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Innovation and commercialisation in the Canadian bioproducts industry 加拿大生物制品行业的创新和商业化
Pub Date : 2012-11-09 DOI: 10.1504/IJBT.2012.050238
Pamela Laughland, J. Cranfield, D. Sparling
Industrial biotechnology is an emerging industry in which firms are developing novel alternatives to petroleum-based goods. Canadian-based firms have an opportunity to capitalise on the availability of biomass from Canadian agriculture and Canada’s broad resource base. However, complexity of the product development process coupled with immaturity of this industry means little is currently known about these firms, their innovation activities and decision making. This study uses data from the 2003 and 2006 bioproduct development surveys to examine the Canadian bioproducts industry, focusing on factors conducive to innovative activity for bioproduct producing firms. Several factors are important in facilitating innovation, such as intellectual property, collaborations, focus on bioproducts relative to other business activities, the dominant product type and region in which the firm operates.
工业生物技术是一个新兴产业,公司正在开发新的石油基产品替代品。加拿大的公司有机会利用加拿大农业和加拿大广泛的资源基础提供的生物质。然而,产品开发过程的复杂性加上该行业的不成熟意味着目前对这些公司,他们的创新活动和决策知之甚少。本研究使用2003年和2006年生物制品开发调查的数据来考察加拿大生物制品行业,重点关注有利于生物制品生产企业创新活动的因素。有几个因素在促进创新方面很重要,例如知识产权、合作、相对于其他商业活动对生物产品的关注、主要产品类型和公司经营的地区。
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引用次数: 0
The use of performance measurements in the biotechnology sector 在生物技术部门使用绩效测量
Pub Date : 2011-09-27 DOI: 10.1504/IJBT.2011.042679
Yunhao Dai, H. G. Chong
Despite its substantial contributions to a country’s Gross Domestic Product (GDP), there is no known systematic study on the governance of the biotechnology sector and how its performance is measured. A questionnaire survey was conducted with the firms registered in the UK Biotechnology Handbook . With a response rate of 38% and rigorous analysis, the results show that, when measuring performance, managers use both the financial and nonfinancial indicators, but emphasise the financial indicators more. The financial indicators include turnover, profit margins, cash reserve and liquidity, while the nonfinancial indicators are about meeting the customers’ needs and expectations. More specifically, the managers place attention to the reporting of the environmental issues of their firms, reflecting their readiness to excel in social corporate responsibilities. The results have implications for the biotechnology sector and regulators for public policy.
尽管生物技术部门对一个国家的国内生产总值(GDP)做出了巨大贡献,但目前还没有已知的关于生物技术部门治理以及如何衡量其表现的系统研究。对在英国生物技术手册中注册的公司进行了问卷调查。通过38%的回复率和严格的分析,结果表明,在衡量绩效时,管理者同时使用财务和非财务指标,但更强调财务指标。财务指标包括营业额、利润率、现金储备和流动性,而非财务指标是关于满足客户的需求和期望。更具体地说,管理人员将注意力放在报告其公司的环境问题上,反映出他们愿意在企业社会责任方面表现出色。研究结果对生物技术部门和公共政策的管理者具有启示意义。
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引用次数: 0
Diffusion and economic impacts of biotechnology – a case study for Germany 生物技术的传播和经济影响——以德国为例
Pub Date : 2011-09-27 DOI: 10.1504/IJBT.2011.042683
S. Wydra, M. Nusser
While the economic impact of biotechnology is disputed, empirical data and research about diffusion and economic impacts of biotechnology in application sectors is rather limited. In this paper, actual and prospective diffusion of biotechnology in different application industries is analysed on a disaggregated level by combining production data with a written expert survey. On the basis of these results, an input-output model was used to calculate the direct and indirect employment effects of biotechnology in Germany for the years 2004 and 2020. The results suggest a further diffusion of biotechnology in all application sectors. The subsequent employment occurs in both application industries and upstream sectors.
虽然生物技术的经济影响存在争议,但关于生物技术在应用部门的传播和经济影响的实证数据和研究相当有限。本文结合生产数据和专家书面调查,对生物技术在不同应用行业的实际和前景进行了分类分析。在此基础上,采用投入产出模型计算了2004年和2020年德国生物技术的直接和间接就业效应。结果表明生物技术在所有应用领域的进一步扩散。随后的就业发生在应用行业和上游部门。
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引用次数: 3
Attitude and purchasing decisions regarding genetically modified foods based on gender and education 基于性别和教育的对转基因食品的态度和购买决定
Pub Date : 2011-09-27 DOI: 10.1504/IJBT.2011.042681
Ori Agmon, Rachel C. Fleisher, D. Zilberman, Amir Heiman
Previous studies have found that gender affects perceptions and resistance to genetically modified food (GMF). Stronger aversion to innovations, lower technical interest, more concern with environment, and higher perceptions of environmental risk on the part of females relative to males have previously explained why females are less supportive of GMF. This study suggests a new explanation based on differences in economic benefits. Based on an empirical study, we show that, while males are more motivated by monetary incentives, females are less likely to prefer GMF if the incentive is price. They are more sensitive to moral and risk-reduction incentives. Education levels did not affect perceptions and preferences and thus cannot serve as explanatory variables to these gender differences. The insights gained may help policy makers in designing their communication campaigns aimed at increasing the adoption of genetically modified technology, which has the potential advantage of solving food scarcity and nutritional deficits.
先前的研究发现,性别影响人们对转基因食品的认知和抵制。与男性相比,女性对创新更强烈的厌恶、更低的技术兴趣、更关注环境以及对环境风险的更高认知,这些都解释了为什么女性不太支持转基因食品。这项研究提出了一种基于经济效益差异的新解释。基于实证研究,我们发现男性更倾向于金钱激励,而女性更倾向于价格激励。他们对道德和降低风险的激励更敏感。教育水平不影响观念和偏好,因此不能作为这些性别差异的解释变量。获得的见解可能有助于决策者设计旨在增加转基因技术采用的宣传活动,转基因技术在解决粮食短缺和营养不足方面具有潜在的优势。
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引用次数: 10
Strategies toward commercial scale of biosurfactant production as potential substitute for it's chemically counterparts 生物表面活性剂作为化学表面活性剂潜在替代品的商业规模生产策略
Pub Date : 2011-09-27 DOI: 10.1504/IJBT.2011.042682
Q. Helmy., E. Kardena, N. Funamizu, Wisjnuprapto
In the past few decades natural emulsifiers/biosurfactants have been intensively studied for their ability as potential substitute for synthetic surfactant usage. Biosurfactants are valuable microbial amphipathic compounds with effective surface active and biological properties which are applicable to several industries and process materials. Several biosurfactants properties are low toxicity, higher biodegradability and ecological acceptability, also synthesised from wide range of raw materials. At present, biosurfactant are unable to compete with the synthetic surfactant due to their high production cost, specific functionality and production capacity to meet the need of intended applications. A considerable number of researches and studies have been published in order to eliminate the economical bottleneck of biosurfactants production process. This review describes alternatives strategies toward commercialisation of biosurfactants on a large scale that might be able to replace their chemical counter parts.
在过去的几十年里,人们对天然乳化剂/生物表面活性剂作为合成表面活性剂的潜在替代品进行了深入的研究。生物表面活性剂是一种有价值的微生物两亲性化合物,具有有效的表面活性和生物特性,适用于多种工业和加工材料。几种生物表面活性剂具有低毒性、高生物可降解性和生态可接受性的特性,并且可以从广泛的原料中合成。目前,生物表面活性剂由于其较高的生产成本、特定的功能和生产能力难以满足预期应用的需要,无法与合成表面活性剂竞争。为了消除生物表面活性剂生产过程中的经济瓶颈,已经发表了大量的研究成果。本文综述了生物表面活性剂大规模商业化的替代策略,这些策略可能能够取代它们的化学对应部分。
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引用次数: 52
The income and production effects of biotech crops globally 1996–2009 1996-2009年全球转基因作物的收入和生产效应
Pub Date : 2011-09-27 DOI: 10.1504/IJBT.2011.042680
G. Brookes, P. Barfoot
This paper provides an assessment of the economic impact at the farm level of agricultural biotechnology on global agriculture. It examines the economic impacts on yields, key costs of production, direct farm income, indirect (non-pecuniary) farm level income effects and impacts on the production base of the four main crops of soybeans, corn, cotton and canola. The analysis shows that there have been substantial net economic benefits at the farm level amounting to $10.8 billion in 2009 and $64.7 billion for the 14-year period (in nominal terms). The non-pecuniary benefits associated with the use of the technology have also had a positive impact on adoption (in the USA accounting for the equivalent of 23% of the total direct farm income benefit). Biotech crops have also made important contributions to increasing global production levels of the four main crops; adding, for example, 83 million tonnes and 130 million tonnes, respectively, to global production of soybeans and corn.
本文评估了农业生物技术对全球农业的经济影响。它审查了对产量、主要生产成本、直接农业收入、间接(非金钱)农业收入的影响以及对大豆、玉米、棉花和油菜四种主要作物生产基础的影响。分析显示,2009年农场层面的净经济效益为108亿美元,14年期间的名义经济效益为647亿美元。与使用该技术相关的非金钱效益也对采用产生了积极影响(在美国占直接农业收入总额的23%)。转基因作物也为提高四种主要作物的全球产量水平作出了重要贡献;例如,全球大豆和玉米产量将分别增加8300万吨和1.3亿吨。
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引用次数: 20
A novel, dual acting, soft pellet formulation, combining cushioning and rapid disintegration properties, and their incorporation into tablet formulations containing film-coated drug pellets 一种新型的双作用软颗粒制剂,结合缓冲和快速崩解特性,并将其纳入含有薄膜包衣药物颗粒的片剂制剂中
Pub Date : 2010-11-08 DOI: 10.1504/IJBT.2010.036599
Jan Pick-Katolik, F. Podczeck
This work reports the concept of a novel, dual-acting, 'soft' pellet formulation, which protects film-coated 'hard' pellets during tabletting. The novel 'soft' pellets were designed to both cushion film-coated pellets during tabletting and ensure rapid disintegration of the tablets when in contact with water. The deformability and disintegration properties of these pellets were controlled using olive oil. 'Hard' pellets, produced by extrusion/spheronisation, were optimised and characterised and were film coated with Kollicoat® SR30D, containing triethyl citrate as plasticiser and fluorescein sodium as marker substance. Several coating thicknesses and plasticiser concentrations were studied using a statistically designed experiment. 'Soft' pellets produced using extrusion/spheronisation or granulation/spheronisation, were tabletted with either film-coated ibuprofen pellets or theophylline pellets and their dissolution and disintegration properties were determined. Granulation/spheronisation was the preferred method of manufacture of the soft pellets and lower percentages of olive oil were found to be more beneficial to the disintegration properties of the compacts.
这项工作报告了一种新颖的、双作用的“软”颗粒配方的概念,该配方在压片过程中保护薄膜涂层的“硬”颗粒。这种新型的“软”颗粒被设计成在片剂过程中缓冲薄膜包被颗粒,并确保片剂在与水接触时快速崩解。用橄榄油控制颗粒的变形性能和崩解性能。通过挤压/球化生产的“硬”颗粒进行了优化和表征,并用kolliccoat®SR30D涂膜,其中含有柠檬酸三乙酯作为增塑剂和荧光素钠作为标记物质。用统计学设计的实验研究了几种涂层厚度和增塑剂浓度。采用挤压/球化或造粒/球化生产的“软”微丸,分别与薄膜包膜布洛芬微丸或茶碱微丸一起片剂,并测定其溶出和崩解性能。造粒/球化是制造软颗粒的首选方法,并且发现较低百分比的橄榄油更有利于压实物的分解特性。
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引用次数: 0
Multiple unit pellet systems (MUPS) obtained by soft compaction of two polymorphic cellulose modifications as coated pellets: influence of the polymorphic modification in MUPS on disintegration time and drug release 两种多形性纤维素修饰软压实制成包被微球的多单元微球体系(MUPS): MUPS中多形性修饰对崩解时间和药物释放的影响
Pub Date : 2010-11-08 DOI: 10.1504/IJBT.2010.036595
V. Balzano, G. Betz, H. Leuenberger
The compaction of UICEL-A/102 and MCC 102 coated pellets into multiple unit pellet systems (MUPS) is presented in this work. MCC 102 and UICEL-A/102 were separately mixed with sodium diclofenac, pelletised and afterwards coated with a water suspension of Kollicoat® SR 30 D. 30%-50% of the so produced coated pellets were embedded in 40%-60% of MCC 102 powder (cushioning) and 10% of either STA-RX® 1500 or UICEL-A/102 (disintegrant). Finally, the tabletting mixtures were compacted into MUPS using a PressterTM Compaction Simulator. Both UICEL-A/102 and MCC 102 MUPS resulted to be mechanically robust (crushing strength of 70-100 N), fast disintegrating in water and maintained the same release profile and similar superficial and inner morphology compared to the uncompressed subunits. UICEL-A/102 proved to be more appropriate as filler for immediate release pellets and MUPS, whereas MCC 102 confirmed to be advantageous filler for controlled release pellets in MUPS.
将UICEL-A/102和MCC - 102包覆颗粒压实成多单元颗粒系统(MUPS)。将MCC 102和UICEL-A/102分别与双氯芬酸钠混合,制成颗粒,然后用kolliccoat®SR 30d的水悬浮液包被,将30%-50%的包被颗粒包被在40%-60%的MCC 102粉末(缓冲液)和10%的STA-RX®1500或UICEL-A/102(崩解剂)中。最后,使用PressterTM压实模拟器将压片混合物压实成MUPS。与未压缩的亚基相比,uel - a /102和MCC 102 MUPS具有机械坚固性(破碎强度为70-100 N),在水中分解速度快,并保持相同的释放曲线和相似的表面和内部形态。UICEL-A/102被证明更适合作为立即释放微丸和MUPS的填充剂,而MCC 102被证实是MUPS控释微丸的有利填充剂。
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引用次数: 0
Characterisation and controlled drug release from a novel two-phase hydrogel system 一种新型两相水凝胶体系的表征和药物释放控制
Pub Date : 2010-11-08 DOI: 10.1504/IJBT.2010.036596
Thomas J. Smith, J. Kennedy, C. Higginbotham
In this work, a two-phase hydrogel system was prepared by physically imbedding a xerogel in the core of a cryogel which was freeze thawed. The cryogels were prepared with poly (vinyl alcohol) (PVA) and poly (acrylic acid) (PAA) while the xerogels were prepared by UV polymerisation of 1-vinyl-2-pyrrolidinone (NVP), acrylic acid (AA) and various percentages of ibuprofen sodium salt. Mechanical and thermal properties were determined by parallel plate rheometry and differential scanning calorimetry (DSC). The results indicated that hydrogels which contained increased percent concentrations of PAA (in the xerogel) were significantly stiffer than those synthesised using PVP alone at test temperatures between 30 and 80°C. The chemical structure of the hydrogels was confirmed by means of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). In all cases, drug dissolution analysis showed that the active agent was released at a slower rate with hydrogels that contained acrylic acid.
在这项工作中,通过将干燥凝胶物理嵌入冷冻凝胶的核心,制备了两相水凝胶体系。用聚乙烯醇(PVA)和聚丙烯酸(PAA)制备低温凝胶,用1-乙烯基-2-吡啶酮(NVP)、丙烯酸(AA)和不同比例的布洛芬钠盐进行紫外聚合制备干凝胶。采用平行板流变法和差示扫描量热法(DSC)测定了材料的力学和热性能。结果表明,在30 ~ 80℃的测试温度下,含有更高浓度PAA(在干凝胶中)的水凝胶比单独使用PVP合成的水凝胶要硬得多。利用衰减全反射傅立叶变换红外光谱(ATR-FTIR)对水凝胶的化学结构进行了确证。在所有情况下,药物溶出度分析表明,含有丙烯酸的水凝胶释放活性药物的速度较慢。
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引用次数: 0
Some aesthetic considerations for over the-counter (OTC) pharmaceutical products 非处方(OTC)药品的一些美学考虑
Pub Date : 2010-11-08 DOI: 10.1504/IJBT.2010.036600
R. Srivastava, Aarti T. More
The research paper studies the consumer's perception for product colour, shape and taste while buying an over the counter (OTC) product. This study also examines the impact of product colour on consumer's expectancies towards the drug. Data collection method was direct questionnaire to consumers. This was done in two phases wherein respondents were exposed to face to face interview. The study shows that there is an influence of products aesthetic attributes of pharmaceutical OTC products on consumption which can translate to brand loyalty and to sales. Red and pink emerged as most preferred colour. Blue and white are other two preferred colours. For 75% of consumers colour is a memory tag for compliance. There is a positive association of colour and shape with compliance. Pink colour is considered to be sweeter compared to red. Yellow is considered to be salty as per this study.
该研究论文研究了消费者在购买非处方(OTC)产品时对产品颜色、形状和味道的感知。本研究还考察了产品颜色对消费者对药物期望的影响。数据收集方法为直接对消费者进行问卷调查。这是在两个阶段完成的,其中受访者接触到面对面的采访。研究表明,药品OTC产品的产品美学属性对消费有影响,并可转化为品牌忠诚度和销售。红色和粉色是最受欢迎的颜色。蓝色和白色是另外两种受欢迎的颜色。对于75%的消费者来说,颜色是一种符合要求的记忆标签。颜色和形状与依从性呈正相关。粉红色被认为比红色更甜。根据这项研究,黄色被认为是咸的。
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引用次数: 15
期刊
International journal of biotechnology
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