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Short Note on Zidovudine 关于齐多夫定的简短说明
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.10.E116
Karthik Nagothi
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引用次数: 0
Oral Candidiasis in Leukemia Patients 白血病患者口腔念珠菌病
Pub Date : 2021-01-01 DOI: 10.37421/2161-0517.21.10.207
O. Hamouda
Oral candidiasis are mycoses resulting from the overgrowth of yeasts of the Candida genus, represents a serious problem for patients with leukemia. The mortality rate of this infection has increased due to fungal septicemia, associated with a primary buccal infection. Objective: The aim of our study is to determine the prevalence of oral candidiasis in leukemia patients, identify the Candida spp. in buccal lesions, differentiate the factors that influence their development. Patients and Methods: This is a retrospective and descriptive study conducted over a four-months period from November 7, 2016 to March 2, 2017, including patients diagnosed with leukemia. Sociodemographic, clinical and biological data from patients fulfilling the inclusion criteria were collected and analyzed. The lesion sample was taken and studied by direct exam and culture on Sabouraud Chloramphenicol and Sabouraud Chloramphenicol Actidionne. The identification of the isolated yeast was done by the filamentation test, carbohydrate fermentation and assimilation.  Results: 56 patients were included in this study. Most of the cases (48,21%) were positive to oral candidiasis Their average age was 33,86 years, they were mainly made up of men (64.28%).  Candida, albicans was the most frequent species found (55,55%), followed by Candida. glabrata (22.22%), Candida tropicalis (14.81%) and Candida krusei (7,40%). The main contributing factor found was parenteral nutrition (55,55%), corticosteroid therapy (55,55%), antibiotherapy (37,03%), neutropenia (25,92%) and diabetes (11,11%). Conclusion: The results suggest that oral candidiasis is a frequent complication in the leukemia patients. C. albicans was the main etiological agent, however, there is an important participation of other Candida species.
口腔念珠菌病是念珠菌属酵母菌过度生长引起的真菌病,对白血病患者来说是一个严重的问题。这种感染的死亡率由于真菌败血症而增加,与原发性口腔感染有关。目的:了解白血病患者口腔念珠菌病的患病率,鉴别口腔病变念珠菌属,并探讨影响其发展的因素。患者和方法:这是一项回顾性和描述性研究,从2016年11月7日到2017年3月2日,为期4个月,包括诊断为白血病的患者。收集并分析符合纳入标准的患者的社会人口学、临床和生物学资料。取病变标本,对沙伯氯霉素和沙伯氯霉素Actidionne进行直接检测和培养。通过成丝试验、碳水化合物发酵和同化对分离酵母进行鉴定。结果:56例患者纳入本研究。口腔念珠菌病检出率最高(48.21%),平均年龄33、86岁,以男性为主(64.28%)。念珠菌、白色念珠菌最多(55.55%),其次为念珠菌。裸露念珠菌(22.22%)、热带念珠菌(14.81%)和克鲁西念珠菌(7.40%)。主要影响因素为肠外营养(55,55%)、皮质类固醇治疗(55,55%)、抗生素治疗(37,03%)、中性粒细胞减少(25,92%)和糖尿病(11.11%)。结论:口腔念珠菌感染是白血病患者常见的并发症。白色念珠菌是主要病原,但其他念珠菌也有重要的参与。
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引用次数: 0
Potential for Biological Control of Postharvest Fungal Rot of White Yam (Dioscorea rotundata Poir) Tubers in Storage with Trichoderma harzianum 哈兹木霉对白山药块茎采后真菌腐病的生物防治潜力
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.10.210
Gwa Vi, E. Ekefan
Potential of Trichoderma harzianum for biological control of postharvest fungal rot of white yam (Dioscorea rotundata Poir) tubers in storage was studied. Pathogenicity test revealed the susceptibility of healthy looking yam tubers to Aspergillus niger, Botryodiplodia theobromae and Fusarium oxysporum f. sp. melonganae after fourteen days of inoculation. Treatments comprising A. niger, B. theobromae and F. oxysporum each paired with T. harzianum and were arranged in completely randomized design and stored for five months between December, 2015 and April, 2016 and December, 2016 and April, 2017. Results revealed that tubers treated with the pathogenic fungi alone caused mean percentage rot of between 6.67% (F. oxysporum) and 22.22% (A. niger) while the paired treatments produced only between 2.22% (T. harzianum X F. oxysporum) and 6.67% (T. harzianum X A. niger). In the second year of storage, mean percentage rots were between 13.33% (F. oxysporum) and 28.89% (A. niger) while in the paired treatment rots were only between 6.67% (F. oxysporum X T. harzianum) and 8.89% (A. niger X T. harzianum). Tubers treated with antagonist alone produced 0.00% and 2.22% in the first and second year respectively. Result revealed that there was a significant difference (P ≤ 0.05) in mean percentage rot between the first year and the second year except where B. theobromae was inoculated alone, A. niger and T. harzianum paired and B. theobromae and T. harzianum paired. The most antagonized fungus in paired treatment for both years was F. oxysporum f. sp. melonganae while the least antagonized was A. niger and B. theobromae. The study recommended the use of T. harzianum in the control of rot causing pathogens of yam tubers in storage as better alternative ways of reducing tuber rot compared with the use of chemical fungicides which are environmentally hazardous.
研究了哈兹木霉对贮藏中白山药块茎采后真菌腐病的生物防治潜力。致病性试验表明,接种14 d后,外观健康的山药块茎对黑曲霉、可可芽孢杆菌和黑孢镰刀菌敏感。采用完全随机设计,分别于2015年12月至2016年4月和2016年12月至2017年4月存放5个月,处理为黑曲霉、可可黑曲霉和尖孢镰刀菌各与哈兹霉配对。结果表明,病原菌单独处理的块茎腐烂率在6.67% ~ 22.22%之间,而配对处理的块茎腐烂率仅在2.22% ~ 6.67%之间。贮藏第二年,平均腐枝率在13.33% ~ 28.89%之间,而配对处理的腐枝率仅在6.67% ~ 8.89%之间。仅用拮抗剂处理的块茎在第一年和第二年的产量分别为0.00%和2.22%。结果表明,除单独接种黑曲霉、黑曲霉与哈茨海默氏菌配对、黑曲霉与哈茨海默氏菌配对外,第一年与第二年的平均腐殖率均有显著差异(P≤0.05)。配对处理中拮抗效果最好的真菌是黑孢霉,拮抗效果最差的真菌是黑霉和可可霉。该研究建议使用哈氏菌来控制储存中的山药块茎的腐病致病菌,与使用对环境有害的化学杀菌剂相比,这是减少块茎腐病的更好的替代方法。
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引用次数: 2
Study of Stavudine 司他夫定的研究
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.10.E115
J. Mery
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引用次数: 0
Pediatric Virology and its collaboration between fundamental science and clinical practice 儿童病毒学及其基础科学与临床实践的合作
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.S1.E001
John Martin
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引用次数: 0
Aggravation related with a hepatitis B contamination can prompt broad liver scarring (Sirrhosis) 与乙肝污染相关的恶化可引起广泛的肝瘢痕形成(肝硬化)。
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.S1.E004
Sharof Meadwle
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引用次数: 0
Top Ten Viruses Reported on Chilly in Southeast Asia 东南亚地区报告的十大感冒病毒
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.10.209
J. Kushwaha, A. Rai, D. Srivastava
Chilly is a common spice crop grown in large quantities in South Asia. India produces 75% of the total chilly crop followed by Nepal at 8% and Bangladesh at 6%, where it is grown primarily by large and small-scale farmers. It can also be found in the kitchen garden. Disease and insect pests are the most significant factors affecting the production of the chilly crop. The viral disease represents a significant threat to chilly production. Recently, 68 viruses have been reported influencing the chilly crop all over the world. Chilly Leaf Curl Virus Disease, Cucumber Mosaic Virus, Tobacco Mosaic Virus, Tomato Spotted Wilt Virus, Potato Virus Y, Alfalfa Mosaic Virus, Pepper Vein Mottle Virus, Beet Curl Top Virus, and Pepper Mild Mottle Virus are among the 68 viruses belonging to seven genera namely, Begomovirus, Cucumovirus, Tobamovirus, Tospovirus, Potyvirus, Alfamovirus and Curtovirus. In chilly cultivation, yield losses vary from 15 to 100%, depending on the virus. This review article is an analysis providing of top ten viruses reported in Chilly, including their geographic range, yield losses, symptomatology, transmission and management in South Asian Countries.
辣椒是一种常见的香料作物,在南亚大量种植。印度生产的低温作物占总产量的75%,其次是尼泊尔占8%,孟加拉国占6%,主要由大型和小规模农民种植。它也可以在厨房花园里找到。病虫害是影响寒凉作物生产的最重要因素。这种病毒性疾病对冷产品构成了重大威胁。最近,全世界报告了68种影响寒冷作物的病毒。这68种病毒分别是begomvirus、Cucumovirus、Tobamovirus、Tospovirus、Potyvirus、alfamvirus和Curtovirus,它们属于7个属,分别是:黄瓜花叶病毒、烟草花叶病毒、番茄斑驳病毒、马铃薯Y病毒、苜蓿花叶病毒、辣椒花叶病毒、辣椒花叶病毒、辣椒花叶病毒、辣椒花叶病毒。在低温栽培中,根据病毒的不同,产量损失从15%到100%不等。这篇综述文章分析了南亚国家报告的十大感冒病毒,包括它们的地理范围、产量损失、症状、传播和管理。
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引用次数: 0
Possible Collaboration of Veterinarians and Medicos over the Fight against Covid-19 with andldquo;One-Health Approachandrdquo; 兽医和医务人员在抗击新冠肺炎方面可能开展的合作;
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.10.200
O. M. U. D. Sofi
As of now, SARS CoV-2 has been identified as seventh human-infected coronavirus. Certain coronaviruses (CoVs) include SARS-CoV, 229E, HKU1, OC43, NL63 and MERS-CoV, of which SARS-CoV and MERS-CoV are zoonotic and have resulted in high-percentage outbreaks over the past two decades, while rest of them is typically associated with mild upper respiratory diseases. On 11 March 2020 the WHO announced the situation to be a pandemic that threatens humanity with a wide range. Of the new, bat and pangolins are thought to be the possible origins of SARSCoV- 2 inchoation. The COVID-19 pandemic is putting uneven stress on public health systems around the world. To mitigate the impact of this rapidly spreading virus a multidisciplinary collaborative approach is needed. Since all pandemic viruses that emerged in the last century originate in the animal world and the ongoing changes in the respective interfaces between humans, animals and the environment have led to an increase in major predisposing factors that allow zoonotic viruses to emerge as novel human pathogens, 'peacetime' pandemic preparedness efforts should follow a 'One Health approach'.
截至目前,SARS - CoV-2已被确定为第七种人类感染的冠状病毒。某些冠状病毒包括SARS-CoV、229E、HKU1、OC43、NL63和中东呼吸综合征- cov,其中SARS-CoV和MERS-CoV是人畜共患的,在过去二十年中导致了高比例的爆发,而其余的冠状病毒通常与轻度上呼吸道疾病有关。2020年3月11日,世卫组织宣布这是一场大流行,对人类构成了广泛威胁。在新的研究中,蝙蝠和穿山甲被认为是SARSCoV- 2的可能起源。COVID-19大流行给世界各地的公共卫生系统带来了不同程度的压力。为了减轻这种迅速传播的病毒的影响,需要采取多学科合作的方法。由于上个世纪出现的所有大流行病毒都起源于动物世界,而人类、动物和环境之间各自界面的持续变化导致了主要诱发因素的增加,从而使人畜共患病毒成为新的人类病原体,因此,“和平时期”的大流行防范工作应遵循“同一个卫生方针”。
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引用次数: 0
Classification of Immunosuppression Drugs 免疫抑制药物的分类
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.10.E114
Rishika Meadwle
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引用次数: 0
Oral Infection with a Low-Risk Strain of HPV 口腔感染低风险株HPV
Pub Date : 2021-01-01 DOI: 10.35248/2161-0517.21.S1.E005
Luise Martin
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引用次数: 0
期刊
Virology & mycology : infectious diseases
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