Pub Date : 2023-06-23DOI: 10.34257/gjmrivol23is1pg1
Saeed Alshlwi, Abdullah Alhudaib, A. Alanazi, Munirah Alhassen, Nouf Algahtani
Laparoscopic cholecystectomy (LC) is the most common elective laparoscopic procedure performed globally and is the gold standard treatment for gallstone disease. A double gallbladder (GB), with or without duplication of cystic duct is a very rare surgical encounter, with an incidence of approximately 1 in 4000–5000 population.Symptomatic conditions of duplicated gallbladder are usually associated with cholecystitis, cholangitis, gallstone disease, and pancreatitis but are rarely diagnosed with carcinoma. Surgery is the ideal treatment choice of symptomatic duplicated gallbladder.Duplication of the GB is rarely detected preoperatively, can lead to difficulties during surgery with increased likelihood of conversion to open surgery and complications. Our patients is a 45-year-old woman admittedas case of symptomatic cholelithiasis. Patient was admitted to the hospital for laparoscopic Cholecystectomy. Preoperative investigations showed that the patient had only Gallstones. Intraoperatively, patient was found to have double gallbladder with double cystic duct.Subsequently,we successfully performed laparoscopic Cholecystectomy after carful identification and dissection of all these critical structures. The patient's recovery was uneventful, and she was discharged on day one post op.All surgeons should be aware of this rare congenital abnormality of the gallbladder, in addition, thorough knowledge of the anatomical variations of the gallbladder and cystic duct greatly aids the surgeon in anticipating duplications, managing it accordingly and avoiding any complications.
{"title":"Intraoperative Diagnosis and Management of Duplicated Gallbladder: A Case Report","authors":"Saeed Alshlwi, Abdullah Alhudaib, A. Alanazi, Munirah Alhassen, Nouf Algahtani","doi":"10.34257/gjmrivol23is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrivol23is1pg1","url":null,"abstract":"Laparoscopic cholecystectomy (LC) is the most common elective laparoscopic procedure performed globally and is the gold standard treatment for gallstone disease. A double gallbladder (GB), with or without duplication of cystic duct is a very rare surgical encounter, with an incidence of approximately 1 in 4000–5000 population.Symptomatic conditions of duplicated gallbladder are usually associated with cholecystitis, cholangitis, gallstone disease, and pancreatitis but are rarely diagnosed with carcinoma. Surgery is the ideal treatment choice of symptomatic duplicated gallbladder.Duplication of the GB is rarely detected preoperatively, can lead to difficulties during surgery with increased likelihood of conversion to open surgery and complications. Our patients is a 45-year-old woman admittedas case of symptomatic cholelithiasis. Patient was admitted to the hospital for laparoscopic Cholecystectomy. Preoperative investigations showed that the patient had only Gallstones. Intraoperatively, patient was found to have double gallbladder with double cystic duct.Subsequently,we successfully performed laparoscopic Cholecystectomy after carful identification and dissection of all these critical structures. The patient's recovery was uneventful, and she was discharged on day one post op.All surgeons should be aware of this rare congenital abnormality of the gallbladder, in addition, thorough knowledge of the anatomical variations of the gallbladder and cystic duct greatly aids the surgeon in anticipating duplications, managing it accordingly and avoiding any complications.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46992427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In ALS patients, diaphragmatic dysfunction is usually assessed by pulmonary function testing (PFTs) that requires patient cooperation. Evidence suggest that diaphragm ultrasound (DU) can be utilized, as an alternative to PFTs, to detect reduced diaphragmatic motility in ALS patients. This study aimed to verify the agreement between the results obtained by DU with those obtained by PFTs in both standing-up and supine positions.Methods: Twenty nine spinal ALS and thirteen healthy controls were studied in standing up and lying 30° supine position. All subjects performed PFTs and DU, to assess of diaphragmatic excursion, delta-thickness between end inspiration and end expiration (ΔT), and the thickening fraction (TF). Results: The standing position, ΔT correlates with VC (r=0.58p=0.001) and FVC (r=0.61 p<0.001); in lying 30° supine position, ΔT correlates with VC(r=0.59 p=0.001) and FVC (r=0.62 p<0.001). In standing up position, TF correlates with VC (r=0.55 p=0.003) and FVC (r=0.53 p=0.005); in lying 30° supine position, TF correlates with VC (r=0.55 p=0.003) and FVC (r=0.51 p=0.007). The following correlations were also observed: the standing position, diaphragmatic excursion correlated with VC(r=0.55 p=0.007) and FVC (r =0.65 p<0.001). In lying 30° supine position, diaphragmatic excursion correlated with VC(r=0.59 p=0.003); and FVC(r=0.63 p=0.001).Conclusion: DU adequately assesses the diaphragmatic impairment in ALS patients. Thickening and excursion appear as complementary indices in the evaluation of diaphragm motility.
During the first two years of a child's life, nutritional status is crucial for his or her well-being and growth. This study explains the risk factors of chronic malnutrition during the first two years of life in south west Benin. The methodological approach uses the construction of Food Consumption Score (FCS), Reduced Coping Strategies Index (rCSI), Household Dietary Diversity Score (HDDS), and Livelihood Coping Strategies (LCS). The Chi2 test helps to examine the dependency between the variables. The simple binary logit model is used to explore the effects of the explanatory variables on the dependent variable. The results show that about 27% of children aged 6-23 months are chronically malnourished. The age range of the child, the type of union, the average monthly income of the head of the household, the food consumption score, and the size of the family determine the chronic malnutrition. During difficult times, households rely on atypical coping strategy mechanisms by disposing of their productive assets. 20.3% of households can marginally cover their minimum food needs using crisis or emergency coping strategy mechanisms.
{"title":"Risk Factors for Chronic Malnutrition in Children Aged 6 to 23 Months in BOPA, Southwest Benin","authors":"G. Onambélé, Laïfoya Moïse Lawin, Arouna Lokoyo, Moïse Djralah, Jeanne Madindé, Achille Ayalé, Odette Alihonou, Anani Agossou, Eunice Amoussou, Cory Sinsin, Ephiphane Ladélé","doi":"10.34257/gjmrlvol23is1pg15","DOIUrl":"https://doi.org/10.34257/gjmrlvol23is1pg15","url":null,"abstract":"During the first two years of a child's life, nutritional status is crucial for his or her well-being and growth. This study explains the risk factors of chronic malnutrition during the first two years of life in south west Benin. The methodological approach uses the construction of Food Consumption Score (FCS), Reduced Coping Strategies Index (rCSI), Household Dietary Diversity Score (HDDS), and Livelihood Coping Strategies (LCS). The Chi2 test helps to examine the dependency between the variables. The simple binary logit model is used to explore the effects of the explanatory variables on the dependent variable. The results show that about 27% of children aged 6-23 months are chronically malnourished. The age range of the child, the type of union, the average monthly income of the head of the household, the food consumption score, and the size of the family determine the chronic malnutrition. During difficult times, households rely on atypical coping strategy mechanisms by disposing of their productive assets. 20.3% of households can marginally cover their minimum food needs using crisis or emergency coping strategy mechanisms.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49629968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-07DOI: 10.34257/gjmrdvol23is1pg1
Frederick Tshibasu Tshienda, Nadia Cherif Idrissi El Ganouni, Oscar Mokambo Eputa, N. Nsimba, Aléine Budiongo Nzazi, Karim Assani, Gueth Kundabi Akoto, Damien Kamate Kiraulu, J. B. Mabiala, Jean René Ngiyulu, Angèle Mbongo Tansia, Gertrude Luyeye Tansia, Jean Mukaya Tshibola, Michel Lelo Tshikwela, A. M. Aundu, F. Kabongo, B. Lebwaze, Benjamin Kabwe Mwilambwe, Jean-Robert Makulo Rissassy, J. Malemba, Antoine Tshimpi Wola Yaba, Jean-Marie Kayembe Ntumba, J. M. Mbuyi Muamba
Objective: T o describe the ultrasonographic profile of nephroblastoma diagnosed at the university clinics of Kinshasa. Materials and methods: T his is a descriptive study; it concerns 45 patients with Wilms' tumor diagnosed by ultrasonography at the university clinics of Kinshasa from 2016 to 2021, i.e. an overall period of six years. Two ultrasound scanners branded Phillips u-22 and Mindray DC-30 were used.
{"title":"Ultra Sonographic Profile of Nephroblastoma at the University Clinics of Kinshasa","authors":"Frederick Tshibasu Tshienda, Nadia Cherif Idrissi El Ganouni, Oscar Mokambo Eputa, N. Nsimba, Aléine Budiongo Nzazi, Karim Assani, Gueth Kundabi Akoto, Damien Kamate Kiraulu, J. B. Mabiala, Jean René Ngiyulu, Angèle Mbongo Tansia, Gertrude Luyeye Tansia, Jean Mukaya Tshibola, Michel Lelo Tshikwela, A. M. Aundu, F. Kabongo, B. Lebwaze, Benjamin Kabwe Mwilambwe, Jean-Robert Makulo Rissassy, J. Malemba, Antoine Tshimpi Wola Yaba, Jean-Marie Kayembe Ntumba, J. M. Mbuyi Muamba","doi":"10.34257/gjmrdvol23is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrdvol23is1pg1","url":null,"abstract":"Objective: T o describe the ultrasonographic profile of nephroblastoma diagnosed at the university clinics of Kinshasa. \u0000Materials and methods: T his is a descriptive study; it concerns 45 patients with Wilms' tumor diagnosed by ultrasonography at the university clinics of Kinshasa from 2016 to 2021, i.e. an overall period of six years. Two ultrasound scanners branded Phillips u-22 and Mindray DC-30 were used.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48589401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-02DOI: 10.34257/gjmravol23is2pg1
Ka-Kit Chua, Hoi-Man Ng
Background: Chinese medicine (CM) industry has developed rapidly in recent years, but the turnover rate among Chinese medicine practitioners (CMPs) in Hong Kong is relatively high. The research on this issue is insufficient, inevitably giving rise to hidden concerns regarding the development of the CM industry. Purpose: Explores the relationship between job satisfaction, work stress and organizational commitment among CMPs in Hong Kong and their turnover intention. Its results provide guidance regarding the CM industry's management and suggest future research directions. Design: Online questionnaire was used to collect data on qualified CMPs in Hong Kong for investigation. After the pilot questionnaire, statistical analysis was used to correct the problem.
{"title":"Relationship between Job Satisfaction, Work Stress, Organizational Commitment and Turnover Intention of Chinese Medicine Practitioners in Hong Kong","authors":"Ka-Kit Chua, Hoi-Man Ng","doi":"10.34257/gjmravol23is2pg1","DOIUrl":"https://doi.org/10.34257/gjmravol23is2pg1","url":null,"abstract":"Background: Chinese medicine (CM) industry has developed rapidly in recent years, but the turnover rate among Chinese medicine practitioners (CMPs) in Hong Kong is relatively high. The research on this issue is insufficient, inevitably giving rise to hidden concerns regarding the development of the CM industry. Purpose: Explores the relationship between job satisfaction, work stress and organizational commitment among CMPs in Hong Kong and their turnover intention. Its results provide guidance regarding the CM industry's management and suggest future research directions. Design: Online questionnaire was used to collect data on qualified CMPs in Hong Kong for investigation. After the pilot questionnaire, statistical analysis was used to correct the problem.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136084770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.34257/ljmhrvol23is5pg1
Michelly Gama Sampaio da Silva, Renan da Silva Bentes, Matheus Mychael Mazzaro Conchy, Raimundo Carlos de Sousa, Joelma Pereira Costa, Bruno Figueiredo dos Santos
The purpose of this research is to analyze prevalence and incidence studies on the seasonality of trauma epidemiology with regard to distal radius fractures through a systematic review, in which cross-sectional and longitudinal studies were selected regarding the analysis of clinical and epidemiological variables associated with fractures of the distal radius. For this, MEDLINE®, LILACS, SCIELO and PUBMED platforms were used. From a total of 45,634 articles, after applying the inclusion and exclusion criteria, 18 scientific publications were eligible among the 64 read in full. According to the review, it appears that there is seasonality in distal radius fractures according to the seasons of the year. The decreased bone strength of these patients was associated with an increased risk of fracture in 10 years and individuals from a rural environment with less hospital support have a greater chance of not having an adequate post- fracture follow-up.
{"title":"Distal Radius Fracture: A Systematic Review of Observational Studies","authors":"Michelly Gama Sampaio da Silva, Renan da Silva Bentes, Matheus Mychael Mazzaro Conchy, Raimundo Carlos de Sousa, Joelma Pereira Costa, Bruno Figueiredo dos Santos","doi":"10.34257/ljmhrvol23is5pg1","DOIUrl":"https://doi.org/10.34257/ljmhrvol23is5pg1","url":null,"abstract":"The purpose of this research is to analyze prevalence and incidence studies on the seasonality of trauma epidemiology with regard to distal radius fractures through a systematic review, in which cross-sectional and longitudinal studies were selected regarding the analysis of clinical and epidemiological variables associated with fractures of the distal radius. For this, MEDLINE®, LILACS, SCIELO and PUBMED platforms were used. From a total of 45,634 articles, after applying the inclusion and exclusion criteria, 18 scientific publications were eligible among the 64 read in full. According to the review, it appears that there is seasonality in distal radius fractures according to the seasons of the year. The decreased bone strength of these patients was associated with an increased risk of fracture in 10 years and individuals from a rural environment with less hospital support have a greater chance of not having an adequate post- fracture follow-up.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43846418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-24DOI: 10.34257/gjmrkvol23is3pg1
H. Amadi, A. Abubakar
Epileptic grid electricity and frequent power blackouts in the night at LMIC neonatal centres hide behind frontline morbidities but contribute significantly to poor treatment outcomes at these centres. Power blackouts make it hard for clinicians and nurses to see clearly when attending to patients in the dark. Hence, many patients have lost their lives during the mistake-prone poor visual setting. This situation gets worse for centres located at more remote regions of LMICs, where power outages could last for many days. A recently published article on “neonatal-rescue-scheme” concept proposed the reversal in neonatal traffic, by taking the interventions to rural places where more needy neonates are to save them. Therefore, it becomes imperative to develop a reliable solar system of independent and sustainable technology that can guarantee dusk-to-dawn facility lighting at such remote locations, which may not have grid electricity.
{"title":"LMIC Facility-Lighting Limitation in Nigeria Fully Resolved by a Novel Frugal Polite-Light-Bank Technology","authors":"H. Amadi, A. Abubakar","doi":"10.34257/gjmrkvol23is3pg1","DOIUrl":"https://doi.org/10.34257/gjmrkvol23is3pg1","url":null,"abstract":"Epileptic grid electricity and frequent power blackouts in the night at LMIC neonatal centres hide behind frontline morbidities but contribute significantly to poor treatment outcomes at these centres. Power blackouts make it hard for clinicians and nurses to see clearly when attending to patients in the dark. Hence, many patients have lost their lives during the mistake-prone poor visual setting. This situation gets worse for centres located at more remote regions of LMICs, where power outages could last for many days. A recently published article on “neonatal-rescue-scheme” concept proposed the reversal in neonatal traffic, by taking the interventions to rural places where more needy neonates are to save them. Therefore, it becomes imperative to develop a reliable solar system of independent and sustainable technology that can guarantee dusk-to-dawn facility lighting at such remote locations, which may not have grid electricity.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42299801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-24DOI: 10.34257/gjmrkvol23is3pg13
Doepp Manfred
It is scientifically controversial so far whether EMF (non-ionizing electromagnetic fields) can have negative effects on the DNA of cell nuclei. In terms of their energy, they could not do so. However, there is clinical and molecular biological evidence that this can be. There exists a 3-stage mechanism of action, via peroxinitrite, which could lead to DNA damage. The sequence of these processes will be described. Therefore, there is a reasonable suspicion that EMF could also cause DNA damage. The organs with fast and high cell division rate are particularly affected. The general exposure to technical electrosmog (especially 5G) must therefore be marked with a question mark.
{"title":"Technical Electrosmog May be Dangerous","authors":"Doepp Manfred","doi":"10.34257/gjmrkvol23is3pg13","DOIUrl":"https://doi.org/10.34257/gjmrkvol23is3pg13","url":null,"abstract":"It is scientifically controversial so far whether EMF (non-ionizing electromagnetic fields) can have negative effects on the DNA of cell nuclei. In terms of their energy, they could not do so. However, there is clinical and molecular biological evidence that this can be. There exists a 3-stage mechanism of action, via peroxinitrite, which could lead to DNA damage. The sequence of these processes will be described. Therefore, there is a reasonable suspicion that EMF could also cause DNA damage. The organs with fast and high cell division rate are particularly affected. The general exposure to technical electrosmog (especially 5G) must therefore be marked with a question mark.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49448301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.34257/ljmhrvol23is4pg1
Madhura Prakash M, K. G N
Wireless capsule endoscopy is a medical procedure that uses a small, pill-sized capsule with a tiny camera inside to examine the inside of the digestive system. The capsule contains a camera that takes pictures as it moves through the digestive tract. The images are transmitted to a small recording device that the patient wears on a belt or shoulder strap. The recording device stores the images, which are later downloaded and examined by a doctor. The pill-sized camera records a video for eight to twelve hours. The purpose of this work is to investigate and put into practise a technique for summarising the capsule endoscopy footage. The method clusters the video frames in order to accomplish this by looking for local maxima in the neighbouring distance graph that is generated from the colour histograms of each video frame. The method then determines the centroid frame for each cluster and produces a key-frame for each cluster. Visualising the conclusion of this investigation is its second objective. This is accomplished by placing each cluster on a timeline according to the size and calibre of the keyframe. The summary of the capsule endoscopy video is generated as a sequence of keyframes. These keyframes are representative frames of the video. The work also proposes a technique to assess the quality and the quantity of the keyframes extracted.
{"title":"Machine Vision based Unsupervised Summarization of Wireless Capsule Endoscopy Video","authors":"Madhura Prakash M, K. G N","doi":"10.34257/ljmhrvol23is4pg1","DOIUrl":"https://doi.org/10.34257/ljmhrvol23is4pg1","url":null,"abstract":"Wireless capsule endoscopy is a medical procedure that uses a small, pill-sized capsule with a tiny camera inside to examine the inside of the digestive system. The capsule contains a camera that takes pictures as it moves through the digestive tract. The images are transmitted to a small recording device that the patient wears on a belt or shoulder strap. The recording device stores the images, which are later downloaded and examined by a doctor. The pill-sized camera records a video for eight to twelve hours. The purpose of this work is to investigate and put into practise a technique for summarising the capsule endoscopy footage. The method clusters the video frames in order to accomplish this by looking for local maxima in the neighbouring distance graph that is generated from the colour histograms of each video frame. The method then determines the centroid frame for each cluster and produces a key-frame for each cluster. Visualising the conclusion of this investigation is its second objective. This is accomplished by placing each cluster on a timeline according to the size and calibre of the keyframe. The summary of the capsule endoscopy video is generated as a sequence of keyframes. These keyframes are representative frames of the video. The work also proposes a technique to assess the quality and the quantity of the keyframes extracted.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.34257/gjmrevol23is1pg1
H. Arab
There has been an abundance of evidence from clinical, animal, and in vitro studies that progesterone (P4) is important for establishing, maintaining, and terminating a pregnancy. P4 exerts its primary action via its two receptors: progesterone receptor A (PGR-A) and B (PGR-B). Analyses of transcriptomeand cistrome genome have unearthed novel members and modifiers of the P4signaling pathway. The increase in serum P4 levels and down-regulation of PGR-B are important in the development of pinopodes, thus marking implantation. Additionally, it promotes the quiescent myometrial cell phenotype, and the inhibition of its production in myometrial cells induces labor and is the key physiologic initiator of parturition.Through genomic and non-genomic intracellular mechanisms involving these PGR isoforms, various physiologic states can be determined such as the quiescent and contractile myometrium during pregnancy.
{"title":"Parturition is Not the Mirror Image of Implantation: The Role of Progesterone","authors":"H. Arab","doi":"10.34257/gjmrevol23is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrevol23is1pg1","url":null,"abstract":"There has been an abundance of evidence from clinical, animal, and in vitro studies that progesterone (P4) is important for establishing, maintaining, and terminating a pregnancy. P4 exerts its primary action via its two receptors: progesterone receptor A (PGR-A) and B (PGR-B). Analyses of transcriptomeand cistrome genome have unearthed novel members and modifiers of the P4signaling pathway. The increase in serum P4 levels and down-regulation of PGR-B are important in the development of pinopodes, thus marking implantation. Additionally, it promotes the quiescent myometrial cell phenotype, and the inhibition of its production in myometrial cells induces labor and is the key physiologic initiator of parturition.Through genomic and non-genomic intracellular mechanisms involving these PGR isoforms, various physiologic states can be determined such as the quiescent and contractile myometrium during pregnancy.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47683788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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