BMC Research Notes最新文献

Objective: In Endodontics, the primary objective of regenerative treatment is to revitalize the pulpo-dentinal complex of immature permanent teeth, promote continued root development, and achieve complete closure of the open apical terminus. Traditionally, apexification has been performed using conventional pulp space therapy for all non-vital immature permanent teeth. In this study, after rubber dam isolation and local anesthesia, routine endodontic procedures were initiated. Access cavity preparation was followed by biomechanical preparation using ProTaper hand files (size F3). Irrigation was carried out with 3% sodium hypochlorite, and two rounds of intracanal calcium hydroxide dressing were placed. At subsequent visits, the dressing was removed, the canals were dried with absorbent points, and an amniotic membrane scaffold (Tata Memorial Hospital, Mumbai, India) was positioned at the apex for two weeks. The entire pulp space was then obturated with Biodentin, and composite resin was used for post-endodontic restoration.

Results: Apexification protocols were followed in ten adult non-vital permanent teeth with open apices. Clinical and radiographic evaluations demonstrated satisfactory healing. The amniotic membrane appeared to contribute to apical closure within two weeks and showed no adverse effects. It may represent a promising scaffold material for apexification in developing non-vital permanent teeth.

Trial registration number: Current Controlled Trials CTRI/2025/11/097852 [Registered on 21/11/2025].

Objective: This study aimed to investigate the effects of catecholamine administration on ICU patients with acute gastrointestinal injury undergoing invasive mechanical ventilation (IMV).

Results: During the study period, 425 patients with a median age of 60 years (interquartile range, 48-70), including 290 males (68%), received IMV during their ICU stay. AGI occurred in 287 patients, with an incidence rate of 67.5%. The most common symptom of AGI was gastric retention (50.52%). Multivariate regression analysis results showed the following as risk factors for AGI: the administration of catecholamine drugs (OR: 2.881, 95% CI 1.525 to 5.441, P = 0.001), Acute Physiology and Chronic Health Evaluation II score (OR: 1.119, 95% CI 1.055 to 1.186, P < 0.001), Nutritional Risk Screening 2002 score (OR: 1.416, 95% CI 1.154 to 1.737, P = 0.001), duration of IMV (OR: 1.142, 95% CI 1.108 to 1.207, P < 0.001), and primary disease involving the respiratory system (OR: 2.097, 95% CI 1.179 to 3.731, P = 0.012).

Objective: The study examined the association between adiponectin levels and markers of Insulin Resistance (IR) in obese and non-obese adults with type 2 diabetes. Insulin Resistance was estimated using HOMA-IR, while group differences were assessed using appropriate statistical tests. Multiple linear regression was applied to evaluate associations between adiponectin and obesity indices while adjusting for HOMA-IR.

Results: Mean serum adiponectin did not differ significantly across obese diabetics, non-obese diabetics, and controls (5.9 ± 3.6 µg/mL, 6.4 ± 3.2 µg/mL, and 6.8 ± 3.5 µg/mL, respectively; p = 0.13). Mean HOMA-IR values were comparable among obese diabetics (1.4 ± 2.1), non-obese diabetics (1.3 ± 1.0), and controls (1.1 ± 0.6). In multivariable regression models, serum adiponectin was not independently associated with obesity indices or HOMA-IR (all p > 0.05). Serum adiponectin levels were not significantly different across the study groups, although numerically lower values were observed in obese individuals with diabetes. No significant relationship was found between adiponectin and clinical or biochemical markers of IR. These findings suggest that adiponectin may have limited utility as an isolated marker of IR in Nigerian adults with type 2 diabetes and underscore the need for larger, longitudinal studies to clarify its role.