Hao Yang, Yi Zhuang, Yulin Jiang, Huilun Xu, Zheng Liu, Yubao Li, Shuyu Zhang, Tao Guo, Lin Qi, Li Zhang
Continuous microenvironment modulation is an ongoing challenge in wound dressing, which includes excessive exudate absorption, oxygen delivery, bacterial inhibition and angiogenesis. Herein, we developed an in situ construction strategy to fabricate a self-retaining double-layered wound dressing, where the top layer precursor was composed of Ca2+-containing polyvinyl butyral (PVB) solution dispersed with hydroxypropyl methylcellulose (HPMC) particles, and the bottom one consisted of sodium alginate (Alg) solution blended with Ag-doped mesoporous bioactive glass powders (Ag-MBG). When in use, both precursors were simultaneously squeezed out from the twin nozzles connected to the individual chambers of a twin-chambered syringe, whereby Ca2+ in the top layer rapidly migrated downwards to crosslink Alg in the bottom layer, leading to the formation of an Alg/Ag-MBG (AA) functional hydrogel for filling an irregular wound. Meanwhile, with the rapid evaporation of low-boiling solvents, the top layer changed into a PVB/HPMC (PH) membrane covering the AA hydrogel and adhering to the surrounding healthy skin to fix the dressing. Practically, HPMC particles in the top layer acting as “micropumps” could drain the wound exudate out, while Ag-MBG in the bottom layer endowed the dressing with anti-bacterial, hemostatic, and pro-healing functions. The integrally constructed PH-AA dressing achieved over 99% bacterial elimination against both E. coli and S. aureus. Biological assessments indicated that the double-layered dressing possessed excellent biocompatibility and enhanced wound healing, demonstrating a wound closure rate of >97% at day 15. This study provides a facile method to directly construct multi-layer dressings on wounds to meet various wound care requirements.
{"title":"Top-down curing to construct self-retaining and moisture-pumping double-layered dressing with enhanced antibacterial, hemostatic, and wound healing performances","authors":"Hao Yang, Yi Zhuang, Yulin Jiang, Huilun Xu, Zheng Liu, Yubao Li, Shuyu Zhang, Tao Guo, Lin Qi, Li Zhang","doi":"10.1039/d4nr04613g","DOIUrl":"https://doi.org/10.1039/d4nr04613g","url":null,"abstract":"Continuous microenvironment modulation is an ongoing challenge in wound dressing, which includes excessive exudate absorption, oxygen delivery, bacterial inhibition and angiogenesis. Herein, we developed an <em>in situ</em> construction strategy to fabricate a self-retaining double-layered wound dressing, where the top layer precursor was composed of Ca<small><sup>2+</sup></small>-containing polyvinyl butyral (PVB) solution dispersed with hydroxypropyl methylcellulose (HPMC) particles, and the bottom one consisted of sodium alginate (Alg) solution blended with Ag-doped mesoporous bioactive glass powders (Ag-MBG). When in use, both precursors were simultaneously squeezed out from the twin nozzles connected to the individual chambers of a twin-chambered syringe, whereby Ca<small><sup>2+</sup></small> in the top layer rapidly migrated downwards to crosslink Alg in the bottom layer, leading to the formation of an Alg/Ag-MBG (AA) functional hydrogel for filling an irregular wound. Meanwhile, with the rapid evaporation of low-boiling solvents, the top layer changed into a PVB/HPMC (PH) membrane covering the AA hydrogel and adhering to the surrounding healthy skin to fix the dressing. Practically, HPMC particles in the top layer acting as “micropumps” could drain the wound exudate out, while Ag-MBG in the bottom layer endowed the dressing with anti-bacterial, hemostatic, and pro-healing functions. The integrally constructed PH-AA dressing achieved over 99% bacterial elimination against both <em>E. coli</em> and <em>S. aureus</em>. Biological assessments indicated that the double-layered dressing possessed excellent biocompatibility and enhanced wound healing, demonstrating a wound closure rate of >97% at day 15. This study provides a facile method to directly construct multi-layer dressings on wounds to meet various wound care requirements.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"22 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Interfacial solar vapor generation (ISVG) accompanied by photocatalytic degradation holds immense potential to mitigate water scarcity and pollution. Distinct from the two detached functional components (photothermal agent and photocatalyst) in a conventional evaporator, in this study, an all-in-one photothermal/catalytic agent, nitrogen-containing honeycomb carbon nanosheets (NHC), was engineered for synergistic high-efficiency steam generation and photocatalysis functions. It was demonstrated that the superoxide radical generated on the surface of NHC conferred its catalytic activity to the photodegradation of organic pollutants under full solar spectrum irradiation. A proof-of-concept multifunctional evaporator (called NHC@PEI/MCE), consisting of NHC grafted with polyethyleneimine (PEI) and a hydrophilic mixed cellulose ester membrane (MCE), was fabricated to achieve both solar-driven desalination and organic pollutant degradation. Owing to its excellent light absorption capability (∼96%), reduced evaporation enthalpy (1358 J g−1) and minimized heat loss (8.8%), the bi-layered evaporator performed a rapid water evaporation rate of 1.66 kg m−2 h−1 under one standard sun illumination. Notably, the edge-preferential crystallization strategy enabled the bi-layered evaporator to maintain long-term stability for continuous water evaporation and salt harvesting over 80 h in a concentrated 3.5 wt% NaCl solution. The design of the all-in-one photothermal/catalytic agent NHC ensured the synchronous removal of organic pollutants. The removal rates of methylene blue and phenol were 99.82% and 79.6%, respectively. Additionally, the reduction rate of total organic carbon (TOC) in the actual coking wastewater was found to be 96.6%. The exceptional purification capabilities across diverse water systems surpassed those of membrane materials lacking NHC. The exploration of the multifunctional evaporator offers a novel approach to achieving high-efficiency utilization of solar energy for the conversion of both seawater and industrial wastewater into freshwater.
{"title":"All-in-one photothermal/catalytic flexible membrane for highly efficient desalination and organic pollutant degradation","authors":"Guanyu Zhao, Xuzhen Wang, Zihan Qiu, Runmeng Zhang, Qinqin Du, Zongbin Zhao, Jieshan Qiu","doi":"10.1039/d4nr04936e","DOIUrl":"https://doi.org/10.1039/d4nr04936e","url":null,"abstract":"Interfacial solar vapor generation (ISVG) accompanied by photocatalytic degradation holds immense potential to mitigate water scarcity and pollution. Distinct from the two detached functional components (photothermal agent and photocatalyst) in a conventional evaporator, in this study, an all-in-one photothermal/catalytic agent, nitrogen-containing honeycomb carbon nanosheets (NHC), was engineered for synergistic high-efficiency steam generation and photocatalysis functions. It was demonstrated that the superoxide radical generated on the surface of NHC conferred its catalytic activity to the photodegradation of organic pollutants under full solar spectrum irradiation. A proof-of-concept multifunctional evaporator (called NHC@PEI/MCE), consisting of NHC grafted with polyethyleneimine (PEI) and a hydrophilic mixed cellulose ester membrane (MCE), was fabricated to achieve both solar-driven desalination and organic pollutant degradation. Owing to its excellent light absorption capability (∼96%), reduced evaporation enthalpy (1358 J g<small><sup>−1</sup></small>) and minimized heat loss (8.8%), the bi-layered evaporator performed a rapid water evaporation rate of 1.66 kg m<small><sup>−2</sup></small> h<small><sup>−1</sup></small> under one standard sun illumination. Notably, the edge-preferential crystallization strategy enabled the bi-layered evaporator to maintain long-term stability for continuous water evaporation and salt harvesting over 80 h in a concentrated 3.5 wt% NaCl solution. The design of the all-in-one photothermal/catalytic agent NHC ensured the synchronous removal of organic pollutants. The removal rates of methylene blue and phenol were 99.82% and 79.6%, respectively. Additionally, the reduction rate of total organic carbon (TOC) in the actual coking wastewater was found to be 96.6%. The exceptional purification capabilities across diverse water systems surpassed those of membrane materials lacking NHC. The exploration of the multifunctional evaporator offers a novel approach to achieving high-efficiency utilization of solar energy for the conversion of both seawater and industrial wastewater into freshwater.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"114 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziwei Fu, Chen Li, Ye Tian, Fakhari Alam, Daqiao Hu, Honglei Shen, Xi Kang, Manzhou Zhu
Investigating the impact of heteroatom alloying extents on regulating the cluster structures is crucial for the fabrication of cluster-based nanomaterials with customized properties. Herein, two structurally comparable PdxAu12 (x = 1, 2) nanoclusters with a uniform surface environment but completely distinct kernel configurations were controllably synthesized and structurally determined. The single Pd-alloyed Pd1Au12 nanocluster retained an icosahedral metal framework, while the Pd2Au12 nanocluster with two Pd heteroatoms exhibited a unique toroidal configuration. The additional Pd heteroatom not only led to significant changes in the cluster frameworks but also profoundly affected their electrocatalytic CO2 reduction performance. The Pd1Au12 nanocluster demonstrated enhanced catalytic performance, exhibiting a higher current density, a lower onset potential, and greater CO faradaic efficiency compared to the Pd2Au12 nanocluster. This work offers new insights into the customization of the structures and properties of gold nanoclusters by regulating the doping degree of Pd heteroatoms.
{"title":"Heteroatom number-dependent cluster frameworks in structurally comparable Pd–Au nanoclusters","authors":"Ziwei Fu, Chen Li, Ye Tian, Fakhari Alam, Daqiao Hu, Honglei Shen, Xi Kang, Manzhou Zhu","doi":"10.1039/d4nr05222f","DOIUrl":"https://doi.org/10.1039/d4nr05222f","url":null,"abstract":"Investigating the impact of heteroatom alloying extents on regulating the cluster structures is crucial for the fabrication of cluster-based nanomaterials with customized properties. Herein, two structurally comparable Pd<small><sub><em>x</em></sub></small>Au<small><sub>12</sub></small> (<em>x</em> = 1, 2) nanoclusters with a uniform surface environment but completely distinct kernel configurations were controllably synthesized and structurally determined. The single Pd-alloyed <strong>Pd<small><sub>1</sub></small>Au<small><sub>12</sub></small></strong> nanocluster retained an icosahedral metal framework, while the <strong>Pd<small><sub>2</sub></small>Au<small><sub>12</sub></small></strong> nanocluster with two Pd heteroatoms exhibited a unique toroidal configuration. The additional Pd heteroatom not only led to significant changes in the cluster frameworks but also profoundly affected their electrocatalytic CO<small><sub>2</sub></small> reduction performance. The <strong>Pd<small><sub>1</sub></small>Au<small><sub>12</sub></small></strong> nanocluster demonstrated enhanced catalytic performance, exhibiting a higher current density, a lower onset potential, and greater CO faradaic efficiency compared to the <strong>Pd<small><sub>2</sub></small>Au<small><sub>12</sub></small></strong> nanocluster. This work offers new insights into the customization of the structures and properties of gold nanoclusters by regulating the doping degree of Pd heteroatoms.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigates the variation in rate constants for nucleation and growth of silver nanowires (AgNWs) synthesized using the polyol method in batch and millifluidic flow reactors (MFRs). In a particular reactor, silver ion concentration at any time is quantified by the method of El-Ghamry et al. and the non-linear two-step Finke-Watzky model is used to determine the rate constants for nucleation (k1) and growth (k2). The results indicate that k1 and k2 for the MFRs are approximately four and two times larger, respectively, than the batch reactor rate constants. Additionally, the concentration, yield, and diameter of the synthesized AgNWs were determined using ultraviolet-visible (UV-vis) spectroscopy data. The results indicated that the concentration and yield of AgNWs synthesized using the MFR were approximately 10 times higher than those obtained with the batch reactor. Overall, AgNW synthesis in MFRs is about three times faster than the batch reactor. The coiled configuration of the MFRs promotes AgNW growth, minimizes temperature transients, and enhances reagent mixing caused by Dean vortices. This study highlights the potential of MFRs for the continuous synthesis of AgNWs and provides insights into the underlying growth mechanism.
{"title":"Kinetic Analysis of Silver Nanowire Synthesis: Polyol Batch and Continuous Millifluidic Methods","authors":"Destiny Williams, James Smay, Shohreh Hemmati","doi":"10.1039/d4nr03812f","DOIUrl":"https://doi.org/10.1039/d4nr03812f","url":null,"abstract":"This study investigates the variation in rate constants for nucleation and growth of silver nanowires (AgNWs) synthesized using the polyol method in batch and millifluidic flow reactors (MFRs). In a particular reactor, silver ion concentration at any time is quantified by the method of El-Ghamry et al. and the non-linear two-step Finke-Watzky model is used to determine the rate constants for nucleation (k1) and growth (k2). The results indicate that k1 and k2 for the MFRs are approximately four and two times larger, respectively, than the batch reactor rate constants. Additionally, the concentration, yield, and diameter of the synthesized AgNWs were determined using ultraviolet-visible (UV-vis) spectroscopy data. The results indicated that the concentration and yield of AgNWs synthesized using the MFR were approximately 10 times higher than those obtained with the batch reactor. Overall, AgNW synthesis in MFRs is about three times faster than the batch reactor. The coiled configuration of the MFRs promotes AgNW growth, minimizes temperature transients, and enhances reagent mixing caused by Dean vortices. This study highlights the potential of MFRs for the continuous synthesis of AgNWs and provides insights into the underlying growth mechanism.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"48 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Changxue Dong, Jin Zhang, Qiuyan Chen, Hongrong Luo, Jinwei Chen, Ruilin Wang
The high photogenerated charge carrier recombination and sluggish oxygen evolution reaction (OER) of polymeric carbon nitride (PCN) photocatalysts limit its application in photocatalytic water splitting. Herein, fluorine (F) doped PCN (PCNF-x) nanosheets with high crystallinity were prepared by dicyandiamide (C2H4N4) and ammonium hydrogen fluoride (NH4HF2) through high temperature thermal polymerization. This process not only resulted in PCNF-x nanosheets with a large number of pores, but also improved the crystallinity of PCNF-x nanosheets. Under illumination, the PCNF-0.5 nanosheets exhibited an excellent photocatalytic water splitting activity with a comparable H2 evolution rate of 135.30 μmol h-1 g-1 and O2 evolution rate of 63.75 μmol h-1 g-1, which were 2.3-fold, 3.3-fold, and 25-fold as compared to that of PCNF-1, PCNF-0.2, and pristine PCN nanosheets, respectively. Photoluminescence (PL) spectra and density functional theory (DFT) calculations indicate that F doping PCN nanosheets brings two changes in PCNF-x nanosheets, the one is the increase in crystallinity after F doping effectively weakens the bulk defects of PCNF nanosheets, which conducive to the directional transfer of charge carriers; the other is the modulation of electronic structure after F doping, which optimize the reaction mechanism of OER in PCNF-x nanosheets. Both the enhancement in charge carrier transfer and the optimization in reaction mechanism significantly contribute to the improved photocatalytic performance of water splitting in the fluorine doped PCN nanosheets.
{"title":"Enhanced directional transfer of charge carriers and optimized electronic structure in fluorine doped polymeric carbon nitride nanosheets for efficient photocatalytic water splitting","authors":"Changxue Dong, Jin Zhang, Qiuyan Chen, Hongrong Luo, Jinwei Chen, Ruilin Wang","doi":"10.1039/d4nr04550e","DOIUrl":"https://doi.org/10.1039/d4nr04550e","url":null,"abstract":"The high photogenerated charge carrier recombination and sluggish oxygen evolution reaction (OER) of polymeric carbon nitride (PCN) photocatalysts limit its application in photocatalytic water splitting. Herein, fluorine (F) doped PCN (PCNF-x) nanosheets with high crystallinity were prepared by dicyandiamide (C2H4N4) and ammonium hydrogen fluoride (NH4HF2) through high temperature thermal polymerization. This process not only resulted in PCNF-x nanosheets with a large number of pores, but also improved the crystallinity of PCNF-x nanosheets. Under illumination, the PCNF-0.5 nanosheets exhibited an excellent photocatalytic water splitting activity with a comparable H2 evolution rate of 135.30 μmol h-1 g-1 and O2 evolution rate of 63.75 μmol h-1 g-1, which were 2.3-fold, 3.3-fold, and 25-fold as compared to that of PCNF-1, PCNF-0.2, and pristine PCN nanosheets, respectively. Photoluminescence (PL) spectra and density functional theory (DFT) calculations indicate that F doping PCN nanosheets brings two changes in PCNF-x nanosheets, the one is the increase in crystallinity after F doping effectively weakens the bulk defects of PCNF nanosheets, which conducive to the directional transfer of charge carriers; the other is the modulation of electronic structure after F doping, which optimize the reaction mechanism of OER in PCNF-x nanosheets. Both the enhancement in charge carrier transfer and the optimization in reaction mechanism significantly contribute to the improved photocatalytic performance of water splitting in the fluorine doped PCN nanosheets.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"4 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Self-organization realizes various nanostructures to control material properties such as superconducting vortex pinning and thermal conductivity. However, the self-organization of nucleation and growth is constrained by the growth geometric symmetry. To realize highly controlled three-dimensional nanostructures by self-organization, nanostructure formation that breaks the growth geometric symmetry thermodynamically and kinetically, such as tilted or in-plane aligned nanostructures, is a challenging issue. A vertically aligned nano-checkerboard is typically formed from ZnMnGaO4 with the twin domain vertically aligned by the stress from the MgO substrate. The change in the template structure is promising to form a different type of nanostructure. The cubic ZnMnGaO4/MgO films were annealed to form nanoscale tetragonal domains in the tilted direction from the surface, which is determined by lattice mismatch, lattice symmetry, and atomic bonding. On the other hand, as a result of free deformation, in-plane aligned twin domains were formed on the SrTiO3 substrate with a thin MgO buffer layer, which does not induce stress in the ZnMnGaO4 film. By annealing the ZnMnGaO4/MgO/SrTiO3 film, the nano-checkerboard with a size of ∼10 nm and a length of ∼200 nm is elongated to the in-plane [100] or [001] direction. This study demonstrates the possibility of fabricating a nanostructure that breaks the growth geometric symmetry, which is not achieved by the previous self-organization. The phase separation with controlled template opens more complicated three-dimensional structures by self-organization.
{"title":"Asymmetric self-organization from a symmetric film by phase separation","authors":"Tomoya Horide, Miya Usuki, Manabu Ishimaru, Yoichi Horibe","doi":"10.1039/d4nr04343j","DOIUrl":"https://doi.org/10.1039/d4nr04343j","url":null,"abstract":"Self-organization realizes various nanostructures to control material properties such as superconducting vortex pinning and thermal conductivity. However, the self-organization of nucleation and growth is constrained by the growth geometric symmetry. To realize highly controlled three-dimensional nanostructures by self-organization, nanostructure formation that breaks the growth geometric symmetry thermodynamically and kinetically, such as tilted or in-plane aligned nanostructures, is a challenging issue. A vertically aligned nano-checkerboard is typically formed from ZnMnGaO<small><sub>4</sub></small> with the twin domain vertically aligned by the stress from the MgO substrate. The change in the template structure is promising to form a different type of nanostructure. The cubic ZnMnGaO<small><sub>4</sub></small>/MgO films were annealed to form nanoscale tetragonal domains in the tilted direction from the surface, which is determined by lattice mismatch, lattice symmetry, and atomic bonding. On the other hand, as a result of free deformation, in-plane aligned twin domains were formed on the SrTiO<small><sub>3</sub></small> substrate with a thin MgO buffer layer, which does not induce stress in the ZnMnGaO<small><sub>4</sub></small> film. By annealing the ZnMnGaO<small><sub>4</sub></small>/MgO/SrTiO<small><sub>3</sub></small> film, the nano-checkerboard with a size of ∼10 nm and a length of ∼200 nm is elongated to the in-plane [100] or [001] direction. This study demonstrates the possibility of fabricating a nanostructure that breaks the growth geometric symmetry, which is not achieved by the previous self-organization. The phase separation with controlled template opens more complicated three-dimensional structures by self-organization.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"22 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Designing antibacterial agents with broad-spectrum antibacterial effects and resistance-free properties is essential for treating bacterial infectious wounds. In this study, we present the design of copper nanoclusters (Cu NCs) that exhibit aggregation-induced emission (AIE). This was achieved by controlling the aggregation state of ligand layers (cysteine and chitosan) through the manipulation of pH and temperature. The AIE properties, characterized by strong photoluminescence (PL), a large Stokes shift, and microsecond-long lifetimes, enable these Cu NCs to generate significant amounts of reactive oxygen species (ROS) upon light illumination for efficient bacterial elimination without inducing drug resistance. As a result, they effectively inactivate various microbial pathogens, including Gram-negative and Gram-positive bacteria, as well as Candida albicans (C. albicans), achieving elimination rates of 99.52% for Escherichia coli (E. coli), 98.89% for Staphylococcus aureus (S. aureus), and 94.60% for C. albicans in vitro. Furthermore, the natural antibacterial properties of chitosan and Cu species enhance the photodynamic antibacterial efficacy of the AIE-typed Cu NCs. Importantly, in vivo experiments demonstrate that these Cu NCs can effectively eradicate bacteria at infection sites, reduce inflammation, and promote collagen synthesis, facilitating nearly 100% wound recovery in S. aureus-infected wounds within 9 days. The findings of this study are of considerable significance, providing a foundation for the application of AIE-typed Cu NCs in photodynamic nanotherapy for bacterial infections.
{"title":"Copper nanoclusters with aggregation-induced emission: an effective photodynamic antibacterial agent for treating bacterial-infected wound","authors":"Zhen Jiang, Yongqi Wei, Yun Wang, Songjie Han, Ze Li, Sihang Liu, Zihao Wang, Zhijun Li, Ting Feng, Haiguang Zhu, Xun Yuan","doi":"10.1039/d4nr04718d","DOIUrl":"https://doi.org/10.1039/d4nr04718d","url":null,"abstract":"Designing antibacterial agents with broad-spectrum antibacterial effects and resistance-free properties is essential for treating bacterial infectious wounds. In this study, we present the design of copper nanoclusters (Cu NCs) that exhibit aggregation-induced emission (AIE). This was achieved by controlling the aggregation state of ligand layers (cysteine and chitosan) through the manipulation of pH and temperature. The AIE properties, characterized by strong photoluminescence (PL), a large Stokes shift, and microsecond-long lifetimes, enable these Cu NCs to generate significant amounts of reactive oxygen species (ROS) upon light illumination for efficient bacterial elimination without inducing drug resistance. As a result, they effectively inactivate various microbial pathogens, including Gram-negative and Gram-positive bacteria, as well as Candida albicans (C. albicans), achieving elimination rates of 99.52% for Escherichia coli (E. coli), 98.89% for Staphylococcus aureus (S. aureus), and 94.60% for C. albicans in vitro. Furthermore, the natural antibacterial properties of chitosan and Cu species enhance the photodynamic antibacterial efficacy of the AIE-typed Cu NCs. Importantly, in vivo experiments demonstrate that these Cu NCs can effectively eradicate bacteria at infection sites, reduce inflammation, and promote collagen synthesis, facilitating nearly 100% wound recovery in S. aureus-infected wounds within 9 days. The findings of this study are of considerable significance, providing a foundation for the application of AIE-typed Cu NCs in photodynamic nanotherapy for bacterial infections.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"13 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lanthanide metal clusters are composed of rigid multinuclear metal cores encapsulated by organic ligands, which have become one of the most interesting research frontiers because of their fantastic architecture, intriguing physical and chemical properties, and potential applications. However, little attention was paid to exploring their potential as highly efficient optical materials. The Gd16 clusters as a new cluster structure that has a rich and varied coordination environment, which is highly conducive to doping and thus controlling luminescence and luminescence color modulation. We achieved green emission by doping Tb3+ ions and red emission by doping Eu3+ ions in the Gd16 cluster structure. Meanwhile, we achieved the red-orange-yellow color-tunable luminescence by controlling the composition of the Tb3+ and Eu3+ ions. Studies on the PL properties show that the Gd16 as the host can be used for doping and efficiently photosensitize the Tb3+ ions and Eu3+ ions. The existence of energy transfer from ligand to Tb3+ ions and Eu3+ ions in the co-doped Ln16 clusters was sufficiently demonstrated by time-resolved photoluminescence spectroscopies tests, and the energy transfer efficiency in the clusters was calculated. Furtherly, the temperature-dependent photoluminescent properties of these clusters were investigated to determine their potential as luminescent thermometers.
{"title":"Doping Gd16 Nanoclusters for Expanded Optical Properties and Thermometry Application","authors":"Tingting Li, Jinyu Liu, Feng Jiang, Sheng-Rong He, Jinzhe Liu, Weinan Dong, Ying Zhang, Li Yanan, Zhennan Wu","doi":"10.1039/d4nr04779f","DOIUrl":"https://doi.org/10.1039/d4nr04779f","url":null,"abstract":"Lanthanide metal clusters are composed of rigid multinuclear metal cores encapsulated by organic ligands, which have become one of the most interesting research frontiers because of their fantastic architecture, intriguing physical and chemical properties, and potential applications. However, little attention was paid to exploring their potential as highly efficient optical materials. The Gd<small><sub>16</sub></small> clusters as a new cluster structure that has a rich and varied coordination environment, which is highly conducive to doping and thus controlling luminescence and luminescence color modulation. We achieved green emission by doping Tb<small><sup>3+</sup></small> ions and red emission by doping Eu<small><sup>3+</sup></small> ions in the Gd<small><sub>16</sub></small> cluster structure. Meanwhile, we achieved the red-orange-yellow color-tunable luminescence by controlling the composition of the Tb<small><sup>3+</sup></small> and Eu<small><sup>3+</sup></small> ions. Studies on the PL properties show that the Gd<small><sub>16</sub></small> as the host can be used for doping and efficiently photosensitize the Tb<small><sup>3+</sup></small> ions and Eu<small><sup>3+</sup></small> ions. The existence of energy transfer from ligand to Tb<small><sup>3+</sup></small> ions and Eu<small><sup>3+</sup></small> ions in the co-doped Ln<small><sub>16</sub></small> clusters was sufficiently demonstrated by time-resolved photoluminescence spectroscopies tests, and the energy transfer efficiency in the clusters was calculated. Furtherly, the temperature-dependent photoluminescent properties of these clusters were investigated to determine their potential as luminescent thermometers.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"87 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sébastien Saou, Mathieu Moreau, Anne Berrou, Vivian Lioret, Marta Hernandez-Garcia, Richard A. Decreau
Liposomes used for the study were prepared and carefully characterized multiple times until all batches indicated the same characterization data (DOPC/cholesterol derivative (1:1.15 mol%), 14 mg(DOPC)/mL, dDLS = 130 nm, 2x1011 liposome/nm3of prepared batch, polydispersity index PDI = 0.1). The study shows that such a liposome suspension raises the yield in Cherenkov Radiation (CR) by 1.6-fold when in presence of [68Ga]-GaCl3, an efficient CR emitter (beta particle energy E = 1800 KeV). Also, liposomes were found to prevent aggregation of a water-soluble phthalocyanine-pyranine PcPy4 dyad upon encapsulation, leading to its spectacular fluorescence restoration. Altogether, upon efficient 68Ga-radiolabelling of NODAGA-chelate immobilized at the liposome surface (99% radiolabelling yield, radio-TLC showed) encapsulating PcPy4 dyad (Caverage = 97 M, Clumen = 300 M), subsequent Cherenkov Radiation Energy Transfer (CRET) at the dyad antenna occurred. Internal energy transfers and fluorescence emission from the emitter dyad led to a 2.6-fold raise in radiance measured in the near-infrared (NIR) window (i.e. ca 400 nm pseudo-Stokes shift). A similar raise in radiance was measured in the green window when encapsulation was achieved with eosin at the same rate. Liposome were found to be stable in PBS over 7 days regardless of the encapsulated fluorophore (no raise in dDLS diameter, no release of encapsulated dyes measured after Sephadex and FPLC repurification sequence), with some decay over 22 hours in a PBS/fetal calf serum mixture (1:1 vol.).
{"title":"Liposome: a tool to raise the Cherenkov Radiation yield and to restore fluorophore properties in aqueous media","authors":"Sébastien Saou, Mathieu Moreau, Anne Berrou, Vivian Lioret, Marta Hernandez-Garcia, Richard A. Decreau","doi":"10.1039/d4nr02605e","DOIUrl":"https://doi.org/10.1039/d4nr02605e","url":null,"abstract":"Liposomes used for the study were prepared and carefully characterized multiple times until all batches indicated the same characterization data (DOPC/cholesterol derivative (1:1.15 mol%), 14 mg(DOPC)/mL, dDLS = 130 nm, 2x1011 liposome/nm3of prepared batch, polydispersity index PDI = 0.1). The study shows that such a liposome suspension raises the yield in Cherenkov Radiation (CR) by 1.6-fold when in presence of [68Ga]-GaCl3, an efficient CR emitter (beta particle energy E = 1800 KeV). Also, liposomes were found to prevent aggregation of a water-soluble phthalocyanine-pyranine PcPy4 dyad upon encapsulation, leading to its spectacular fluorescence restoration. Altogether, upon efficient 68Ga-radiolabelling of NODAGA-chelate immobilized at the liposome surface (99% radiolabelling yield, radio-TLC showed) encapsulating PcPy4 dyad (Caverage = 97 M, Clumen = 300 M), subsequent Cherenkov Radiation Energy Transfer (CRET) at the dyad antenna occurred. Internal energy transfers and fluorescence emission from the emitter dyad led to a 2.6-fold raise in radiance measured in the near-infrared (NIR) window (i.e. ca 400 nm pseudo-Stokes shift). A similar raise in radiance was measured in the green window when encapsulation was achieved with eosin at the same rate. Liposome were found to be stable in PBS over 7 days regardless of the encapsulated fluorophore (no raise in dDLS diameter, no release of encapsulated dyes measured after Sephadex and FPLC repurification sequence), with some decay over 22 hours in a PBS/fetal calf serum mixture (1:1 vol.).","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The assembly of two-dimensional (2D) materials on substrates presents a wide range of potential applications in nanomaterials. However, the tunable nucleation process in molecular assembly is less information available in the literature. In this paper, a neurodegenerative disease-related short peptide and a small molecule named Fast Green (FG) were selected for their binding affinity with mica / highly oriented pyrolytic graphite (HOPG) substrates. Based on atomic force microscopy (AFM) and molecular dynamics (MD) simulation, we investigated the control of 2D assemblies. With the tuning of FG small molecules and substrates, the assemblies grew epitaxially from nanosheets to nanofilms on mica and highly ordered nanofilaments on HOPG substrates. Notably, the nuclei formed in an orderly array without a critical size or lag phase in the presence of FG molecules on the HOPG substrate, facilitating a quicker co-assembly of ordered filaments compared to bulk conditions. Our MD simulations further demonstrated that the interaction between Aβ16-22 molecules and HOPG substrate was primarily due to π-π interactions between aromatic rings, which led to the formation of single-layer filaments by lying on the surface of HOPG. Additionally, parallel π-π stacking acted as the primary force to inhibit the aggregation of peptides into fibrils. Overall, our results provide a strategy for modulating the interaction of amyloid peptides with small molecules and substrates in the assembly of 2D nanomaterials.
{"title":"Changing amyloid nucleation process by small molecule and substrate: a way to build two-dimensional materials","authors":"Chao Chen, Chenyang Wu, Tiantian Yang, Wenhui Zhao, Jiangtao Lei, Dongdong Lin","doi":"10.1039/d4nr04624b","DOIUrl":"https://doi.org/10.1039/d4nr04624b","url":null,"abstract":"The assembly of two-dimensional (2D) materials on substrates presents a wide range of potential applications in nanomaterials. However, the tunable nucleation process in molecular assembly is less information available in the literature. In this paper, a neurodegenerative disease-related short peptide and a small molecule named Fast Green (FG) were selected for their binding affinity with mica / highly oriented pyrolytic graphite (HOPG) substrates. Based on atomic force microscopy (AFM) and molecular dynamics (MD) simulation, we investigated the control of 2D assemblies. With the tuning of FG small molecules and substrates, the assemblies grew epitaxially from nanosheets to nanofilms on mica and highly ordered nanofilaments on HOPG substrates. Notably, the nuclei formed in an orderly array without a critical size or lag phase in the presence of FG molecules on the HOPG substrate, facilitating a quicker co-assembly of ordered filaments compared to bulk conditions. Our MD simulations further demonstrated that the interaction between Aβ16-22 molecules and HOPG substrate was primarily due to π-π interactions between aromatic rings, which led to the formation of single-layer filaments by lying on the surface of HOPG. Additionally, parallel π-π stacking acted as the primary force to inhibit the aggregation of peptides into fibrils. Overall, our results provide a strategy for modulating the interaction of amyloid peptides with small molecules and substrates in the assembly of 2D nanomaterials.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"51 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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