Pub Date : 2017-05-01DOI: 10.15406/icpjl.2017.04.00106
P. Bhattacharya
low income countries (LICS) and this disparity is likely to be due to differential access to screening of cervical pre cancerous lesions, treatment facilities available in primary level and taking preventive measures with new HPV-9 vaccinesas use of Human papilloma virus vaccinations continues to be lag in the low middle income countries (LMICS). Dramatic benefits were observed from vaccinations of HPV and early cervical precancerous lesions.1 The new HPV-9 vaccine which includes 9 or more HPV types there is good chance after several decades cervical cancer screening may no longer be warranted. But that is for the high income countries. What about for LMICS and MICS like India or in West Bengal Province of India? Hundreds and millions of women are already beyond the age of adolescence and age of vaccination and remains without screening and preventive treatment due to lack of human resources like trained pathologists & laboratory technicians as resource personals and this author apprehends that some 25millions women will die of cervical cancer by next 25years in MICS and LMICS.
{"title":"Save women from cervical cancer in low middle income countries and middle income countries","authors":"P. Bhattacharya","doi":"10.15406/icpjl.2017.04.00106","DOIUrl":"https://doi.org/10.15406/icpjl.2017.04.00106","url":null,"abstract":"low income countries (LICS) and this disparity is likely to be due to differential access to screening of cervical pre cancerous lesions, treatment facilities available in primary level and taking preventive measures with new HPV-9 vaccinesas use of Human papilloma virus vaccinations continues to be lag in the low middle income countries (LMICS). Dramatic benefits were observed from vaccinations of HPV and early cervical precancerous lesions.1 The new HPV-9 vaccine which includes 9 or more HPV types there is good chance after several decades cervical cancer screening may no longer be warranted. But that is for the high income countries. What about for LMICS and MICS like India or in West Bengal Province of India? Hundreds and millions of women are already beyond the age of adolescence and age of vaccination and remains without screening and preventive treatment due to lack of human resources like trained pathologists & laboratory technicians as resource personals and this author apprehends that some 25millions women will die of cervical cancer by next 25years in MICS and LMICS.","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41863167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-28DOI: 10.15406/ICPJL.2017.04.00104
F. Vilela, Le, R. Cortés, Guilherme Henrique Ferreira da Costa, J. A. B. E. Salles
Approximately 250,000 procedures of TAVR have been performed worldwide in more than 1,000 centers, and about 15,000 patients were randomized in clinical trials showing that TAVR is a respected treatment option for symptomatic patients with severe AS [1]. The prognosis of these patients with symptomatic severe AS is poor without valve replacement, and the mortality rate is 50% at 2 years [2,3]. The aortic valve replacement (AVR) is the only treatment that has proved helpful in increasing survival rates of population and no clinical treatment has shown any efficacy in improving outcomes. Despite the 2014 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for AVR as a class I indication for severe symptomatic AS [4], nearly one third of patients with severe symptomatic AS are not referred for surgical AVR.3 This is often because multiple comorbidities and frailty all result in poor prognosis and high mortality rates for surgical AVR [5]. Several new TAVR devices are now being used with modern features that address the limitations of the first-generation devices including paravalvular leak (i.e., lower profile, easier positioning, repositionability and retrievability). In this mini review, we will focus on the most important characteristics of TAVR procedure. Other purpose is to stimulate the development of new trial in the TARV field. Understanding the severe AS and the indications of valve replacement
{"title":"Transcatheter aortic valve replacement","authors":"F. Vilela, Le, R. Cortés, Guilherme Henrique Ferreira da Costa, J. A. B. E. Salles","doi":"10.15406/ICPJL.2017.04.00104","DOIUrl":"https://doi.org/10.15406/ICPJL.2017.04.00104","url":null,"abstract":"Approximately 250,000 procedures of TAVR have been performed worldwide in more than 1,000 centers, and about 15,000 patients were randomized in clinical trials showing that TAVR is a respected treatment option for symptomatic patients with severe AS [1]. The prognosis of these patients with symptomatic severe AS is poor without valve replacement, and the mortality rate is 50% at 2 years [2,3]. The aortic valve replacement (AVR) is the only treatment that has proved helpful in increasing survival rates of population and no clinical treatment has shown any efficacy in improving outcomes. Despite the 2014 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for AVR as a class I indication for severe symptomatic AS [4], nearly one third of patients with severe symptomatic AS are not referred for surgical AVR.3 This is often because multiple comorbidities and frailty all result in poor prognosis and high mortality rates for surgical AVR [5]. Several new TAVR devices are now being used with modern features that address the limitations of the first-generation devices including paravalvular leak (i.e., lower profile, easier positioning, repositionability and retrievability). In this mini review, we will focus on the most important characteristics of TAVR procedure. Other purpose is to stimulate the development of new trial in the TARV field. Understanding the severe AS and the indications of valve replacement","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41722652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-28DOI: 10.15406/icpjl.2017.04.00105
P. Mal, Javed Altaf, M. R. Ansari, Abdul Mannan Junejo, M. Lal
Introduction: Hepatorenal syndrome is a complex syndrome. In addition to severe derangement in renal function due to renal vasoconstriction, there is impairment in systemic hemodynamic, activation of renin-angiotensin and sympathetic nervous systems and antidiuretic hormone, vasoconstriction of brain, muscle and skin, and dilutional Hyponatraemia. This study shows frequency of HRS in patients with liver cirrhosis associated with HCV.
{"title":"Determine the frequency of hepatorenal syndrome in patients with cirrhosis associated with Hepatitis C","authors":"P. Mal, Javed Altaf, M. R. Ansari, Abdul Mannan Junejo, M. Lal","doi":"10.15406/icpjl.2017.04.00105","DOIUrl":"https://doi.org/10.15406/icpjl.2017.04.00105","url":null,"abstract":"Introduction: Hepatorenal syndrome is a complex syndrome. In addition to severe derangement in renal function due to renal vasoconstriction, there is impairment in systemic hemodynamic, activation of renin-angiotensin and sympathetic nervous systems and antidiuretic hormone, vasoconstriction of brain, muscle and skin, and dilutional Hyponatraemia. This study shows frequency of HRS in patients with liver cirrhosis associated with HCV.","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46917194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.15406/icpjl.2017.04.00101
Mamta Gupta, F. Lobo, D. Adiga
Chordoma was originally described by Virchow in 1857 and further characterized by Ribbert in 1894. It is a rare low to intermediate grade malignant notochordal tumor that recapitulates the notochord and has a tendency for recurrences and metastasis.1,2 They represent 1–4% of all malignant bone tumors. Most prevailing theory regarding the development of chordoma is that the notochord fails to degenerate and undergoes malignant transformation. Approximately 50% of chordomas are sacrococcygeal in origin and usually present as destructive bone lesions with a large soft tissue mass.3–5
{"title":"Fine needle aspiration cytology of sacrococcygeal chordoma- utility in a case of clinical dilemma","authors":"Mamta Gupta, F. Lobo, D. Adiga","doi":"10.15406/icpjl.2017.04.00101","DOIUrl":"https://doi.org/10.15406/icpjl.2017.04.00101","url":null,"abstract":"Chordoma was originally described by Virchow in 1857 and further characterized by Ribbert in 1894. It is a rare low to intermediate grade malignant notochordal tumor that recapitulates the notochord and has a tendency for recurrences and metastasis.1,2 They represent 1–4% of all malignant bone tumors. Most prevailing theory regarding the development of chordoma is that the notochord fails to degenerate and undergoes malignant transformation. Approximately 50% of chordomas are sacrococcygeal in origin and usually present as destructive bone lesions with a large soft tissue mass.3–5","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47580845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-24DOI: 10.15406/ICPJL.2017.04.00102
D. Nampijja
Patterns and prevalence of heart diseases are different between the high income countries and low income countries.1,2 Acquired heart diseases like RHD, cardiomyopathies, pericarditis are still a public health burden while congenital heart diseases still carry a poor outcome among children.3 Uganda is one of the countries that contribute to the highest prevalence of congenital heart disease in Sub Saharan Africa.4 The absence of early diagnosis, surgical intervention and inadequate access to medication coupled with the existing burden of communicable diseases increases the strain on a staggering economy of most sub Saharan countries.4 Unlike in the developed countries, children with heart disease in LMIC present late with severe complications to hospitals that are inadequately equipped to manage both the simple and complex heart diseases.5–8 Over the years, good will organizations have come to aid in providing surgical intervention for the children with heart diseases within and out of their countries.2–8 However, the burden still remains unclear and the outcome of the children who don’t get the opportunity of surgery is still not well known.
{"title":"Burden of heart diseases in children attending cardiology clinic in a regional referral hospital in Uganda","authors":"D. Nampijja","doi":"10.15406/ICPJL.2017.04.00102","DOIUrl":"https://doi.org/10.15406/ICPJL.2017.04.00102","url":null,"abstract":"Patterns and prevalence of heart diseases are different between the high income countries and low income countries.1,2 Acquired heart diseases like RHD, cardiomyopathies, pericarditis are still a public health burden while congenital heart diseases still carry a poor outcome among children.3 Uganda is one of the countries that contribute to the highest prevalence of congenital heart disease in Sub Saharan Africa.4 The absence of early diagnosis, surgical intervention and inadequate access to medication coupled with the existing burden of communicable diseases increases the strain on a staggering economy of most sub Saharan countries.4 Unlike in the developed countries, children with heart disease in LMIC present late with severe complications to hospitals that are inadequately equipped to manage both the simple and complex heart diseases.5–8 Over the years, good will organizations have come to aid in providing surgical intervention for the children with heart diseases within and out of their countries.2–8 However, the burden still remains unclear and the outcome of the children who don’t get the opportunity of surgery is still not well known.","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47743738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-12DOI: 10.15406/ICPJL.2017.04.00099
N. Girish, Prathima
{"title":"Rhinosporidosis of lacrimal sac: a case report","authors":"N. Girish, Prathima","doi":"10.15406/ICPJL.2017.04.00099","DOIUrl":"https://doi.org/10.15406/ICPJL.2017.04.00099","url":null,"abstract":"","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42618974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-06DOI: 10.15406/icpjl.2017.04.00097
A. Roy, A. Roy, B. ArupRatan, Yopadhyay
Cervical cancer is considered to be a preventable health problem, but each year nearly about 530,000 women worldwide contract the disease. 275,000 women die from cervical cancer at the same time almost [1]. This makes cervical cancer the second most common cancer and third in terms of cancer-caused deaths among women worldwide [2]. Cervical cancer affects mostly women under 50 years of age [3]. Multiple social barriers for accessing basic screening and treatment services have posed or taking the Indian women at greater risk of developing the disease [4]. Eighty-six percent of all cervical cancer diagnosed and 88% of death due to cervical cancer occur in developing regions of the world. Cervical cancer is the most frequent cancer among women between 15 and 44 years of age in India [5]. India bears about one fifth of the world’s burden of cervical cancer. More than 100,000 new cases are detected in India per year and it causes 20 percent of all female deaths in India [6].
{"title":"A study on cervical cancer awareness among the Bengalee Women, Kolkata, West Bengal","authors":"A. Roy, A. Roy, B. ArupRatan, Yopadhyay","doi":"10.15406/icpjl.2017.04.00097","DOIUrl":"https://doi.org/10.15406/icpjl.2017.04.00097","url":null,"abstract":"Cervical cancer is considered to be a preventable health problem, but each year nearly about 530,000 women worldwide contract the disease. 275,000 women die from cervical cancer at the same time almost [1]. This makes cervical cancer the second most common cancer and third in terms of cancer-caused deaths among women worldwide [2]. Cervical cancer affects mostly women under 50 years of age [3]. Multiple social barriers for accessing basic screening and treatment services have posed or taking the Indian women at greater risk of developing the disease [4]. Eighty-six percent of all cervical cancer diagnosed and 88% of death due to cervical cancer occur in developing regions of the world. Cervical cancer is the most frequent cancer among women between 15 and 44 years of age in India [5]. India bears about one fifth of the world’s burden of cervical cancer. More than 100,000 new cases are detected in India per year and it causes 20 percent of all female deaths in India [6].","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41368779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-04DOI: 10.15406/ICPJL.2017.04.00096
DR DHIRAJ B NIKUMBH, R. Thakur, Roopali D. Nikumbh
Dengue fever is the most common tropical and arthropod borne viral infection in the World. The present study aimed to highlight the importance of hematological, biochemical and serological markers correlation for early diagnosis of dengue fever with NS1 antigen for timely management. The cross sectional observational study was done on 42 out of 74 patients of clinical features of dengue over a period of one year from May 2015 to April 2016. We observed a strong correlation of pancytopenia with NS1 positive patients with deranged SGPT values.
{"title":"Hematological, biochemical and serological predictors of NS1 positive dengue patients: a laboratory practical perspective.","authors":"DR DHIRAJ B NIKUMBH, R. Thakur, Roopali D. Nikumbh","doi":"10.15406/ICPJL.2017.04.00096","DOIUrl":"https://doi.org/10.15406/ICPJL.2017.04.00096","url":null,"abstract":"Dengue fever is the most common tropical and arthropod borne viral infection in the World. The present study aimed to highlight the importance of hematological, biochemical and serological markers correlation for early diagnosis of dengue fever with NS1 antigen for timely management. The cross sectional observational study was done on 42 out of 74 patients of clinical features of dengue over a period of one year from May 2015 to April 2016. We observed a strong correlation of pancytopenia with NS1 positive patients with deranged SGPT values.","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46228329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-27DOI: 10.15406/ICPJL.2017.04.00094
G. Gogoi, Brinkal Patel, Jasmine Teronpi, Hardik Patel
Introduction: Paraganglioma are rare neuroendocrine neoplasm, affecting about 1 in 2,000,000 populations, which arise in the extra-adrenal chromaffin cells of the autonomic nervous system. It is a generic term applied to all tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking one of the common primary pancreatic lesions.
{"title":"Pancreatic paraganglioma: an extremely rare entity with unusual age presentation and uncommom site","authors":"G. Gogoi, Brinkal Patel, Jasmine Teronpi, Hardik Patel","doi":"10.15406/ICPJL.2017.04.00094","DOIUrl":"https://doi.org/10.15406/ICPJL.2017.04.00094","url":null,"abstract":"Introduction: Paraganglioma are rare neuroendocrine neoplasm, affecting about 1 in 2,000,000 populations, which arise in the extra-adrenal chromaffin cells of the autonomic nervous system. It is a generic term applied to all tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking one of the common primary pancreatic lesions.","PeriodicalId":92215,"journal":{"name":"International clinical pathology journal","volume":"68 s1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41264413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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