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Mechanisms of formation of oncological and neurodegenerative diseases on the basis of viral theory of signal transduction 基于病毒信号转导理论的肿瘤和神经退行性疾病的形成机制
Pub Date : 2019-02-25 DOI: 10.15406/aowmc.2019.09.00266
V. Sargsyan
Actually, oncology and neurodegeneration are two sides of the same coin. Both groups of diseases are considered to be the most important problems of modern humanity, the solution of which should be based on a review of fundamental principles of life. It is requested to review such a general biological theory as a cell theory.1 In our recently published articles we present these issues and rehabilitate the cellular theory. The valid scientific decision is given showing that viruses are not obligate parasites and independent life forms, but they are migrating organelles of cells. In nature they impliminate numerous useful and vital functions, but as we all know they can damage cellular forms of life.2–4 It appears to be, that according to the position of the original cell theory all the living being is composed of one or numerous cells. It is actually true that no viruses should be regarded as noncellular forms of life. Moreover, if viruses can be considered as a part of us and our cells then they perform horizontal gene transfer rather intensively than it has been known in science before.5 The following is shown in our scientific articles; the formation of human’s nervous activity and the difference of people from chimpanzees relying on our new biological theory.6 All that occurs in nature due to the acquired genome, so of the genome plasticity.
实际上,肿瘤学和神经变性是同一枚硬币的两面。这两类疾病都被认为是现代人类面临的最重要的问题,解决这些问题应该基于对生命基本原则的回顾。要求复习一下像细胞理论这样的一般生物学理论在我们最近发表的文章中,我们提出了这些问题并恢复了细胞理论。给出了有效的科学结论,表明病毒不是专性寄生虫和独立的生命形式,而是细胞的迁移细胞器。在自然界中,它们干扰了许多有用和重要的功能,但我们都知道它们会破坏细胞形式的生命。根据原始细胞论的观点,一切生物似乎都是由一个或多个细胞组成的。事实上,任何病毒都不应被视为非细胞形式的生命。此外,如果病毒可以被认为是我们和我们细胞的一部分,那么它们进行水平基因转移的强度比以前科学上所知道的要大得多以下内容摘自我们的科学文章:人类神经活动的形成以及人与黑猩猩的区别,都是基于我们新的生物学理论自然界中发生的一切都是由于获得性基因组,以及基因组的可塑性。
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引用次数: 3
Evaluation of functional and pasting properties of instant pounded yam/plantain flour 即食山药车前草粉的功能及糊化性能评价
Pub Date : 2019-01-28 DOI: 10.15406/AOWMC.2019.09.00265
Olumurewa Jav, Ibidapo Po, Adebileje Jf
Plantain (Musa paradisiaca) is an important staple crop that contributes to the calories and subsistence economies in Africa. They are good sources of carbohydrate, (Marriott et.al., 1981). Plantain cultivation is attractive to farmers due to low labour requirements for production compared with cassava, maize, rice and yam (Marriott and Lancaster, 1983). Musa paradisiaca are important starchy staple and commercial crop in West and Central Africa where 50% of the world plantain crop is produced.1 In Nigeria, plantains and bananas are both important staples and are sources of income for subsistence farm families. There has been increasing trend towards large scale production of the crop.2 They contribute significantly to food security and provide more than 25% and 10% of the daily intake of carbohydrate and calories, respectively, for more than 70 million people in sub Saharan Africa.3 In Nigeria, plantain production was estimated at 2,722.000 metric tons in 2009, with an average consumption level of 190 kg/person/year (FAO, 2011). However about 3560% postharvest loss was reported.4 This means that these surpluses have to be exported or processed (Dankye et al., 2007). Hence the need to process them into shelf stable forms that will be made available all the year round. Unripe plantain flour is generally consumed for this purpose especially to manage type 2 diabetes. Results from metabolic studies have suggested that carbohydrate with high glycemic index (a qualitative indicator of carbohydrate ability to raise blood glucose levels) increase insulin demand and heighten hyper insulinemia.5–7 Yam (Dioscorea species) is an important tropical root crop. It ranked as the fourth major root crop in the world after cassava, potatoes and sweet potatoes (Adeleke, 2010). It is also an important source of carbohydrate for many people of the Sub-Sahara region, especially in the yam zone of West Africa.8 Nigeria is the world largest producer of edible yam with D.rotundata and D. alata as the two most cultivated yam species in the country. It was reported that yam contributes more than 200 dietary calories per capital daily for more than 150 million people in West Africa and serves as an important source of income to the people (Babaleye, 2003). Yams are characterized by high moisture content, which renders the tubers more susceptible to microbial attacks and brings about high perish ability of the tubers (FOS, 2011). Nutritionally, yam constitutes a significant carbohydrate and fiber food sources. Others nutrient present in yam are caloric proteins, minerals and vitamins. The crop is important in household food security, diet diversification, employment and income generation
大蕉(Musa paradisiaca)是一种重要的主要作物,为非洲的热量和自给经济做出了贡献。它们是碳水化合物的良好来源(Marriott等人)。, 1981)。与木薯、玉米、水稻和山药相比,种植大蕉对农民有吸引力,因为生产大蕉所需的劳动力较低(Marriott and Lancaster, 1983)。大蕉是西非和中非重要的淀粉类主食和经济作物,占世界大蕉产量的50%在尼日利亚,大蕉和香蕉都是重要的主食,也是自给农业家庭的收入来源。这种作物大规模生产的趋势日益明显它们对粮食安全做出了重大贡献,为撒哈拉以南非洲7000多万人提供了超过25%和10%的碳水化合物和卡路里日摄入量。3在尼日利亚,2009年大蕉产量估计为2,72.2万吨,平均消费量为190公斤/人/年(粮农组织,2011年)。然而,采后损失约为3560%这意味着这些盈余必须出口或加工(Dankye et al., 2007)。因此,需要将它们加工成货架稳定的形式,以便全年可用。未成熟的大蕉粉通常用于此目的,特别是治疗2型糖尿病。代谢研究结果表明,具有高血糖指数的碳水化合物(碳水化合物提高血糖水平的定性指标)会增加胰岛素需求并加剧高胰岛素血症。山药(薯蓣属)是重要的热带块根作物。它是继木薯、土豆和红薯之后的世界第四大块根作物(Adeleke, 2010)。对于撒哈拉以南地区的许多人来说,它也是碳水化合物的重要来源,特别是在西非的山药区。8尼日利亚是世界上最大的食用山药生产国,圆形山药和阿拉塔山药是该国种植最多的两种山药。据报道,山药为西非超过1.5亿人每人每天提供超过200卡路里的膳食热量,是人们的重要收入来源(Babaleye, 2003)。山药的特点是高水分含量,这使得块茎更容易受到微生物的攻击,从而导致块茎的高腐烂能力(FOS, 2011)。从营养上讲,山药是一种重要的碳水化合物和纤维食物来源。山药中存在的其他营养物质是高热量蛋白质、矿物质和维生素。这种作物在家庭粮食安全、饮食多样化、就业和创收方面具有重要意义
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引用次数: 3
Understanding and predicting fasting plasma glucose to control type 2 diabetes (math-physical medicine) 了解和预测空腹血糖以控制2型糖尿病(数理医学)
Pub Date : 2019-01-01 DOI: 10.15406/aowmc.2019.09.00270
Gerald C. Hsu
During 2010 to 2011, he studied six chronic diseases: obesity, diabetes, hypertension, hyperlipidemia, heart attack, and stroke. Concurrently, he developed a customized software to collect related data of both lifestyle management details and medical conditions. Thus far, using this computer program, he has collected 8,878 glucose data including 7,206 postprandial glucose (PPG) and 1,672 fasting plasma glucose (FPG) for the past 4.7 years from 1/1/2014 to 8/25/2018.
在2010年至2011年期间,他研究了六种慢性疾病:肥胖、糖尿病、高血压、高脂血症、心脏病发作和中风。同时,他开发了一个定制软件来收集生活方式管理细节和医疗状况的相关数据。到目前为止,他使用这个计算机程序收集了从2014年1月1日到2018年8月25日4.7年的8,878个血糖数据,其中包括7,206个餐后血糖(PPG)和1,672个空腹血糖(FPG)。
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引用次数: 0
Correlation between nutritional state, blood pressure and waist circumference in sedentary women 久坐女性的营养状况、血压和腰围的关系
Pub Date : 2019-01-01 DOI: 10.15406/aowmc.2019.09.00291
D. Mello
Cardiovascular disease (CVD) is the leading cause of death worldwide.1 Individuals with similar body mass index may have distinct metabolic and cardiovascular risk profiles. Susceptibility to obesity-related cardiometabolic complications is not solely mediated by overall body fat mass, but is largely dependent upon individual differences in regional body fat distribution and ability of subcutaneous adipose tissue to expand.2 CVD risk factors, incidence and death increases comparing to women in reproductive age to menopaused. And a healthy lifestyle can prevent CVD, but it is unclear which lifestyle factors may help maintain and improve cardiovascular health for women after menopausal transition.3 Incident CVD events occurred in more middle-aged men and women in overweight (37% and 28%, respectively), obese (47% and 39%), and morbidly obese (65% and 48%) strata compared with adults in the normal Body Mass Index (BMI) group.4
心血管疾病(CVD)是世界范围内导致死亡的主要原因体重指数相似的个体可能有不同的代谢和心血管风险概况。对肥胖相关的心脏代谢并发症的易感性不仅仅是由全身脂肪量介导的,而在很大程度上取决于个体在局部体脂分布和皮下脂肪组织扩张能力方面的差异心血管疾病的危险因素,发病率和死亡率与育龄妇女相比增加到更年期。健康的生活方式可以预防心血管疾病,但目前尚不清楚哪些生活方式因素可以帮助维持和改善绝经后妇女的心血管健康与正常体重指数(BMI)组的成年人相比,超重(分别为37%和28%)、肥胖(分别为47%和39%)和病态肥胖(分别为65%和48%)组的中年男性和女性心血管疾病事件发生率更高
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引用次数: 0
Nuritional care for the remission of type 2 diabetes in adults undergoing metabolic surgery: a narrative review and propose of educational tool 成人代谢手术后2型糖尿病缓解的营养护理:叙述回顾和教育工具的建议
Pub Date : 2019-01-01 DOI: 10.15406/aowmc.2019.09.00287
Mnc Soto Novia Araceli Alejandra
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引用次数: 1
Battle of the super obese sexes: female versus male variation in pre-operative clinical characteristics among 1,673 surgical patients undergoing bilio-pancreatic bypass/duodenal switch (BPD/DS) 超级肥胖性别之战:1673例行胆胰分流术/十二指肠转换术(BPD/DS)患者术前临床特征的男女差异
Pub Date : 2019-01-01 DOI: 10.15406/aowmc.2019.09.00273
G. Slotman, Danielle Tamburrini Do
Morbid obesity has risen steadily over the last three decades with Body Mass Index (BMI) increasing at 0.4 kg/m2 per decade worldwide.1 Obese patients have become integral to every surgical practice, not just bariatric surgeons. Every clinical insight helps manage these medically fragile individuals. In this context, understanding differences between sexes in clinical characteristics and in weight-related medical problems between women and men with the most extreme levels of obesity would be important to surgeons. Some medical problems vary between normal weight males and females. Cardiomyopathies occur more commonly in men and more women are affected by asthma and autoimmune disorders.2 In chronic obstructive pulmonary disease (COPD), females suffer more metabolic disorders, gastrointestinal diseases, gallstones and osteoporosis, and males higher cardiopulmonary co-morbidities such as pneumonia, pleural effusions and respiratory failure.3 Whether or not these sex differences in co-morbid conditions translate to super-obese patients is unknown. Previously we have reported clinical variation by sex in patients who were pre-operative for laparoscopic Roux-en-Y gastric bypass.4 Nevertheless, whether or not these variations by sex affect also the most severely obese, high-risk surgical patients is unknown. Therefore, the objective of this study was to identify variation in weight, demographics, and the distribution of pre-operative clinical characteristics between super obese females versus males who chose to undego BPD/DS.
在过去的三十年中,病态肥胖稳步上升,全球体重指数(BMI)以每十年0.4 kg/m2的速度增长肥胖患者已经成为所有外科手术不可或缺的一部分,而不仅仅是减肥外科医生。每一个临床见解都有助于管理这些医学上脆弱的个体。在这种情况下,了解临床特征的性别差异以及极度肥胖的女性和男性之间体重相关医学问题的差异对外科医生来说非常重要。一些健康问题在正常体重的男性和女性之间是不同的。心肌病更常见于男性,更多的女性受哮喘和自身免疫性疾病的影响在慢性阻塞性肺疾病(COPD)中,女性患有更多的代谢紊乱、胃肠道疾病、胆结石和骨质疏松症,而男性则有更多的心肺合并症,如肺炎、胸腔积液和呼吸衰竭这些合并症的性别差异是否转化为超肥胖患者尚不清楚。以前我们已经报道了术前腹腔镜Roux-en-Y胃旁路手术患者的临床差异然而,这些性别差异是否也会影响最严重的肥胖、高危手术患者还不得而知。因此,本研究的目的是确定选择BPD/DS的超级肥胖女性与男性在体重、人口统计学和术前临床特征分布方面的差异。
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引用次数: 2
Good fats vs bad fats: an insight on the utilization of fats 好脂肪vs坏脂肪:洞察脂肪的利用
Pub Date : 2019-01-01 DOI: 10.15406/aowmc.2019.09.00283
S. Mustafa
{"title":"Good fats vs bad fats: an insight on the utilization of fats","authors":"S. Mustafa","doi":"10.15406/aowmc.2019.09.00283","DOIUrl":"https://doi.org/10.15406/aowmc.2019.09.00283","url":null,"abstract":"","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90637740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole grain cereals & millets: one of the dietary interventions for obesity management in Indian scenario 全谷物和小米:印度情景中肥胖管理的饮食干预之一
Pub Date : 2018-11-30 DOI: 10.15406/AOWMC.2018.08.00264
Ushma Haria
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引用次数: 0
Adult as well as childhood obesity with metabolic syndrome 成人和儿童肥胖伴代谢综合征
Pub Date : 2018-11-21 DOI: 10.15406/AOWMC.2018.08.00263
Fadel Al Abdullatif, Khaled Hoobani, Hasan Al Shehab, Ahmad Bo Jbara, Faisal Al Dera, S. Mohiuddin
Obesity is become one of a major health problem with worldwide distribution particularly in developed and some developing countries. Incidence of obesity became doubled since 1980.1 In 2014, there were more than 600million people were obese. 13% of adult were obese. Overweight and obesity kills more people than underweight.2 The rate of increase of childhood overweight and obesity in developing countries has been more than 30% higher than that of developed countries.3 In Kingdom of Saudi Arabia here are almost 3.5million children who are overweight. About 28.7% of adult people in Saudi Arabia are obese out of that female were 33.5% and male were 24.1%. There are 20,000 death from obesity and its complications every year.4 According to WHO criteria body mass index greater than or equal to 25 is considered as overweight and greater than or equal to 30 is considered as obesity. Body mass index (BMI) is defined as weight in kilograms divided by the square of an individual’s height in meters (kg/m2). In young children, obesity and overweight are measured as weight for length percentile on the growth curve.
肥胖已成为世界性的主要健康问题之一,特别是在发达国家和一些发展中国家。自1980年以来,肥胖发病率翻了一番。2014年,肥胖人口超过6亿。13%的成年人肥胖。超重和肥胖比体重不足造成的死亡人数更多2 .发展中国家儿童超重和肥胖的增长率比发达国家高出30%以上在沙特阿拉伯王国,有近350万儿童超重。沙特阿拉伯约有28.7%的成年人肥胖,其中女性为33.5%,男性为24.1%。每年有2万人死于肥胖及其并发症根据世卫组织的标准,体重指数大于或等于25被认为是超重,大于或等于30被认为是肥胖。体重指数(BMI)的定义是体重(公斤)除以个人身高(米)的平方(kg/m2)。在幼儿中,肥胖和超重是用生长曲线上的体重长度百分位数来衡量的。
{"title":"Adult as well as childhood obesity with metabolic syndrome","authors":"Fadel Al Abdullatif, Khaled Hoobani, Hasan Al Shehab, Ahmad Bo Jbara, Faisal Al Dera, S. Mohiuddin","doi":"10.15406/AOWMC.2018.08.00263","DOIUrl":"https://doi.org/10.15406/AOWMC.2018.08.00263","url":null,"abstract":"Obesity is become one of a major health problem with worldwide distribution particularly in developed and some developing countries. Incidence of obesity became doubled since 1980.1 In 2014, there were more than 600million people were obese. 13% of adult were obese. Overweight and obesity kills more people than underweight.2 The rate of increase of childhood overweight and obesity in developing countries has been more than 30% higher than that of developed countries.3 In Kingdom of Saudi Arabia here are almost 3.5million children who are overweight. About 28.7% of adult people in Saudi Arabia are obese out of that female were 33.5% and male were 24.1%. There are 20,000 death from obesity and its complications every year.4 According to WHO criteria body mass index greater than or equal to 25 is considered as overweight and greater than or equal to 30 is considered as obesity. Body mass index (BMI) is defined as weight in kilograms divided by the square of an individual’s height in meters (kg/m2). In young children, obesity and overweight are measured as weight for length percentile on the growth curve.","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73574454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to microbiota mitochondria 微生物群线粒体介绍
Pub Date : 2018-11-15 DOI: 10.15406/aowmc.2018.08.00262
R. Haddad
{"title":"Introduction to microbiota mitochondria","authors":"R. Haddad","doi":"10.15406/aowmc.2018.08.00262","DOIUrl":"https://doi.org/10.15406/aowmc.2018.08.00262","url":null,"abstract":"","PeriodicalId":93066,"journal":{"name":"Advances in obesity, weight management & control","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88975971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Advances in obesity, weight management & control
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