Pub Date : 2015-01-01DOI: 10.5455/JIHP.20141223024355
Aminder Singh, B. Garg, N. Sood, H. Puri, V. Narang, S. Grover
Objective: The present study is a five-year analysis of all the tumors of small and large intestine received in the Pathology Department of Dayanand Medical College and Hospital, Ludhiana. Methods: All the cases were grossly and microscopically examined and were staged according to Astler Coller Staging and classified and subtyped according to WHO classification. The important differences between the small and large intestine tumors were also analyzed. Results: There were 400 cases out of which 356 were in large intestine while 44 were in the small intestine. There were only 56 benign neoplasms while 344 were malignant tumors. Adenomas were the most common benign tumors while majority of malignant tumors were adenocarcinomas. Lymphomas, mesenchymal tumors, and carcinoid tumors were much more common in a small intestine as compared to large intestine. Majority of adenocarcinomas were located in the large intestine with most of them being moderately differentiated having Astler Coller Stage B II. Mucinous carcinomas had the worst prognosis as compared to adenocarcinomas. Anal canal had mainly squamous cell carcinomas. Conclusions: Tumors of large intestine were much commoner than of small intestine. There was a higher incidence of tumor in males with M:F ratio of 2.2:1. Mean age of presentation of benign tumor was younger, i.e., 32.6 years when compared to 54.5 years for malignant tumors. Tubular adenoma was the most common benign tumor and adenocarcinoma the commonest malignant neoplasm.
{"title":"Spectrum of Intestinal Neoplasms: A study of 400 cases -","authors":"Aminder Singh, B. Garg, N. Sood, H. Puri, V. Narang, S. Grover","doi":"10.5455/JIHP.20141223024355","DOIUrl":"https://doi.org/10.5455/JIHP.20141223024355","url":null,"abstract":"Objective: The present study is a five-year analysis of all the tumors of small and large intestine received in the Pathology Department of Dayanand Medical College and Hospital, Ludhiana. Methods: All the cases were grossly and microscopically examined and were staged according to Astler Coller Staging and classified and subtyped according to WHO classification. The important differences between the small and large intestine tumors were also analyzed. Results: There were 400 cases out of which 356 were in large intestine while 44 were in the small intestine. There were only 56 benign neoplasms while 344 were malignant tumors. Adenomas were the most common benign tumors while majority of malignant tumors were adenocarcinomas. Lymphomas, mesenchymal tumors, and carcinoid tumors were much more common in a small intestine as compared to large intestine. Majority of adenocarcinomas were located in the large intestine with most of them being moderately differentiated having Astler Coller Stage B II. Mucinous carcinomas had the worst prognosis as compared to adenocarcinomas. Anal canal had mainly squamous cell carcinomas. Conclusions: Tumors of large intestine were much commoner than of small intestine. There was a higher incidence of tumor in males with M:F ratio of 2.2:1. Mean age of presentation of benign tumor was younger, i.e., 32.6 years when compared to 54.5 years for malignant tumors. Tubular adenoma was the most common benign tumor and adenocarcinoma the commonest malignant neoplasm.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/jihp.20141121120051
S. Pai, S. Krishnamurthy, K. Umapathy, K. Bhagwat, Manjunath Lakmapurnath
Childhood spondylodiscitis is an extremely rare entity that often presents as a nonspecific clinical picture that may delay the diagnosis [1-3]. It is a combination of discitis which means inflammation of one or more intervertebral disc spaces and spondylitis which means inflammation of one or more vertebrae. It is also known to extend into the paravertebral soft tissues, the epidural space, meninges, and spinal cord [3-6].
{"title":"Spondylodiscitis with Bronchopneumonia in Infancy: A Rare Entity","authors":"S. Pai, S. Krishnamurthy, K. Umapathy, K. Bhagwat, Manjunath Lakmapurnath","doi":"10.5455/jihp.20141121120051","DOIUrl":"https://doi.org/10.5455/jihp.20141121120051","url":null,"abstract":"Childhood spondylodiscitis is an extremely rare entity that often presents as a nonspecific clinical picture that may delay the diagnosis [1-3]. It is a combination of discitis which means inflammation of one or more intervertebral disc spaces and spondylitis which means inflammation of one or more vertebrae. It is also known to extend into the paravertebral soft tissues, the epidural space, meninges, and spinal cord [3-6].","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/jihp.20141118013119
S. Desale, DR DHIRAJ B NIKUMBH, S. Kanthikar, Akshay Surana
Mycetoma/madura foot is a chronic suppurative granulomatous disease characterized by localized subcutaneous swelling with multiple sinus tracts discharging granules. The infection caused by true fungi (eumycetoma) in 40% or filamentous bacteria (actinomycetoma) in 60% of the cases [1]. Actinomycetoma may be due to Actinomadura madurae, Actinomadura peliietieri, Streptomyces somaliensis, Nocardia species [1].
{"title":"Cytodiagnosis of Primary Actinomycotic Mycetoma of The Foot: A Case Report","authors":"S. Desale, DR DHIRAJ B NIKUMBH, S. Kanthikar, Akshay Surana","doi":"10.5455/jihp.20141118013119","DOIUrl":"https://doi.org/10.5455/jihp.20141118013119","url":null,"abstract":"Mycetoma/madura foot is a chronic suppurative granulomatous disease characterized by localized subcutaneous swelling with multiple sinus tracts discharging granules. The infection caused by true fungi (eumycetoma) in 40% or filamentous bacteria (actinomycetoma) in 60% of the cases [1]. Actinomycetoma may be due to Actinomadura madurae, Actinomadura peliietieri, Streptomyces somaliensis, Nocardia species [1].","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"42-44"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20141217072254
Anuradha Rao, V. Monappa, Sandeep Kumar
Liposarcoma (LS) in the head and neck region is a rare tumor. The sclerosing variant of LS is a subtype of well-differentiated LS characterized by areas of conventional LS admixed with hypocellular areas of stromal sclerosis that show atypical lipomatous cells. The (poorly differentiated) sclerosing LS, on the other hand, is more cellular with atypical, pleomorphic and often bizarre giant tumor cells admixed with atypical lipoblasts. We report a case of poorly differentiated sclerosing LS of temporal region in a 49-year-old man. Radiologically, the tumor was dumbbell shaped with intra and extra cranial extension. In this case, we discuss the clinico-radiological and pathological findings of an unusual tumor in a rare location.
{"title":"Primary (Poorly Differentiated) Sclerosing Liposarcoma of Temporal Region. An Uncommon Tumor in a Rare Site: A Case Report -","authors":"Anuradha Rao, V. Monappa, Sandeep Kumar","doi":"10.5455/JIHP.20141217072254","DOIUrl":"https://doi.org/10.5455/JIHP.20141217072254","url":null,"abstract":"Liposarcoma (LS) in the head and neck region is a rare tumor. The sclerosing variant of LS is a subtype of well-differentiated LS characterized by areas of conventional LS admixed with hypocellular areas of stromal sclerosis that show atypical lipomatous cells. The (poorly differentiated) sclerosing LS, on the other hand, is more cellular with atypical, pleomorphic and often bizarre giant tumor cells admixed with atypical lipoblasts. We report a case of poorly differentiated sclerosing LS of temporal region in a 49-year-old man. Radiologically, the tumor was dumbbell shaped with intra and extra cranial extension. In this case, we discuss the clinico-radiological and pathological findings of an unusual tumor in a rare location.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"33-35"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20151005122350
G. Vasudevan, Arijit Bishnu
Sclerosing stromal tumour of the ovary is an uncommon benign ovarian neoplasm of sex cord stromal origin with distinct clinical and radiological features. We describe a cystic SST in a 35 year old female who presented with right lower abdominal pain. CT-scan revealed a complex ovarian cyst. Right sided Salpingo-oophorectomy was done with intra-operative frozen section which ruled out malignancy. Histopathology showed features consistent with SST ovary. In this report we discuss the differential diagnosis and role of histopathology in confirming the benign nature of the neoplasm,so a conservative surgery can be performed.
{"title":"Cystic sclerosing stromal tumor of the ovary: A case report and review of literature","authors":"G. Vasudevan, Arijit Bishnu","doi":"10.5455/JIHP.20151005122350","DOIUrl":"https://doi.org/10.5455/JIHP.20151005122350","url":null,"abstract":"Sclerosing stromal tumour of the ovary is an uncommon benign ovarian neoplasm of sex cord stromal origin with distinct clinical and radiological features. We describe a cystic SST in a 35 year old female who presented with right lower abdominal pain. CT-scan revealed a complex ovarian cyst. Right sided Salpingo-oophorectomy was done with intra-operative frozen section which ruled out malignancy. Histopathology showed features consistent with SST ovary. In this report we discuss the differential diagnosis and role of histopathology in confirming the benign nature of the neoplasm,so a conservative surgery can be performed.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"142-145"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20151029070700
S. Shankar, Bhaskaran Ashokan, M. Reddy, H. Anantharamaiah
Paratesticular LPS of the spermatic cord are rare tumor, accounting for about 7% of all paratesticular sarcomas [2]. Until date, about 200 cases have been reported in literature, most being reported as isolated cases; hence, the natural history and biological behavior of this rare tumor are less understood [3,4]. Most patients usually present with a slowly growing painless inguinoscrotal mass mimicking hernias or testicular tumors clinically [3].
{"title":"Paratesticular Liposarcoma of the Spermatic Cord: A Rare Case -","authors":"S. Shankar, Bhaskaran Ashokan, M. Reddy, H. Anantharamaiah","doi":"10.5455/JIHP.20151029070700","DOIUrl":"https://doi.org/10.5455/JIHP.20151029070700","url":null,"abstract":"Paratesticular LPS of the spermatic cord are rare tumor, accounting for about 7% of all paratesticular sarcomas [2]. Until date, about 200 cases have been reported in literature, most being reported as isolated cases; hence, the natural history and biological behavior of this rare tumor are less understood [3,4]. Most patients usually present with a slowly growing painless inguinoscrotal mass mimicking hernias or testicular tumors clinically [3].","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"138-141"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20150117112544
N. El-sherif, A. El-Mehi
Background: Semicarbazide (SEM) is an azodicarbonamide byproduct present in a glass jar packaged foods especially baby foods. A relatively high consumption of these products by infants can result in higher exposure compared with other consumers. Objectives: This study was performed to throw light on the effect of SEM on the testis of juvenile male albino rat. Materials and Methods: This study was carried out on 20 juvenile male albino rats divided into the control group, and SEM treated group. Animals of the SEM treated group were administered 40 mg of SEM orally once daily for 30 days. At the end of the experiment, animals were weighed and then sacrificed. The parameters examined were gonadal index, epididymal spermatozoal examination, histological study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in addition to ultrastructural study. Morphometric study and statistical analysis of the results were carried out. Results: The gonadal index of SEM treated group showed a significant decrease compared with the control group. Loss of germ cells was confirmed by a significantly low sperm count. SEM induced variable degrees of tubular affection in the form of distorted seminiferous tubules, cellular disorganization, sloughing and cytoplasmic vacuolation. Acidophilic hyaline material, vacuolations, and congested blood vessels were present in most of the interstitial spaces. Immunohistochemically, SEM treatment induced a marked reduction in the number of PCNA immunoreactive cells. An ultrastructural alteration of spermatogenic cells and wide separation in between germ cells were observed. Conclusions: These results suggest that growing animals are more susceptible to gonadal toxicity of SEM. It is better to avoid food products sold in glass jars, especially during the juvenile period.
{"title":"Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat","authors":"N. El-sherif, A. El-Mehi","doi":"10.5455/JIHP.20150117112544","DOIUrl":"https://doi.org/10.5455/JIHP.20150117112544","url":null,"abstract":"Background: Semicarbazide (SEM) is an azodicarbonamide byproduct present in a glass jar packaged foods especially baby foods. A relatively high consumption of these products by infants can result in higher exposure compared with other consumers. Objectives: This study was performed to throw light on the effect of SEM on the testis of juvenile male albino rat. Materials and Methods: This study was carried out on 20 juvenile male albino rats divided into the control group, and SEM treated group. Animals of the SEM treated group were administered 40 mg of SEM orally once daily for 30 days. At the end of the experiment, animals were weighed and then sacrificed. The parameters examined were gonadal index, epididymal spermatozoal examination, histological study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in addition to ultrastructural study. Morphometric study and statistical analysis of the results were carried out. Results: The gonadal index of SEM treated group showed a significant decrease compared with the control group. Loss of germ cells was confirmed by a significantly low sperm count. SEM induced variable degrees of tubular affection in the form of distorted seminiferous tubules, cellular disorganization, sloughing and cytoplasmic vacuolation. Acidophilic hyaline material, vacuolations, and congested blood vessels were present in most of the interstitial spaces. Immunohistochemically, SEM treatment induced a marked reduction in the number of PCNA immunoreactive cells. An ultrastructural alteration of spermatogenic cells and wide separation in between germ cells were observed. Conclusions: These results suggest that growing animals are more susceptible to gonadal toxicity of SEM. It is better to avoid food products sold in glass jars, especially during the juvenile period.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20150128125706
Paula R S Câmara
Several congenital diseases are particularly attractive candidates for intervention using gene therapy since the underlying molecular bases for most of the monogenic disorders are well-understood. Transplantation of ex vivo genetically modified stem cells has also shown promise. Although all of these systems are meritorious and worthy of continued investigation, this mini-review article focused on the platforms that have received the most attention and that are maturing in the clinical setting; in particular, the potential of in vivo gene therapy and human-induced pluripotent stem cells. Studies of apparently disparate diseases that are presumably linked through shared metabolic pathways are likely to provide greater insights into the biology of the diseases. This and other opportunities for exchange will hopefully foster acceleration in the development of new and innovative therapies for these devastating diseases.
{"title":"Gene Therapy and Stem Cells in the Treatment of Congenital Diseases","authors":"Paula R S Câmara","doi":"10.5455/JIHP.20150128125706","DOIUrl":"https://doi.org/10.5455/JIHP.20150128125706","url":null,"abstract":"Several congenital diseases are particularly attractive candidates for intervention using gene therapy since the underlying molecular bases for most of the monogenic disorders are well-understood. Transplantation of ex vivo genetically modified stem cells has also shown promise. Although all of these systems are meritorious and worthy of continued investigation, this mini-review article focused on the platforms that have received the most attention and that are maturing in the clinical setting; in particular, the potential of in vivo gene therapy and human-induced pluripotent stem cells. Studies of apparently disparate diseases that are presumably linked through shared metabolic pathways are likely to provide greater insights into the biology of the diseases. This and other opportunities for exchange will hopefully foster acceleration in the development of new and innovative therapies for these devastating diseases.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20150304022713
A. Ozcan
{"title":"Overview of the Last Two Years","authors":"A. Ozcan","doi":"10.5455/JIHP.20150304022713","DOIUrl":"https://doi.org/10.5455/JIHP.20150304022713","url":null,"abstract":"","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"66 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.5455/JIHP.20150425032738
M. Valiathan, P. Jaiprakash, G. Vasudevan
The term adenomyoepithelioma has been applied to a broad range of biphasic lesions composed of epithelial and myoepithelial cells. They show diverse morphologic patterns due to the admixture of the two components which may lead to a diagnosis of malignancy. We present a case of bilateral adenomyoepithelioma in a lactating woman who had a concomitant breast abscess. A 25-year-old lady presented with bilateral breast lumps since 2 years, with acute pain. With a clinical diagnosis of an abscess, superimposed on fibrocystic disease, drainage of abscess, and lumpectomy was performed. The clinicopathological features of this entity are discussed.
{"title":"Bilateral Adenomyoepithelioma of the Breast Presenting With Breast Abscess in a Lactating Woman: A Case Report -","authors":"M. Valiathan, P. Jaiprakash, G. Vasudevan","doi":"10.5455/JIHP.20150425032738","DOIUrl":"https://doi.org/10.5455/JIHP.20150425032738","url":null,"abstract":"The term adenomyoepithelioma has been applied to a broad range of biphasic lesions composed of epithelial and myoepithelial cells. They show diverse morphologic patterns due to the admixture of the two components which may lead to a diagnosis of malignancy. We present a case of bilateral adenomyoepithelioma in a lactating woman who had a concomitant breast abscess. A 25-year-old lady presented with bilateral breast lumps since 2 years, with acute pain. With a clinical diagnosis of an abscess, superimposed on fibrocystic disease, drainage of abscess, and lumpectomy was performed. The clinicopathological features of this entity are discussed.","PeriodicalId":91320,"journal":{"name":"Journal of interdisciplinary histopathology","volume":"3 1","pages":"71-73"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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