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"5-Fluorouracil Neurotoxicity – Diagnostic and Clinical Implications" 5-氟尿嘧啶神经毒性-诊断和临床意义
Pub Date : 2023-09-11 DOI: 10.26717/bjstr.2023.52.008307
Robert Wiraszka
The aim of the study is to present the current state of knowledge on the rare side effect of 5-fluorouracil, what is neurotoxicity. Knowledge on this subject comes from a few studies, and many of the suggested mechanisms are still hypothesized. Also imaging diagnostics (MRI) or EEG do not provide certain diagnostic guidelines. Also, causal treatment in some patients has not yet been established. According to the summary of product characteristics, before starting treatment, the concentration of dihydropyridimine dehydrogenase (DPD) should be determined, the deficiency of which may cause serious complications, including fatal ones.
本研究的目的是介绍目前对5-氟尿嘧啶罕见副作用的认识状况,即神经毒性。关于这个问题的知识来自一些研究,许多建议的机制仍然是假设的。此外,成像诊断(MRI)或脑电图不提供一定的诊断指南。此外,一些患者的因果治疗尚未确定。根据产品特性总结,在开始治疗前,应测定二氢吡啶脱氢酶(dihydropyridimine dehydrogenase, DPD)的浓度,缺乏DPD可引起严重并发症,甚至致命。
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引用次数: 0
Skin Minimalism - What is the New Beauty Trend? 皮肤极简主义-什么是新的美容趋势?
Pub Date : 2023-09-08 DOI: 10.26717/bjstr.2023.52.008303
Joanna Igielska Kalwat
The assumptions of the “less is more” trend are becoming more attractive to more and more consumers. In the last few years, we can see the development of many new cosmetic companies. In social media, we are faced with many advertisements for more and more new products available on the market. Often it is under the influence of external stimuli that we buy new cosmetics, which very often end up on our shelves and then into the trash. The minimalism trend educates consumers to be prudent about excessive consumerism. We lose money, stimulate the skin and contribute to environmental pollution. The idea of skin minimalism assumes not only limiting the amount of products used every day, but also reducing the number of used cosmetics packaging.
“少即是多”趋势的假设对越来越多的消费者越来越有吸引力。在过去的几年里,我们可以看到许多新的化妆品公司的发展。在社交媒体上,我们面临着市场上越来越多的新产品的广告。通常是在外界刺激的影响下,我们才会购买新的化妆品,而这些化妆品最终往往会出现在我们的货架上,然后被扔进垃圾桶。极简主义趋势教育消费者对过度消费要谨慎。我们赔了钱,刺激了皮肤,还造成了环境污染。皮肤极简主义的理念不仅要限制每天使用的产品数量,还要减少使用化妆品包装的数量。
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引用次数: 0
"Isolation and Structure Elucidation of Bis(2-Ethylhexyl) Terephthalate from Barks of Acacia Xanthophloea" 金合欢树皮中双(2-乙基己基)对苯二甲酸酯的分离及结构分析
Pub Date : 2023-09-08 DOI: 10.26717/bjstr.2023.52.008304
Cheloti Michael
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引用次数: 0
"Study on Central Sensitization in Elite Athletes of the National Softball Team" 《国家垒球队优秀运动员中枢敏感化研究》
Pub Date : 2023-09-08 DOI: 10.26717/bjstr.2023.52.008302
Peng Zhao
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引用次数: 0
"Treatment of Uterine Arteriovenous Malformation and Subsequent Successful Pregnancy: A Case Report" 子宫动静脉畸形治疗及妊娠成功1例
Pub Date : 2023-09-07 DOI: 10.26717/bjstr.2023.52.008297
Ana Dugandžić Šimić
Uterine Arteriovenous Malformation (AVM) is a rare, but potentialy life- treatening condition, as patients may present with profouse bleeding [1]. This case report details the management of a 26-year-old woman, who experienced a miscarriage at 16 weeks of gestation accompanied by persistent bleeding throughout her pregnancy. Following the miscarriage, she was presented to the hospital due to severe bleeding and anemia. A thorough evaluation revealed the presence of an Arteriovenous (AV) malformation within the uterus.
子宫动静脉畸形(AVM)是一种罕见但可能危及生命的疾病,患者可能出现大量出血[1]。本病例报告详细介绍了一名26岁妇女的处理情况,她在妊娠16周时经历了流产,并在妊娠期间持续出血。流产后,她因严重出血和贫血被送到医院。彻底的评估显示子宫内存在动静脉(AV)畸形。
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引用次数: 0
"‘Sereni Orizzonti’: A Leading Player in the Italian Residential Care Market for the Elderly" “Sereni Orizzonti”:意大利老年人住宿护理市场的领导者
Pub Date : 2023-09-06 DOI: 10.26717/bjstr.2023.52.008295
Matteo Maria Cati
Italy is one of the fastest aging countries in the world. This aging population is putting a strain on the Italian healthcare system, which is already struggling to cope with the demand for care. ‘Sereni Orizzonti’ is a leading provider of residential care for the elderly in Italy. The company is committed to providing high-quality care, and it is also committed to sustainability.
意大利是世界上老龄化速度最快的国家之一。人口老龄化给意大利的医疗保健系统带来了压力,该系统已经在努力应对护理需求。“Sereni Orizzonti”是意大利老年人住宿护理的领先供应商。公司致力于提供高质量的护理,同时也致力于可持续发展。
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引用次数: 0
"Molecular Profile of Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Multicentric Study in Lebanon" 非鳞状非小细胞肺癌的分子特征:黎巴嫩多中心回顾性研究
Pub Date : 2023-09-05 DOI: 10.26717/bjstr.2023.52.008287
Fadi El Karak
Testing for driver mutations in non-squamous non-small cell lung cancer (NSCLC) before treatment is recommended. Next Generation Sequencing (NGS) allows simultaneous testing of multiple genes. NGS results for NS-NSCLC in Lebanon have not yet been reported.
建议在治疗前检测非鳞状非小细胞肺癌(NSCLC)的驱动突变。下一代测序(NGS)允许同时检测多个基因。黎巴嫩nsclc的NGS结果尚未报道。
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引用次数: 0
"Applying Lean Management Principles for Enhanced Outpatient Waiting Times" “应用精益管理原则提高门诊候诊时间”
Pub Date : 2023-09-05 DOI: 10.26717/bjstr.2023.52.008290
Muhammad Usman Hassan Siddiqui
The escalation in patient numbers, complications in patient management, and limitations imposed by healthcare schemes have led to extended queues in patient wait times. This has resulted in diminished service quality, decreased patient satisfaction, and financial strain in outpatient departments worldwide. A strategic approach centered on the zero-waste philosophy has been adopted to achieve optimal resource utilization.
患者数量的增加、患者管理中的并发症以及医疗保健计划所施加的限制导致了患者等待时间的延长。这导致服务质量下降,患者满意度下降,门诊部门的财政紧张。采用了以零浪费理念为中心的战略方针,以实现资源的最佳利用。
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引用次数: 0
"Bacteriological Assessment of Some Raw, Chilled Chicken Meat Cuts in Benha City" 《边哈市部分生冷鸡肉切片的细菌学评价》
Pub Date : 2023-09-04 DOI: 10.26717/bjstr.2023.52.008286
Fahim A Shaltout
Chicken meat is a popular, highly nutritious, and easily digestible source of protein. Chicken meat is a desirable target for direct or indirect bacterial contamination at each stage of production, from rearing to ready-to-eat meal. Therefore, the present study was conducted to evaluate the bacteriological quality of 120 random samples of raw, chilled chicken cuts (breast, thigh, drumstick, and wings,30 of each) sold in Benha city’s local markets and their risk to public health.
鸡肉是一种受欢迎的、高营养的、容易消化的蛋白质来源。鸡肉在从饲养到即食的每个生产阶段都是直接或间接细菌污染的理想目标。因此,本研究对在本哈市当地市场销售的120份生冷鲜鸡肉(胸肉、大腿肉、鸡腿肉和鸡翅各30份)的随机样本进行了细菌学质量评估,并对其对公众健康的风险进行了评估。
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引用次数: 0
"The Cytotoxicity of Metformin and Misoprostol Overwhelms their Antiviral Activity in SARS-CoV-2-Infected Vero-E6 Cell Culture" 二甲双胍和米索前列醇在sars - cov -2感染的Vero-E6细胞培养中的细胞毒性超过其抗病毒活性
Pub Date : 2023-09-01 DOI: 10.26717/bjstr.2023.52.008281
Sherine Abdelmissih
Coronavirus disease 2019 (COVID-19) due to the acute respiratory syndrome coronavirus- 2 (SARS-CoV-2) caused a global health crisis that called for re-purposing of many medications. Both the implication of diabetes mellitus (DM) in increasing the risk of COVID-19-associated respiratory complications, together with the claims about the involvement of acidic pH in exacerbating acute lung injury as well as SARS-CoV-2 invasion, growth, and replication, guided our interest towards possible efficacy of antidiabetic and anti-peptic ulcer medications in such condition. The present work aimed to evaluate the safety and antiviral efficacy of the oral antidiabetic, metformin, and the anti-ulcer, misoprostol, on SARS-CoV2-infected Vero-E6 cell line.
由急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2)引起的2019冠状病毒病(COVID-19)引发了全球健康危机,要求重新利用许多药物。糖尿病(DM)在增加covid -19相关呼吸系统并发症风险中的作用,以及关于酸性pH值加剧急性肺损伤以及SARS-CoV-2侵袭、生长和复制的说法,都引导了我们对抗糖尿病和抗消化性溃疡药物在这种情况下的可能疗效的兴趣。本研究旨在评估口服降糖药二甲双胍和抗溃疡药米索前列醇对sars - cov2感染的Vero-E6细胞系的安全性和抗病毒疗效。
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引用次数: 0
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Biomedical Journal of Scientific and Technical Research
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