Pub Date : 2017-05-04DOI: 10.15406/JSRT.2017.02.00076
A. Carreón‐Rodríguez, Mónica Martínez-Martínez, Rocío RodríguezValentín
{"title":"ET3 promotes the glial phenotype in enteric neural progenitors when used in parallel or after gdnf stimulus","authors":"A. Carreón‐Rodríguez, Mónica Martínez-Martínez, Rocío RodríguezValentín","doi":"10.15406/JSRT.2017.02.00076","DOIUrl":"https://doi.org/10.15406/JSRT.2017.02.00076","url":null,"abstract":"","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"44 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76762637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-26DOI: 10.15406/JSRT.2017.02.00074
Katie E Schouweiler, Chen Zhao
An 89-year old man with a history of prostatic adenocarcinoma presents with fatigue, mild splenomegaly and lymphadenopathy, and pancytopenia. The bone marrow biopsy was received for consultation from an outside institution. The aspirate smears contain scant, largely acellular particles and scattered grape-like clusters of large atypical cells (A, upper panel). The atypical cells have irregular centrally to eccentrically placed nuclei, relatively fine chromatin, distinct nucleoli and variable amounts of pale blue cytoplasm (A, lower panel). Flow cytometric analysis of the marrow aspirate shows no increased blasts and no atypical myeloid or lymphoid populations.
{"title":"CD5+ diffuse large b-cell lymphoma mimicking metastatic carcinoma to bone marrow","authors":"Katie E Schouweiler, Chen Zhao","doi":"10.15406/JSRT.2017.02.00074","DOIUrl":"https://doi.org/10.15406/JSRT.2017.02.00074","url":null,"abstract":"An 89-year old man with a history of prostatic adenocarcinoma presents with fatigue, mild splenomegaly and lymphadenopathy, and pancytopenia. The bone marrow biopsy was received for consultation from an outside institution. The aspirate smears contain scant, largely acellular particles and scattered grape-like clusters of large atypical cells (A, upper panel). The atypical cells have irregular centrally to eccentrically placed nuclei, relatively fine chromatin, distinct nucleoli and variable amounts of pale blue cytoplasm (A, lower panel). Flow cytometric analysis of the marrow aspirate shows no increased blasts and no atypical myeloid or lymphoid populations.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76120974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.15406/jsrt.2017.02.00073
Arati Adhe-Rojekar, M. Rojekar
Hematopoietic stem cells (HSCs), are multipotent stem cells that give rise to all the cell types of myeloid and lymphoid lineages. There are various markers that can be used to detect HSCs. Ex. CD34, CD59, Thy1, CD38, C-kit, lin etc.3 HSCs have some functional characteristics. They can renew and differentiate, can be mobilized from bone marrow to blood and reverse also. It also can undergo for programmed cell death. As stem cells, HSCs are defined by their ability to replenish all blood cell types (Multipotency) and their ability to self-renew.4 It is known that a small number of HSCs can expand to generate a very large number of daughter HSCs. This phenomenon is used in bone marrow transplantation, when a small number of HSCs reconstitute the hematopoietic system.5 This indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur.
{"title":"Hematopoietic & mesenchymal - the two lineages of bone marrow stem cells","authors":"Arati Adhe-Rojekar, M. Rojekar","doi":"10.15406/jsrt.2017.02.00073","DOIUrl":"https://doi.org/10.15406/jsrt.2017.02.00073","url":null,"abstract":"Hematopoietic stem cells (HSCs), are multipotent stem cells that give rise to all the cell types of myeloid and lymphoid lineages. There are various markers that can be used to detect HSCs. Ex. CD34, CD59, Thy1, CD38, C-kit, lin etc.3 HSCs have some functional characteristics. They can renew and differentiate, can be mobilized from bone marrow to blood and reverse also. It also can undergo for programmed cell death. As stem cells, HSCs are defined by their ability to replenish all blood cell types (Multipotency) and their ability to self-renew.4 It is known that a small number of HSCs can expand to generate a very large number of daughter HSCs. This phenomenon is used in bone marrow transplantation, when a small number of HSCs reconstitute the hematopoietic system.5 This indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81373844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-21DOI: 10.15406/JSRT.2017.2.00071
R. J. Jha, E. Choi, Ihn Han
{"title":"Comparison of the Direct and Indirect Non-Thermal Atmospheric Plasma Effect on Human Periodontal Ligament Mesenchymal Stem Cells","authors":"R. J. Jha, E. Choi, Ihn Han","doi":"10.15406/JSRT.2017.2.00071","DOIUrl":"https://doi.org/10.15406/JSRT.2017.2.00071","url":null,"abstract":"","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"23 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78825141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-17DOI: 10.15406/JSRT.2017.02.00070
A. Sharma, ini Gokulch, H. Sane, P. Kulkarni, S. Pai, V. Ganwir, P. Badhe
Autism is a complex neurodevelopmental disorder defined by a triad of deficits including impaired social interaction, communication and behaviour. With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathology of autism. Here is a case of a six and a half year old boy with autism who was administered autologous bone marrow mononuclear cells (BMMNCs) intrathecally followed by an intensive rehabilitation program. On follow up at 3 months and 7 months post intervention, he showed significant symptomatic improvements with no major side effects. At the end of 7 months, ISAA score improved from 98 to 81. The Wee FIM showed improvement 80 to 89.1. CARS score reduced from 28.5 (mild to moderate autism) to 23.5 (mild autism). PET CT scan of the brain performed pre intervention and seven months post showed a balancing effect in the metabolism of affected areas. It also showed reduction in hypermetabolism of the frontal, parietal and temporal lobe bilaterally and increase in metabolism of the previously hypometabolic bilateral cerebelli. The changes observed on the PET CT scan of the brain correlated with clinical improvements. We hypothesize that cellular therapy holds great potential as a treatment modality for autism in combination with standard rehabilitation therapy. Randomized controlled trials are warranted to study their long term effects in treating autism.
{"title":"A case of autism showing clinical improvements after cellular Therapy along with PET CT evidence","authors":"A. Sharma, ini Gokulch, H. Sane, P. Kulkarni, S. Pai, V. Ganwir, P. Badhe","doi":"10.15406/JSRT.2017.02.00070","DOIUrl":"https://doi.org/10.15406/JSRT.2017.02.00070","url":null,"abstract":"Autism is a complex neurodevelopmental disorder defined by a triad of deficits including impaired social interaction, communication and behaviour. With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathology of autism. Here is a case of a six and a half year old boy with autism who was administered autologous bone marrow mononuclear cells (BMMNCs) intrathecally followed by an intensive rehabilitation program. On follow up at 3 months and 7 months post intervention, he showed significant symptomatic improvements with no major side effects. At the end of 7 months, ISAA score improved from 98 to 81. The Wee FIM showed improvement 80 to 89.1. CARS score reduced from 28.5 (mild to moderate autism) to 23.5 (mild autism). PET CT scan of the brain performed pre intervention and seven months post showed a balancing effect in the metabolism of affected areas. It also showed reduction in hypermetabolism of the frontal, parietal and temporal lobe bilaterally and increase in metabolism of the previously hypometabolic bilateral cerebelli. The changes observed on the PET CT scan of the brain correlated with clinical improvements. We hypothesize that cellular therapy holds great potential as a treatment modality for autism in combination with standard rehabilitation therapy. Randomized controlled trials are warranted to study their long term effects in treating autism.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90068809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-12DOI: 10.15406/JSRT.2017.02.00069
Banu Asima, Venkatesh Samhitha, Presteena, S. Karthik
Methods: This was a prospective cross-sectional study at a tertiary care hospital. Patients upto the age of 80, having otorrhea for more than 6-12 weeks [2,3] and attending the ENT outpatient department were included. Samples of pus were collected from the deeper aspect of external auditory meatus and processed using standard techniques for culture and sensitivity. Biofilm detection was done. Results were compiled and statistically analysed.
{"title":"Spectrum and Antibiogram of Bacteria in Chronic Suppurative Otitis Media and Biofilm Formation","authors":"Banu Asima, Venkatesh Samhitha, Presteena, S. Karthik","doi":"10.15406/JSRT.2017.02.00069","DOIUrl":"https://doi.org/10.15406/JSRT.2017.02.00069","url":null,"abstract":"Methods: This was a prospective cross-sectional study at a tertiary care hospital. Patients upto the age of 80, having otorrhea for more than 6-12 weeks [2,3] and attending the ENT outpatient department were included. Samples of pus were collected from the deeper aspect of external auditory meatus and processed using standard techniques for culture and sensitivity. Biofilm detection was done. Results were compiled and statistically analysed.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90609543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ERK/MSC Transplantation of MSC Modifications Improves Neurological Function by Enhancing Survival of Implanted Cells and Modulating Neuronal De-Differentiation/Neuroinflammation after Strokein Rats","authors":"Xiaoqing Gao, Haibo Dou, Jiaqi Huang, Chao Zhang, Lifen Li, B. Liu, Q. Yuan","doi":"10.15406/jsrt.2017.02.00068","DOIUrl":"https://doi.org/10.15406/jsrt.2017.02.00068","url":null,"abstract":"","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"17 7 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2017-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89910979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-31DOI: 10.15406/JSRT.2017.02.00067
Dan Li, S. Song
distinct markers and eliminating them in a process termed immune surveillance. However, one hallmark of tumor cells is their ability to escape immune recognition, and even suppress the body’s natural immune response.2 The idea of manipulating immune cells to fight cancer dates back more than a century ago. It has been shown that B cells as well as T cells, natural killer cells, monocytes and other immune cells could infiltrate into tumor mass and actively regulate its growth and metastasis. Extensive studies have been performed to better understand the cross talk between cancer cells and immune components. Recently, in addition to traditional treatments targeting malignant cancer cells, increasing emphasis has been put on redirecting the immune responses to eradicate tumor cells, so-called cancer immunotherapy.
{"title":"Engineer immune cells to fight cancer","authors":"Dan Li, S. Song","doi":"10.15406/JSRT.2017.02.00067","DOIUrl":"https://doi.org/10.15406/JSRT.2017.02.00067","url":null,"abstract":"distinct markers and eliminating them in a process termed immune surveillance. However, one hallmark of tumor cells is their ability to escape immune recognition, and even suppress the body’s natural immune response.2 The idea of manipulating immune cells to fight cancer dates back more than a century ago. It has been shown that B cells as well as T cells, natural killer cells, monocytes and other immune cells could infiltrate into tumor mass and actively regulate its growth and metastasis. Extensive studies have been performed to better understand the cross talk between cancer cells and immune components. Recently, in addition to traditional treatments targeting malignant cancer cells, increasing emphasis has been put on redirecting the immune responses to eradicate tumor cells, so-called cancer immunotherapy.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74479831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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