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The link between gut microbiota and atherosclerosis 肠道微生物群和动脉粥样硬化之间的联系
Pub Date : 2023-10-15 DOI: 10.18231/j.ijcap.2023.032
Divyakshi Patel, Gauri Mahajan, Neeraj Mahajan
Infections have been linked to development of cardiovascular complaint and atherosclerosis. Cardio vascular conditions like atherosclerosis are the major cause of mortality and morbidity in the ultramodern society. The rupture of atherosclerotic plaque can induce thrombus conformation, which is the main cause of acute cardiovascular events. Lately, numerous studies have demonstrated that there are some connections between microbiota and atherosclerosis. There are three metabolite pathways by which gut microbiota can affect atherosclerosis. Either original or distant- causing inflammation which might lead to atherosclerotic plaque formation and rupture. Second, metabolism of lipids and cholesterol by gut microbiota can affect atheromatous atheromatous plaque conformation. Third, diet and specific factors that are metabolized by gut microbiota can have various effects on atherosclerosis; for illustration, salutary fiber is beneficial, whereas the bacterial metabolite trimethylamine- N- oxide (TMAO) is considered dangerous. We'll conclude by discussing new remedial strategies for targeting gut microbiota to ameliorate atherosclerosis and related cardiovascular issues.
感染与心血管疾病和动脉粥样硬化的发展有关。动脉粥样硬化等心血管疾病是超现代社会中死亡率和发病率的主要原因。动脉粥样硬化斑块破裂可诱发血栓形成,血栓形成是急性心血管事件的主要原因。最近,许多研究表明,微生物群与动脉粥样硬化之间存在一些联系。肠道菌群影响动脉粥样硬化的代谢途径有三种。原发或远处引起的炎症,可能导致动脉粥样硬化斑块形成和破裂。其次,肠道菌群对脂质和胆固醇的代谢会影响动脉粥样硬化斑块的形成。第三,饮食和肠道菌群代谢的特定因素可对动脉粥样硬化产生多种影响;例如,有益纤维是有益的,而细菌代谢产物三甲胺- N-氧化物(TMAO)被认为是危险的。最后,我们将讨论针对肠道微生物群改善动脉粥样硬化和相关心血管问题的新治疗策略。
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引用次数: 0
A cadaveric case study of the fibulo calcaneus internus muscle as a rare accessory muscle of calf region 腓骨跟内肌作为小腿区域罕见的副肌的尸体案例研究
Pub Date : 2023-10-15 DOI: 10.18231/j.ijcap.2023.042
Lahange Sandeep Madhukar, Vikash Bhatnagar, Archana Nivrutti Bhangare, Suwalal Gupta
The fibulocalcaneus (peroneocalcaneus) Internus (FCI) muscle which is also called as Peroneo calcaneus Internus (PCI) muscle (of MacAlister) is a rare variation of calf muscle with a low prevalence of <1%-3% in cadaveric dissection and imaging studies. The FCI arises from the posterior-medial aspect of the distal 1/3 of the fibula, descends posterior and lateral to the flexor hallucis longus (FHL) muscle. It than traverses the tarsal tunnel inferior to the sustentaculum tali of the Calcaneus, and get inserted into the plantar surface of the calcaneus. However, controversy exists concerning the exact location of the insertion site of FCI muscle. Recently the insertion of the FCI muscle has been described as distal to the coronoid fossa, a small depression between the anterior tuberosity and the anterior apex of the sustentaculum tali of the calcaneus. However, chronological descriptions described the FCI as inserting into either the sustentaculum tali itself or a small tubercle on the medical surface of the calcaneus distal to the sustentaculum tali. During routine dissection for under graduate students, about 56-year old Indian male, a Fibulocalcaneus (peroneocalcaneus) Internus (FCI) muscle was identified, which originated from the posterior medial surface of distal third of the fibula and tendon merges with 2 slip of flexor digitorum longus and get inserted on base of distal phalanx of second toe. Knowledge of the FCI muscle is important due its involvement with various ankle pathologies, including predisposing individuals to tarsal tunnel syndrome, FHL tenosynovitis, and posterior ankle impingement and pain. The FCI muscle is one of the least common muscular variants associated with the ankle joint, and it has been implicated in posterior ankle pain and impingement. This muscle is often confused with the flexor digitorum accessorius longus (FDAL) muscle. Additionally, this study describes ways to differentiate between the FCI and FDAL muscles in the lower leg. Radiologists and clinicians should be aware of this anomalous muscle when considering various diagnoses, interpreting radiographs, and pursuing surgical involvement to reduce symptoms of posterior ankle region.
腓骨局部caneus (peroneocalcaneus) Internus (FCI)肌,也被称为腓骨跟肌内肌(PCI)肌(MacAlister),是一种罕见的小腿肌肉变异,在尸体解剖和影像学研究中患病率为1%-3%。FCI起源于腓骨远端1/3的后内侧,向下至拇长屈肌(FHL)的后部和外侧。然后穿过跟骨支撑下的跗骨隧道,并插入跟骨的足底表面。然而,FCI肌的确切插入位置存在争议。最近,FCI肌的止点被描述为冠状窝的远端,前粗隆和跟骨支撑带前尖之间的一个小凹陷。然而,按照时间顺序的描述,FCI要么插入支撑骨本身,要么插入与支撑骨远端的跟骨医学表面上的一个小结节。在对56岁左右的印度男性本科生进行常规解剖时,发现腓骨(腓骨)内肌(FCI),起源于腓骨远端三分之一后内侧面,肌腱与指长屈肌2滑汇合,插入第二趾远端指骨基部。FCI肌的知识很重要,因为它与各种踝关节病变有关,包括个体易患跗骨隧道综合征、FHL腱鞘炎、后踝关节撞击和疼痛。FCI肌是与踝关节相关的最不常见的肌肉变异之一,它与踝关节后痛和撞击有关。这块肌肉常与指长副屈肌(FDAL)混淆。此外,本研究描述了区分小腿FCI和FDAL肌肉的方法。放射科医生和临床医生在考虑各种诊断、解释x线片和寻求手术介入以减轻后踝区症状时应注意这种异常肌肉。
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引用次数: 0
Morphological variations of the suprascapular notch and its clinical correlation with suprascapular nerve entrapment syndrome 肩胛上切迹的形态变化及其与肩胛上神经卡压综合征的临床关系
Pub Date : 2023-10-15 DOI: 10.18231/j.ijcap.2023.035
Vijayalakshmi Mannan Keerthi, Guna Sekhar Moorthyee Kollipara, Shruthi Sridhar, Padmalatha Kadirappa, Anushree Burade, Shiva Sandesh Hossali Math, Niranjan Kumar
The suprascapular notch present medial to the coracoid process serves as a passage for the suprascapular nerve which supplies the rotator cuff muscles and ligaments in the acromio-clavicular and shoulder joints. The suprascapular nerve is commonly compressed at the suprascapular notch, which can result in severe shoulder pain, weakness of the arm, restricted range of movement, and eventually, atrophy of the muscles supplied by the nerve. The syndrome of suprascapular nerve entrapment is a significant differential diagnosis of shoulder pain. Unfortunately, it is often neglected while diagnosing shoulder pain or discomfort. Our study's main objective is to examine how often different morphological variations occur in the suprascapular notch and their potential role in causing suprascapular nerve entrapment syndrome. We grossly examined 70 scapula to identify the presence, absence and type of suprascapular notch. We documented the observed variations of the suprascapular notch by capturing photographs and organizing the findings in a table. According to our findings, Type 3 (U-shaped notch) was the most frequently observed morphological variation of the suprascapular notch, while Type 1 (absence of suprascapular notch) was the least commonly found. Our findings provide fresh perspectives when compared to prior research. Having knowledge of the morphological variations of the suprascapular notch plays a vital role in accurately diagnosing suprascapular nerve entrapment syndrome using non-invasive diagnostic imaging and planning the most suitable surgical interventions.
肩胛上切迹位于喙突内侧是肩胛上神经的通道肩胛上神经支配肩锁关节和肩关节中的肩袖肌肉和韧带。肩胛上神经通常在肩胛上切迹处受压,可导致严重的肩痛、手臂无力、活动范围受限,并最终导致由该神经支配的肌肉萎缩。肩胛上神经卡压综合征是肩关节疼痛的重要鉴别诊断。不幸的是,在诊断肩部疼痛或不适时,它经常被忽视。我们研究的主要目的是检查肩胛上切迹发生不同形态变异的频率,以及它们在引起肩胛上神经卡压综合征中的潜在作用。我们对70例肩胛骨进行了粗略检查,以确定肩胛上切迹的存在、缺失和类型。我们记录了观察到的肩胛上切迹的变化通过捕捉照片和组织在一个表的发现。根据我们的研究结果,3型(u形切迹)是肩胛上切迹最常见的形态学变化,而1型(没有肩胛上切迹)是最不常见的。与之前的研究相比,我们的发现提供了新的视角。了解肩胛上切迹的形态变化,对于利用无创影像诊断准确诊断肩胛上神经卡压综合征,并制定最合适的手术干预方案至关重要。
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引用次数: 0
Morphometric analysis of adult human mandible and their ratios 成人下颌骨形态计量学分析及其比例
Pub Date : 2023-10-15 DOI: 10.18231/j.ijcap.2023.034
Neeta Gautam Shroff, Shamama Shaikh, Gautam A Shroff, Vaishali Mandhana, Sana Khan
Mandible is the strongest bone in the face region required for the process of mastication. The inferior alveolar nerve travels inside the bone in the mandibular canal to supply the lower teeth. The measurement of various parameters of mandible allows the proper localisation of nerve for anaesthetic block. Also, the ratios between factors assists during surgeries. A cross-sectional observational study was conducted on 97 dry adult human mandibles. Height of symphysis menti, ramus breadth and height, and distance of mandibular foramen from mandibular notch and base of mandible of both sides are measured. Ratios between ramus height and breadth and distances of mandibular foramen from above mentioned landmarks were computed. The mean height of symphysis menti was found to be 25.52 ± 4.32 mm. The mean values of height of ramus on right side was 46.18 ± 4.43 mm and on left was 46.57 ± 4.24 mm. The mean breadth of ramus was 32.29 ± 3.57 mm (right side) and 32.59 ± 3.75 mm (left side). It was found that mandibular foramen was closer to the mandibular notch than to the base of mandible on both sides. The ratios between the right and left side showed no significant differences. Inferior alveolar nerve block is required in various dental procedures for which mandibular foramen localisation is must. Dimensions of mandible help in surgical restructuring. Similarly, it aids in understanding the evolution of the bone.
下颌骨是咀嚼过程中面部最坚硬的骨骼。下牙槽神经在骨内的下颌管中传导,支配下牙。通过对下颌骨各项参数的测量,可以对麻醉阻滞的神经进行适当的定位。此外,各因素之间的比率有助于手术。对97块干成人下颌骨进行了横断面观察研究。测量两侧下颌联合高度、支宽、支高、下颌孔距下颌切迹及下颌基部的距离。计算分支高度与宽度的比值以及下颌孔与上述标志的距离。神经联合的平均高度为25.52±4.32 mm。右侧支高46.18±4.43 mm,左侧支高46.57±4.24 mm。平均分支宽度为32.29±3.57 mm(右侧)和32.59±3.75 mm(左侧)。结果表明,两侧的下颌孔离下颌切迹较近,离下颌基部较近。左右两侧的比值无显著差异。下牙槽神经阻滞需要在各种牙科手术,下颌孔定位是必须的。下颌骨的尺寸对外科重建有帮助。同样,它有助于理解骨骼的进化。
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引用次数: 0
To assess the effect of increasing age on body composition parameters in young and middle-aged healthy obese females by body segment analyzer 应用体段分析仪评价年龄增长对中青年健康肥胖女性体组成参数的影响
Pub Date : 2023-07-15 DOI: 10.18231/j.ijcap.2023.023
Jeewandeep Kaur, A. Batra
Aging is often associated with changes in body composition that includes total fat mass and decreased total lean body mass. In addition to changes in total fat mass, visceral or centrally located fat stores increase in size. To assess the effect of increasing age on body composition parameters in young and middle-aged healthy obese females by Body Segment Analyzer and framing preventive health measures that reduce the changes in body composition during middle age, thus setting the stage for a healthy old age. The study was conducted in Department of Physiology (CRL), BPS GMC for Women, Kanpur Kalan, Sonepat. The data for this comparative study was collected from 150 females of which 75 were of group I and 75 were of group II. Group I had cover a range from 18 to 34 years and group II had cover a range from 35 to 50 years. The present study showed, the effect of age on body fat mass, fat free mass, soft lean mass and percentage body fat was found to be highly significant (p < 0.05) but skeletal muscle mass in both the groups was not found to be significant (p = 0.434).: From the present study it was concluded that age had severe effect on body composition parameters that is body fat, fat free mass, soft lean mass and percentage body fat in obese females.
衰老通常与身体成分的变化有关,包括总脂肪量和总瘦体重的减少。除了总脂肪量的变化外,内脏或中央脂肪库的体积也会增加。通过身体段分析仪评估年龄增长对中青年健康肥胖女性身体成分参数的影响,并制定预防性健康措施,减少中年期间身体成分的变化,从而为健康老年奠定基础。这项研究在索内帕特坎普尔卡兰BPS GMC妇女生理学系(CRL)进行。本比较研究的数据收集自150名女性,其中75人属于第一组,75人属于第二组。第一组为18至34岁,第二组为35至50岁。本研究表明,年龄对体脂量、无脂量、软瘦量和体脂百分比的影响非常显著(p<0.05),但两组的骨骼肌质量均不显著(p=0.434),肥胖女性的软瘦质量和体脂百分比。
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引用次数: 0
Alternative natural and chemical substances to traditional formalin-based embalming fluid for cadaveric dissection: A review 传统福尔马林防腐液的天然和化学替代物质研究进展
Pub Date : 2023-07-15 DOI: 10.18231/j.ijcap.2023.016
B. Satapathy, B. Kar
Formalin, a widely used embalming fluid in the preservation of cadavers, poses significant health risks to anatomists, medical students, and the environment. This review article evaluates alternative natural and chemical substances for embalming fluid in cadaveric dissection. We conducted a comprehensive literature search on PubMed, Scopus, and Web of Science, focusing on alternative embalming fluids in the past 20 years. The main outcome of interest was the effectiveness of alternative fluids in preserving cadavers for dissection. The review identified several alternatives, including Thiel's solution, modified Larssen solution, Genelyn, and natural alternatives such as honey and essential oils. Thiel's solution has emerged as a popular alternative, providing excellent preservation and flexibility of cadavers. However, the high costs and the need for specialized equipment limit its widespread adoption. Essential oils and honey have also shown potential as effective, environmentally friendly alternatives to formalin. Future research should optimise the composition and application of these alternatives to improve their cost-effectiveness, feasibility, and environmental impact.
福尔马林是一种广泛用于尸体保存的防腐液,对解剖学家、医科学生和环境构成重大的健康风险。本文综述了尸体解剖中可供选择的天然和化学防腐液。我们在PubMed, Scopus和Web of Science上进行了全面的文献检索,重点是过去20年的替代防腐液。研究的主要结果是替代液体在保存尸体以供解剖方面的有效性。该综述确定了几种替代方案,包括Thiel溶液、改性Larssen溶液、Genelyn溶液以及蜂蜜和精油等天然替代品。蒂尔的解决方案已经成为一种流行的替代方案,提供了出色的尸体保存和灵活性。然而,高昂的成本和对专用设备的需求限制了它的广泛采用。精油和蜂蜜也显示出作为有效、环保的福尔马林替代品的潜力。未来的研究应该优化这些替代品的组成和应用,以提高它们的成本效益、可行性和环境影响。
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引用次数: 0
Study to examine diverse locations of greater palatine foramen in dry human skulls 研究在干燥的人类头骨中检查腭大孔的不同位置
Pub Date : 2023-07-15 DOI: 10.18231/j.ijcap.2023.020
Vaishakhi Gonsai, Janki Jadav, S. Kanani, Ankur Zalawadia
Greater palatine foramen gives passage to greater palatine nerve which innervates posterior part of hard palate. Anesthetic block is given to greater palatine nerve for surgical procedures over upper molar, maxillary sinus & nasal region. In this study, we measured the location of greater palatine foramen (GPF), according to clinically identifiable anatomical landmarks. All measurements were taken bilaterally & directly on dry human skulls. Observations were recorded in millimeters, using a digital vernier caliper. After the data collection, data were analyzed using the standard statistical software (SPSS). The situation of the GPF in relation to 3maxillary molar was in 25% of the skulls. The average values of the distance between the GPF & midline palatine suture (MPS) & posterior border of hard palate (PBHP) were 15.9 mm (SD 1.2) & 5.9 mm (SD 1.1), respectively.: Diverse locations of greater palatine foramen arouse difficulties in locating exact position during anaesthesia. Therefore, understanding the different positions of greater palatine foramen can help surgeons to improve their surgical procedures.
腭大孔通向支配硬腭后部的腭大神经。在上磨牙、上颌窦和鼻区进行外科手术时,麻醉阻滞给予腭大神经。在这项研究中,我们根据临床可识别的解剖标志测量了腭大孔(GPF)的位置。所有测量都是在干燥的人类头骨上进行的。使用数字游标卡尺以毫米为单位记录观察结果。数据收集完成后,采用标准统计软件SPSS对数据进行分析。与上颌磨牙相关的GPF情况占颅骨总数的25%。GPF与腭中线缝合线(MPS)与硬腭后缘(PBHP)之间的距离平均值分别为15.9 mm (SD 1.2)和5.9 mm (SD 1.1)。:在麻醉过程中,由于腭大孔位置不同,难以准确定位。因此,了解腭大孔的不同位置可以帮助外科医生改进他们的手术方法。
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引用次数: 0
Persistent median artery with absence of superficial palmar arch- Case report 持续性正中动脉伴掌浅弓缺失1例
Pub Date : 2023-07-15 DOI: 10.18231/j.ijcap.2023.026
Urvi Sharma, A. Tirpude, R. K. Ukey
Variations in the vascular supply of palm is commonly described. While regular cadaveric dissection of undergraduate students one such variation was reported in our college is the persistent median artery with absent superficial palmar arch. Palm arterial supply is by both palmar arches (superficial and deep). In our study, the ulnar and median arteries supply the palm of the cadaver's right extremity without forming an arch. Awareness of arterial supply of the palm is essential in surgical emergencies and procedures related to angiography.
手掌血管供应的变化通常被描述。在我们学院的本科生尸体解剖中,有一个这样的变异是持续存在的正中动脉,没有掌浅弓。掌动脉由掌弓(浅弓和深弓)供应。在我们的研究中,尺动脉和正中动脉供应尸体右肢的手掌,但没有形成弓。意识到手掌的动脉供应在外科急诊和与血管造影有关的程序中是必不可少的。
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引用次数: 0
Morpho-metrical analysis of upper humerus- A study from Central Maharashtra 上肱骨形态计量学分析——来自马哈拉施特拉邦中部的一项研究
Pub Date : 2023-07-15 DOI: 10.18231/j.ijcap.2023.025
S. Farheen, G. Shroff, Sadaf Tanveer Khan
The humerus is largest bone of the upper limb and also defines the human brachium. The shoulder joint is ball and socket joint formed by articulation of hemispherical head of humerus and shallow glenoid cavity of scapula. The sizes of Humeri & Glenoid can impact decision making during surgery for shoulder replacement and shoulder instability. Study of humerus is helpful for providing data and correlation factors which has enormous importance while making prosthesis for replacement surgery.: A retrospective study was conducted on 61 cadaveric humeri - 31 from left side and 30 from right side. Length, AP diameter, MLD and head size was calculated using vernier calliper, scale, no elastic thread and osteometer. The combined length of humerus was 309.84±17.91 mm. Left and right sided length was 308.42±17.859 mm and 311.30±17.91 mm respectively. AP diameter on left and right side was 39.10±2.791mm and 39.54±2.544 mm respectively. MLD combined was 42.959±3.264 mm and head height was 30.92±2.53 respectively. The morpho-metric dimensions of right side of humerus was more than that of left side.Proper measurements are required when surgical procedures are to be done. More studies should be conducted measuring head height.
肱骨是上肢最大的骨头,也决定了人的肱。肩关节是由肱骨半球形头和肩胛骨浅盂连接而成的球窝关节。肱骨和关节盂的大小可以影响肩关节置换术和肩关节不稳定手术的决策。肱骨的研究有助于为假体的制作提供数据和相关因素,对假体置换手术具有重要意义。对61例肱骨标本进行回顾性研究,其中左肱骨31例,右肱骨30例。使用游标卡尺、比例尺、无弹性螺纹和骨计计算长度、AP直径、MLD和头部大小。肱骨总长度为309.84±17.91 mm。左右两侧长度分别为308.42±17.859 mm和311.30±17.91 mm。左侧AP直径为39.10±2.791mm,右侧AP直径为39.54±2.544 mm。MLD合计为42.959±3.264 mm,头高30.92±2.53。肱骨右侧形态尺度大于左侧形态尺度。在进行外科手术时,需要进行适当的测量。应该进行更多的研究来测量头高。
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引用次数: 0
Neuromodulation of sleep through electrical vestibular nerve stimulation: An update 前庭神经电刺激对睡眠的神经调节:最新进展
Pub Date : 2023-07-15 DOI: 10.18231/j.ijcap.2023.029
S. Goothy, R. Parvathi
Sleep is the state of unconsciousness where some of the bodily activities are increased and some are decreased. Adequate sleep is essential for homeostasis. Lack of adequate sleep is one of the major public health issues and needs major attention. Prolonged insomnia leads to excessive anxiety and suicidal ideation. The existing pharmacological therapies are effective and associated with side effects. Hence, there is a need for alternative therapy with minimum or no side effects. The vestibular system consists of minute sensory receptors which are basically for regulating posture. However, the vestibular system involves multiple functions related to homeostasis from the level of reflexes to the level of cognition. That is the reason why the vestibular system is called the sixth sense. There are multiple methods to stimulate the vestibular system. Linear stimulation by swinging on a swing, caloric stimulation, vestibular exercises, and electrical vestibular nerve stimulation. Whatever the method adopted, the important thing is the amount of stimulation applied. It should be an optimal stimulus to get beneficial effects from vestibular stimulation. Electrical vestibular nerve stimulation is a safe and non-invasive mode of stimulating the vestibular nerve. Animal studies demonstrated that rhythmical linear acceleration in mice promotes sleep. Here we review the mechanisms behind the sleep-promoting actions of vestibular stimulation. Understanding the mechanisms helps to plan the management of sleep disorders effectively.
睡眠是一种无意识状态,其中一些身体活动增加,一些活动减少。充足的睡眠对体内平衡至关重要。睡眠不足是主要的公共卫生问题之一,需要引起人们的高度重视。长期失眠会导致过度焦虑和自杀念头。现有的药物治疗是有效的,并且有副作用。因此,需要副作用最小或无副作用的替代疗法。前庭系统由微小的感觉受体组成,这些受体主要用于调节姿势。然而,前庭系统涉及从反射水平到认知水平的与稳态相关的多种功能。这就是前庭系统被称为第六感的原因。刺激前庭系统有多种方法。通过在秋千上摆动的线性刺激、热量刺激、前庭锻炼和前庭神经电刺激。无论采用何种方法,重要的是施加的刺激量。它应该是从前庭刺激中获得有益效果的最佳刺激。前庭神经电刺激是一种安全、无创的前庭神经刺激方式。动物研究表明,小鼠有节奏的线性加速可以促进睡眠。在此,我们回顾前庭刺激促进睡眠的机制。了解这些机制有助于制定有效的睡眠障碍管理计划。
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引用次数: 0
期刊
Indian journal of clinical anatomy and physiology
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