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Influence of torque and bone type on stability quotient of two implant platforms: a clinical trial. 扭矩和骨质类型对两种种植体平台稳定性商数的影响:一项临床试验。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0049
Lisiane Cristina Bannwart, Daniela Micheline Dos Santos, João Paulo do Vale Souza, Clóvis Lamartine de Moraes Melo Neto, Emily Vivianne Freitas da Silva, José Vitor Quinelli Mazaro, Leda Maria Piscinini Salzedas, Marcelo Coelho Goiato

The objective of this study was to analyze the influence of insertion torque, bone type, and peri-implant bone loss on implant stability quotient (ISQ) of cylindrical external hexagon (EH) and Morse Taper (MT) implants. Forty-four single implants were placed in the edentulous areas of 20 patients who met the inclusion and exclusion criteria. Immediately after implant placement (t1) and after osseointegration (four and six months for mandible and maxilla, respectively) (t2), insertion torque, resonance frequency, and peri-implant bone loss were measured using probing depths and digital periapical radiography. A significant difference was noted in the ISQ values between t1 and t2 in type III bone for EH and MT implants. No significant difference in bone loss values was observed when comparing bone types for EH or MT in all evaluated sites. Based on marginal bone loss assessed using radiography, there was no significant difference between the MT and EH groups. A positive correlation between torque and ISQ t1 value was observed for MT (correlation: 0.439; p = 0.041) and EH (correlation: 0.461; p = 0.031) implants. For EH and MT implants, the greater the insertion torque, the greater was the ISQ value (moderately positive correlation). A weak negative correlation was found between bone type and ISQ t1 for MT implants. Contrarily, no correlation was observed between bone type and ISQ t1 for EH implants. In all cases, bone loss around the implants was clinically normal.

本研究旨在分析插入扭矩、骨类型和种植体周围骨质流失对圆柱形外六角(EH)和莫尔斯锥形(MT)种植体稳定性商数(ISQ)的影响。在符合纳入和排除标准的 20 位患者的无牙区植入了 44 个单颗种植体。在种植体植入后(t1)和骨结合后(下颌和上颌分别为四个月和六个月)(t2),使用探查深度和数字根尖周放射摄影测量了植入扭矩、共振频率和种植体周围骨质流失。EH和MT种植体在III型骨中的ISQ值在t1和t2之间存在明显差异。在所有评估部位,比较 EH 和 MT 种植体的骨质类型,未发现骨质流失值有明显差异。根据X光片对边缘骨质流失的评估,MT组和EH组之间没有明显差异。MT(相关性:0.439;p = 0.041)和 EH(相关性:0.461;p = 0.031)种植体的扭矩和 ISQ t1 值之间呈正相关。对于 EH 和 MT 种植体,插入扭矩越大,ISQ 值也越大(中度正相关)。骨类型与 MT 种植体的 ISQ t1 之间存在微弱的负相关。相反,骨类型与 EH 种植体的 ISQ t1 之间没有相关性。在所有病例中,种植体周围的骨质流失在临床上都是正常的。
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引用次数: 0
Effect of treatment with phosphate, casein phosphopeptide and fluoride on the remineralization: in vitro study. 用磷酸盐、酪蛋白磷酸肽和氟化物处理对再矿化的影响:体外研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0036
Marília Andrade Figueiredo de Oliveira, Francyenne Maira Castro Gonçalves, Alberto Carlos Botazzo Delbem, Gabriela Leal Peres Fernandes, Mark L Cannon, Marcelle Danelon

This study aimed to evaluate in vitro the effect protocols and anticaries agents containing casein amorphous calcium fluoride phosphopeptide-phosphate (CPP-ACPF, MI Paste Plus), sodium trimetaphosphate (TMP) and fluoride (F), in remineralization of caries lesions. Bovine enamel blocks with initial caries lesions were divided into groups (n = 12): 1) Toothpaste without F-TMP-MI Plus (Placebo); 2) Toothpaste 1100 ppm F (1100F), 3) 1100F + MI Paste Plus (1100F-MI Paste Plus), 4) Toothpaste with 1100F + Neutral gel with 4,500 ppm F + 5%TMP (1100F + Gel TMP) and 5) Toothpaste with 1100F + Neutral gel with 9,000 ppm F (1100F + Gel F). For the 4 and 5 groups the gel was applied only once for 1 minute, initially to the study. For the 3 group, after treatment with 1100F, MI Paste Plus was applied 2x/day for 3 minute. After pH cycling, the percentage of surface hardness recovery (%SHR); integrated loss of subsurface hardness (ΔKHN); profile and depth of the subsuperficial lesion (PLM); concentrations of F, calcium (Ca) and phosphorus (P) in enamel was determined. The data were analyzed by ANOVA (1-criterion) and Student-Newman-Keuls test (p < 0.001). Treatment with 1100F alone led to ~ 28% higher remineralization when compared to treatment with 1100F associated with MI Paste Plus (p < 0.001). The 1100F and 1100F + Gel F groups showed similar values for %SHR (p = 0.150). 1100F + Gel TMP treatment also remineralized the enamel surface by ~ 30% and 20% when compared to the 1100F + Gel F and 1100F groups (p < 0.001). The lower lesion depth (ΔKHN) was observed for the 1100F + Gel TMP group (p < 0.001), where it was 54% and 44% lower in comparison to the 1100F and 1100F + Gel F groups (p < 0.001). Polarized light microscopy photomicrographs showed subsurface lesions in all groups, but these lesions were present to a lower extent in the 1100F + Gel TMP group (p < 0.001). Treatment with 1100F + Gel TMP promoted an increase in the concentration of Ca in the enamel by ~ 57% and ~ 26% when compared to the 1100F and 1100F + MI Paste Plus groups (p < 0.001), respectively. There were no significant differences between the 1100F, 1100F + MI Paste Plus and 1100F + Gel F groups (p > 0.001). Similar values of P in the enamel were observed in the 1100F, 1100F + MI Paste Plus and 1100F + Gel F groups (p > 0.001), except for the 1100F + Gel TMP group, which presented a high concentration (p < 0.001). We conclude that the 1100F+TMP gel treatment/protocol led to a significant increased remineralization when compared to the other treatments/protocols and may be a promising strategy for patients with early caries lesions.

本研究旨在体外评估含有酪蛋白无定形氟化钙磷肽-磷酸酯(CPP-ACPF,MI Paste Plus)、三偏磷酸钠(TMP)和氟化物(F)的方案和抗龋剂对龋病再矿化的影响。将有初始龋损的牛珐琅质块分为几组(n = 12):1)牙膏不含 F-TMP-MI Plus(安慰剂);2)牙膏含 1100 ppm F(1100F);3)1100F + MI Paste Plus(1100F-MI Paste Plus);4)牙膏含 1100F + 中性凝胶含 4500 ppm F + 5%TMP(1100F + Gel TMP);5)牙膏含 1100F + 中性凝胶含 9000 ppm F(1100F + Gel F)。对于 4 组和 5 组,研究开始时只使用一次凝胶,每次 1 分钟。对于 3 组,在使用 1100F 处理后,MI Paste Plus 每天使用 2 次,每次 3 分钟。pH 循环后,测定表面硬度恢复百分比 (%SHR);表面下硬度综合损失 (ΔKHN);表面下病变的轮廓和深度 (PLM);釉质中的磷、钙和磷浓度。数据分析采用方差分析(1标准)和Student-Newman-Keuls检验(P < 0.001)。与使用 1100F 和 MI Paste Plus 的治疗相比,单独使用 1100F 的再矿化率要高出 28%(p < 0.001)。1100F 组和 1100F + Gel F 组的 %SHR 值相似(p = 0.150)。与 1100F + Gel F 组和 1100F 组相比,1100F + Gel TMP 治疗也使釉质表面的矿化度分别提高了约 30% 和 20%(p < 0.001)。1100F + Gel TMP 组的病变深度(ΔKHN)较低(p < 0.001),与 1100F 组和 1100F + Gel F 组相比,分别降低了 54% 和 44%(p < 0.001)。偏光显微镜下的显微照片显示,所有组别都有表面下病变,但 1100F + Gel TMP 组的病变程度较低(p < 0.001)。与 1100F 组和 1100F + MI Paste Plus 组相比(p < 0.001),1100F + Gel TMP 可使釉质中的钙浓度分别增加约 57% 和约 26%。1100F 组、1100F + MI Paste Plus 组和 1100F + Gel F 组之间没有明显差异(p > 0.001)。在 1100F、1100F + MI Paste Plus 和 1100F + Gel F 组中观察到的珐琅质中的 P 值相似(p > 0.001),但 1100F + Gel TMP 组除外,该组的 P 浓度较高(p < 0.001)。我们的结论是,与其他治疗/方案相比,1100F+TMP 凝胶治疗/方案可显著提高再矿化率,对于早期龋损患者来说,这可能是一种很有前途的策略。
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引用次数: 0
Depressive symptoms and oral mucositis in children with oncological diseases: a cross-sectional study. 肿瘤患儿的抑郁症状与口腔黏膜炎:一项横断面研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0033
Felipe Barreto Lemos, Andressa Chang Fernandes Rodrigues da Silva, Fernanda Pereira Lima, Fernanda Conceição Machado, Luanderson Lopes Pereira, Arnaldo França Caldas, Bruna Bustani Dos Santos, Andréia Cristina Leal Figueiredo

The aim of this study was to investigate the correlation between depressive symptoms and the occurrence of oral mucositis in children with oncological diseases treated at a reference hospital. This was a cross-sectional study conducted with individuals aged 4 to 18 years, diagnosed with primary neoplasms. Data was collected by using a questionnaire that assessed the degree of oral mucositis according to the World Health Organization index, the risk of oral mucositis according to the Child's International Mucositis Evaluation Scale, and depressive symptoms using the Children's Depression Inventory. The data were analyzed and subjected to Spearman's correlation, chi-square test, and Fisher's exact test, considering p<0.05. A statistically significant correlation was observed between depressive symptoms and the degree of oral mucositis (p = 0.044), and also between the "pain" variable within the risk of oral mucositis and depressive symptoms (p = 0.021). Based on the findings, it can be inferred that oral mucositis may be associated with the development of depressive symptoms and may be influenced by the individual's hospitalization, thereby affecting the quality of life of pediatric patients.

本研究旨在调查在一家参考医院接受治疗的肿瘤患儿的抑郁症状与口腔黏膜炎发生率之间的相关性。这是一项横断面研究,研究对象是被诊断患有原发性肿瘤的 4 至 18 岁儿童。通过问卷收集数据,根据世界卫生组织的指数评估口腔黏膜炎的程度,根据儿童国际口腔黏膜炎评估量表评估口腔黏膜炎的风险,并使用儿童抑郁量表评估抑郁症状。对数据进行了分析,并进行了斯皮尔曼相关性检验、卡方检验和费雪精确检验,考虑了 P
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引用次数: 0
Reliability of the color measurement of resin composites using images obtained using a stereoscopic loupe. 使用立体放大镜获得的图像测量树脂复合材料颜色的可靠性。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0032
Alexsandra Santos Albuquerque, Rafaella Bragança, Oscar Emilio Pecho, André Luis Faria-E-Silva

This study assessed the reliability of a color measurement method using images obtained from a charge-coupled device (CCD) camera and a stereoscopic loupe. Disc-shaped specimens were created using the composite Filtek Z350 XT (shades DA1, DA2, DA3, and DA4) (n = 3). CIELAB color coordinates of the specimens were measured using the spectrophotometer SP60 over white and black backgrounds. Images of the same specimens were taken using a CCD camera attached to a stereoscopic loupe. The color of the image was measured (red-green-blue [RGB]) using an image processing software and converted to CIELAB coordinates. For each color coordinate, data from images were adjusted using linear regressions predicting those values from SP60. The whiteness index for dentistry (WID) and translucency parameter (TP00) of the specimens as well as the color differences (ΔE00) among pairwise shades were calculated. Data were analyzed via repeated-measures analysis of variance and Tukey's post hoc test (α = 0.05). Images obtained using the loupe tended to be darker and redder than the actual color. Data adjustment resulted in similar WID, ΔE00, and TP00 values to those observed for the spectrophotometer. Differences were observed only for the WID of shade DA3 and ΔE00 for comparing DA1 and DA3 over the black background. However, these differences were not clinically relevant. The use of adjusted data from images taken using a stereoscopic loupe is considered a feasible method for color measurement.

本研究使用电荷耦合器件 (CCD) 相机和立体放大镜获得的图像,评估了颜色测量方法的可靠性。使用复合 Filtek Z350 XT(色调 DA1、DA2、DA3 和 DA4)制作了圆盘状试样(n = 3)。使用分光光度计 SP60 在白色和黑色背景上测量试样的 CIELAB 色坐标。使用安装在立体放大镜上的 CCD 相机拍摄相同标本的图像。使用图像处理软件测量图像的颜色(红-绿-蓝 [RGB])并转换为 CIELAB 坐标。对于每个颜色坐标,使用线性回归预测 SP60 的值来调整图像数据。计算样本的牙科白度指数(WID)和半透明参数(TP00),以及成对色调之间的色差(ΔE00)。数据分析采用重复测量方差分析和 Tukey 后检验(α = 0.05)。使用放大镜获得的图像往往比实际颜色更深更红。数据调整后的 WID、ΔE00 和 TP00 值与分光光度计观察到的值相似。只有在黑色背景上比较 DA1 和 DA3 的色调 DA3 的 WID 和 ΔE00 时才会观察到差异。不过,这些差异与临床无关。使用立体放大镜拍摄的图像调整数据被认为是一种可行的颜色测量方法。
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引用次数: 0
Acid challenge exacerbates activation of matrix metalloproteinases in permanent teeth undergoing radiotherapy. 酸挑战会加剧接受放射治疗的恒牙中基质金属蛋白酶的活化。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0034
Alexandra Mussolino de Queiroz, Claudia María Carpio Bonilla, Taíssa Cássia de Souza Furtado, Regina Guenka Palma-Dibb, Harley Francisco de Oliveira, Maya Fernanda Manfrin Arnez, Fabrício Kitazono de Carvalho, Francisco Wanderley Garcia Paula-Silva

The aim of this study was to investigate the effect of acid challenge on the activation of matrix metalloproteinases (MMPs) in the Dentinoenamel junction of primary and permanent teeth submitted to radiotherapy. For this purpose, a total of 178 dental fragments obtained from molars were used, and randomly divided into 2 groups (primary and permanent teeth) / 4 experimental subgroups (irradiated and non-irradiated, demineralized and non-demineralized). The fragments were exposed to radiation, with a dose fraction of 2 Gy, for 5 consecutive days, until a total dose of 60 Gy was reached, with a total of 30 cycles, for 6 weeks. To determine the activity of MMPs on the dentinoenamel junction (DEJ), in situ zymography assays on 0.6mm dental fragments were performed. To assess whether MMP activity would be impacted by an acidic environment, the fragments were placed in a demineralizing solution (pH of 4.8). The finding was that irradiation activated MMPs in DEJ and these effects were more evident in permanent when compared with primary teeth. When the effect of an acid challenge on MMPs activity was investigated, demineralization was observed not to increase MMPs activity in non-irradiated teeth, but it did increase MMPs activity in irradiated teeth. In conclusion, an acid challenge was found to exacerbate activation of MMPs in DEJ of permanent teeth submitted to irradiation, but not in primary teeth.

本研究旨在探讨酸挑战对接受放射治疗的原牙和恒牙牙釉质交界处基质金属蛋白酶(MMPs)活化的影响。为此,研究人员使用了178颗从磨牙中提取的牙片,并将其随机分为2组(基牙和恒牙)/4个实验分组(辐照组和非辐照组、脱矿组和非脱矿组)。这些牙片连续 5 天接受剂量分数为 2 Gy 的辐射,直到总剂量达到 60 Gy,共 30 个周期,持续 6 周。为了确定牙本质釉质交界处(DEJ)上 MMPs 的活性,对 0.6 毫米的牙片进行了原位酶谱分析。为了评估 MMP 的活性是否会受到酸性环境的影响,将牙片置于脱矿物质溶液(pH 值为 4.8)中。结果发现,辐照激活了 DEJ 中的 MMPs,与基牙相比,这些影响在恒牙中更为明显。在研究酸挑战对 MMPs 活性的影响时,发现脱矿不会增加未受辐照牙齿中 MMPs 的活性,但会增加受辐照牙齿中 MMPs 的活性。总之,研究发现酸挑战会加剧辐照后恒牙DEJ中MMPs的活化,但不会加剧基牙中MMPs的活化。
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引用次数: 0
Salivary immunoglobulin levels and periodontal indices in Brazilian children with and without type 1 diabetes. 患有和未患有 1 型糖尿病的巴西儿童的唾液免疫球蛋白水平和牙周指数。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0043
Thyciana Rodrigues Ribeiro, Sara Maria Silva, Renata Asfor Rocha Carvalho Martins, Cláudia Ferreira Santos, Paulo Goberlânio de Barros Silva, Adriana Costa E Forti, Fábio Wildson Gurgel Costa, Manassés Claudino Fonteles, Cristiane Sá Roriz Fonteles

This cross-sectional study evaluated the association between salivary immunoglobulins, plaque index, and gingival index in Brazilian children with and without type 1 diabetes mellitus (DM1). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for the reporting of observational studies was followed. The DM1 group had 38 children, and an equal number of volunteers matched by sex and age were recruited as controls. Clinical examination was performed for plaque index and gingival index determination. Non-stimulated whole saliva was collected. Concentrations of IgA, IgG, and IgM were determined by ELISA test. Data were tested by the Kolmogorov-Smirnov, Mann-Whitney, and Spearman tests and a multiple linear regression model (p<0.05) was performed. Gingival index was higher in the Control (DM1: 0.16±0.17; Control: 0.24±0.23, p=0.040). In DM1, there was a correlation between IgA and age (rho=0.371, p=0.024), IgM and IgG (rho=0.459, p=0.007), and IgM and gingival index (rho=0.394, p=0.014). In DM1, multiple linear regression showed that age (p=0.041; β=0.363), gingival index (p=0.041; β=0.398), and plaque index (p=0.008; β=-0.506) were good predictors of IgA levels in saliva. Thus, IgA was the only researched immunoglobulin that was directly associated with plaque and gingival indices in Brazilian children with DM1, but not in control subjects.

这项横断面研究评估了患有和未患有1型糖尿病(DM1)的巴西儿童唾液免疫球蛋白、牙菌斑指数和牙龈指数之间的关系。该研究遵循了加强流行病学观察性研究报告(STROBE)的观察性研究报告清单。DM1 组有 38 名儿童,对照组招募了同等数量的性别和年龄相匹配的志愿者。临床检查用于测定牙菌斑指数和牙龈指数。收集非刺激性全唾液。通过酶联免疫吸附试验测定 IgA、IgG 和 IgM 的浓度。数据通过 Kolmogorov-Smirnov、Mann-Whitney 和 Spearman 检验以及多元线性回归模型进行检验(P<0.05)。
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引用次数: 0
The effects of sodium alendronate on socket healing after tooth extraction: a systematic review of animal studies. 阿仑膦酸钠对拔牙后牙槽骨愈合的影响:动物研究的系统回顾。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0038
Nilo Guliberto Martins Chavarry, Pedro Villas Boas Abreu, Eduardo Jorge Feres-Filho, Daniele Masterson Tavares Pereira, Lucianne Cople Maia, Rafael Scaf De Molon

The aim of this systematic review was to answer the following question: "Does alendronate, a nitrogen-containing bisphosphonate, improve or impair alveolar socket healing after tooth extraction in animal models"? To this end, a systematic review of the literature was carried out in PubMed, Scopus, LILACS, Web of Science, as well as in the gray literature up to May 2023. Preclinical studies that evaluated alveolar healing after tooth extraction and the intake of sodium alendronate compared with placebo were included. Two investigators were responsible for screening the articles independently, extracting the data, and assessing their quality through the SYRCLE's RoB tool for randomized trials in animal studies. The study selection process, study characteristics, risk of bias in studies, impact of alendronate on bone healing, and certainty of evidence were described in text and table formats. Methodological differences among the studies were restricted to the synthesis methods. The synthesis of qualitative results followed the Synthesis Without Meta-analysis (SWiM) reporting guideline. From the 19 included studies, five were considered to have low risk, three were of unclear risk, and eleven presented a high risk of bias. The studies were considered heterogeneous regarding alendronate posology, including its dosage and route of administration. Furthermore, a variety of animal species, different age ranges, diverse teeth extracted, and exposure or not to ovariectomy contributed to the lack of parity of the selected studies. Our results indicated that alendronate monotherapy negatively affects the early phase of wound healing after tooth extraction in preclinical studies, suggesting that the bone resorption process after tooth extraction in animals treated with alendronate might impair the bone healing process of the extraction socket. In conclusion, alendronate administration restrains bone resorption, thereby delaying alveolar socket healing . Future studies should be conducted to validate these findings and to better understand the effects of alendronate therapy on oral tissues.

本系统综述旨在回答以下问题:"阿仑膦酸钠是一种含氮的双膦酸盐,在动物模型中是否会改善或损害拔牙后牙槽骨的愈合?为此,我们在 PubMed、Scopus、LILACS、Web of Science 以及截至 2023 年 5 月的灰色文献中进行了系统的文献综述。纳入了评估拔牙后牙槽骨愈合以及阿仑膦酸钠摄入量与安慰剂摄入量比较的临床前研究。两名研究人员负责独立筛选文章、提取数据,并通过 SYRCLE 的 RoB 工具评估其质量,该工具适用于动物研究中的随机试验。研究的筛选过程、研究特点、研究的偏倚风险、阿仑膦酸钠对骨愈合的影响以及证据的确定性均以文字和表格的形式进行了描述。各研究在方法上的差异仅限于综合方法。定性结果的综述遵循了无荟萃分析综述(SWiM)报告指南。在纳入的 19 项研究中,5 项被认为风险较低,3 项风险不明确,11 项存在较高的偏倚风险。这些研究被认为在阿仑膦酸钠的体位学方面存在异质性,包括其剂量和给药途径。此外,动物种类不同、年龄范围不同、拔除的牙齿不同、是否暴露于卵巢切除术等因素也导致了所选研究缺乏均等性。我们的研究结果表明,在临床前研究中,阿仑膦酸钠单药治疗对拔牙后伤口愈合的早期阶段有负面影响,这表明使用阿仑膦酸钠治疗的动物拔牙后的骨吸收过程可能会损害拔牙窝的骨愈合过程。总之,阿仑膦酸钠能抑制骨吸收,从而延缓牙槽窝愈合。今后的研究应验证这些发现,并更好地了解阿仑膦酸钠疗法对口腔组织的影响。
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引用次数: 0
TNF-α promoter hypomethylation is frequent in oncopediatric patients who recovered from mucositis. TNF-α启动子低甲基化在从粘膜炎中康复的肿瘤儿科患者中很常见。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0042
José Maria Chagas Viana Filho, Marina de Castro Coêlho, José Nunes de Queiroz Neto, Beatriz Fernandes de Souza, Ana Maria Gondim Valença, Naila Francis Paulo de Oliveira

The aim of this study was to investigate the DNA methylation profile in genes encoding catalase (CAT) and superoxide dismutase (SOD3) enzymes, which are involved in oxidative stress mechanisms, and in genes encoding pro-inflammatory cytokines interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-α) in the oral mucosa of oncopediatric patients treated with methotrexate (MTX®). This was a cross-sectional observational study and the population comprised healthy dental patients (n = 21) and those with hematological malignancies (n = 64) aged between 5 and 19 years. Oral conditions were evaluated using the Oral Assessment Guide and participants were divided into 4 groups: 1- healthy individuals; 2- oncopediatric patients without mucositis; 3- oncopediatric patients with mucositis; 4- oncopediatric patients who had recovered from mucositis. Methylation of DNA from oral mucosal cells was evaluated using the Methylation-Specific PCR technique (MSP). For CAT, the partially methylated profile was the most frequent and for SOD3 and IL6, the hypermethylated profile was the most frequent, with no differences between groups. For TNF-α, the hypomethylated profile was more frequent in the group of patients who had recovered from mucositis. It was concluded that the methylation profiles of CAT, SOD3, and IL6 are common profiles for oral cells of children and adolescents and have no association with oral mucositis or exposure to chemotherapy with MTX®. Hypomethylation of TNF-α is associated with oral mucosal recovery in oncopediatric patients who developed oral mucositis during chemotherapy.

本研究旨在调查接受甲氨蝶呤(MTX®)治疗的肿瘤儿科患者口腔黏膜中编码过氧化氢酶(CAT)和超氧化物歧化酶(SOD3)的基因以及编码促炎细胞因子白细胞介素-6(IL6)和肿瘤坏死因子-α(TNF-α)的基因的 DNA 甲基化情况。这是一项横断面观察研究,研究对象包括健康牙科患者(21 人)和血液恶性肿瘤患者(64 人),年龄在 5 至 19 岁之间。研究人员使用《口腔评估指南》对患者的口腔状况进行评估,并将其分为四组:1-健康人;2-未患粘膜炎的肿瘤儿科患者;3-患粘膜炎的肿瘤儿科患者;4-已从粘膜炎中康复的肿瘤儿科患者。使用甲基化特异性 PCR 技术(MSP)评估了口腔黏膜细胞 DNA 的甲基化情况。对于 CAT 而言,部分甲基化是最常见的情况,而对于 SOD3 和 IL6 而言,高甲基化是最常见的情况,组间无差异。就 TNF-α 而言,在从粘膜炎中恢复的患者组中,甲基化程度低的情况更为常见。结论是,CAT、SOD3 和 IL6 的甲基化图谱是儿童和青少年口腔细胞的常见图谱,与口腔黏膜炎或接触 MTX® 化疗无关。TNF-α的低甲基化与化疗期间出现口腔黏膜炎的肿瘤儿童患者的口腔黏膜恢复有关。
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引用次数: 0
Correlation between general quality of life and oral health related quality in the mixed dentition. 混合牙列中一般生活质量与口腔健康相关质量之间的相关性。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0039
Diego Patrik Alves Carneiro, Grazielle Araújo Dos Santos, Caroline Nogueira de Moraes, Marcelo de Castro Meneghim, Silvia Amélia Scudeler Vedovello

The aim of this study was to evaluate the convergence between the domains of the Autoquestionnaire Qualité de Vie Enfant image (AUQUEI) and the Child Perceptions Questionnaire (CPQ8-10) in the mixed dentition. A sample of 676 children aged 8 to 10 years responded to the health-related quality of life (HRQoL) and oral health-related quality of life (OHRQoL) questionnaires using the AUQUEI and the CPQ8-10, respectively. Clinical (dental caries and malocclusion) and socioeconomic variables were assessed. The validity of convergence between scores (total and per domain) of the two instruments was assessed by Spearman correlation analysis, considering that non-zero coefficient values represented a correlation between scores. The median was calculated to compare the scores of each questionnaire relative to the variables, and the nonparametric Mann-Whitney test was applied to determine statistically significant differences between the categories. A weak significant correlation (between 0.30 and 0.50) was observed between the domains and the total scores of instruments (p < 0.05), except for the leisure domain (p > 0.05). Participants with a lower family income had worse HRQoL (p < 0.05), and those with caries and malocclusion experience had worse OHRQoL (p < 0.05). In conclusion, the AUQUEI and CPQ8-10 instruments showed a weak correlation. Income and clinical variables had a negative impact on the AUQUEI and CPQ8-10, respectively.

本研究的目的是评估混合牙列中儿童生活质量自动问卷(AUQUEI)和儿童认知问卷(CPQ8-10)各领域之间的趋同性。676 名 8 至 10 岁的儿童样本分别使用 AUQUEI 和 CPQ8-10 回答了健康相关生活质量 (HRQoL) 和口腔健康相关生活质量 (OHRQoL) 问卷。对临床变量(龋齿和咬合不正)和社会经济变量进行了评估。通过斯皮尔曼相关分析评估了两份问卷得分(总分和每个领域的得分)之间的一致性,认为非零系数值代表了得分之间的相关性。通过计算中位数来比较每份问卷相对于变量的得分,并采用非参数曼-惠特尼检验来确定不同类别之间在统计上的显著差异。除休闲领域(p>0.05)外,其他领域与工具总分之间存在弱相关性(介于 0.30 和 0.50 之间)(p<0.05)。家庭收入较低的参与者的 HRQoL 较差(p < 0.05),有龋齿和错颌畸形经历的参与者的 OHRQoL 较差(p < 0.05)。总之,AUQUEI 和 CPQ8-10 工具显示出微弱的相关性。收入和临床变量分别对 AUQUEI 和 CPQ8-10 有负面影响。
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引用次数: 0
Oral health-related quality of life in the LGBTIQ+ population: a cross-sectional study. LGBTIQ+ 人口中与口腔健康相关的生活质量:一项横断面研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI: 10.1590/1807-3107bor-2024.vol38.0041
Luiz Eduardo de Almeida, Pablo Fellipe de Souza Almeida, Valéria de Oliveira, Fábio Luiz Mialhe

The aim of this cross-sectional study was to investigate the associations between oral health-related quality of life (OHRQoL) and socioeconomic and demographic variables, suicidal ideation, self-perception of oral health, and experiences of dental care in the Brazilian adult LGBTIQ+ population. A sample of 464 participants completed self-administered online questionnaires and provided information for OHRQoL assessment, using the OHIP-14 instrument at three hierarchical levels of explanatory variables: LGBTIQ+ identities; socioeconomic and demographic data and existential suffering; and self-perception of oral health and experience of dental care. The collected data were fitted to hierarchical multiple logistic regression models, in which the associations between each independent variable with the OHIP-14 prevalence outcome were analyzed. The OHIP-14-prevalence index showed that 33.2% of the participants answered 'frequently' or 'always', and the highest frequencies were obtained for the psychological discomfort (27.8%), psychological disability (18.3%), and physical pain (17.5%) domains. According to the adjusted final model, LGBTIQ+ individuals who were more likely to have their OHRQoL affected were those who were indifferent (OR=3.21; 95% CI: 1.26-8.20), dissatisfied (OR=10.45; 95% CI: 3.86-28.26), or very dissatisfied (OR=53.93; 95% CI: 12.12-239.93) with their oral health status, and also those who had or have difficulty accessing dental treatment (OR=2.06; 95% CI: 1.24-3.41) (p<0.05). It may be concluded that the OHRQoL of the investigated Brazilian LGBTIQ+ population showed associations with individual aspects and with access to dental services.

这项横断面研究旨在调查巴西成年 LGBTIQ+ 人口中与口腔健康相关的生活质量(OHRQoL)与社会经济和人口变量、自杀意念、对口腔健康的自我认知以及牙科保健经历之间的关联。464 名参与者填写了自填式在线问卷,并提供了用于 OHRQoL 评估的信息:LGBTIQ+ 身份;社会经济和人口数据及生存痛苦;以及对口腔健康的自我认知和牙科保健经验。将收集到的数据拟合到分层多元逻辑回归模型中,分析每个独立变量与 OHIP-14 流行率结果之间的关联。OHIP-14患病率指数显示,33.2%的参与者回答 "经常 "或 "总是",其中心理不适(27.8%)、心理残疾(18.3%)和身体疼痛(17.5%)领域的患病率最高。根据调整后的最终模型,LGBTIQ+ 患者的 OHRQoL 更有可能受到影响的是那些无所谓(OR=3.21;95% CI:1.26-8.20)、不满意(OR=10.45;95% CI:3.86-28.26),或非常不满意(OR=53.93;95% CI:12.12-239.93),以及曾经或很难获得牙科治疗的人群(OR=2.06;95% CI:1.24-3.41)(p
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Brazilian oral research
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