Objective: Apoptosis is an autonomous cell death process controlled by genes that can keep the internal environment of cells relatively stable. Lately, many studies have shown that apoptosis plays an important role in the construction of tumor microenvironment, mainly through the release of a series of regulatory factors to control cell growth. Therefore, it is very valuable to find and explore the possible role of apoptosis in the pathogenesis of lung cancer and its impact on the prognosis of patients. Materials and Methods: We selected 10 apoptosis-related genes and used different statistical methods to construct a model to predict the survival and prognosis of patients with lung adenocarcinoma. Univariate and multivariate Cox analysis were used to evaluate the predictive power and value of prognostic models, as well as receiver operating characteristic (ROC) curve analysis. Results: We defined two subgroups (cluster1 and cluster2). Compared with cluster1, cluster2 was named "apoptosis inhibition subgroup". The survival prognosis of cluster1 was significantly better than that of cluster2, and the infiltration of immune cells in cluster2 suggested that its immune system was inhibited. Then, we established a new prognostic model of apoptosis-related genes to identify high-risk patients with lung adenocarcinoma. Two types of Cox proportional hazards analysis and ROC curve showed that our model can be used as a new independent factor for the prognosis of lung adenocarcinoma patients, and had strong predictive ability. Conclusion: Apoptosis is involved in the formation and development of lung adenocarcinoma and plays an important role. Our survival model can better predict the survival and prognosis of lung adenocarcinoma, and our study may be helpful for further research on new therapeutic targets and precise individualized treatment in the future.
{"title":"Establishment and Validation of Prognostic Model of Lung Adenocarcinoma Based on Apoptosis-Related Genes","authors":"Yu Liu","doi":"10.31579/2690-4861/307","DOIUrl":"https://doi.org/10.31579/2690-4861/307","url":null,"abstract":"Objective: Apoptosis is an autonomous cell death process controlled by genes that can keep the internal environment of cells relatively stable. Lately, many studies have shown that apoptosis plays an important role in the construction of tumor microenvironment, mainly through the release of a series of regulatory factors to control cell growth. Therefore, it is very valuable to find and explore the possible role of apoptosis in the pathogenesis of lung cancer and its impact on the prognosis of patients. Materials and Methods: We selected 10 apoptosis-related genes and used different statistical methods to construct a model to predict the survival and prognosis of patients with lung adenocarcinoma. Univariate and multivariate Cox analysis were used to evaluate the predictive power and value of prognostic models, as well as receiver operating characteristic (ROC) curve analysis. Results: We defined two subgroups (cluster1 and cluster2). Compared with cluster1, cluster2 was named \"apoptosis inhibition subgroup\". The survival prognosis of cluster1 was significantly better than that of cluster2, and the infiltration of immune cells in cluster2 suggested that its immune system was inhibited. Then, we established a new prognostic model of apoptosis-related genes to identify high-risk patients with lung adenocarcinoma. Two types of Cox proportional hazards analysis and ROC curve showed that our model can be used as a new independent factor for the prognosis of lung adenocarcinoma patients, and had strong predictive ability. Conclusion: Apoptosis is involved in the formation and development of lung adenocarcinoma and plays an important role. Our survival model can better predict the survival and prognosis of lung adenocarcinoma, and our study may be helpful for further research on new therapeutic targets and precise individualized treatment in the future.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135439223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Behçet's disease (BD) is a chronic inflammatory illness that affects the entire body and is characterized by recurring episodes of oral aphthae, ocular and cutaneous lesions, and scrotal or vaginal ulcerations. The involvement of other organs and systems increases mortality in addition to the significant morbidity. This study involved a total of 40 participants, 20 of whom were healthy controls and 20 of whom were patients (of the 20 Behçet's patients, 12 (60%) were in the active phase and 8 (40%) were in the inactive phase). There was no therapy being given to any of the 20 patients that would have affected their cytokine levels. Only young men made up the patient and control groups because both early onset and male sex are signs of poor prognosis. The ELISA method was used to measure the levels of serum cytokines. The statistical analysis of the derived numerical values employed the Mann-Whitney U Test. We found a significant correlation between serum cytokine levels and classical acute phase markers in active Behçet’s patients. ESR (P < 0,001), CRP (P < 0,001), fibrinogen (P < 0,001), IL-10 (P < 0,001), IL-6 (P < 0,001), SIL-2R (P < 0,001) and TNFα (P < 0,001). There was no statistically significant difference in serum levels of classical acute phase markers ESR (P = 0,746), CRP (P = 0,476) and fibrinogen (P = 0,940) when inactive Behçet’s patients and healthy controls were compared. However, serum levels of IL-10 (P < 0,001), IL-6 (P = 0,001), SIL-2R (P < 0,001) and TNFα (P = 0,001) were statistically different between inactive Behcet's patients and the control group. Our research shows that even in the inactive phase, serum cytokine levels of Behçet’s patients are much higher than the healthy control group. However, the levels of ESR, CRP and fibrinogen, which are classical acute phase markers, were found at normal levels in Behçet’s patients in the inactive phase. These findings show that measurement of serum interleukin levels will enable us to take preventive measures for morbidity and mortality follow-up of Behçet's patients.
{"title":"Comparison of Serum Levels of SIL-2R, IL-6, IL-10, TNF-α, CRP, ESR and Fibrinogen in Patients with Active and Inactive Behçet’s Disease","authors":"Ali Osman AVCI","doi":"10.31579/2690-4861/312","DOIUrl":"https://doi.org/10.31579/2690-4861/312","url":null,"abstract":"Behçet's disease (BD) is a chronic inflammatory illness that affects the entire body and is characterized by recurring episodes of oral aphthae, ocular and cutaneous lesions, and scrotal or vaginal ulcerations. The involvement of other organs and systems increases mortality in addition to the significant morbidity. This study involved a total of 40 participants, 20 of whom were healthy controls and 20 of whom were patients (of the 20 Behçet's patients, 12 (60%) were in the active phase and 8 (40%) were in the inactive phase). There was no therapy being given to any of the 20 patients that would have affected their cytokine levels. Only young men made up the patient and control groups because both early onset and male sex are signs of poor prognosis. The ELISA method was used to measure the levels of serum cytokines. The statistical analysis of the derived numerical values employed the Mann-Whitney U Test. We found a significant correlation between serum cytokine levels and classical acute phase markers in active Behçet’s patients. ESR (P < 0,001), CRP (P < 0,001), fibrinogen (P < 0,001), IL-10 (P < 0,001), IL-6 (P < 0,001), SIL-2R (P < 0,001) and TNFα (P < 0,001). There was no statistically significant difference in serum levels of classical acute phase markers ESR (P = 0,746), CRP (P = 0,476) and fibrinogen (P = 0,940) when inactive Behçet’s patients and healthy controls were compared. However, serum levels of IL-10 (P < 0,001), IL-6 (P = 0,001), SIL-2R (P < 0,001) and TNFα (P = 0,001) were statistically different between inactive Behcet's patients and the control group. Our research shows that even in the inactive phase, serum cytokine levels of Behçet’s patients are much higher than the healthy control group. However, the levels of ESR, CRP and fibrinogen, which are classical acute phase markers, were found at normal levels in Behçet’s patients in the inactive phase. These findings show that measurement of serum interleukin levels will enable us to take preventive measures for morbidity and mortality follow-up of Behçet's patients.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135439222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cardiovascular diseases have become one of the severe health problems in both developing and developed countries. This research aimed to develop a risk level prediction model and clinical decision support system for CVD in Ethiopia using data mining techniques. A total of 4004 datasets were used to develop the model. Moreover, primary data was collected from the domain experts via interviews and questionnaires. The domain experts identified thirty-one risk factors, of which only eleven attributes were selected after experimentation to develop the model. Based on the result of experimentation, the model was developed by an unpruned J48 classifier algorithm which produced F-Measure 0.877, which is comparatively the best algorithm. The prototype system was developed by Visual C# studio tool. The developed prototype system helps health care providers to identify risk level CVD diseases. It was developed using a data mining technique, which can efficiently predict cardiovascular disease risk levels. However, developing the model by using more datasets and changing the default setting of WEKA, a data mining tool, will be the future work of this study.
{"title":"Developing Risk Level Prediction Model and Clinical Decision Support System for Cardiovascular Diseases in Ethiopia","authors":"Chala Diriba","doi":"10.31579/2690-4861/311","DOIUrl":"https://doi.org/10.31579/2690-4861/311","url":null,"abstract":"Cardiovascular diseases have become one of the severe health problems in both developing and developed countries. This research aimed to develop a risk level prediction model and clinical decision support system for CVD in Ethiopia using data mining techniques. A total of 4004 datasets were used to develop the model. Moreover, primary data was collected from the domain experts via interviews and questionnaires. The domain experts identified thirty-one risk factors, of which only eleven attributes were selected after experimentation to develop the model. Based on the result of experimentation, the model was developed by an unpruned J48 classifier algorithm which produced F-Measure 0.877, which is comparatively the best algorithm. The prototype system was developed by Visual C# studio tool. The developed prototype system helps health care providers to identify risk level CVD diseases. It was developed using a data mining technique, which can efficiently predict cardiovascular disease risk levels. However, developing the model by using more datasets and changing the default setting of WEKA, a data mining tool, will be the future work of this study.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135439221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Standard Helicobacter pylori eradication therapy is based on proton pump inhibitors and antibiotics. There are, however, important limitations: increasing antibiotic resistance of Helicobacter pylori, medical contraindications, and an increasing unwillingness among patients to use antibiotics. Case presentations: We present three exemplary case reports of successful antibiotic-free Helicobacter pylori eradication therapies, one for each of these limiting categories: a 61-year-old female Caucasian patient refractory to prior eradication therapy, an 80-year-old female Caucasian patient with contraindication to antibiotics, and a 41-year-old male Caucasian patient refusing antibiotics. A review of the literature attempts to provide a scientific rationale for proton pump inhibitor-based and probiotics-supported Helicobacter pylori eradication. Conclusion: Antibiotics-free Helicobacter pylori eradication may offer a therapeutic option for patients in whom classical eradication therapy cannot be conducted or who are refractory to antibiotics. Clinical trials are needed to scientifically evaluate the concept presented here.
{"title":"Antibiotic-Free Helicobacter Pylori Eradication – Case Reports and Review of The Literature","authors":"Babak Bahadori","doi":"10.31579/2690-4861/310","DOIUrl":"https://doi.org/10.31579/2690-4861/310","url":null,"abstract":"Background: Standard Helicobacter pylori eradication therapy is based on proton pump inhibitors and antibiotics. There are, however, important limitations: increasing antibiotic resistance of Helicobacter pylori, medical contraindications, and an increasing unwillingness among patients to use antibiotics. Case presentations: We present three exemplary case reports of successful antibiotic-free Helicobacter pylori eradication therapies, one for each of these limiting categories: a 61-year-old female Caucasian patient refractory to prior eradication therapy, an 80-year-old female Caucasian patient with contraindication to antibiotics, and a 41-year-old male Caucasian patient refusing antibiotics. A review of the literature attempts to provide a scientific rationale for proton pump inhibitor-based and probiotics-supported Helicobacter pylori eradication. Conclusion: Antibiotics-free Helicobacter pylori eradication may offer a therapeutic option for patients in whom classical eradication therapy cannot be conducted or who are refractory to antibiotics. Clinical trials are needed to scientifically evaluate the concept presented here.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135439220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Beneficial Effect of Limited Tobacco-Use (Thrice-Daily) with RiskIdentification and Medical Rewarding in Tobacco-Cessation in Heavy-Users Resistant to Previous Drug-Therapy and Conventional Counselling","authors":"K. El-Reshaid, Abdulmohsen Al-Bader","doi":"10.46527/2582-5038.253","DOIUrl":"https://doi.org/10.46527/2582-5038.253","url":null,"abstract":"","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74462127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does MDCT Unravel the Hidden Domains of Conventional Radiography in Calcaneal Fractures?","authors":"J. Iqbal, Moonisah Rafiq, A. Hussain","doi":"10.46527/2582-5038.255","DOIUrl":"https://doi.org/10.46527/2582-5038.255","url":null,"abstract":". Does","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"1067 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77274030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erysipelas in a Case of Uncontrolled Diabetes Mellitus","authors":"Abhinav Kumar, H. P","doi":"10.46527/2582-5038.256","DOIUrl":"https://doi.org/10.46527/2582-5038.256","url":null,"abstract":"","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73084157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amal Yousif, H. Alwulayi, Elsharif. A. Bazie, F. M. Alharbi
Citation: Yousif A, Alwulayi HH, Bazie EA, et al. Case Report: Glucagon-Inducing Vomiting for a Mid-Esophageal Coin Ingestion. Clin Case Rep Open Access. 2023;6(2):254.
引用本文:Yousif A, alulayi HH, Bazie EA等。病例报告:胰高血糖素诱导呕吐中期食道硬币摄入。临床病例报告开放获取。2023;6(2):254。
{"title":"Case Report: Glucagon-Inducing Vomiting for a Mid-Esophageal Coin Ingestion","authors":"Amal Yousif, H. Alwulayi, Elsharif. A. Bazie, F. M. Alharbi","doi":"10.46527/2582-5038.254","DOIUrl":"https://doi.org/10.46527/2582-5038.254","url":null,"abstract":"Citation: Yousif A, Alwulayi HH, Bazie EA, et al. Case Report: Glucagon-Inducing Vomiting for a Mid-Esophageal Coin Ingestion. Clin Case Rep Open Access. 2023;6(2):254.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90111453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The discussion and specification of a model for the study of reproductive choice was the objective of the present work. A documentary study was conducted with an intentional selection of sources indexed to Dialnet, Latindex, Publindex, Redalyc and Scielo from 2020 to 2023. The relationship between the calculation of costs and benefits with risk behaviors was established, although the design of the investigation limited the discussion with the literature consulted, suggesting the extension of the work based on the information published in Copernicus, Ebsco, Scopus and WoS.
{"title":"Network of sexual violence in the literature from 2020 to 2023","authors":"Jorge Hernández Valdés","doi":"10.31579/2690-4861/305","DOIUrl":"https://doi.org/10.31579/2690-4861/305","url":null,"abstract":"The discussion and specification of a model for the study of reproductive choice was the objective of the present work. A documentary study was conducted with an intentional selection of sources indexed to Dialnet, Latindex, Publindex, Redalyc and Scielo from 2020 to 2023. The relationship between the calculation of costs and benefits with risk behaviors was established, although the design of the investigation limited the discussion with the literature consulted, suggesting the extension of the work based on the information published in Copernicus, Ebsco, Scopus and WoS.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"312 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136084924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The gastric bypass operation is an effective procedure to achieve weight loss in overweight patients. But long-term chronic complications after Roux-en-Y gastric bypass are possible, such as König’s syndrome or candy cane syndrome.
{"title":"A Complication in Gastric Bypass: Gastro-Jejunal Twist","authors":"Gianfranco Gioia","doi":"10.31579/2690-4861/304","DOIUrl":"https://doi.org/10.31579/2690-4861/304","url":null,"abstract":"The gastric bypass operation is an effective procedure to achieve weight loss in overweight patients. But long-term chronic complications after Roux-en-Y gastric bypass are possible, such as König’s syndrome or candy cane syndrome.","PeriodicalId":93010,"journal":{"name":"International journal of clinical case reports and reviews : open access","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136084925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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