Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-28-33
E. Vazhnichaya, O. Y. Baliuk, N. O. Bobrova
{"title":"OXIDATIVE STRESS: CLASSIC DOCTRINE AND ITS UPDATE","authors":"E. Vazhnichaya, O. Y. Baliuk, N. O. Bobrova","doi":"10.29254/2077-4214-2023-2-169-28-33","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-28-33","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90188784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2523-4110-2023-2-169/addition-29-30
Олексій Бакалець, Л. Я. Федонюк, Н. Б. Бегош, Т. А. Заєць
{"title":"ІНДИВІДУАЛЬНА ОСВІТНЯ ТРАЄКТОРІЯ ЗДОБУВАЧІВ ВИЩОЇ ОСВІТИ – СУЧАСНИЙ ШЛЯХ ПРОФЕСІЙНОГО РОЗВИТКУ","authors":"Олексій Бакалець, Л. Я. Федонюк, Н. Б. Бегош, Т. А. Заєць","doi":"10.29254/2523-4110-2023-2-169/addition-29-30","DOIUrl":"https://doi.org/10.29254/2523-4110-2023-2-169/addition-29-30","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90396669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-454-462
Z. Nazarenko, V. O. Mikitenko, I. M. Tkachenko, N. M. Brailko, L. I. Lyashenko, Y. Vodoriz
{"title":"EFFECT OF ROOT CANAL OBLITERATION ON THE SUCCESS OF ENDODONTIC TREATMENT","authors":"Z. Nazarenko, V. O. Mikitenko, I. M. Tkachenko, N. M. Brailko, L. I. Lyashenko, Y. Vodoriz","doi":"10.29254/2077-4214-2023-2-169-454-462","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-454-462","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77282809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2523-4110-2023-2-169/addition-33-34
Валентина Павлівна Білаш, Володимир Григорович Гринь, Наталія Леонідівна Свінцицька, Ольга Дмитриевна Лисаченко, Олег Біланов, Андрій Любославович Каценко, В. В. Бобух
{"title":"ФОРМУВАННЯ ТОЛЕРАНТНОСТІ МАЙБУТНІХ ПРАЦІВНИКІВ ГАЛУЗІ ОХОРОНИ ЗДОРОВ’Я ЯК СКЛАДОВОЇ ПРОФЕСІЙНОЇ КОМПЕТЕНТНОСТІ","authors":"Валентина Павлівна Білаш, Володимир Григорович Гринь, Наталія Леонідівна Свінцицька, Ольга Дмитриевна Лисаченко, Олег Біланов, Андрій Любославович Каценко, В. В. Бобух","doi":"10.29254/2523-4110-2023-2-169/addition-33-34","DOIUrl":"https://doi.org/10.29254/2523-4110-2023-2-169/addition-33-34","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77381569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-415-423
N. Tsyndrenko, M. Lyndin, N. Hyriavenko, K. Sikora, D. H. Tsepochko, A. Romaniuk
To determine the degree of dependence between the histological variants of HPE (non-atypical EH (NAEH), Hyperplastic processes of the endometrium (HPE) are a common pathology of the female reproductive system. Excess estrogenic stimulation is a significant role in their development in the case of insufficient progesterone influ - ence. Estrogen receptors (ER) alpha are the main isoforms that mediate endometrial proliferation in hyperplastic processes. Our study aimed to determine the degree of ER expression in different types of HPE and to study the dependence of their expression on the histological variant and anthropometric indicators. Tissue samples were divided into groups depending on the obtained result of histological examination, namely, atypical endometrial hyperplasia, endometrial glandular polyps, and endometrial glandular-fibrous polyps. It has been established that endometrial glandular polyps occur at a younger age compared to atypical endome - trial hyperplasia and glandular-fibrous endometrial polyps. In general, there is a tendency to increase the body mass index in women with HPE. There is no dependence of the type of endometrial hyperplastic processes on growth, body weight, and body mass index. Researching the expression of ER revealed a violation of the receptor status in HPE in the form of their uneven expression in the epithelial and stromal components. An increase in the expression of ER in the endometrial glands compared with the stroma was found to be uneven in intensity and concentration. Violation of the receptor status in hyperplastic processes of the endometrium is characterized by uneven expres - sion of ER in the epithelial and stromal components. Uneven expression of estrogen receptors in the glands and stroma of the endometrium is observed, which does not depend on the anthropometric parameters of the patients. A direct correlation between the expression of estrogen receptors in the epithelium and the stroma of the endome - trium was established. The obtained results can serve as criteria for a differentiated approach to selecting treatment tactics for women with hyperplastic processes of the endometrium.
{"title":"IMMUNOHISTOCHEMICAL CHARACTERISTICS OF ENDOMETRIAL TISSUES IN HYPERPLASTIC PROCESSES","authors":"N. Tsyndrenko, M. Lyndin, N. Hyriavenko, K. Sikora, D. H. Tsepochko, A. Romaniuk","doi":"10.29254/2077-4214-2023-2-169-415-423","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-415-423","url":null,"abstract":"To determine the degree of dependence between the histological variants of HPE (non-atypical EH (NAEH), Hyperplastic processes of the endometrium (HPE) are a common pathology of the female reproductive system. Excess estrogenic stimulation is a significant role in their development in the case of insufficient progesterone influ - ence. Estrogen receptors (ER) alpha are the main isoforms that mediate endometrial proliferation in hyperplastic processes. Our study aimed to determine the degree of ER expression in different types of HPE and to study the dependence of their expression on the histological variant and anthropometric indicators. Tissue samples were divided into groups depending on the obtained result of histological examination, namely, atypical endometrial hyperplasia, endometrial glandular polyps, and endometrial glandular-fibrous polyps. It has been established that endometrial glandular polyps occur at a younger age compared to atypical endome - trial hyperplasia and glandular-fibrous endometrial polyps. In general, there is a tendency to increase the body mass index in women with HPE. There is no dependence of the type of endometrial hyperplastic processes on growth, body weight, and body mass index. Researching the expression of ER revealed a violation of the receptor status in HPE in the form of their uneven expression in the epithelial and stromal components. An increase in the expression of ER in the endometrial glands compared with the stroma was found to be uneven in intensity and concentration. Violation of the receptor status in hyperplastic processes of the endometrium is characterized by uneven expres - sion of ER in the epithelial and stromal components. Uneven expression of estrogen receptors in the glands and stroma of the endometrium is observed, which does not depend on the anthropometric parameters of the patients. A direct correlation between the expression of estrogen receptors in the epithelium and the stroma of the endome - trium was established. The obtained results can serve as criteria for a differentiated approach to selecting treatment tactics for women with hyperplastic processes of the endometrium.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81274635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-185-196
Y. Dytiatkovska, N. Nedohybchenko
the negative effect of the dis - ease on quality of life also considerably reduced. However, at the end of the observation, the severity of urticaria and all domains of the negative impact of the disease on the quality of life remained pronounced in patients of this group. Treatment with omalizumab at a dosage of 150 mg once every 21 days in this patient category can be considered an effective therapy method that eliminates the symptoms of urticaria and significantly improves the quality of life.
{"title":"THE QUALITY OF LIFE OF PATIENTS WITH FREQUENTLY RECURRING URTICARIA AND THE EFFECT OF DIFFERENT TREATMENT METHODS","authors":"Y. Dytiatkovska, N. Nedohybchenko","doi":"10.29254/2077-4214-2023-2-169-185-196","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-185-196","url":null,"abstract":"the negative effect of the dis - ease on quality of life also considerably reduced. However, at the end of the observation, the severity of urticaria and all domains of the negative impact of the disease on the quality of life remained pronounced in patients of this group. Treatment with omalizumab at a dosage of 150 mg once every 21 days in this patient category can be considered an effective therapy method that eliminates the symptoms of urticaria and significantly improves the quality of life.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79257364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-14-17
O. Udod
{"title":"IN MEMORY OF PROFESSOR VITALIY GRHYROVYCH TSENTYL","authors":"O. Udod","doi":"10.29254/2077-4214-2023-2-169-14-17","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-14-17","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75661493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-1-168-8-11
O. Udod
{"title":"A LIFE DEDICATED TO PEOPLE (to the anniversary of Professor Yuriy Vasyliovych Dumanskyi)","authors":"O. Udod","doi":"10.29254/2077-4214-2023-1-168-8-11","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-1-168-8-11","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"57 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75732508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-353-360
H. Lukyantseva, O. M. Bakunovsky, S. Malyuga, T. Oliinyk
{"title":"CHANGES IN THE WORK OF THE HEART AND CENTRAL HEMODYNAMICS IN THE PERIOD OF EARLY RECOVERY AFTER STATIC PHYSICAL EXERCISE","authors":"H. Lukyantseva, O. M. Bakunovsky, S. Malyuga, T. Oliinyk","doi":"10.29254/2077-4214-2022-4-167-353-360","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-353-360","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72752709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-326-333
V. Pastukhova, A. I. Pastukhova, V. O. Tarnavskyi, T. Cherkas
{"title":"CORRECTION OF THE DIET OF HOCKEY PLAYERS TO ELIMINATE A PREMORBID CONDITION","authors":"V. Pastukhova, A. I. Pastukhova, V. O. Tarnavskyi, T. Cherkas","doi":"10.29254/2077-4214-2022-4-167-326-333","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-326-333","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78566654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：