Introduction: Guillain-Barré syndrome (GBS) is an acute polyneuropathy accompanied by muscle weakness, myalgia, and bulbar involvement. Objectives: We evaluated demographic, clinical and paraclinical features of children with this disease. Patients and Methods: In this cross-sectional study, the data of 83 patients with GBS were studied. All data about age, gender, place of residence (urban, rural), season of infection, history of infection or vaccination in the last month, clinical demonstrations and spinal magnetic resonance imaging findings with contrast, electromyography (EMG), nerve conduction velocity (NCV), cerebrospinal fluid (CSF), C-reactive protein (CRP) analysis was analyzed. Results: In this study, the highest incidence of GBS was in the summer (30.12%). Regarding clinical symptoms, 54.21% of patients were unable to walk, and around14.45 % of cases had positive Gowers’ sign. Additionally, 27.71% of patients reported pain, since 7.22% of them had severe respiratory distress with the need for mechanical ventilation. In patients who underwent EMG-NCV, findings were in favor of GBS in most cases (89.83%). In lumbar puncture, 53% of patients had normal CSF. Most patients (75.9%) had an erythrocyte sedimentation rate (ESR) below 30 mm/h. CRP of most patients (83.33%) was less than 10 mg/L. Conclusion: The predominant clinical symptoms of patients with GBS are the inability to walk, imbalance, positive Gowers’ sign, pain and respiratory distress, since ESR and CRP less than 30 and 10 mg/L are helpful, respectively.
{"title":"Evaluation of demographic, clinical and paraclinical features of children with Guillain-Barré syndrome","authors":"A. Ghazavi, E. Abbasi, S. Mohammadi","doi":"10.34172/JPE.2020.23","DOIUrl":"https://doi.org/10.34172/JPE.2020.23","url":null,"abstract":"Introduction: Guillain-Barré syndrome (GBS) is an acute polyneuropathy accompanied by muscle weakness, myalgia, and bulbar involvement. Objectives: We evaluated demographic, clinical and paraclinical features of children with this disease. Patients and Methods: In this cross-sectional study, the data of 83 patients with GBS were studied. All data about age, gender, place of residence (urban, rural), season of infection, history of infection or vaccination in the last month, clinical demonstrations and spinal magnetic resonance imaging findings with contrast, electromyography (EMG), nerve conduction velocity (NCV), cerebrospinal fluid (CSF), C-reactive protein (CRP) analysis was analyzed. Results: In this study, the highest incidence of GBS was in the summer (30.12%). Regarding clinical symptoms, 54.21% of patients were unable to walk, and around14.45 % of cases had positive Gowers’ sign. Additionally, 27.71% of patients reported pain, since 7.22% of them had severe respiratory distress with the need for mechanical ventilation. In patients who underwent EMG-NCV, findings were in favor of GBS in most cases (89.83%). In lumbar puncture, 53% of patients had normal CSF. Most patients (75.9%) had an erythrocyte sedimentation rate (ESR) below 30 mm/h. CRP of most patients (83.33%) was less than 10 mg/L. Conclusion: The predominant clinical symptoms of patients with GBS are the inability to walk, imbalance, positive Gowers’ sign, pain and respiratory distress, since ESR and CRP less than 30 and 10 mg/L are helpful, respectively.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79371506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main aim of this study is to review the general characteristics of this virus and its relationship with diabetes according to studies that have been done about this relevance. We investigated and searched related articles to this topic in EBSCO, Medline/PubMed, Scopus, Web of Science, Embase, Directory of Open Access Journals (DOAJ) and Google Scholar. According to numerous studies, diabetes is currently recognized as a risk factor for further complications of COVID-19.
本研究的主要目的是根据已有的相关研究综述该病毒的一般特征及其与糖尿病的关系。我们在EBSCO, Medline/PubMed, Scopus, Web of Science, Embase, Directory of Open Access Journals (DOAJ)和Google Scholar中调查和检索了与该主题相关的文章。根据大量研究，糖尿病目前被认为是COVID-19进一步并发症的危险因素。
{"title":"COVID-19 in diabetic patients; impacts and implications","authors":"Mohaddeseh Bahmani, R. Chegini, H. Nasri","doi":"10.34172/jpe.2020.29","DOIUrl":"https://doi.org/10.34172/jpe.2020.29","url":null,"abstract":"The main aim of this study is to review the general characteristics of this virus and its relationship with diabetes according to studies that have been done about this relevance. We investigated and searched related articles to this topic in EBSCO, Medline/PubMed, Scopus, Web of Science, Embase, Directory of Open Access Journals (DOAJ) and Google Scholar. According to numerous studies, diabetes is currently recognized as a risk factor for further complications of COVID-19.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77791231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Coronavirus disease 2019 (COVID-19) from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important epidemiological events in the past 100 years has become, the consequences for public health and economic systems around the world. Vitamin D is an important micronutrient that has been reported to improve immunity and protect against respiratory diseases. In this study, we intend to review articles that examine the relationship between COVID-19 and vitamin D. Methods: This is a review that uses articles from studies published in 2020 on the relationship between COVID-19 and vitamin D in databases such as; Web of Science, Science Direct, SID, Magiran, Google Scholar and PubMed. Keywords used included; serum levels of 25-hydroxyvitamin D, vitamin D, COVID-19, SARS-COV-2 and coronavirus 2. With this search, 32 articles were finally selected for this purpose and their results were reviewed Results: Of the 32 studies reviewed, only three showed no association between vitamin D levels in the blood and COVID-19 disease. Other studies had a relationship between the severity of the disease, mortality rate and length of hospital stay, in different age, gender and location groups. Conclusion: It seems that the level of vitamin D in the blood has a potential effect on COVID-19 disease. Checking the serum vitamin D levels and supplementation in people with hypovitaminosis D can be a good solution to reduce the complications and problems caused by COVID-19.
导语:2019年冠状病毒病(COVID-19)源于严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)是过去100年来最重要的流行病学事件之一，已成为世界各地公共卫生和经济系统的后果。维生素D是一种重要的微量营养素，据报道可以提高免疫力，预防呼吸系统疾病。在这项研究中，我们打算回顾研究COVID-19与维生素D之间关系的文章。方法:这是一项综述，使用了2020年发表的关于COVID-19与维生素D之间关系的研究中的文章，这些数据库包括;Web of Science, Science Direct, SID, Magiran, Google Scholar和PubMed。使用的关键词包括;血清25-羟基维生素D、维生素D、COVID-19、SARS-COV-2和冠状病毒水平通过这项搜索，最终选择了32篇文章，并对其结果进行了回顾。结果:在回顾的32项研究中，只有3项研究显示血液中维生素D水平与COVID-19疾病之间没有关联。其他研究在不同年龄、性别和地点群体中发现了疾病严重程度、死亡率和住院时间之间的关系。结论:血液中维生素D水平似乎对COVID-19疾病有潜在影响。检查维生素D缺乏症患者的血清维生素D水平并补充维生素D是减少COVID-19引起的并发症和问题的一个很好的解决方案。
{"title":"The relationship between serum vitamin D level and COVID-19; a review study","authors":"Yasaman Koohshoori, Ehsan Ramanian, Nasrin Moradi, Shahrzad Shadabi, Minoo Motahhar, M. Mousavi, Mahmood Banoore","doi":"10.34172/jpe.2020.34","DOIUrl":"https://doi.org/10.34172/jpe.2020.34","url":null,"abstract":"Introduction: Coronavirus disease 2019 (COVID-19) from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important epidemiological events in the past 100 years has become, the consequences for public health and economic systems around the world. Vitamin D is an important micronutrient that has been reported to improve immunity and protect against respiratory diseases. In this study, we intend to review articles that examine the relationship between COVID-19 and vitamin D. Methods: This is a review that uses articles from studies published in 2020 on the relationship between COVID-19 and vitamin D in databases such as; Web of Science, Science Direct, SID, Magiran, Google Scholar and PubMed. Keywords used included; serum levels of 25-hydroxyvitamin D, vitamin D, COVID-19, SARS-COV-2 and coronavirus 2. With this search, 32 articles were finally selected for this purpose and their results were reviewed Results: Of the 32 studies reviewed, only three showed no association between vitamin D levels in the blood and COVID-19 disease. Other studies had a relationship between the severity of the disease, mortality rate and length of hospital stay, in different age, gender and location groups. Conclusion: It seems that the level of vitamin D in the blood has a potential effect on COVID-19 disease. Checking the serum vitamin D levels and supplementation in people with hypovitaminosis D can be a good solution to reduce the complications and problems caused by COVID-19.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83443150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Jangi, H. Tabesh, Mahin Ghorban Sabbagh, Ebrahim Khaleghi Baigi, S. M. Mostafavi, Mahmoud Tara
Introduction: End-stage renal disease (ESRD) continues to be a public health challenge. In ESRD patients, renal replacement therapy is essential. Kidney transplantation is considered as an effective therapeutic procedure for ESRD. On the advice of a qualified nephrologist, ESRD patients are registered on a waiting list, seeking organ transplantation. Objectives: This study aimed to report the status of the waiting list for kidney transplantation in the northeastern Iran region, with data covering the time period until 2017. Patients and Methods: The study was conducted at Montaserie hospital in Mashhad, Iran. We reviewed the clinical records of all ESRD patients referred to the hospital, retrospectively. Patients’ data were completed using a data linkage method and analyzed using SPSS version 23. Results: A total of 1956 patients were studied from the waiting list with a mean age of 44.7 ± 14.4 years (3-80 years). The described etiology reveals that the main causes of ESRD were unknown sources (44.1%), diabetes (18.4%) and hypertension (10.9%). Hemodialysis therapy was conducted for 91.1% of the patients. The maximum registered waiting time was 295 months and the minimum was one month, with an average of 63 months. The proportion of patients waiting for the first, second and third kidney transplantation was 86%, 13.2% and 0.7%, respectively. Conclusion: This study highlights that in the population under study, the number of registered patients on the waiting list followed an increasing pattern, while the age of patients decreased. Unfortunately, in most case studies in Iran, the true etiology of nephrology diseases is still unknown. More effort to define the ESRD causes is necessary. The most likely reason for reported cases with unknown etiology is delays in referral problems.
{"title":"A survey of waiting lists for kidney transplantation in northeastern Iran","authors":"M. Jangi, H. Tabesh, Mahin Ghorban Sabbagh, Ebrahim Khaleghi Baigi, S. M. Mostafavi, Mahmoud Tara","doi":"10.34172/JPE.2020.20","DOIUrl":"https://doi.org/10.34172/JPE.2020.20","url":null,"abstract":"Introduction: End-stage renal disease (ESRD) continues to be a public health challenge. In ESRD patients, renal replacement therapy is essential. Kidney transplantation is considered as an effective therapeutic procedure for ESRD. On the advice of a qualified nephrologist, ESRD patients are registered on a waiting list, seeking organ transplantation. Objectives: This study aimed to report the status of the waiting list for kidney transplantation in the northeastern Iran region, with data covering the time period until 2017. Patients and Methods: The study was conducted at Montaserie hospital in Mashhad, Iran. We reviewed the clinical records of all ESRD patients referred to the hospital, retrospectively. Patients’ data were completed using a data linkage method and analyzed using SPSS version 23. Results: A total of 1956 patients were studied from the waiting list with a mean age of 44.7 ± 14.4 years (3-80 years). The described etiology reveals that the main causes of ESRD were unknown sources (44.1%), diabetes (18.4%) and hypertension (10.9%). Hemodialysis therapy was conducted for 91.1% of the patients. The maximum registered waiting time was 295 months and the minimum was one month, with an average of 63 months. The proportion of patients waiting for the first, second and third kidney transplantation was 86%, 13.2% and 0.7%, respectively. Conclusion: This study highlights that in the population under study, the number of registered patients on the waiting list followed an increasing pattern, while the age of patients decreased. Unfortunately, in most case studies in Iran, the true etiology of nephrology diseases is still unknown. More effort to define the ESRD causes is necessary. The most likely reason for reported cases with unknown etiology is delays in referral problems.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74879866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Abbasi, A. Ghazavi, Kamran Dehghan, M. Soleimani
Introduction: Infantile colic affects 5% to 19% of infants. Objectives: This study aimed to investigate the relationship between infantile colic crying and migraine in parents. Patients and Methods: In this study, the infants referred to Urmia health centers with 4 to 12 weeks old were investigated. According to the definition of infantile colic and questioning the parents, those infants were identified who cried at least three hours a day, at least three days a week, for at least 3 weeks. By filling out a questionnaire on infantile colic and migraine in parents, the relationship between migraine in parents and colic in infants was examined. Results: In this study, 195 infants aged 4 to 12 weeks were included. Around 107 (54.9%) were male. The mean age of infants was 6.50 ± 2.10 weeks. Of the 195 infants, 65 (33.3%) had colic, 32 (49.2%) were male and 33 (50.8%) were female (P = 0.26). Around 47 (24.1%) of parents had migraine and 148 (75.9%) had no history of migraine. Of 65 infants with colic, 38 (58.5%) had migraine parents and 27 (41.5%) had no history of parental migraine. Of 130 infants without colic, 9 (6.9%) of the parents had a history of migraine and 121 (93.1%) of them had no migraine (P = 0.001). Of 65 infants with colic, 31 of the mothers had migraine, since of 130 infants without colic, none of their mothers complained about migraine (P = 0.001). Conclusion: Infantile colic was significantly associated with parental migraine and it could be an early sign of disease in infants.
{"title":"Assessing the relationship between infantile colic and parental migraine in infants aged 4 to 12 weeks in Urmia","authors":"E. Abbasi, A. Ghazavi, Kamran Dehghan, M. Soleimani","doi":"10.34172/JPE.2020.22","DOIUrl":"https://doi.org/10.34172/JPE.2020.22","url":null,"abstract":"Introduction: Infantile colic affects 5% to 19% of infants. Objectives: This study aimed to investigate the relationship between infantile colic crying and migraine in parents. Patients and Methods: In this study, the infants referred to Urmia health centers with 4 to 12 weeks old were investigated. According to the definition of infantile colic and questioning the parents, those infants were identified who cried at least three hours a day, at least three days a week, for at least 3 weeks. By filling out a questionnaire on infantile colic and migraine in parents, the relationship between migraine in parents and colic in infants was examined. Results: In this study, 195 infants aged 4 to 12 weeks were included. Around 107 (54.9%) were male. The mean age of infants was 6.50 ± 2.10 weeks. Of the 195 infants, 65 (33.3%) had colic, 32 (49.2%) were male and 33 (50.8%) were female (P = 0.26). Around 47 (24.1%) of parents had migraine and 148 (75.9%) had no history of migraine. Of 65 infants with colic, 38 (58.5%) had migraine parents and 27 (41.5%) had no history of parental migraine. Of 130 infants without colic, 9 (6.9%) of the parents had a history of migraine and 121 (93.1%) of them had no migraine (P = 0.001). Of 65 infants with colic, 31 of the mothers had migraine, since of 130 infants without colic, none of their mothers complained about migraine (P = 0.001). Conclusion: Infantile colic was significantly associated with parental migraine and it could be an early sign of disease in infants.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74242704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Nurses should carry out the necessary research, training and counseling services to guide hemodialysis (HD) patients in acquiring healthy lifestyle behaviors. Objectives: This study was conducted to determine the healthy lifestyle behaviors in HD patients and affecting factors. Patients and Methods: This descriptive study was conducted at a university hospital in Eastern Turkey between November 13, 2017 and November 16, 2018. The study was carried out with 140 patients who were registered in the HD units of the relevant hospitals and met the sampling criteria. The study data were collected using the patient introduction form and the Health-Promoting Lifestyle Profile II (HPLP II). Results: Patients’ mean total score in the HPLP II was found to be 117.80±37.07. When we look at the mean scores of the patients in the sub-scales, it was found that the highest mean score was 22.44±7.01 points in the health responsibility sub-scale and the lowest mean score was 14.38±6.70 points in the physical activity sub-scale. Conclusion: As a result of the study, patients were found to have moderate healthy lifestyle behaviors and very low physical activity scores. Based on these results, it is recommended to organize special exercise programs in order to increase the physical activity levels of HD patients with low levels of activity.
{"title":"Evaluation of healthy lifestyle behaviors and affecting factors of hemodialysis patients","authors":"Ayşenur Sarıaslan, Mehtap Kavurmacı","doi":"10.34172/JPE.2020.19","DOIUrl":"https://doi.org/10.34172/JPE.2020.19","url":null,"abstract":"Introduction: Nurses should carry out the necessary research, training and counseling services to guide hemodialysis (HD) patients in acquiring healthy lifestyle behaviors. Objectives: This study was conducted to determine the healthy lifestyle behaviors in HD patients and affecting factors. Patients and Methods: This descriptive study was conducted at a university hospital in Eastern Turkey between November 13, 2017 and November 16, 2018. The study was carried out with 140 patients who were registered in the HD units of the relevant hospitals and met the sampling criteria. The study data were collected using the patient introduction form and the Health-Promoting Lifestyle Profile II (HPLP II). Results: Patients’ mean total score in the HPLP II was found to be 117.80±37.07. When we look at the mean scores of the patients in the sub-scales, it was found that the highest mean score was 22.44±7.01 points in the health responsibility sub-scale and the lowest mean score was 14.38±6.70 points in the physical activity sub-scale. Conclusion: As a result of the study, patients were found to have moderate healthy lifestyle behaviors and very low physical activity scores. Based on these results, it is recommended to organize special exercise programs in order to increase the physical activity levels of HD patients with low levels of activity.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89420566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Large intestine cancer is considered as one of the prevalent cancers among societies. Histological studies have shown that cancers in large intestine often originate from polyps from internal layer of the intestinal epithelial tissue. Objectives: The aim of this study was to investigate the types of polyps in large intestine biopsies in patients referring to Al-Zahra hospital in Iran. Patients and Methods: This is a cross-sectional study conducted on patients undergoing colonoscopy in 2014-2019. Characteristics of polyps were noted based on reports of colonoscopy and pathology. Results: In this study, 372 biopsies from patients aged between 10-96 years were analyzed. No significant difference was observed between two genders regarding location, size, histology, and morphology of polyps (P > 0.05). Adenomatous epithelial polyps are the most common types in all ages). Further analysis showed that most of the discovered polyps (23.3%) were in transverse colon. Conclusion: Adenomatous epithelial polyps are more frequent in patients because most of the discovered polyps were in transverse colon and most of them were adenomatous epithelial. These data were in line with the most of previous studies; however some paradoxical results were reported. More studies on larger populations should be performed.
{"title":"Histological types of polyps in large intestine biopsies; a single center experience","authors":"Parisa Masoum Zadeh, S. Ghorbani, M. Derakhshan","doi":"10.34172/JPE.2020.18","DOIUrl":"https://doi.org/10.34172/JPE.2020.18","url":null,"abstract":"Introduction: Large intestine cancer is considered as one of the prevalent cancers among societies. Histological studies have shown that cancers in large intestine often originate from polyps from internal layer of the intestinal epithelial tissue. Objectives: The aim of this study was to investigate the types of polyps in large intestine biopsies in patients referring to Al-Zahra hospital in Iran. Patients and Methods: This is a cross-sectional study conducted on patients undergoing colonoscopy in 2014-2019. Characteristics of polyps were noted based on reports of colonoscopy and pathology. Results: In this study, 372 biopsies from patients aged between 10-96 years were analyzed. No significant difference was observed between two genders regarding location, size, histology, and morphology of polyps (P > 0.05). Adenomatous epithelial polyps are the most common types in all ages). Further analysis showed that most of the discovered polyps (23.3%) were in transverse colon. Conclusion: Adenomatous epithelial polyps are more frequent in patients because most of the discovered polyps were in transverse colon and most of them were adenomatous epithelial. These data were in line with the most of previous studies; however some paradoxical results were reported. More studies on larger populations should be performed.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74482231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Osteoporosis is the most common metabolic bone disease worldwide. In this disease, the bone mass decreases and as it progresses, the risk of fracture increases. Osteopenia occurs in the early stages of bone loss. Studies on the effective dose for treatment of osteopenia have been controversial. Objectives: In this randomized clinical trial, low doses versus high doses of alendronate were assessed during the osteopenic stage in postmenopausal women. Patients and Methods: The present study is a randomized clinical trial (RCT) that was performed on 152 postmenopausal women who were visited in Al-Zahra rheumatology clinic between 2016 and 2017. Patients were randomly divided into two groups. The first group with 35 and the second group with 70 mg of weekly alendronate were treated and followed for two years. Densitometry was performed on patients before and 2 years after the intervention, and the findings were compared. Results: The two groups were not significantly different in terms of age, gender, height, weight, body mass index (BMI) and menopause (P>0.05). The bone mineral density (BMD) findings of both groups, including Fracture Risk Assessment Tool (FRAX) hip and vertebra/wrist, T-score hip and vertebrae, as well as Z-score hip and vertebrae, improved significantly after two years (P<0.001), However, a comparison of the two therapeutic doses did not show a significant difference in terms of BMD improvements (P>0.05). Conclusion: The findings of this study reported favorable results for the preventive treatment of alendronate in osteopenic women. In addition, due to gastrointestinal problems that are the main complaint of alendronate use, according to the results, a weekly dose of 35 mg can be recommended
{"title":"A randomized clinical trial on improving osteopenia in postmenopausal women after two years of preventive treatment with alendronate; a dose of 35 mg per week is more effective or a dose of 70 mg?","authors":"mansoor karimifar, Negar Botlani, A. Salari","doi":"10.34172/JPE.2020.16","DOIUrl":"https://doi.org/10.34172/JPE.2020.16","url":null,"abstract":"Introduction: Osteoporosis is the most common metabolic bone disease worldwide. In this disease, the bone mass decreases and as it progresses, the risk of fracture increases. Osteopenia occurs in the early stages of bone loss. Studies on the effective dose for treatment of osteopenia have been controversial. Objectives: In this randomized clinical trial, low doses versus high doses of alendronate were assessed during the osteopenic stage in postmenopausal women. Patients and Methods: The present study is a randomized clinical trial (RCT) that was performed on 152 postmenopausal women who were visited in Al-Zahra rheumatology clinic between 2016 and 2017. Patients were randomly divided into two groups. The first group with 35 and the second group with 70 mg of weekly alendronate were treated and followed for two years. Densitometry was performed on patients before and 2 years after the intervention, and the findings were compared. Results: The two groups were not significantly different in terms of age, gender, height, weight, body mass index (BMI) and menopause (P>0.05). The bone mineral density (BMD) findings of both groups, including Fracture Risk Assessment Tool (FRAX) hip and vertebra/wrist, T-score hip and vertebrae, as well as Z-score hip and vertebrae, improved significantly after two years (P<0.001), However, a comparison of the two therapeutic doses did not show a significant difference in terms of BMD improvements (P>0.05). Conclusion: The findings of this study reported favorable results for the preventive treatment of alendronate in osteopenic women. In addition, due to gastrointestinal problems that are the main complaint of alendronate use, according to the results, a weekly dose of 35 mg can be recommended","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72798106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kazemifar, S. M. Mirakbari, Z. Yazdi, Bita Bitazar, P. Soleimani
Introduction: Poisoning is regarded as a matter of concern for health providers as the burden of health resources loss can be high. Since nature and diversity of poisoning are different among various regions around the country, this study was conducted to demonstrate type and reasons for poisonings in Qazvin province, Iran. Objectives: The aim of this study was to demonstrate the reason of toxic events as well as presenting symptoms and outcome of poisonings. Patients and Methods: This prospective, cross-sectional and hospital-based study was conducted during a one-year period. The patients recruited to the study were consecutive intoxicated cases presenting to the hospital with alleged poisoning. Relevant epidemiological and clinical data from patients were collected and then analyzed using SPSS software. Results: A total of 23161 patients were admitted to the hospital, out of which 766 (3.3%) intoxicated patients were enrolled in the study. Mean age was 29.8 years old. Females outnumbered males but difference was not significant. The majority of the poisonings were deliberate (95.2%). Main clinical features of poisoning were decreased consciousness (47.4%), followed by lethargy (38.1%) and nausea/vomiting (31.9%). The benzodiazepines were the predominant agent ingested by patients, followed by opioids. Mortality rate was found to be 1%. Conclusion: Although the majority of poisoning cases are deliberate, however according to the type of pharmaceuticals involved in the poisonings and low-mortality rate, it is believed that the occurrence of the toxic events in many cases arises from impulsive behaviors originated from minor familial conflicts and incompetent life skills. Improving mental health and efficient coping skills can contribute to the reduction of intentional poisonings which in turn reduces the burden of hospital costs.
{"title":"Clinicoepidemiologic profile of patients with poisoning presenting to a tertiary care hospital; a one year preliminary descriptive study","authors":"A. Kazemifar, S. M. Mirakbari, Z. Yazdi, Bita Bitazar, P. Soleimani","doi":"10.34172/JPE.2020.15","DOIUrl":"https://doi.org/10.34172/JPE.2020.15","url":null,"abstract":"Introduction: Poisoning is regarded as a matter of concern for health providers as the burden of health resources loss can be high. Since nature and diversity of poisoning are different among various regions around the country, this study was conducted to demonstrate type and reasons for poisonings in Qazvin province, Iran. Objectives: The aim of this study was to demonstrate the reason of toxic events as well as presenting symptoms and outcome of poisonings. Patients and Methods: This prospective, cross-sectional and hospital-based study was conducted during a one-year period. The patients recruited to the study were consecutive intoxicated cases presenting to the hospital with alleged poisoning. Relevant epidemiological and clinical data from patients were collected and then analyzed using SPSS software. Results: A total of 23161 patients were admitted to the hospital, out of which 766 (3.3%) intoxicated patients were enrolled in the study. Mean age was 29.8 years old. Females outnumbered males but difference was not significant. The majority of the poisonings were deliberate (95.2%). Main clinical features of poisoning were decreased consciousness (47.4%), followed by lethargy (38.1%) and nausea/vomiting (31.9%). The benzodiazepines were the predominant agent ingested by patients, followed by opioids. Mortality rate was found to be 1%. Conclusion: Although the majority of poisoning cases are deliberate, however according to the type of pharmaceuticals involved in the poisonings and low-mortality rate, it is believed that the occurrence of the toxic events in many cases arises from impulsive behaviors originated from minor familial conflicts and incompetent life skills. Improving mental health and efficient coping skills can contribute to the reduction of intentional poisonings which in turn reduces the burden of hospital costs.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83728158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: IgA nephropathy is the most common glomerulonephritis in the world. Objectives: In this study we aimed to find the relationship between morphological lesions of Oxford classification for IgA nephropathy with clinical findings and some laboratory data. Patients and Methods: All kidney biopsy conducted from 2009 to 2019 conducted in medical centers and were sent to a reference laboratory in Isfahan. All kidney biopsies included two samples for immunofluorescence and light microscopy. After definitive diagnosis of IgAN (IgA nephropathy), the slides were examined to classify the disease based on the Oxford-MEST (M; mesangial hypercellularity, E; endocapillary hypercellularity, S; segmental glomerulosclerosis, and T; tubular atrophy/interstitial fibrosis and also C; crescent) classification. Results: Our study on 238 biopsy proven IgA nephropathy patients showed that 78 patients (32.8%) were male. Mean ± SD of age individuals was 38.00 ±13.68 years. The mean± SD of serum creatinine level was 1.42 ± 0.79 mg/dL and the mean ± SD of proteinuria was 1780.94 ± 1168.75 mg/d. Our study showed no significant association between M, E and S variables with patients’ age. However, a statistically significant relationship between T variable and patients’ age (P=0.028) was detected. Furthermore, morphologic variables of M, E and S were not significantly associated with proteinuria while T variable was positively associated with the quantity of proteinuria (P=0.021). Conclusion: The association of tubular atrophy/interstitial fibrosis (T variable) with quantity of proteinuria showed significance of interstitial lesion on the prognosis IgA nephropathy.
{"title":"Oxford MEST classification in Iranian patients with IgA nephropathy, with regards to extracapillary proliferation; a single center experience","authors":"M. Akhavansepahi, M. Rafieyan, H. Nasri","doi":"10.34172/JPE.2020.14","DOIUrl":"https://doi.org/10.34172/JPE.2020.14","url":null,"abstract":"Introduction: IgA nephropathy is the most common glomerulonephritis in the world. Objectives: In this study we aimed to find the relationship between morphological lesions of Oxford classification for IgA nephropathy with clinical findings and some laboratory data. Patients and Methods: All kidney biopsy conducted from 2009 to 2019 conducted in medical centers and were sent to a reference laboratory in Isfahan. All kidney biopsies included two samples for immunofluorescence and light microscopy. After definitive diagnosis of IgAN (IgA nephropathy), the slides were examined to classify the disease based on the Oxford-MEST (M; mesangial hypercellularity, E; endocapillary hypercellularity, S; segmental glomerulosclerosis, and T; tubular atrophy/interstitial fibrosis and also C; crescent) classification. Results: Our study on 238 biopsy proven IgA nephropathy patients showed that 78 patients (32.8%) were male. Mean ± SD of age individuals was 38.00 ±13.68 years. The mean± SD of serum creatinine level was 1.42 ± 0.79 mg/dL and the mean ± SD of proteinuria was 1780.94 ± 1168.75 mg/d. Our study showed no significant association between M, E and S variables with patients’ age. However, a statistically significant relationship between T variable and patients’ age (P=0.028) was detected. Furthermore, morphologic variables of M, E and S were not significantly associated with proteinuria while T variable was positively associated with the quantity of proteinuria (P=0.021). Conclusion: The association of tubular atrophy/interstitial fibrosis (T variable) with quantity of proteinuria showed significance of interstitial lesion on the prognosis IgA nephropathy.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75320285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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