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The relationship between COVID-19 and blood vitamin C; a systematic review study COVID-19与血液维生素C的关系系统回顾研究
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.31
S. Hosseinpour, Nasrin Moradi, Reyhane Izadi, Shahrzad Shadabi, Raheleh Behzadi, M. Mousavi, Abuzar Shirazi, Ebrahim Moayedi
Introduction: The rapid worldwide spread of COVID-19 has caused a global health crisis. Unfortunately, no vaccine or special antiviral drug has been developed against COVID-19 to date, symptomatic supportive care has been the most common treatment. Objectives: the purpose of this systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19. Methods: In this review, we identified studies published in 2020 that describe on the relationship between COVID-19 and vitamin C. We searched PubMed, Google Scholar, Scopus, Magiran, SID and Web of Science for research articles published up to 23 December 2020 using the keywords of vitamin C, COVID-19, SARS-COV-2 and coronavirus 2. Results: At the initial stage of screening, 181articles were excluded after reviewing the title and removing irrelevant and duplicate titles, 52 articles were selected to review the abstract. After reviewing the abstract (or in articles without abstracts after reviewing the original text), nine articles were finally considered suitable for this purpose and were reviewed and finalized. Vitamin C is a pivotal component of the immune system, with proven antioxidant, cytokine storm suppressor and anti-inflammatory properties and has been tested in numerous studies for its role in severe sepsis and ICU care, especially when used as a continuous high-dose intravenous infusion. In addition, some studies indicated high-dose intravenous vitamin C treatment was associated with fewer days on mechanical ventilation, shorter ICU stay, and earlier recovery compared to the average length of mechanical ventilation, disease duration, and ICU stay in critical COVID-19 patients. Conclusion: Vitamin C can significantly improve clinical symptoms, inflammatory response, immune and organ function in COVID-19 patients. In patients affected with COVID-19, high-dose intravenous vitamin C is expected to improve pulmonary function and reduce mortality for patients with COVID-19 and can be beneficial in aspects of inflammatory response, immune and organ function for aggravation of COVID-19 patients, however further clinical trials are necessary.
2019冠状病毒病(COVID-19)在世界范围内的迅速传播已造成全球卫生危机。不幸的是,迄今为止尚未开发出针对COVID-19的疫苗或特殊抗病毒药物,对症支持治疗是最常见的治疗方法。目的:本系统综述的目的是对维生素C在治疗COVID-19患者中的作用提供及时、严格和不断更新的现有证据摘要。方法:在本综述中,我们选取了2020年发表的描述COVID-19与维生素C之间关系的研究。我们检索了PubMed、谷歌Scholar、Scopus、Magiran、SID和Web of Science,检索了截至2020年12月23日发表的研究文章,关键词为维生素C、COVID-19、SARS-COV-2和冠状病毒2。结果:筛选初期,通过对标题的审查和去除不相关和重复的标题,排除181篇文章,选择52篇文章对摘要进行审查。在审查摘要后(或在审查原文后没有摘要的文章中),最终认为有9篇文章适合这一目的,并进行审查和定稿。维生素C是免疫系统的关键组成部分,具有抗氧化、细胞因子风暴抑制和抗炎特性,并已在许多研究中测试其在严重败血症和ICU护理中的作用,特别是作为连续大剂量静脉输注时。此外,一些研究表明,与COVID-19危重患者的平均机械通气时间、疾病持续时间和ICU住院时间相比,高剂量静脉注射维生素C治疗与机械通气天数更短、ICU住院时间更短、恢复更早相关。结论:维生素C可显著改善COVID-19患者的临床症状、炎症反应、免疫和器官功能。在COVID-19患者中,高剂量静脉注射维生素C有望改善COVID-19患者的肺功能并降低死亡率,并且在COVID-19加重患者的炎症反应、免疫和器官功能方面可能有益,但需要进一步的临床试验。
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引用次数: 1
Evaluation of irritable bowel syndrome prevalence in medical students 医学生肠易激综合征患病率评估
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.21
Samin Maghsoudi, Azam Teimouri
Introduction: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder and requires early diagnosis due to its negative impacts on the quality of life. According to the lifestyle pattern of medical students, IBS has a significant prevalence in these individuals. Objectives: The present study aims to investigate the prevalence and factors associated with IBS in medical students. Patients and Methods: This cross-sectional study has been conducted on 100 medical students studying at Isfahan University of Medical Sciences in 2019-2020. The Rome IV diagnostic criteria were administered to diagnose IBS and individuals were divided into four groups of constipation-dominant (IBS-C), diarrhea-dominant (IBS-D), mixed type (IBS-M) and unspecified (IBS-U). The association of studying grade, gender and residence with IBS was evaluated. Results: The mean age of the students was 23.2±4.8 years, including 68 (68%) women. According to Rome -IV criteria, 24 (24%) ones were diagnosed with IBS. The IBS cases were dominantly in IBS-C group (54.16%). IBS was not associated with gender (P=0.498), educational grade (P=0.661) and type of residence (P=0.562) in the studied medical students. Conclusion: According to the present study, the prevalence of IBS was 24% among medical students, which was higher among women. Most patients had IBS-C, but IBS did not show a statistically significant relationship with gender, educational grade and type of residence.
肠易激综合征(IBS)是一种功能性胃肠道疾病,由于其对生活质量的负面影响,需要早期诊断。根据医学生的生活方式,IBS在这些个体中有显著的患病率。目的:了解医学生肠易激综合征的患病率及相关因素。患者与方法:本横断面研究以2019-2020年在伊斯法罕医科大学就读的100名医学生为研究对象。采用Rome IV诊断标准诊断肠易激综合征,并将患者分为便秘型(IBS- c)、腹泻型(IBS- d)、混合型(IBS- m)和未确诊型(IBS- u)四组。评估学习年级、性别和居住地与肠易激综合征的关系。结果:学生平均年龄23.2±4.8岁,其中女性68人(68%)。根据Rome -IV标准,24例(24%)被诊断为IBS。IBS以IBS- c组居多(54.16%)。医学生的IBS与性别(P=0.498)、学历(P=0.661)和居住类型(P=0.562)无关。结论:根据本研究,医学生中肠易激综合征的患病率为24%,其中女性较高。大多数患者患有IBS- c,但IBS与性别、教育程度和居住类型没有统计学意义的关系。
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引用次数: 0
World Kidney Day 2021 with the theme of living well with kidney disease; a review of current concepts 2021年世界肾脏日,主题为“与肾病共存”;对当前概念的回顾
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.08
M. Bahadoram, Saeede Labaykee, B. Lakkakula, B. Keikhaei, M. Nekouei Shahraki, Soroush Mohammadi Jouabadi, M. Onuigbo, F. Ahmadizar, M. Mahmoudian-sani, P. Peymani
Since 2006, by considering one dimension of kidney disease, each year, the International Society of Nephrology (ISN) and the International Federation of Kidney Foundations (IFKF) have consistently and unanimously declared a World Kidney Day (WKD) around a specific kidney disease to increase the global awareness about kidney diseases. WKD, which is celebrated in more than 150 countries worldwide, is an international kidney health awareness campaign emphasizing the importance of the kidneys to reduce the global prevalence of kidney diseases and their related health problems by promoting patients and providing education. The present review aims to summarize the themes of previous WKD campaigns and the advocacy of the 2021 WKD campaign theme "Living well with kidney disease". The 2021 WKD Steering Committee advocates for the empowerment of CKD patients, their family members, and care partners, along with both drug and non-drug therapeutic programs to achieve better health outcomes.
自2006年以来,通过考虑肾脏疾病的一个维度,每年,国际肾脏学会(ISN)和国际肾脏基金会联合会(IFKF)一致宣布围绕特定肾脏疾病的世界肾脏日(WKD),以提高全球对肾脏疾病的认识。世界肾脏日在全球150多个国家庆祝,是一项国际肾脏健康意识运动,强调肾脏的重要性,通过促进患者和提供教育来减少肾脏疾病及其相关健康问题的全球患病率。本综述旨在总结以往WKD活动的主题以及2021年WKD活动主题“与肾脏疾病一起生活”的宣传。2021年WKD指导委员会倡导赋予CKD患者,其家庭成员和护理伙伴权力,以及药物和非药物治疗计划,以实现更好的健康结果。
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引用次数: 0
Effect of semen washing methods on diminishing the transmission of viral infections in artificial reproductive technology 精液洗涤方法对减少人工生殖技术中病毒感染传播的影响
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.33
Fereshte Aliakbari, Neda Taghizabet, Fatemeh Rezaei-Tazangi, Ebrahim Kharazi Nejad
Seminal infections were considered to be an etiologic factor of male infertility. Semen washing is used as an appropriate technique in artificial reproductive technology (ART) for serodiscordant couples when the partner of male is contaminated. The aim of this study was to investigate the role of semen washing methods in reducing the transmission of viral infections in ART. In this narrative review we investigated accessible information from Google Scholar, PubMed, Scopus, Web of Science, IranMedex, Irandoc, Magiran, SID, MEDLIB and Scientific Information Database until 2019. The MeSH terms of semen washing, HIV, assisted reproduction, serodiscordant, and virus transmission were used. According to the search strategy, 89 articles were discovered. After checking the titles, abstracts and manuscripts, a collection of 45 papers were chosen pursuant to the suitability indexes. The studies were performed around different categories of semen washing (swim up, density gradient) in serodiscordant couples. Some studies highlighted that semen washings can completely prevent viral transmission, but a few do not believe this claim. However, scientific researchers have revealed that sperm washing may diminish the possibility of infection in serodiscordant couples where the male partner is infected. Swim up in combination with density gradient is a suitable method to diminish the transmission of infections.
精液感染被认为是男性不育的一个病因。精液清洗技术是一种适合于血清不和谐夫妇的人工生殖技术。本研究的目的是探讨精液洗涤方法在减少抗逆转录病毒治疗中病毒感染传播中的作用。在这篇叙述性综述中,我们调查了谷歌Scholar、PubMed、Scopus、Web of Science、IranMedex、Irandoc、Magiran、SID、MEDLIB和科学信息数据库中截至2019年的可访问信息。使用洗精、HIV、辅助生殖、血清不一致、病毒传播等MeSH术语。根据搜索策略,共发现89篇文章。通过对论文题目、摘要和原稿的检查,根据适宜性指标筛选出45篇论文。研究围绕不同类别的精液洗涤(向上游动,密度梯度)在血清不一致的夫妇中进行。一些研究强调,精液洗涤可以完全防止病毒传播,但也有少数人不相信这种说法。然而,科学研究人员发现,在男性感染的血清不一致的夫妇中,洗精可能会减少感染的可能性。向上游动与密度梯度相结合是减少感染传播的较好方法。
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引用次数: 1
Study of the relationship between neutrophil-to-lymphocyte ratio and parathyroid hormone levels in patients undergoing hemodialysis, Isfahan, Iran 伊朗伊斯法罕血液透析患者中性粒细胞与淋巴细胞比值与甲状旁腺激素水平关系的研究
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.19
A. Baradaran, S. Hosseini, Reyhaneh Shirvani, P. Hedayati, Z. Hoseini
Introduction: Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health (1). Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) elevate in patients with end-stage renal disease (ESRD). Systemic inflammation is correlated with cardiovascular disease. Furthermore, parathyroid hormone (PTH) causes releasing of IL-6 from liver and osteoblast. IL-6 increases lifetime and activity of neutrophils. Therefore, PTH may have a direct correlation with neutrophil-to-lymphocyte ratio (NLR). Objectives: In this study, we aimed to determine the performance of NLR in hemodialysis and its possible correlation with PTH. Patients and Methods: This is a cross-sectional study to evaluate the correlation of NLR and serum intact PTH (iPTH), Ca (calcium) and P (phosphorus) and also Ca×P products (mg2 /dL2 ) in a group of stable hemodialysis patients, including male and female gender subgroups, diabetic versus non-diabetic patients, and also patients with or without chronic hypertensive disease. Results: This study consisted of 136 hemodialysis patients. Our study showed no statistically significant correlation between iPTH (intact parathormone) and NLR in hemodialysis patients (P>0.05). In addition, we test their correlation in other subgroups including hypertensive and normotensive, diabetic and non-diabetics, and male versus female patients. We found no significant correlation between iPTH and NLR in the mentioned subgroups, too. Conclusion: Observed correlation between PTH and NLR in hemodialysis patients may be due to our small sample size. Therefore, further studies on this subject are suggested.
慢性肾脏疾病(CKD)是一种进行性和不可逆的疾病,现在被认为是一般健康最重要的问题之一(1)。终末期肾脏疾病(ESRD)患者血清中炎症介质如c反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)水平升高。全身性炎症与心血管疾病相关。此外,甲状旁腺激素(PTH)引起肝脏和成骨细胞释放IL-6。IL-6增加中性粒细胞的寿命和活性。因此,甲状旁腺激素可能与中性粒细胞与淋巴细胞比值(NLR)有直接关系。目的:在本研究中,我们旨在确定NLR在血液透析中的表现及其与甲状旁腺激素的可能相关性。患者和方法:这是一项横断面研究,旨在评估一组稳定血液透析患者NLR与血清完整PTH (iPTH)、Ca(钙)和P(磷)以及Ca×P产物(mg2 /dL2)的相关性,包括男性和女性亚组、糖尿病患者与非糖尿病患者,以及伴有或不伴有慢性高血压疾病的患者。结果:本研究共纳入136例血液透析患者。我们的研究显示血透患者iPTH(完整甲状旁激素)与NLR无统计学意义(P>0.05)。此外,我们还在其他亚组中测试了它们的相关性,包括高血压和正常血压,糖尿病和非糖尿病患者,以及男性和女性患者。在上述亚组中,我们也没有发现iPTH与NLR之间的显著相关性。结论:在血液透析患者中观察到PTH与NLR的相关性可能是由于我们的样本量小。因此,建议对这一问题进行进一步的研究。
{"title":"Study of the relationship between neutrophil-to-lymphocyte ratio and parathyroid hormone levels in patients undergoing hemodialysis, Isfahan, Iran","authors":"A. Baradaran, S. Hosseini, Reyhaneh Shirvani, P. Hedayati, Z. Hoseini","doi":"10.34172/jpe.2021.19","DOIUrl":"https://doi.org/10.34172/jpe.2021.19","url":null,"abstract":"Introduction: Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health (1). Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) elevate in patients with end-stage renal disease (ESRD). Systemic inflammation is correlated with cardiovascular disease. Furthermore, parathyroid hormone (PTH) causes releasing of IL-6 from liver and osteoblast. IL-6 increases lifetime and activity of neutrophils. Therefore, PTH may have a direct correlation with neutrophil-to-lymphocyte ratio (NLR). Objectives: In this study, we aimed to determine the performance of NLR in hemodialysis and its possible correlation with PTH. Patients and Methods: This is a cross-sectional study to evaluate the correlation of NLR and serum intact PTH (iPTH), Ca (calcium) and P (phosphorus) and also Ca×P products (mg2 /dL2 ) in a group of stable hemodialysis patients, including male and female gender subgroups, diabetic versus non-diabetic patients, and also patients with or without chronic hypertensive disease. Results: This study consisted of 136 hemodialysis patients. Our study showed no statistically significant correlation between iPTH (intact parathormone) and NLR in hemodialysis patients (P>0.05). In addition, we test their correlation in other subgroups including hypertensive and normotensive, diabetic and non-diabetics, and male versus female patients. We found no significant correlation between iPTH and NLR in the mentioned subgroups, too. Conclusion: Observed correlation between PTH and NLR in hemodialysis patients may be due to our small sample size. Therefore, further studies on this subject are suggested.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"34 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77975415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of family medicine role in breast cancer prevention: A systematic review 家庭医学在乳腺癌预防中的作用研究:系统综述
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.32
Z. Sadr, Mehrnaz Jamali Moghaddam, Hamideh Sabet Rouhani, Nadia Sani’ee, M. Biglari Abhari
Breast cancer is one of the most common cancers and is one of the biggest health threats in women around the world. Since the systematic review study in Iran has not been conducted so far, this study was designed to determine the role of family physicians or first-level care physicians in preventing breast cancer at various levels. In this systematic review, we found family physicians could play a significant role in all levels of breast cancer prevention, including roles in education, risk assessment and early detection of cancer, treatment and follow-up of patients with breast cancer and rehabilitation, and help improve quality of life. Survivors and those treated for breast cancer.
乳腺癌是最常见的癌症之一,也是全球女性最大的健康威胁之一。由于伊朗目前尚未开展系统评价研究,本研究旨在确定家庭医生或一级护理医生在各级预防乳腺癌中的作用。在本系统综述中,我们发现家庭医生可以在乳腺癌预防的各个层面发挥重要作用,包括教育,风险评估和早期发现癌症,乳腺癌患者的治疗和随访以及康复,并帮助提高生活质量。幸存者和接受乳腺癌治疗的患者。
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引用次数: 2
Comparison the impact of face-to-face training package for resuscitation with presentation by messaging software on emergency medicine rotation interns 比较急诊医学轮转实习生面对面急救培训与即时通讯软件宣讲的效果
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.06
Farnaz Takavar, M. Momeni, Narges Mohammadrezaie, Ahmad Ghoochani Khorasani, Mehrad Aghili
Introduction: Conventional approaches in advanced cardiac life support (ACLS) are used, including; lectures, video presentations, practical educations on moulage, also employing messenger applications can potentially be regarded as a method to train interns. Objectives: The current study aims to compare two methods of face-to-face and virtual training by WhatsApp messenger, regarding the impact of training on interns’ knowledge and satisfaction for advanced cardio resuscitation rotational interns in emergency medicine. Patients and Methods: In this cross-sectional study, 73 rotation interns of emergency medicine of Tehran University of Medical Sciences from 2017 to 2018 were divided into two groups: 1) face-to-face training, 2) virtual training by using WhatsApp messenger application. Initially, a pretest of 10 questions about main topics in advanced cardiac support was conducted on interns. At the end of training course, a posttest of 20 questions was conducted for both groups. Results: Mean value of pretest was 6.46 for face-to-face training group and 5.97 for WhatsApp group (P=0.29). Posttest mean score was 14.08 for face-to-face group and 12.03 for WhatsApp (P=0.003). Interns’ satisfaction scores were 7.68 and 7.36 for face-to-face and WhatsApp group respectively (P=0.25). Mean scores of pretest and posttest within group had no significant differences between groups, but Cohen’s effect size for face-to-face group was greater than WhatsApp trained group. Conclusion: Face-to-face training was associated with better results in promoting knowledge of interns, compared to WhatsApp training. That’s advisable to employ face-to-face training for interns.
简介:在高级心脏生命支持(ACLS)中使用传统方法,包括;讲座、视频演示、关于模式化的实践教育,以及使用即时通讯应用程序,都可能被视为培训实习生的一种方法。目的:本研究旨在比较面对面培训和WhatsApp messenger虚拟培训两种方式对急诊医学高级心肺复苏轮转实习生知识和满意度的影响。患者与方法:本横断面研究将2017 - 2018年德黑兰医科大学急诊医学轮转实习生73名分为两组:1)面对面培训,2)使用WhatsApp即时通讯应用进行虚拟培训。最初,对实习生进行了关于晚期心脏支持主要话题的10个问题的预测。在培训课程结束时,对两组进行了20个问题的后测。结果:面授组前测均值为6.46,WhatsApp组前测均值为5.97 (P=0.29)。面对面组后测平均分为14.08分,WhatsApp组后测平均分为12.03分(P=0.003)。面对面组和WhatsApp组实习生满意度分别为7.68分和7.36分(P=0.25)。组内前测和后测平均得分在组间无显著差异,但面对面组的Cohen效应量大于WhatsApp训练组。结论:与WhatsApp培训相比,面对面培训在促进实习生知识方面效果更好。建议对实习生进行面对面的培训。
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引用次数: 0
A study of the relationship between tuberculosis disease and the severity of COVID-19; a systematic review study 结核病与COVID-19严重程度关系的研究系统回顾研究
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.35
Abuzar Shirazi, Nasrin Moradi, Bahareh Behzadi, M. Mousavi, S. Hosseinpour, Ebrahim Moayedi
Introduction: Studies on COVID-19 disease in patients with tuberculosis (TB) have not yet been widely performed and clear results have not been presented. It was found that; COVID-19 infection in TB patients quickly leads to disease and causes death in a small number of them. However, the prognosis of co-infection has not been evaluated in long run, since the association between TB and covid-19 cannot be ruled out, and therefore appropriate precautions and health system preparation are needed to deal with the impending burden of co-infection. The aim of this study was to provide a clear picture of the effects of these two diseases with each other. Methods: This study is considered as a systematic review of secondary studies. The statistical population is the studies that have been conducted in relation to the above topic and in the world. These articles were extracted from the databases of PubMed, Magiran, Science Direct, and Google Scholar. Out of 180 articles, 52 articles were related to our subject were selected, while 30 duplicates were removed from this number, hence 30 articles were selected. Finally, after a qualitative review, 12 articles were included in the study and the results of five articles were analyzed. Results: Studies have shown that co-infection with COVID-19 and tuberculosis can increase mortality; TB is also likely to exacerbate the course of COVID-19 for the infected population and may increase the TB epidemic in the short term after the end of the COVID-19 epidemic is effective, so appropriate precautions and preparation of the health system are needed to deal with the impending burden of co-infection. Conclusion: COVID-19 disease and its limitations may have a significant impact on the presentation and monitoring of TB control strategies nationally and globally. Concerns about delays in treating TB patients make their disease worse, and therefore broader management should be conducted.
前言:目前尚未广泛开展关于结核病患者COVID-19疾病的研究,也没有明确的结果。研究发现;结核病患者感染COVID-19可迅速导致疾病,并导致少数患者死亡。然而,长期来看,合并感染的预后尚未得到评估,因为不能排除结核病与covid-19之间的关联,因此需要采取适当的预防措施和卫生系统准备,以应对即将到来的合并感染负担。这项研究的目的是提供这两种疾病相互影响的清晰画面。方法:本研究是对二级研究的系统回顾。统计人口是指在世界范围内进行的与上述主题有关的研究。这些文章摘自PubMed、Magiran、Science Direct和Google Scholar的数据库。在180篇文章中,我们选择了52篇与我们的主题相关的文章,并从中剔除了30篇重复的文章,因此我们选择了30篇文章。最后,经过定性回顾,纳入12篇文章,并对其中5篇文章的结果进行分析。结果:研究表明,合并感染COVID-19和结核病可增加死亡率;结核病还可能加剧感染人群的COVID-19病程,并可能在COVID-19疫情有效结束后的短期内增加结核病流行,因此需要卫生系统采取适当的预防措施并做好准备,以应对即将到来的合并感染负担。结论:COVID-19疾病及其局限性可能对国家和全球结核病控制战略的提出和监测产生重大影响。对结核病患者治疗延误的担忧会使他们的病情恶化,因此应该进行更广泛的管理。
{"title":"A study of the relationship between tuberculosis disease and the severity of COVID-19; a systematic review study","authors":"Abuzar Shirazi, Nasrin Moradi, Bahareh Behzadi, M. Mousavi, S. Hosseinpour, Ebrahim Moayedi","doi":"10.34172/jpe.2021.35","DOIUrl":"https://doi.org/10.34172/jpe.2021.35","url":null,"abstract":"Introduction: Studies on COVID-19 disease in patients with tuberculosis (TB) have not yet been widely performed and clear results have not been presented. It was found that; COVID-19 infection in TB patients quickly leads to disease and causes death in a small number of them. However, the prognosis of co-infection has not been evaluated in long run, since the association between TB and covid-19 cannot be ruled out, and therefore appropriate precautions and health system preparation are needed to deal with the impending burden of co-infection. The aim of this study was to provide a clear picture of the effects of these two diseases with each other. Methods: This study is considered as a systematic review of secondary studies. The statistical population is the studies that have been conducted in relation to the above topic and in the world. These articles were extracted from the databases of PubMed, Magiran, Science Direct, and Google Scholar. Out of 180 articles, 52 articles were related to our subject were selected, while 30 duplicates were removed from this number, hence 30 articles were selected. Finally, after a qualitative review, 12 articles were included in the study and the results of five articles were analyzed. Results: Studies have shown that co-infection with COVID-19 and tuberculosis can increase mortality; TB is also likely to exacerbate the course of COVID-19 for the infected population and may increase the TB epidemic in the short term after the end of the COVID-19 epidemic is effective, so appropriate precautions and preparation of the health system are needed to deal with the impending burden of co-infection. Conclusion: COVID-19 disease and its limitations may have a significant impact on the presentation and monitoring of TB control strategies nationally and globally. Concerns about delays in treating TB patients make their disease worse, and therefore broader management should be conducted.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74034113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of HIV infection in a patient with ulcerative colitis; a case report 溃疡性结肠炎患者HIV感染的成功治疗病例报告
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.17
Z. Majid, Shoaib Ahmed Khan, Hina Ismail, Nishat Akbar, Rajesh Mandhwani, N. Luck
Human immunodeficiency virus (HIV) is an infectious disease that is rarely seen in ulcerative colitis patients. Both diseases commonly involve the colon. It has been shown that treating these patients with anti-tumor necrosis factor (anti-TNF) therapy leads to remission of both conditions. We hereby present the case of a 7-year-old boy who was initially managed as a case ulcerative colitis after undergoing extensive workup and later on tested positive for HIV infection and was managed via mesalamine and highly active antiretroviral therapy (HAART). Mesalamine therapy along with HAART can be used to treat ulcerative colitis patients infected with HIV infection in resource limited countries.
人类免疫缺陷病毒(HIV)是一种在溃疡性结肠炎患者中罕见的传染病。这两种疾病通常都累及结肠。研究表明,用抗肿瘤坏死因子(anti-TNF)疗法治疗这些患者可使这两种疾病得到缓解。我们在此报告一个7岁男孩的病例,他在接受广泛的检查后,最初被诊断为溃疡性结肠炎,后来被检测为HIV感染阳性,并通过美沙拉明和高效抗逆转录病毒治疗(HAART)进行治疗。在资源有限的国家,美沙拉明联合高效抗逆转录病毒疗法可用于治疗感染艾滋病毒的溃疡性结肠炎患者。
{"title":"Successful management of HIV infection in a patient with ulcerative colitis; a case report","authors":"Z. Majid, Shoaib Ahmed Khan, Hina Ismail, Nishat Akbar, Rajesh Mandhwani, N. Luck","doi":"10.34172/jpe.2021.17","DOIUrl":"https://doi.org/10.34172/jpe.2021.17","url":null,"abstract":"Human immunodeficiency virus (HIV) is an infectious disease that is rarely seen in ulcerative colitis patients. Both diseases commonly involve the colon. It has been shown that treating these patients with anti-tumor necrosis factor (anti-TNF) therapy leads to remission of both conditions. We hereby present the case of a 7-year-old boy who was initially managed as a case ulcerative colitis after undergoing extensive workup and later on tested positive for HIV infection and was managed via mesalamine and highly active antiretroviral therapy (HAART). Mesalamine therapy along with HAART can be used to treat ulcerative colitis patients infected with HIV infection in resource limited countries.","PeriodicalId":91739,"journal":{"name":"Journal of epidemiology and preventive medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74639494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on the relationship of cervical cancer with vaginal microbiota and trichomoniasis infection; a single center study 宫颈癌与阴道菌群、滴虫感染关系的研究单中心研究
Pub Date : 2021-01-01 DOI: 10.34172/jpe.2021.22
P. Hedayat, M. Derakhshan, Reda Bazzal
Introduction: Cervical cancer is the most prevalent cancer associated with infection, which is provoked by the human papillomavirus (HPV). Natural vaginal microbes, known as vaginal microbiota, play an important role in regulating vaginal pH and are therefore important in the risk of cervical cancer. Trichomoniasis vaginalis is a genital infection that reports 250 million new infections worldwide each year and can increase the risk of developing cervical cancer in the general population. Objectives: The aim of this study was to investigate the relationship between cervical cancer and vaginal microbiota or trichomoniasis infection by examining several risk factors. Patients and Methods: This prospective case study was conducted from 2014 to 2018 from an educational pathology group in Isfahan, 200 samples are included in this study. The groups consist of women over 18 years old. The study group included patients with cervical cancer lesions. For participants, a questionnaire containing information about age, gender, abortion, age at first delivery, smoking or passive smoking and the result of Pap smear test (HPV, vaginal microbiota or Trichomonas) was completed. Results: Results suggested that cancerous and precancerous lesion development is not associated with parity, age at first child’s birth. However, it is statistically associated with lower vaginal microbiota, increased Trichomonas infection, old age, increased abortion rate, smoking, and the presence of HPV infection on Pap smear. Conclusion: Protection from harmful factors that affect a healthy vaginal microbiome, such as Trichomonas infections, can reduce the risk of cervical cancer.
宫颈癌是最常见的与感染相关的癌症,它是由人乳头瘤病毒(HPV)引起的。天然阴道微生物,即阴道微生物群,在调节阴道pH值方面发挥着重要作用,因此对宫颈癌的风险也很重要。阴道毛滴虫病是一种生殖器感染,据报道全世界每年有2.5亿新发感染病例,可增加一般人群患宫颈癌的风险。目的:本研究的目的是通过检查几个危险因素来探讨宫颈癌与阴道微生物群或滴虫感染的关系。患者和方法:本前瞻性病例研究于2014年至2018年在伊斯法罕的一个教育病理学组进行,共纳入200例样本。这些团体由18岁以上的妇女组成。研究组包括宫颈癌病变患者。参与者填写了一份问卷,内容包括年龄、性别、流产、初产年龄、吸烟或被动吸烟以及巴氏涂片检查结果(HPV、阴道微生物群或滴虫)。结果:结果提示癌和癌前病变的发展与胎次、第一胎年龄无关。然而,从统计上看,它与阴道微生物群减少、毛滴虫感染增加、年龄增大、流产率增加、吸烟和宫颈抹片检查中存在HPV感染有关。结论:预防影响健康阴道微生物群的有害因素,如滴虫感染,可以降低宫颈癌的风险。
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Journal of epidemiology and preventive medicine
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