Brazilian oral research最新文献

This study aimed to evaluate the influence of pacifier use, bottle feeding, and finger/thumb sucking on the occurrence of otitis media in children. Searches were conducted in grey literature and six databases: Web of Science, Cochrane Library, LILACS, Scopus, MEDLINE/PubMed, and EMBASE, from inception through May 2025. Observational studies investigating the association between harmful sucking habits and otitis media in newborns, infants, preschoolers, and older children were included. Risk of bias was assessed using the Joanna Briggs Institute tool. Meta-analysis results were reported as odds ratios (ORs) with 95% confidence intervals (CIs), and the certainty of evidence was also evaluated. A total of 36 studies were included, most of which were cohort studies (n = 14), with sample sizes ranging from 46 to 35,613. Eleven studies were incorporated into meta-analyses. Children who used a pacifier were 1.17 times more likely to develop otitis media (95%CI: 1.00-1.33) and 1.54 times more likely to develop acute otitis media (95%CI: 1.01-2.36) compared to those who did not use a pacifier. No significant association was found between bottle feeding and otitis media (OR = 0.83; 95%CI: 0.59-1.17). Most studies did not report a significant association between finger or thumb sucking and otitis media. The certainty of evidence was rated as very low. These findings suggest that pacifier use may increase the likelihood of developing otitis media, particularly acute otitis media, with potentially relevant implications.

Guided bone regeneration (GBR) is a critical strategy for repairing large bone defects. This study aimed to assess the osteopromotive potential of a porcine cross-linked collagen membrane in critical calvaria-defects in rats. Seventy-two rats were divided into three groups: blood clot (CG - negative control), Bio-Gide® membrane (BG - positive control), and Ossix Plus® membrane (OSX - test). The defects were covered according to each group, and the experimental times were 7, 15, 30, and 60 days postoperatively. The collected samples were evaluated by histometric analysis, inflammatory profile, immunohistochemistry, and micro-computed tomography (micro-CT). At 7 days, no significant differences in bone neoformation were observed. At 15 days, the OSX group showed increased new bone formation compared to CG (p = 0.031). At 30 days, the BG group exhibited the most significant increase compared to both OSX (p < 0.001) and CG (p < 0.001). At 60 days, OSX demonstrated the highest osteopromotive potential, significantly outperforming CG (p < 0.001) and BG (p < 0.001). MicroCT analysis revealed that the OSX group had a bone volume (BV) of 17.33 ± 1.74 mm3, significantly higher than BG (8.06 ± 1.26 mm3, p < 0.05). The cross-linked collagen membrane was biologically more favorable for bone regeneration being a promising option for GBR procedures.

This study aimed to evaluate the impact of the blooming artifact reduction (BAR) algorithm on the measurement of various sealing materials (Biodentine, MTA ProRoot, MTAFlow, and amalgam) for furcal perforation repair using cone-beam computed tomography (CBCT). A total of 105 extracted human mandibular first and second molars were prepared and root-filled. Furcal perforations were created, and the specimens were randomly organized into five groups based on the sealing material used: (1) Biodentine, (2) MTA ProRoot, (3) MTAFlow, (4) Amalgam, and (5) Control (no sealing material). After setting, the specimens were embedded in wax, and the crowns were sectioned to measure the diameter of the sealing materials using a digital micrometer. CBCT scans were acquired using the Prexion 3D Elite® CT scanner. The dimensional measurements of sealing materials on the CBCT images was measured using DICOM files and the e-Vol DX software measurement tool, configured to thousandths of a millimeter. BAR algorithms were applied as follows: BAR 3 for the control group, Biodentine, and MTAFlow; BAR 2 for MTA ProRoot; and BAR 1 for amalgam. Statistical analysis was performed using ANOVA and Tukey's test with a significance level of 5%. No significant differences were observed between the diameters of sealing materials measured using the micrometer and those obtained from CBCT images processed with BAR algorithms (Biodentine, MTA ProRoot, MTAFlow, and amalgam). The BAR algorithm in the e-Vol DX software preserved the dimensional accuracy of CBCT images for the tested sealing materials.

Orofacial pain impairs quality of life, and current therapies, limited in efficacy and associated with adverse effects, drive the search for new treatments. Thiophene derivatives exhibit remarkable therapeutic properties, including antinociceptive and anti-inflammatory activities, with recent studies demonstrating superior activity compared to commercial drugs, highlighting their relevance in the design of novel agents. This study investigated the antinociceptive effect of the thiophene derivative 2-[(4-diethylamino-benzylidene)-amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile (7CN03) and its possible mechanisms of action. In vivo tests were performed on male mice (n = 6 per group), and nociception was induced by formalin, capsaicin, and glutamate 1 h after treatment. Facial rubbing was used as a parameter to measure nociceptive behavior. 7CN03 exhibited significant action during the neurogenic phase of the formalin test at different doses (1 mg/kg, 0.1 mg/kg, and 0.01 mg/kg), reducing nociceptive behavior by up to 56%. During the inflammatory phase, the 1 mg/kg dose exerted an antinociceptive effect, reducing nociceptive behavior by 32% (p < 0.05). In the glutamate test, 7CN03 blocked nociception by up to 90% (p < 0.001), and in the capsaicin test, it reduced nociceptive behavior by up to 74%. Molecular docking studies predicted higher binding affinity of 7CN03 for µ-opioid (-97.00 Kcal/mol), TRPV1 (-87.79 Kcal/mol), and NMDA (-104.86 Kcal/mol) receptors when compared with cocrystallized ligands. The findings suggest that the evaluated thiophene derivative exhibits an orofacial antinociceptive effect, with a mechanism of action likely mediated by opioid, transient receptor potential vanilloid, and glutamatergic receptors.

The aim of this study was to translate and validate the 14-item Oral Health Impact Profile (OHIP-14) into the Collao variant of the Quechua language for the population of southern Peru. A cross-sectional instrumental study was carried out with 288 participants of both sexes aged between 18 and 65 years (M = 37.53 years; SD = 10.38) who were residents of the department of Cusco, Peru. A convenience sampling method was used. The cultural adaptation process included initial translation, back-translation, review by a committee, focus group evaluation for comprehension and clarity of the items, and a pilot test to ensure the cultural adequacy of the questionnaire. Content validity was evaluated by three evaluators using Aiken's V coefficient. The internal structure was assessed through confirmatory factor analysis (CFA), which tests a three-factor model. The fit indices demonstrated an acceptable model fit, with χ2 = 156.25 (df = 74), RMSEA = 0.062 (90%CI: 0.049-0.076), CFI = 0.999, and TLI = 0.999. The standardized factor loadings exceeded 0.70 for all the items. The corrected item-total correlations indicated strong internal consistency. Reliability was assessed with Cronbach's alpha, which is a high value across all dimensions. The evaluators' assessment demonstrated a high level of agreement for all the items, with Aiken's V coefficient above 0.70. This finding demonstrates that the OHIP-14 is a valid and reliable instrument for the Quechua-speaking population of the Collao variant in Cusco. The study received approval from an ethics committee and adhered to the ethical principles of the Declaration of Helsinki.

This cross-sectional study aimed to evaluate the moderating role of social capital in the relationship between income and oral health-related quality of life (OHRQoL) among pregnant women. The study was conducted using a random sample of pregnant women registered with the public health system in southern Brazil. Women with sensory or cognitive impairments, non-Brazilian nationality, or high-risk pregnancies were excluded. The Oral Health Impact Profile (OHIP-14) was used to assess OHRQoL. Social capital was evaluated through "perceived social support" and "pregnancy group attendance." The monthly household income was assessed in Brazilian Reais and categorized as either high (≥ 1,000 BRL) or low (< 1,000 BRL). The moderating role of social capital on the relationship between income and OHRQoL was tested using multilevel Poisson regression analysis. The results are presented as rate ratio (RR) with 95% confidence intervals (CI). A total of 520 pregnant women were assessed, with a response rate of 93%. Approximately 25.6% had low income. Both social capital variables demonstrated a moderating effect on the relationship between income and OHRQoL. Among pregnant women with a low household income, those without social support and those who did not attend pregnancy groups had 44% (RR = 1.44, 95%CI: 1.22-1.72) and 22% (RR = 1.22, 95%CI: 1.05-1.42) higher overall OHIP-14 scores, respectively, compared to their counterparts. This means that social support and group attendance substantially mitigate the negative effects of low income on OHRQoL. Our findings highlight the potential role of social capital promotion in this population.

This prospective, double-blind, randomized clinical trial aimed to evaluate the effect of an additional instrument following the single-file instrumentation approach on postoperative pain. Fifty-six mandibular molars with asymptomatic apical periodontitis were randomly assigned to two groups: G1 - instrumentation using a single reciprocating file; G2 - additional enlargement. The frequency and intensity of postoperative pain were assessed at 24 h, 48 h, and 7 days after endodontic treatment using the numerical pain assessment scale (NPAS) (Mann-Whitney U test). Analgesic intake was also recorded and analyzed using chi-square or Fisher's exact tests. The incidence of root canal filling extrusion was also evaluated (chi-square). Statistical significance was set at p < 0.05. At 24 h, the incidence of postoperative pain was higher when additional enlargement was performed (p = 0.019). The incidence of pain was similar between groups after 48 h (p = 0.121) and 7 days (p = 1.000). The intensity of pain was also higher at 24 h in Group 2 (p = 0.019), while it was similar between groups after 48 h (p = 0.177) and 7 days (p = 1.000). The frequency of analgesic intake was higher in Group 2 after 24 h (p = 0.019). The incidence of root canal filling material extrusion was similar in both groups (p = 0.181). In conclusion, additional enlargement following single-file root canal preparation resulted in a higher incidence and intensity of postoperative pain immediately after treatment (24 h), with no significant impact at 48 h and 7 days.

In the state of Roraima, Brazil, indigenous populations have distinct cultural habits and ethnic characteristics compared to those of the nonindigenous population. Changes in the oral health of indigenous people are critical areas of investigation for generating oral health indicators, which significantly influence the overall health of this population, given their fundamental role in the development of public health policies. Our objective was to compare the oral conditions of indigenous people of the Yanomamis (YANs) and Macuxis (MACs) ethnicities in the state of Roraima. A total of 148 indigenous people were evaluated: 83 (53.50%) YANs and 65 (46.50%) MACs. All indigenous participants were assessed at the Indigenous Health House (CASAI), in the municipality of Boa Vista/RR, and data regarding oral condition, DMFT index, periodontal indices, basic erosive wear examination (BEWE) index, and eating habits were obtained. Significant differences were found in the DMFT index, which was higher for MAC individuals than for YAN individuals (P<0.05). Periodontal evaluation revealed a significantly larger probing depth in YAN individuals aged over 35 years. Plaque index was higher for YAN individuals, with a significant difference noted in all compared groups. As for the BEWE index, no statistically significant difference was observed between YAN and MAC individuals. With respect to eating habits, YAN individuals consumed significantly more native foods, whereas MAC individuals consumed predominantly processed foods. Periodontal indices are affected by poor oral hygiene, and oral hygiene instruction and guidance are necessary and could help reduce the incidence of dental caries and periodontal disease.

This cross-sectional study aimed to evaluate the association between the degree of depression, anxiety, and stress and oral health-related quality of life (OHRQoL) of adolescents aged 11 to 19 years from Santa Maria, Brazil. The Child Perception Questionnaire (CPQ 11-14) was used to evaluate OHRQoL. The degree of anxiety, depression, and stress was assessed using the Depression, Anxiety and Stress Scale - Short Form (DASS-21). Additionally, sociodemographic, clinical, and psychosocial variables were considered. Adjusted Poisson regression models were applied to examine the associations between predictive variables and overall CPQ11-14 scores. Results are reported as rate ratio (RR) and 95% confidence intervals (95% CI). A total of 164 adolescents were evaluated. The mean DASS-21 scores for depression, anxiety, and stress were 6.9 (standard deviation [SD] 9.0), 8.7 (SD 8.9), and 11.9 (SD 9.7), respectively. The mean CPQ 11-14 score was 12.2 (SD 10.3). Adolescents with high levels of depression (RR = 1.03; 95%CI: 1.02-1.05) and stress (RR = 1.02; 95%CI: 1.01-1.04) presented higher CPQ 11-14 scores, indicating a significant impact of those symptoms on OHRQoL. In conclusion, adolescents with high depression and stress scores experienced poorer OHRQoL, highlighting the need for integrated mental health and oral health interventions to improve their overall well-being.

Specific measures for assessing dental anxiety and fear are crucial in pediatric dentistry for their management. This cross-sectional study aimed to test the validity and reliability of the Brazilian Portuguese version of the Modified Child Dental Anxiety Scale - Faces (MCDASf). A total of 189 children enrolled in public schools in Pelotas, Southern Brazil, and their parents were included. The children completed an interview that included the MCDASf, Children's Fear Survey Schedule-Dental Subscale (CFSS-DS), Dental Anxiety Question (DAQ), and self-reported oral health-related outcomes. The parents provided sociodemographic data and information on dental visits and pain. Descriptive statistics, comparison and correlation tests, and psychometric analyses were conducted. The MCDASf scores were positively correlated with the CFSS-DS scores (rho = 0.60; p < 0.001). Children reporting dental anxiety (DAQ) had higher MCDASf scores. Exploratory factor analysis (EFA) was conducted on MCDASf items. The factor model was supported by Bartlett's test of sphericity (p < 0.001) and the Kaiser-Meyer-Olkin (KMO) measure (0.782). The loadings indicated that the two factors explained 18.9% and 13.9% of the variance. Factor 1 included items 1-3, 5, 7, and 8, whereas Factor 2 included items 4 and 6. The MCDASf showed satisfactory internal consistency: Cronbach's α = 0.73 and McDonald's ω = 0.82 for the total scale, with α and ω > 0.66 for both factors. Coefficients ≥ 0.70 are considered acceptable. This study provided psychometric evidence supporting the Brazilian MCDASf (B-MCDASf) as a reliable self-report tool for assessing dental anxiety in children in both clinical and research settings.