BMC Research Notes最新文献

Objectives: This serial cross-sectional study evaluated trends in mean body mass index (BMI) and obesity prevalence among young Thai men from 2009 to 2024. We defined obesity using both Asia-Pacific (BMI ≥ 25 kg/m²) and World Health Organization (WHO) (BMI ≥ 30 kg/m²) cutoffs and identified associated factors.

Results: The analysis included 54,622 men with a mean age of 21.2 years. Over the 16 years, age-adjusted mean BMI significantly increased from 21.7 kg/m² (2009) to 22.5 kg/m² (2024) (P-trend < 0.001). Using the Asia-Pacific cutoff, age-adjusted obesity prevalence rose from 12.5% (95% confidence interval [CI]: 11.0-13.9) to 22.6% (95% CI 21.0-24.1) (P-trend < 0.001), with the most substantial increases in the central (13.4% to 31.8%) and northern regions (14.7% to 26.2%). According to the WHO cutoff, prevalence increased from 2.2% (95% CI 1.6-2.8) to 6.2% (95% CI 5.3-7.1) (P-trend < 0.001), with similar trends observed across all regions. Factors associated with the increase in obesity prevalence (BMI ≥ 25 kg/m²) included older age, indoor occupation, and residence in the northern, central, or northeastern regions. Regular exercise was identified as a protective factor against obesity. We highlighted that obesity poses a significant health risk in this population.

Objective: This study developed a predictive model to identify the high-risk patients for sequential oxygen therapy (SOT) following the extubation from invasive mechanical ventilation (IMV) in patients with coronary artery bypass grafting (CABG).

Results: A total of 152 patients were included in this study. Both univariate and multivariate logistic regression analyses identified the potential risk factors associated with the need for SOT following the extubation from IMV in patients with CABG, including the timing of endotracheal extubation (OR = 0.40, 95%CI = 0.29-0.52), duration of IMV (OR = 7.37, 95%CI = 4.28-10.47), simple/combined CABG (OR = 4.31, 95%CI = 1.95-6.67), 1-hour postoperative creatine kinase (CK) levels (OR = 1.60, 95%CI = 1.17-2.02), oxygenation index (OI) (OR = 0.74, 95%CI = 0.63-0.85), and base excess (BE) (OR = 0.47, 95%CI = 0.36-0.57) at the time of extubation. The nomogram demonstrated a consistency index (C-index) and an area under the ROC curve of 0.700. The calibration curve indicated a high degree of agreement between predicted and observed values, and the DCA confirmed the practical utility of the identified indicators.

Objective: We aimed to begin studying, more empirically, within our ethics department,scientific integrity itself, considering scientific integrity as an integral part of morality. We therefore decided to start with a preliminary meta-ethics study, based on a small sample of chapters from two conference proceedings, published exclusively in French in 2016 and 2021, to which two of us have actively contributed .

Results: A thematic analysis of secondary information extracted from this sample enabled us to identify three principal themes in scientific integrity: its institutionalization, definition and applicability. And these themes, with their subthemes, highlighted two trends. On the one hand, scientific morality tends towards moral absolutism, whereas, on the other, it tends towards moral relativism. In other words, context does not, morally, justify anything in the first case, but can, ethically, justify certain things in the second. We think that it would be questionable to formalize scientific integrity as a moral absolutism, but this does not necessarily tip the balance in favor of radical moral relativism either. Scientific integrity should allow a contextualization of certain scientific practices within the framework of the activities of research ethics committees applying pragmatist ethical theories.