原发性腹膜癌:临床病理的灰色地带
Pub Date : 2014-01-01 DOI: 10.5455/JIHP.20140214013415
Kajal B. Punyashetty, A. Shankar, T. Katti
Extraovarian primary peritoneal carcinoma (EOPPC) is a rare disease entity, arising from extra ovarian peritoneum with abdominal carcinomatosis, uninvolved or minimally involved ovaries and no identifiable primary. Since an overlap of clinical manifestations and histologic appearances of EOPPC and papillary serous ovarian carcinoma exists, various diagnostic modalities like cytology, tumor markers, gross and histomorphological features, collectively help in arriving at a definitive diagnosis. As very few cases have been reported in literature, we hereby document one such interesting case.
卵巢外原发性腹膜癌(EOPPC)是一种罕见的疾病,发生于卵巢外腹膜伴腹部癌,不累及或极少累及卵巢,原发不明。由于EOPPC和乳头状浆液性卵巢癌的临床表现和组织学表现存在重叠,各种诊断方式,如细胞学、肿瘤标志物、大体和组织形态学特征,共同有助于得出明确的诊断。由于文献中很少有病例报道,我们在此记录一个这样有趣的病例。
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引用次数: 4
Cytologically Diagnosed Ovarian Carcinoma Turned Out To Be a Case of Chronic Ectopic Pregnancy 细胞学诊断为卵巢癌是一例慢性异位妊娠
Pub Date : 2014-01-01 DOI: 10.5455/JIHP.20140218010028
S. Chaudhuri, S. Datta, P. Paul, S. Mukherjee, S. Malo
The diagnosis of chronic ectopic pregnancy is often difficult as there is a shortage of literature in which this disease is diagnosed as an entity separate from the condition of acute ectopic pregnancy. Experience with fine needle aspiration cytology in chronic ectopic pregnancy is not reported previously. A 29-year-old para 3 woman presented with lower abdominal pain and irregular menstruation since two months. Transvaginal ultrasonography showed a well-defined heterogeneous, solid-cystic right adnexal mass with normal serum beta HCG, and mildly elevated CA 125 level. Fine needle aspiration cytology (FNAC) from the mass was performed, and cytological findings suggested possibility of serous cystadenocarcinoma. Abdominal hysterectomy with bilateral salpingo-oophorectomy and infra-colic omentectomy was done. Pathological findings were consistent with chronic ectopic pregnancy. It is possible to retrieve trophoblastic cells through fine needle aspiration even after 2 months of tubal rupture and this experience can be utilized to diagnose chronic ectopic pregnancy preoperatively.
慢性异位妊娠的诊断通常是困难的,因为缺乏文献将这种疾病诊断为与急性异位妊娠分开的一个实体。细针穿刺细胞学检查在慢性异位妊娠中的应用尚未见报道。女,29岁,第3段,下腹疼痛,月经不调两个月。经阴道超声检查显示右附件肿块,界限分明,不均匀,实性囊性,血清- HCG正常,ca125水平轻度升高。对肿块进行细针吸细胞学检查,细胞学结果提示浆液性囊腺癌的可能性。行腹部子宫切除术、双侧输卵管卵巢切除术及结肠下网膜切除术。病理表现符合慢性异位妊娠。即使在输卵管破裂2个月后,仍可通过细针抽吸恢复滋养细胞,这一经验可用于慢性异位妊娠的术前诊断。
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引用次数: 1
Analysis of the First Year Publishing Experience and the Future Goals 第一年出版经验与未来目标分析
Pub Date : 2014-01-01 DOI: 10.5455/jihp.20140227081417
A. Ozcan
Journal of Interdisciplinary Histopathology (JIHP) began to be published as a vivid source of research 15 months ago. At the current state, we are pleased for having successfully finalized our first volume on time with published 5 issues, as announced. Now, with this new issue, the second volume of our journal starts to be published quarterly. JIHP follows an open access publication policy with no fees from the authors or the readers under the sponsorship of the publisher. We do not have a plan to charge fees in the near future, too.
15个月前,《跨学科组织病理学杂志》(Journal of Interdisciplinary Histopathology, JIHP)作为一个生动的研究来源开始出版。在目前的状态下,我们很高兴如期完成了我们的第一卷,出版了5期,正如宣布的那样。现在,有了这一期,我们杂志的第二卷开始按季度出版。JIHP遵循开放获取出版政策,在出版商的赞助下,不向作者或读者收取任何费用。我们近期也没有收费的计划。
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引用次数: 0
Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in Locally Advance Oral Squamous Cell Carcinoma 乳腺丝氨酸蛋白酶抑制剂(MASPIN)在局部进展期口腔鳞状细胞癌中的亚细胞表达
Pub Date : 2014-01-01 DOI: 10.5455/JIHP.20141029023315
S. Zaheer, A. Nagi
Objectives: Mammary serine protease inhibitor (MASPIN) has numerous interactions with tumor pathogenesis and progression. Its relationships with apoptosis and angiogenesis have proven the impact on prognosis. However, its exact role is not known and needs further work in relation to various human cancers. Current study was planned to investigate the subcellular expression of MASPIN in oral squamous cell carcinoma (OSCC) and to observe its relation with tumor grade. Methods: It was a descriptive study, conducted at the Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore. Histological diagnosis of squamous cell carcinoma was confirmed in 50 cases, and expression of MASPIN was determined by avidinbiotin-peroxidase complex method of immunohistochemical staining. MASPIN expression was scored on the basis of intensity of staining and the percentage of the cells that stained positively. Data was analyzed with SPSS using appropriate statistical procedures. Results: Mean age of the patients was 56.84 ± 1.58 years with male to female ratio 1.3:1. All tumors were locally advancing (Stage III). Histologically, 58% tumors were Grade 1, other grades were less common. MASPIN expression was observed in 32 (64%) cases, and it was localized to the cytoplasm of the tumor cells in all cases. Among the positive cases, its expression was focal in 15 (44.1%), diffuse but moderate in 13 (38.2%) and diffuse and intense in 6(17.7%) cases. MASPIN expression was significantly associated (P: 0.043) and negatively correlated (P: 0.034) with tumor grade. Conclusions: MASPIN expression was observed in the majority of OSCC. However, it was localized to the cytoplasm of tumor cells in all cases. Loss of MASPIN expression was observed more frequently in poorly differentiated cancers.
目的:乳腺丝氨酸蛋白酶抑制剂(MASPIN)与肿瘤的发病和进展有许多相互作用。其与细胞凋亡和血管生成的关系已被证实对预后有影响。然而,它的确切作用尚不清楚,需要进一步研究与各种人类癌症的关系。本研究拟探讨MASPIN在口腔鳞状细胞癌(OSCC)中的亚细胞表达,并观察其与肿瘤分级的关系。方法:这是一项描述性研究,在拉合尔卫生科学大学病态解剖与组织病理学系进行。50例确诊为鳞状细胞癌,采用免疫组化染色亲和生物素-过氧化物酶复合物法检测MASPIN的表达。根据染色强度和阳性细胞百分比对MASPIN表达进行评分。采用SPSS统计软件对数据进行分析。结果:患者平均年龄56.84 ±1.58岁,男女比例为1.3:1。所有肿瘤均局部进展(III期)。组织学上,58%的肿瘤为1级,其他级别较少见。32例(64%)患者表达MASPIN,且均定位于肿瘤细胞的细胞质中。阳性15例(44.1%)表现为局灶性,13例(38.2%)表现为弥漫但中度,6例(17.7%)表现为弥漫而强烈。MASPIN表达与肿瘤分级呈显著相关(P: 0.043),与肿瘤分级呈负相关(P: 0.034)。结论:在大多数OSCC中可见MASPIN的表达。然而,在所有病例中,它都定位于肿瘤细胞的细胞质。在低分化癌症中,MASPIN的表达缺失更为常见。
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引用次数: 1
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Journal of interdisciplinary histopathology
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