Pranjal Sur, Anurag Upadhyaya, Manoj Varma, Prabal K. Maiti
After the successful commercialization of DNA sequencing using biological nanopores, the next frontier for nanopore technology is protein sequencing, a significantly more complex task. Molecules passing through the solid-state nanopores produce current blockades that correlate linearly with their volume in the simplest model. As thinner membranes provide better volume sensitivity, 2D materials such as graphene and MoS2 membranes have been explored. Molecular dynamics studies have primarily focused on the translocation of the homogeneous polypeptide chains through 2D membranes. In this study, we investigated the translocation of 20 single amino acids through the monolayer and bilayer graphene nanopores using the all-atom molecular dynamics. These studies were motivated by the fact that single amino acids, as fundamental units of peptide chains, provide a simpler model for understanding pore-molecule interactions during translocations by eliminating the neighbour effects found in chains. Herein, it is shown that the correlation between the ionic current blockade and the volume of single amino acids is strongly affected by their orientation at the pore, especially when the molecule is static at the pore. We explained this phenomenon by the fact that with increasing vdW volume, the amino acid in a particular orientation has a longer projection along the perpendicular direction of the pore plane. We demonstrated distinctive current and force signals for different amino-acid translocations. We observed that some of the smaller amino acids with low molecular volume produced disproportionately high current blockades in a particular orientation due to their lower structural fluctuations during translocation. We investigated how the dipole moment (of the translocating amino acids) and its alignment with the electric field in the pores were linked with our observations.
在利用生物纳米孔成功实现 DNA 测序商业化之后，纳米孔技术的下一个前沿领域是蛋白质测序，这是一项复杂得多的任务。分子通过固态纳米孔会产生电流阻塞，在最简单的模型中，电流阻塞与分子体积成线性关系。由于更薄的膜能提供更好的体积灵敏度，人们开始探索二维材料，如石墨烯和 MoS2 膜。分子动力学研究主要集中在均质多肽链在二维膜中的转移。在本研究中，我们使用全原子分子动力学方法研究了 20 个单个氨基酸通过单层和双层石墨烯纳米孔的易位。之所以进行这些研究，是因为单个氨基酸作为肽链的基本单位，消除了肽链中的相邻效应，为理解转位过程中孔隙与分子之间的相互作用提供了一个更简单的模型。本文表明，离子电流阻断与单个氨基酸体积之间的相关性受其在孔道中的取向影响很大，尤其是当分子在孔道中静止不动时。我们对这一现象的解释是，随着 vdW 体积的增加，特定取向的氨基酸沿孔平面垂直方向的投影更长。我们展示了不同氨基酸转位时的不同电流和力信号。我们观察到，一些分子体积较小的氨基酸在特定方向上会产生不成比例的高电流阻滞，这是因为它们在转位过程中的结构波动较小。我们研究了（易位氨基酸的）偶极矩及其与孔中电场的排列如何与我们的观察结果相关联。
{"title":"Orientation dependence of current blockade in single amino acid translocation through a graphene nanopore","authors":"Pranjal Sur, Anurag Upadhyaya, Manoj Varma, Prabal K. Maiti","doi":"10.1039/d4nr04630g","DOIUrl":"https://doi.org/10.1039/d4nr04630g","url":null,"abstract":"After the successful commercialization of DNA sequencing using biological nanopores, the next frontier for nanopore technology is protein sequencing, a significantly more complex task. Molecules passing through the solid-state nanopores produce current blockades that correlate linearly with their volume in the simplest model. As thinner membranes provide better volume sensitivity, 2D materials such as graphene and MoS<small><sub>2</sub></small> membranes have been explored. Molecular dynamics studies have primarily focused on the translocation of the homogeneous polypeptide chains through 2D membranes. In this study, we investigated the translocation of 20 single amino acids through the monolayer and bilayer graphene nanopores using the all-atom molecular dynamics. These studies were motivated by the fact that single amino acids, as fundamental units of peptide chains, provide a simpler model for understanding pore-molecule interactions during translocations by eliminating the neighbour effects found in chains. Herein, it is shown that the correlation between the ionic current blockade and the volume of single amino acids is strongly affected by their orientation at the pore, especially when the molecule is static at the pore. We explained this phenomenon by the fact that with increasing vdW volume, the amino acid in a particular orientation has a longer projection along the perpendicular direction of the pore plane. We demonstrated distinctive current and force signals for different amino-acid translocations. We observed that some of the smaller amino acids with low molecular volume produced disproportionately high current blockades in a particular orientation due to their lower structural fluctuations during translocation. We investigated how the dipole moment (of the translocating amino acids) and its alignment with the electric field in the pores were linked with our observations.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"74 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sertan Kiziloz, Emma Jade Ward, Daniel Hawthorne, Avick Sinha, Grace Cooksley, Cyril Crua, Dipak Kumar Sarker, Andrew W Lloyd, Christopher E Shuck, Y. Gogotsi, Susan R. Sandeman
Chronic non-healing wounds represent a growing global health challenge that is poorly addressed by current advances in wound care dressings. Hyperosmotic stress linked, for example, to poor glycaemic control, is a known but under-investigated contributor to the chronic wound environment and a known inflammatory stimulus. MXene (Ti3C2Tx) has been considered for smart dressing applications but has not been investigated for use with bioactive agents to directly moderate hyperosmotic stress for improved wound care. In this study, Ti3C2Tx, in combination with osmolyte betaine, was used to investigate hyperosmotic stress-induced effects on wound closure. The effect of these materials was measured using a wound closure scratch assay, and data was used to mathematically model changes in HaCaT human keratocyte migratory rate and velocity. Changes in the upregulation of apoptotic and inflammatory markers were measured, and qualitative changes in phalloidin-labelled actin cytoskeletal structure were observed. A tert-butyl glycine betainate (tBu-GB) polyacrylate microgel loaded Ti3C2Tx dressing was then fabricated and tested for biocompatibility and slow elution of osmolyte over time. Osmotic stress at levels that did not induce cell death reduced the migratory capacity of keratocytes to close the scratch. Migration by osmotically stressed keratocytes was reduced by more than 50% at 24 h and remained at 65% (+/- 5%) at 48 h compared to complete scratch closure at 24 h in the cell only control. This reduction was reversed by a Ti3C2Tx coating, allowing complete scratch closure by 48 h in the osmotically stressed group. Exposure of osmotically stressed cells to betaine increased normalised wound closure in the osmotically stressed keraotycte group at each time point and this was augmented by the presence of a Ti3C2Tx coating. Osmotic stress induced upregulation of inflammatory markers IL-6, IL-1α, IL-1β, CXCL1, and CXCL8 by at least 10-fold. The effect was significantly greater in the presence of bacterial LPS and this was significantly reduced by the presence of Ti3C2Tx alone and in combination with betaine. Sustained and slow release of betaine was demonstrated from a tBu-GB-microgel loaded Ti3C2Tx dressing over 48 h supporting the use of such dressings to improve osmotic stress induced, poor wound closure rates.
{"title":"Ti3C2Tx MXene augments osmo-adaptive repression of the inflammatory stress response for improved wound repair","authors":"Sertan Kiziloz, Emma Jade Ward, Daniel Hawthorne, Avick Sinha, Grace Cooksley, Cyril Crua, Dipak Kumar Sarker, Andrew W Lloyd, Christopher E Shuck, Y. Gogotsi, Susan R. Sandeman","doi":"10.1039/d4nr04622f","DOIUrl":"https://doi.org/10.1039/d4nr04622f","url":null,"abstract":"Chronic non-healing wounds represent a growing global health challenge that is poorly addressed by current advances in wound care dressings. Hyperosmotic stress linked, for example, to poor glycaemic control, is a known but under-investigated contributor to the chronic wound environment and a known inflammatory stimulus. MXene (Ti3C2Tx) has been considered for smart dressing applications but has not been investigated for use with bioactive agents to directly moderate hyperosmotic stress for improved wound care. In this study, Ti3C2Tx, in combination with osmolyte betaine, was used to investigate hyperosmotic stress-induced effects on wound closure. The effect of these materials was measured using a wound closure scratch assay, and data was used to mathematically model changes in HaCaT human keratocyte migratory rate and velocity. Changes in the upregulation of apoptotic and inflammatory markers were measured, and qualitative changes in phalloidin-labelled actin cytoskeletal structure were observed. A tert-butyl glycine betainate (tBu-GB) polyacrylate microgel loaded Ti3C2Tx dressing was then fabricated and tested for biocompatibility and slow elution of osmolyte over time. Osmotic stress at levels that did not induce cell death reduced the migratory capacity of keratocytes to close the scratch. Migration by osmotically stressed keratocytes was reduced by more than 50% at 24 h and remained at 65% (+/- 5%) at 48 h compared to complete scratch closure at 24 h in the cell only control. This reduction was reversed by a Ti3C2Tx coating, allowing complete scratch closure by 48 h in the osmotically stressed group. Exposure of osmotically stressed cells to betaine increased normalised wound closure in the osmotically stressed keraotycte group at each time point and this was augmented by the presence of a Ti3C2Tx coating. Osmotic stress induced upregulation of inflammatory markers IL-6, IL-1α, IL-1β, CXCL1, and CXCL8 by at least 10-fold. The effect was significantly greater in the presence of bacterial LPS and this was significantly reduced by the presence of Ti3C2Tx alone and in combination with betaine. Sustained and slow release of betaine was demonstrated from a tBu-GB-microgel loaded Ti3C2Tx dressing over 48 h supporting the use of such dressings to improve osmotic stress induced, poor wound closure rates.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"3 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, one-dimensional Van der Waals crystal Ta4SiTe4has been reported as a promising component to form flexible organic/inorganic thermoelectric films due to their unique structure and excellent electronic transport properties. However, Ta4SiTe4 based flexible composite films carefully tuned by element doping have not been studied yet. In this study, we systematically synthesized (Ta1-xMox)4SiTe4whiskers, and a series of (Ta1-xMox)4SiTe4/PVDF composite films by varying Mo doping concentration were also prepared. Upon doping Mo at the Ta-sites, the electrical conductivity is dramatically enhanced, while the Seebeck coefficient is reduced with higher doping content. As a result, the (Ta0.995Mo0.005)4SiTe4/PVDF exhibited a maximum power factor of 547.5 µW/m·K², which is among the highest organic-inorganic composite films and is more than double that of undoped Ta4SiTe4/PVDF composite film.
{"title":"Enhanced thermoelectric performance in (Ta1-xMox)4SiTe4/polyvinylidene fluoride (PVDF) organic-inorganic flexible thermoelectric composite films","authors":"Miao Liu, Dudi Ren, Chenyu Ye, Tingwei Yin, Sanyin Qu, Pengan Zong","doi":"10.1039/d5nr00816f","DOIUrl":"https://doi.org/10.1039/d5nr00816f","url":null,"abstract":"Recently, one-dimensional Van der Waals crystal Ta4SiTe4has been reported as a promising component to form flexible organic/inorganic thermoelectric films due to their unique structure and excellent electronic transport properties. However, Ta4SiTe4 based flexible composite films carefully tuned by element doping have not been studied yet. In this study, we systematically synthesized (Ta1-xMox)4SiTe4whiskers, and a series of (Ta1-xMox)4SiTe4/PVDF composite films by varying Mo doping concentration were also prepared. Upon doping Mo at the Ta-sites, the electrical conductivity is dramatically enhanced, while the Seebeck coefficient is reduced with higher doping content. As a result, the (Ta0.995Mo0.005)4SiTe4/PVDF exhibited a maximum power factor of 547.5 µW/m·K², which is among the highest organic-inorganic composite films and is more than double that of undoped Ta4SiTe4/PVDF composite film.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhen Gu, Siyang Cheng, Zhe Huang, Heng An, liping zhou, Yongqiang Wen
Preventing infections and managing excessive exudate in dynamic joints are vital for effective wound treatment. Accurately fitting dressings to wound shapes remains a significant challenge, which can adversely affect both healing and patient comfort. This study introduces a self-pumping dressing with tailored shape and tensile properties. This dressing channels excessive wound fluid in a unidirectional manner, achieved by electrospinning hydrophobic nanofibers embedded with silver nanoparticles (AgNPs) onto a hydrophilic 3D-printed patch featuring a kirigami structure. By systematically adjusting parameters-cutting length l, horizontal spacing d, and vertical spacing ℎ, we enabled the elongation of the 3D-printed patch to range from 26% to 244%. Our personalized self-pumping dressings demonstrated effective antibacterial activity, unidirectional fluid transmission, and biocompatibility, thereby accelerating wound healing. This research establishes a promising pathway for personalized and precise local wound care.
{"title":"3D-Printed Kirigami-Inspired Asymmetric Dressings: Custom Elasticity and Self-Pumping for Enhanced Wound Healing","authors":"Zhen Gu, Siyang Cheng, Zhe Huang, Heng An, liping zhou, Yongqiang Wen","doi":"10.1039/d4nr05506c","DOIUrl":"https://doi.org/10.1039/d4nr05506c","url":null,"abstract":"Preventing infections and managing excessive exudate in dynamic joints are vital for effective wound treatment. Accurately fitting dressings to wound shapes remains a significant challenge, which can adversely affect both healing and patient comfort. This study introduces a self-pumping dressing with tailored shape and tensile properties. This dressing channels excessive wound fluid in a unidirectional manner, achieved by electrospinning hydrophobic nanofibers embedded with silver nanoparticles (AgNPs) onto a hydrophilic 3D-printed patch featuring a kirigami structure. By systematically adjusting parameters-cutting length l, horizontal spacing d, and vertical spacing ℎ, we enabled the elongation of the 3D-printed patch to range from 26% to 244%. Our personalized self-pumping dressings demonstrated effective antibacterial activity, unidirectional fluid transmission, and biocompatibility, thereby accelerating wound healing. This research establishes a promising pathway for personalized and precise local wound care.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"183 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ghada Abdelmageed, Rashad F. Kahwagi, Anthony El-Halaby, Joelle Korkomaz, Adam Leontowich, Sean Hinds, Ghada I. Koleilat
Reliability, scalability, and excellent film properties with large crystals and low grain boundaries are essential for successfully commercializing perovskites in optoelectronic applications. Our previous reports introduced meniscus-guided blade-coating, referred to as one-step blade coating in the present study, as a promising deposition technique for scalable perovskite films with millimetre-sized crystals, meeting two of the necessary criteria. As a subsequent study, we are investigating the stability of the films in response to humidity by employing a readily accessible hydrophobic molecule, oleic acid (OA), through surface passivation. We compared the competence of the surface treatment on films produced via one-step and two-step deposition methods utilizing spin and blade coating techniques while subjecting them to continuous exposure to high humidity levels. Initially, we applied OA to the films using spin-coating, which is the standard method for surface passivation. Our results prove that the film properties resulting from the deposition technique determine the effectiveness of the passivation process. A quick surface treatment using OA via spin coating can be highly effective for perovskite films with smooth surfaces and smaller grain sizes, in contrast to textured films with larger crystal sizes. By tailoring the surface treatment method from spin coating to dip coating, we demonstrated that OA can prolong the stability of perovskites for months under continuous high-humidity exposure.
{"title":"The Efficacy of Oleic Acid Treatment in Passivating MAPbI3 Films","authors":"Ghada Abdelmageed, Rashad F. Kahwagi, Anthony El-Halaby, Joelle Korkomaz, Adam Leontowich, Sean Hinds, Ghada I. Koleilat","doi":"10.1039/d5nr00325c","DOIUrl":"https://doi.org/10.1039/d5nr00325c","url":null,"abstract":"Reliability, scalability, and excellent film properties with large crystals and low grain boundaries are essential for successfully commercializing perovskites in optoelectronic applications. Our previous reports introduced meniscus-guided blade-coating, referred to as one-step blade coating in the present study, as a promising deposition technique for scalable perovskite films with millimetre-sized crystals, meeting two of the necessary criteria. As a subsequent study, we are investigating the stability of the films in response to humidity by employing a readily accessible hydrophobic molecule, oleic acid (OA), through surface passivation. We compared the competence of the surface treatment on films produced via one-step and two-step deposition methods utilizing spin and blade coating techniques while subjecting them to continuous exposure to high humidity levels. Initially, we applied OA to the films using spin-coating, which is the standard method for surface passivation. Our results prove that the film properties resulting from the deposition technique determine the effectiveness of the passivation process. A quick surface treatment using OA via spin coating can be highly effective for perovskite films with smooth surfaces and smaller grain sizes, in contrast to textured films with larger crystal sizes. By tailoring the surface treatment method from spin coating to dip coating, we demonstrated that OA can prolong the stability of perovskites for months under continuous high-humidity exposure.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"59 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ewelina Wyrzykowska, Mateusz Balicki, Iwona Anusiewicz, Ian Rouse, Vladimir Lobaskin, Piotr Skurski, Tomasz Puzyn
The adsorption of biomolecules on the surface of nanomaterials (NMs) is a critical determinant of their behavior, toxicity, and efficacy in biological systems. Experimental testing of these phenomena is often costly or complicated. Computational approaches, particularly the integrating methods of various theoretical levels, can provide essential insights into nano–bio interactions and bio-corona formation, facilitating the efficient design of nanomaterials for biomedical applications. This study presents a hybrid, meta-modeling approach that integrates physics-based molecular modeling with machine learning algorithms to predict the interaction energy between NMs and biomolecules extracted from the potential of mean force (PMF). Novel descriptors for the surface properties of NMs are developed and combined with structural descriptors of biomolecules to derive quantitative structure–property relationships (QSPRs). The developed QSPR model (training set: R2 = 0.84, RMSE = 1.52, Rcv2 = 0.83, and RMSEcv = 1.34; validation set: R2 = 0.70, RMSE = 1.94, and Rcv2 = 0.72, RMSEcv = 1.88) helps in understanding and predicting the interactions between NMs (including carbon-based materials, metals, metal oxides, metalloids, and cadmium selenide) and biomolecules (including amino acids and amino acid derivatives). The model facilitates safe and sustainable design of nanomaterials for various applications, particularly for nanomedicine, by providing insight into nano–bio interactions, identification of toxicity risk and optimizing functionalization for safety according to the risk mitigation policy of regulatory authorities. Additionally, a dedicated application has been developed and is available on GitHub, enabling researchers to analyze the surface properties of nanomaterials belonging to the above-mentioned groups of NMs.
{"title":"Predicting biomolecule adsorption on nanomaterials: a hybrid framework of molecular simulations and machine learning","authors":"Ewelina Wyrzykowska, Mateusz Balicki, Iwona Anusiewicz, Ian Rouse, Vladimir Lobaskin, Piotr Skurski, Tomasz Puzyn","doi":"10.1039/d4nr05366d","DOIUrl":"https://doi.org/10.1039/d4nr05366d","url":null,"abstract":"The adsorption of biomolecules on the surface of nanomaterials (NMs) is a critical determinant of their behavior, toxicity, and efficacy in biological systems. Experimental testing of these phenomena is often costly or complicated. Computational approaches, particularly the integrating methods of various theoretical levels, can provide essential insights into nano–bio interactions and bio-corona formation, facilitating the efficient design of nanomaterials for biomedical applications. This study presents a hybrid, meta-modeling approach that integrates physics-based molecular modeling with machine learning algorithms to predict the interaction energy between NMs and biomolecules extracted from the potential of mean force (PMF). Novel descriptors for the surface properties of NMs are developed and combined with structural descriptors of biomolecules to derive quantitative structure–property relationships (QSPRs). The developed QSPR model (training set: <em>R</em><small><sup>2</sup></small> = 0.84, RMSE = 1.52, <em>R</em><small><sub>cv</sub></small><small><sup>2</sup></small> = 0.83, and RMSE<small><sub>cv</sub></small> = 1.34; validation set: <em>R</em><small><sup>2</sup></small> = 0.70, RMSE = 1.94, and <em>R</em><small><sub>cv</sub></small><small><sup>2</sup></small> = 0.72, RMSE<small><sub>cv</sub></small> = 1.88) helps in understanding and predicting the interactions between NMs (including carbon-based materials, metals, metal oxides, metalloids, and cadmium selenide) and biomolecules (including amino acids and amino acid derivatives). The model facilitates safe and sustainable design of nanomaterials for various applications, particularly for nanomedicine, by providing insight into nano–bio interactions, identification of toxicity risk and optimizing functionalization for safety according to the risk mitigation policy of regulatory authorities. Additionally, a dedicated application has been developed and is available on GitHub, enabling researchers to analyze the surface properties of nanomaterials belonging to the above-mentioned groups of NMs.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"60 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dingshu Tian, Chuan Ke, Bai Sun, Haotian Liang, Ziran Qian, Qifan Wen, Xueqi Chen, Chuan Yang, Min Xu, Yong Zhao
Traditional computing systems struggle to keep pace with the development of artificial intelligence, as well as the development of the economy and continuous innovation in science and technology. Therefore, there is an urgent need for a new generation of powerful yet low-power computing technologies to replace them. Quantum dots have been incorporated into memristors due to their unique electrical properties, and the development of quantum dot memristors is expected to solve the problems faced by traditional memristors, including cycle stability, high energy consumption, and conductivity uniformity. This article reviews the research progress of quantum dot memristors and their simulation applications in artificial synapses. It summarizes some of the current challenges faced in the development of quantum dot memristors and discusses the potential future applications of these memristors in the field of artificial intelligence.
{"title":"Quantum dot-based memristors for information processing and artificial intelligence applications","authors":"Dingshu Tian, Chuan Ke, Bai Sun, Haotian Liang, Ziran Qian, Qifan Wen, Xueqi Chen, Chuan Yang, Min Xu, Yong Zhao","doi":"10.1039/d5nr00136f","DOIUrl":"https://doi.org/10.1039/d5nr00136f","url":null,"abstract":"Traditional computing systems struggle to keep pace with the development of artificial intelligence, as well as the development of the economy and continuous innovation in science and technology. Therefore, there is an urgent need for a new generation of powerful yet low-power computing technologies to replace them. Quantum dots have been incorporated into memristors due to their unique electrical properties, and the development of quantum dot memristors is expected to solve the problems faced by traditional memristors, including cycle stability, high energy consumption, and conductivity uniformity. This article reviews the research progress of quantum dot memristors and their simulation applications in artificial synapses. It summarizes some of the current challenges faced in the development of quantum dot memristors and discusses the potential future applications of these memristors in the field of artificial intelligence.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"39 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiral recognition plays a vital role in chemical, biological, and pharmaceutical studies. However, differentiating enantiomers is still challenging. This study presents a new approach to enhance the distinction between enantiomers in surface-enhanced Raman scattering (SERS) by leveraging the coupling effect of propagating surface plasmon (PSP) and localized surface plasmons (LSP). We construct a SERS substrate that integrates laser-induced periodic surface structures with chiral plasmonic nanoparticle 432 helicoid III, creating a PSP-LSP coupling mechanism. The results demonstrate that the composite substrate not only enhances the SERS signal but also effectively amplifies the disparity between enantiomers. This advancement paves a new way in chiral SERS substrate design and the research of enantiomeric disparity amplification.
{"title":"Disparity-Amplified Chiral SERS Using PSP-LSP Coupling Substrate","authors":"Chiyi Wei, Yanlong Li, Haijiao Xu, Molei Hao, Tianxi Wang, Weiyuan Huang, Wanlu Cao, Zihao Li, xiaoming wei, Zhongmin Yang","doi":"10.1039/d5nr00088b","DOIUrl":"https://doi.org/10.1039/d5nr00088b","url":null,"abstract":"Chiral recognition plays a vital role in chemical, biological, and pharmaceutical studies. However, differentiating enantiomers is still challenging. This study presents a new approach to enhance the distinction between enantiomers in surface-enhanced Raman scattering (SERS) by leveraging the coupling effect of propagating surface plasmon (PSP) and localized surface plasmons (LSP). We construct a SERS substrate that integrates laser-induced periodic surface structures with chiral plasmonic nanoparticle 432 helicoid III, creating a PSP-LSP coupling mechanism. The results demonstrate that the composite substrate not only enhances the SERS signal but also effectively amplifies the disparity between enantiomers. This advancement paves a new way in chiral SERS substrate design and the research of enantiomeric disparity amplification.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"36 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the cruxes of developing high-performance lithium–oxygen batteries (LOBs) is the rational design and controllable synthesis of a promising cathode catalyst. High-entropy alloys (HEAs) have been considered as prospective catalytic materials for LOBs due to their adjustable composition and excellent catalytic performance. Herein, ∼50 nm PtFeCoNiCu HEA NPs with uniformly distributed elements embedded on few-layer reduced graphene oxide (PtFeCoNiCu@rGO) were successfully synthesized via a high-temperature annealing route. The LOBs with the PtFeCoNiCu@rGO cathode exhibited a high initial discharge capacity of 13 949 mA h g−1, a low overpotential of 0.77 V, and remarkable cycling stability over 148 cycles with a limited capacity of 500 mA h g−1 at 100 mA g−1. The dominant discharge product was Li2O2, and no by-products were detected. These excellent electrochemical performances arose from the combined effects of reduced graphene oxide (rGO) and HEA NPs. Reduced graphene oxide, with a large specific surface area and omnipresent pores with diverse size distribution, provided sufficient storage space for Li2O2 and facilitated transport channels for Li+ and O2, while the highly conductive HEA NPs, with optimized catalytic efficiency, further accelerated the kinetics of ORR/OER. This work presents a feasible alternative HEA-based catalyst design strategy for applicable LOBs.
{"title":"High-entropy alloy nanoparticles functionalized with reduced graphene oxide as a high-performance cathode for lithium–oxygen batteries","authors":"Runsheng Wu, Qichen Zhang, Qingchao Yang, Zhengguang Hu, Yong Zhao","doi":"10.1039/d5nr00300h","DOIUrl":"https://doi.org/10.1039/d5nr00300h","url":null,"abstract":"One of the cruxes of developing high-performance lithium–oxygen batteries (LOBs) is the rational design and controllable synthesis of a promising cathode catalyst. High-entropy alloys (HEAs) have been considered as prospective catalytic materials for LOBs due to their adjustable composition and excellent catalytic performance. Herein, ∼50 nm PtFeCoNiCu HEA NPs with uniformly distributed elements embedded on few-layer reduced graphene oxide (PtFeCoNiCu@rGO) were successfully synthesized <em>via</em> a high-temperature annealing route. The LOBs with the PtFeCoNiCu@rGO cathode exhibited a high initial discharge capacity of 13 949 mA h g<small><sup>−1</sup></small>, a low overpotential of 0.77 V, and remarkable cycling stability over 148 cycles with a limited capacity of 500 mA h g<small><sup>−1</sup></small> at 100 mA g<small><sup>−1</sup></small>. The dominant discharge product was Li<small><sub>2</sub></small>O<small><sub>2</sub></small>, and no by-products were detected. These excellent electrochemical performances arose from the combined effects of reduced graphene oxide (rGO) and HEA NPs. Reduced graphene oxide, with a large specific surface area and omnipresent pores with diverse size distribution, provided sufficient storage space for Li<small><sub>2</sub></small>O<small><sub>2</sub></small> and facilitated transport channels for Li<small><sup>+</sup></small> and O<small><sub>2</sub></small>, while the highly conductive HEA NPs, with optimized catalytic efficiency, further accelerated the kinetics of ORR/OER. This work presents a feasible alternative HEA-based catalyst design strategy for applicable LOBs.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"16 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanzhang Zhou, Mengxuan Zhang, Takeharu Yoshii, Devis Di Tommaso, Hirotomo Nishihara
Three-dimensional (3D) graphene materials have attracted significant attention across various fields, including energy storage and catalysis, due to their exceptional properties such as developed nanoporosity, corrosion resistance, electrical conductivity, and mechanical flexibility. The first step in synthesizing nanoporous 3D graphene involves the generation of the graphene framework through the decomposition of methane at high temperatures on thermally stable oxide ceramics. Thus, a thorough understanding of the reaction mechanism involved in this initial step is crucial. This article reviews recent advancements in elucidating the mechanisms of methane activation and subsequent graphene growth on various types of oxide ceramics, including alumina (Al2O3), magnesia (MgO), calcium oxide (CaO), and silica (SiO2).
{"title":"Mechanism of methane activation and graphene growth on oxide ceramics","authors":"Hanzhang Zhou, Mengxuan Zhang, Takeharu Yoshii, Devis Di Tommaso, Hirotomo Nishihara","doi":"10.1039/d5nr00569h","DOIUrl":"https://doi.org/10.1039/d5nr00569h","url":null,"abstract":"Three-dimensional (3D) graphene materials have attracted significant attention across various fields, including energy storage and catalysis, due to their exceptional properties such as developed nanoporosity, corrosion resistance, electrical conductivity, and mechanical flexibility. The first step in synthesizing nanoporous 3D graphene involves the generation of the graphene framework through the decomposition of methane at high temperatures on thermally stable oxide ceramics. Thus, a thorough understanding of the reaction mechanism involved in this initial step is crucial. This article reviews recent advancements in elucidating the mechanisms of methane activation and subsequent graphene growth on various types of oxide ceramics, including alumina (Al<small><sub>2</sub></small>O<small><sub>3</sub></small>), magnesia (MgO), calcium oxide (CaO), and silica (SiO<small><sub>2</sub></small>).","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"59 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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