M. Shakhmardanov, V. Nikiforov, N. Tereshkin, Shakhmardan E Shakhmardanov, A. Skryabina, Y. N. Tomilin
Brucellosis is one of the most common zoonotic diseases in the world. The epidemiological situation of brucellosis in the Russian Federation is characterized as unfavorable. The problem of brucellosis remains of particular relevance in regions with developed animal husbandry. Many different clinical manifestations and the absence of specific symptoms of brucellosis make it difficult to diagnose this disease. The clinical case presented in this paper illustrates the delayed diagnosis of brucellosis in a 10-year-old patient with fever, enlarged lymph nodes, liver and spleen. The defects in the provision of medical care were based on the lack of alertness of doctors regarding brucellosis, insufficient interpretation of epidemiological history data and incorrect assessment of the totality of clinical syndromes of the disease and laboratory parameters. As a result, brucellosis was diagnosed only six months after the onset of the disease. Subsequent etiotropic therapy led to stabilization of the patient's condition, who was discharged from the hospital with recommendations under the supervision of an infectious disease specialist.
{"title":"Subacute brucellosis: a case report","authors":"M. Shakhmardanov, V. Nikiforov, N. Tereshkin, Shakhmardan E Shakhmardanov, A. Skryabina, Y. N. Tomilin","doi":"10.17816/eid320928","DOIUrl":"https://doi.org/10.17816/eid320928","url":null,"abstract":"Brucellosis is one of the most common zoonotic diseases in the world. The epidemiological situation of brucellosis in the Russian Federation is characterized as unfavorable. The problem of brucellosis remains of particular relevance in regions with developed animal husbandry. Many different clinical manifestations and the absence of specific symptoms of brucellosis make it difficult to diagnose this disease. The clinical case presented in this paper illustrates the delayed diagnosis of brucellosis in a 10-year-old patient with fever, enlarged lymph nodes, liver and spleen. The defects in the provision of medical care were based on the lack of alertness of doctors regarding brucellosis, insufficient interpretation of epidemiological history data and incorrect assessment of the totality of clinical syndromes of the disease and laboratory parameters. As a result, brucellosis was diagnosed only six months after the onset of the disease. Subsequent etiotropic therapy led to stabilization of the patient's condition, who was discharged from the hospital with recommendations under the supervision of an infectious disease specialist.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85056828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.23937/2474-3658/1510297
Mastroianni Antonio, Greco Sonia, Vangeli Valeria, Mauro Maria Vittoria, M. Roberto
{"title":"Acute Thyroiditis Complicating a Systemic Parvovirus B-19 Infection: A Unique Adult Case Report in Italy and Literature Review","authors":"Mastroianni Antonio, Greco Sonia, Vangeli Valeria, Mauro Maria Vittoria, M. Roberto","doi":"10.23937/2474-3658/1510297","DOIUrl":"https://doi.org/10.23937/2474-3658/1510297","url":null,"abstract":"","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48044768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.23937/2474-3658/1510298
Mastroianni Antonio, Greco Sonia, Vangeli Valeria, Mauro Maria Vittoria, M. Roberto
We report a case series of fatal invasive diseases due to Staphylococcus caprae . We describe the first cases of S. caprae sepsis in two italian patients. In the first patient there was also evidence of the fourth case reported in the English language literature of mitral endocarditis. We also discuss the main features of differential diagnosis on the basis of a literature review.
{"title":"Invasive Diseases Due to Fatal Staphylococcus caprae Infection: A Case Series and Literature Review","authors":"Mastroianni Antonio, Greco Sonia, Vangeli Valeria, Mauro Maria Vittoria, M. Roberto","doi":"10.23937/2474-3658/1510298","DOIUrl":"https://doi.org/10.23937/2474-3658/1510298","url":null,"abstract":"We report a case series of fatal invasive diseases due to Staphylococcus caprae . We describe the first cases of S. caprae sepsis in two italian patients. In the first patient there was also evidence of the fourth case reported in the English language literature of mitral endocarditis. We also discuss the main features of differential diagnosis on the basis of a literature review.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46550974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.23937/2474-3658/1510295
Scott Godfred Yawson, Ezie Kengo Nathan, Dauda Zakariya'u, Andigema Angyiba Serge, Amekpor Felix
{"title":"Occupational Exposure to Infectious Diseases among Health Workers: Effects, Managements and Recommendations","authors":"Scott Godfred Yawson, Ezie Kengo Nathan, Dauda Zakariya'u, Andigema Angyiba Serge, Amekpor Felix","doi":"10.23937/2474-3658/1510295","DOIUrl":"https://doi.org/10.23937/2474-3658/1510295","url":null,"abstract":"","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45162493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Little information exists on maternal deaths related to COVID-19 disease. We investigated maternal death due to COVID-19 infection and identify risk factors in Sierra Leone, 2021. We collected demographic and clinical data, reviewed medical records, and COVID-19 vaccination status. The decedent was nurse, 34-years-old, pregnant, 20 weeks gestation, and working at the district hospital. The pregnant woman died on June 26, 2021 with positive COVID-19 result. Deceased took one dose of COVID-19 vaccine. Delay to diagnosis COVID-19 infection caused death of the pregnant women. We recommended prioritizing COVID 19 testing for pregnant women particularly health care workers.
{"title":"Maternal Death Due to Late COVID-19 Diagnosis in Moyamba District Sierra Leone, 2021, Case Report","authors":"Gamanga Brima Akwame, Elduma Adel Hussein, Saffa Gbessay, Hakizimana Jean Leonard, Kamara Kassim, Sheriff Amara Alhaji, Gebru Gebrekrstos Negash","doi":"10.23937/2474-3658/1510296","DOIUrl":"https://doi.org/10.23937/2474-3658/1510296","url":null,"abstract":"Little information exists on maternal deaths related to COVID-19 disease. We investigated maternal death due to COVID-19 infection and identify risk factors in Sierra Leone, 2021. We collected demographic and clinical data, reviewed medical records, and COVID-19 vaccination status. The decedent was nurse, 34-years-old, pregnant, 20 weeks gestation, and working at the district hospital. The pregnant woman died on June 26, 2021 with positive COVID-19 result. Deceased took one dose of COVID-19 vaccine. Delay to diagnosis COVID-19 infection caused death of the pregnant women. We recommended prioritizing COVID 19 testing for pregnant women particularly health care workers.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48651813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Relevance. To develop a comprehensive approach with the participation of an infectious disease specialist, an epidemiologist, a psychologist to monitor discordant couples in which a man is HIV positive, a woman has HIV negative status at the stage of pregnancy and childbirth in the Saratov region. Materials and methods. Statistical materials were obtained for the period from 2018 to 2021 from contact cards of pregnant women, outpatient cards of HIVinfected partners from discordant couples planning to conceive naturally, and using methods of assisted reproductive technologies. Statistical data processing was carried out using a software package for statistical processing Excel and an online service //math.semestr.ru //. The characteristics of partners in discordant couples by age, epidemiological risk factors, laboratory tests, pregnancy outcomes are given. Conclusion. It is necessary to develop, approve and implement an algorithm for monitoring discordant couples from the moment of their registration, examination of sexual partners of pregnant women in 100% of cases.
{"title":"EXPERIENCE IN ORGANIZING DYNAMIC SUPERVISION OF PREGNANT WOMEN CONTACT WITH HIV-INFECTED SEXUAL PARTNERS IN THE SARATOV REGION","authors":"T. Gridneva, A. Danilov, T. L. Abramyan","doi":"10.17816/eid115229","DOIUrl":"https://doi.org/10.17816/eid115229","url":null,"abstract":"Abstract \u0000Relevance. To develop a comprehensive approach with the participation of an infectious disease specialist, an epidemiologist, a psychologist to monitor discordant couples in which a man is HIV positive, a woman has HIV negative status at the stage of pregnancy and childbirth in the Saratov region. \u0000Materials and methods. Statistical materials were obtained for the period from 2018 to 2021 from contact cards of pregnant women, outpatient cards of HIVinfected partners from discordant couples planning to conceive naturally, and using methods of assisted reproductive technologies. Statistical data processing was carried out using a software package for statistical processing Excel and an online service //math.semestr.ru //. The characteristics of partners in discordant couples by age, epidemiological risk factors, laboratory tests, pregnancy outcomes are given. Conclusion. It is necessary to develop, approve and implement an algorithm for monitoring discordant couples from the moment of their registration, examination of sexual partners of pregnant women in 100% of cases.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75546989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Efremov, Ainur Razifovich Khuramshin, S. S. Кozlov, A. A. Prokhorchik, Nikolay Ivanovich Gulyaev
The article describes a clinical case of co-infection with COVID-19 and tropical malaria. Patient Z., 37 years old, arrived from the Central African Republic with a diagnosis of "New coronavirus infection COVID-19, confirmed (PCR RNA SARS-CoV-2 "+" from 27.01.22) mild form." During an objective examination, the subictericity of the sclera and skin integuments attracted attention, during thermometry - an increase in body temperature to 39.00C. Consciousness at the level of somnolence. Hemodynamics is unstable, episodes of arterial hypotension. Heart rate 96 per minute. Respiratory rate 24 in 1 minute, SpO2 95%, inspiratory dyspnea. According to a laboratory study, severe thrombocytopenia, pronounced signs of hepatic and renal insufficiency, hyperbilirubinemia, an increase in the concentration of C-reactive protein, procalcitonin were revealed. A differential diagnostic search was carried out between acute viral hepatitis and malaria. Blood microscopy revealed young trophozoites of Plasmodium falciparum (++++) using thick drop method. Antimalarial therapy was prescribed with Malacur, which was then replaced with parenteral Quinine followed by mefloquine. In parallel, extracorporeal detoxification operations were carried out. Against the background of adequate etiotropic therapy, complex intensive care measures, the patient's condition was stabilized, on the 40th day the patient was discharged from the hospital with the restoration of health.
{"title":"Co-infection with COVID-19 and tropical malaria (clinical case)","authors":"D. Efremov, Ainur Razifovich Khuramshin, S. S. Кozlov, A. A. Prokhorchik, Nikolay Ivanovich Gulyaev","doi":"10.17816/eid278272","DOIUrl":"https://doi.org/10.17816/eid278272","url":null,"abstract":"The article describes a clinical case of co-infection with COVID-19 and tropical malaria. Patient Z., 37 years old, arrived from the Central African Republic with a diagnosis of \"New coronavirus infection COVID-19, confirmed (PCR RNA SARS-CoV-2 \"+\" from 27.01.22) mild form.\" During an objective examination, the subictericity of the sclera and skin integuments attracted attention, during thermometry - an increase in body temperature to 39.00C. Consciousness at the level of somnolence. Hemodynamics is unstable, episodes of arterial hypotension. Heart rate 96 per minute. Respiratory rate 24 in 1 minute, SpO2 95%, inspiratory dyspnea. According to a laboratory study, severe thrombocytopenia, pronounced signs of hepatic and renal insufficiency, hyperbilirubinemia, an increase in the concentration of C-reactive protein, procalcitonin were revealed. A differential diagnostic search was carried out between acute viral hepatitis and malaria. Blood microscopy revealed young trophozoites of Plasmodium falciparum (++++) using thick drop method. Antimalarial therapy was prescribed with Malacur, which was then replaced with parenteral Quinine followed by mefloquine. In parallel, extracorporeal detoxification operations were carried out. Against the background of adequate etiotropic therapy, complex intensive care measures, the patient's condition was stabilized, on the 40th day the patient was discharged from the hospital with the restoration of health.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79275551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina V. Nikolaeva, F. S. Gilmullina, Aleksander Yu. Kazancev, B. S. Fatkullin
This case describes a rare case of food botulism F in a 42-year-old man, which developed after he ate dried fish. The disease proceeded in a severe form with the development of ophthalmoplegia, tetraparesis, and respiratory failure. Monovalent antitoxic serums against botulinum toxins A, B, and E were administered to the patient. However, on the third day of the disease, he developed fulminant toxic myocarditis with asystole. Despite successful resuscitation, the patient developed a post-resuscitation disease and anoxic encephalopathy. The disease was complicated by severe aspiration pneumonia caused by Klebsiella pneumoniae (ESBL+). The duration of mechanical ventilation was 12 days. His hemodynamics stabilized on the eighth day of illness, and on the 19th day of illness, physical activity and a state of minimal consciousness appeared. The patient was transferred to the rehabilitation department on the 22nd day of the illness. Doctors should be informed about the possibility of the development and severity of botulism caused by botulinum toxin type F. It is necessary to introduce polyvalent antibotulinic serum into clinical practice, including antitoxins against rare types of botulinum toxin.
{"title":"The case of food botulism F","authors":"Irina V. Nikolaeva, F. S. Gilmullina, Aleksander Yu. Kazancev, B. S. Fatkullin","doi":"10.17816/eid120021","DOIUrl":"https://doi.org/10.17816/eid120021","url":null,"abstract":"This case describes a rare case of food botulism F in a 42-year-old man, which developed after he ate dried fish. The disease proceeded in a severe form with the development of ophthalmoplegia, tetraparesis, and respiratory failure. Monovalent antitoxic serums against botulinum toxins A, B, and E were administered to the patient. However, on the third day of the disease, he developed fulminant toxic myocarditis with asystole. Despite successful resuscitation, the patient developed a post-resuscitation disease and anoxic encephalopathy. The disease was complicated by severe aspiration pneumonia caused by Klebsiella pneumoniae (ESBL+). The duration of mechanical ventilation was 12 days. His hemodynamics stabilized on the eighth day of illness, and on the 19th day of illness, physical activity and a state of minimal consciousness appeared. The patient was transferred to the rehabilitation department on the 22nd day of the illness. \u0000Doctors should be informed about the possibility of the development and severity of botulism caused by botulinum toxin type F. It is necessary to introduce polyvalent antibotulinic serum into clinical practice, including antitoxins against rare types of botulinum toxin.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85685258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Kraeva, Lidiya Sergeevna Konkova, Olga Alexandrovna Burgasova, S. Dolinny
In recent years, there has been a catastrophic increase in the resistance of bacterial strains to antibacterial drugs. The spread of the pandemic of the new coronavirus infection COVID-19 has led to excessive use of antibiotics, which has caused an even wider spread of resistant strains in hospitals. Taking into account the accumulated positive experience of using bacteriophages, it is advisable to use them for the treatment of patients after determining the sensitivity of each strain of isolated bacteria to bacteriophages. Since, according to numerous sources, Klebsiella pneumoniae bacteria were most often isolated in complicated forms of COVID-19, it became necessary to quickly determine the sensitivity of these and other gram-negative bacteria to the corresponding bacteriophages. The developed express method for determining the sensitivity of gram-negative bacteria to bacteriophages makes it possible to reduce the study time by 6 times, namely up to 3 hours. This will significantly reduce the timing of the selection of etiotropic therapy in the form of bacteriophages for individual therapy of patients.
{"title":"Express method for determining the sensitivity of pathogens of bacterial complications in COVID-19 to bacteriophages","authors":"L. Kraeva, Lidiya Sergeevna Konkova, Olga Alexandrovna Burgasova, S. Dolinny","doi":"10.17816/eid181621","DOIUrl":"https://doi.org/10.17816/eid181621","url":null,"abstract":"In recent years, there has been a catastrophic increase in the resistance of bacterial strains to antibacterial drugs. The spread of the pandemic of the new coronavirus infection COVID-19 has led to excessive use of antibiotics, which has caused an even wider spread of resistant strains in hospitals. Taking into account the accumulated positive experience of using bacteriophages, it is advisable to use them for the treatment of patients after determining the sensitivity of each strain of isolated bacteria to bacteriophages. Since, according to numerous sources, Klebsiella pneumoniae bacteria were most often isolated in complicated forms of COVID-19, it became necessary to quickly determine the sensitivity of these and other gram-negative bacteria to the corresponding bacteriophages. The developed express method for determining the sensitivity of gram-negative bacteria to bacteriophages makes it possible to reduce the study time by 6 times, namely up to 3 hours. This will significantly reduce the timing of the selection of etiotropic therapy in the form of bacteriophages for individual therapy of patients.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87862367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Every year, a steady, progressive increase in the number of atypical, chronic, active forms of infections caused by herpesviruses (AHA-HVI) is recorded. The diagnosis and selection of adequate therapeutic strategies for the treatment of these forms of infections presents significant difficulties for physicians of therapeutic, neurological profile, immunologists, infectious disease specialists, due to the polysyndromicity and the presence of many clinical masks of these infections. Aims: determining the prevalence of AHA-HVI among patients infected with herpes virus infections, as well as studying the features of the etiological structure and clinical manifestations/criterion signs of atypically occurring chronic forms of herpes viral infections. Materials and methods: Under our supervision at the Medsi CDC in Belorusskaya (Moscow) there were 98 patients (SG) of both sexes aged 23 to 60 years suffering from AHA-HVI. The comparison group consisted of 30 conditionally healthy subjects comparable in sex and age to SG patients. In addition to traditional methods (history collection, physical examination methods, CBC, etc.), serodiagnosis methods with ELISA were used to detect herpes-viral infections; PCR method for detecting the genome of viruses in biomaterials. The study was approved by the ethics committee, and all patients received informed consent to participate in the study. Statistical analysis was performed using adequate methods of statistic studies. Results: The study of the etiological structure of herpes virus infections in patients with AHA-HVI, mixed HVI was shown to occur in 83.4% of patients, and mono-HVI in 16.6% of cases. It was shown that EBV was the dominant virus among patients with both mono and mixed GVI. A high rate of EBV DNA detection was demonstrated in saliva (84.2%), posterior pharyngeal wall scraping (73.5%) and tonsils (42.9%), urine (12.6%) and blood (8.3%) is a marker of high replicative activity of the virus. The main clinical syndromes associated with the course of mono and mixed AHA-HVI were identified. Conclusions: Identification and quantitative assessment of the viral load associated with the severity of the course and severity of clinical manifestations of ACA-HVI, as well as clarification of the features of clinical manifestations and syndromes in patients suffering from various mono-, mixed-herpesvirus infections, allow us to outline goals for the further development of an adequate diagnostic algorithm for these atypical forms of herpesvirus infections and the concept of targeted, personalized etio- and immunopathogenetic therapy.
{"title":"ATYPICAL CHRONIC ACTIVE HERPESVIRUS INFECTIONS: ETIOLOGICAL STRUCTURE, FREQUENCY OF OCCURRENCE, CLINICAL SYNDROMES ASSOCIATED WITH THEM","authors":"Tatiana Suranova","doi":"10.17816/eid121817","DOIUrl":"https://doi.org/10.17816/eid121817","url":null,"abstract":"Background: Every year, a steady, progressive increase in the number of atypical, chronic, active forms of infections caused by herpesviruses (AHA-HVI) is recorded. The diagnosis and selection of adequate therapeutic strategies for the treatment of these forms of infections presents significant difficulties for physicians of therapeutic, neurological profile, immunologists, infectious disease specialists, due to the polysyndromicity and the presence of many clinical masks of these infections. \u0000Aims: determining the prevalence of AHA-HVI among patients infected with herpes virus infections, as well as studying the features of the etiological structure and clinical manifestations/criterion signs of atypically occurring chronic forms of herpes viral infections. \u0000Materials and methods: Under our supervision at the Medsi CDC in Belorusskaya (Moscow) there were 98 patients (SG) of both sexes aged 23 to 60 years suffering from AHA-HVI. The comparison group consisted of 30 conditionally healthy subjects comparable in sex and age to SG patients. In addition to traditional methods (history collection, physical examination methods, CBC, etc.), serodiagnosis methods with ELISA were used to detect herpes-viral infections; PCR method for detecting the genome of viruses in biomaterials. The study was approved by the ethics committee, and all patients received informed consent to participate in the study. Statistical analysis was performed using adequate methods of statistic studies. \u0000Results: The study of the etiological structure of herpes virus infections in patients with AHA-HVI, mixed HVI was shown to occur in 83.4% of patients, and mono-HVI in 16.6% of cases. It was shown that EBV was the dominant virus among patients with both mono and mixed GVI. A high rate of EBV DNA detection was demonstrated in saliva (84.2%), posterior pharyngeal wall scraping (73.5%) and tonsils (42.9%), urine (12.6%) and blood (8.3%) is a marker of high replicative activity of the virus. The main clinical syndromes associated with the course of mono and mixed AHA-HVI were identified. \u0000Conclusions: Identification and quantitative assessment of the viral load associated with the severity of the course and severity of clinical manifestations of ACA-HVI, as well as clarification of the features of clinical manifestations and syndromes in patients suffering from various mono-, mixed-herpesvirus infections, allow us to outline goals for the further development of an adequate diagnostic algorithm for these atypical forms of herpesvirus infections and the concept of targeted, personalized etio- and immunopathogenetic therapy.","PeriodicalId":93465,"journal":{"name":"Journal of infectious diseases and epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81110327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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