Neuromorphic devices, inspired by the human brain's efficiency and adaptability, hold great potential for artificial intelligence (AI) hardware to overcome the limitations of traditional von Neumann architecture. As a subclass, multimodal and multifunctional neuromorphic devices have recently gained a lot of attention due to their advantages in in-sensor computing and sophisticated behaviors. In this review, recent advances in materials, device structures, and applications in this field are systematically presented. It includes optical, electrical, mechanical, and chemical sensing in multimodal neuromorphic device, which enable in-sensor computing to minimize energy consumption and enhance real-time decision-making. The materials applied in this field such as phase-change, 2D materials, and ferroelectrics are summarized for their roles in achieving synaptic plasticity, nonvolatile memory for multifunctional neuromorphic devices. Structural innovations, including reconfigurable, multi-terminal, and 3D-integrated designs, further optimize parallel processing and multifunctional integration. Besides, application scenarios of multimodal and multifunctional neuromorphic devices and their advantages for improving the efficiency of AI are reviewed. Finally, challenges in material stability and commercialization are discussed, it emphasizes the need for interdisciplinary efforts to bridge the gap. This review provides critical insights and future directions for developing brain-inspired, energy-efficient AI hardware.
{"title":"Neuromorphic Device Based on Material and Device Innovation toward Multimode and Multifunction","authors":"Feng Guo, Hongda Ren, Yang Zhang, Jianhua Hao","doi":"10.1002/aisy.202500477","DOIUrl":"https://doi.org/10.1002/aisy.202500477","url":null,"abstract":"<p>Neuromorphic devices, inspired by the human brain's efficiency and adaptability, hold great potential for artificial intelligence (AI) hardware to overcome the limitations of traditional von Neumann architecture. As a subclass, multimodal and multifunctional neuromorphic devices have recently gained a lot of attention due to their advantages in in-sensor computing and sophisticated behaviors. In this review, recent advances in materials, device structures, and applications in this field are systematically presented. It includes optical, electrical, mechanical, and chemical sensing in multimodal neuromorphic device, which enable in-sensor computing to minimize energy consumption and enhance real-time decision-making. The materials applied in this field such as phase-change, 2D materials, and ferroelectrics are summarized for their roles in achieving synaptic plasticity, nonvolatile memory for multifunctional neuromorphic devices. Structural innovations, including reconfigurable, multi-terminal, and 3D-integrated designs, further optimize parallel processing and multifunctional integration. Besides, application scenarios of multimodal and multifunctional neuromorphic devices and their advantages for improving the efficiency of AI are reviewed. Finally, challenges in material stability and commercialization are discussed, it emphasizes the need for interdisciplinary efforts to bridge the gap. This review provides critical insights and future directions for developing brain-inspired, energy-efficient AI hardware.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"8 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202500477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-small cell lung cancer (NSCLC) comprises the largest subtype of lung cancer with the most cases. Lung adenocarcinoma and lung squamous cell carcinoma are two NSCLC subtypes that pose challenges for accurate diagnosis using conventional methods, including histological examination and imaging, which can be slow and inconclusive. To address these concerns, RPSLearner is proposed, which combines random projection (RP) for dimensionality reduction and stacking ensemble learning to accurately predict lung cancer subtypes. Specifically, multiple independent RP matrices are first generated to project the high-dimensional RNA-seq data into a lower-dimensional space, whose features are subsequently concatenated. After that, the concatenated RP features are fed into a stack of diverse base classifiers, and integrated the predictions from base models via a deep linear layer network. Benchmarking tests on 1 333 NSCLC patients demonstrated that RPSLearner outperformed state-of-the-art approaches for lung cancer subtype classification. Specifically, RPSLearner efficiently preserved sample-to-sample distances even after significant dimension reduction, and the meta-model in RPSLearner yielded consistently higher scores than individual base models. In addition, the feature fusion method outperformed conventional score ensemble methods. We believe RPSLearner is a promising model for downstream lung cancer clinical diagnosis, and it holds the potential to be extended to subtyping of other types of cancer.
{"title":"RPSLearner: A Novel Approach Based on Random Projection and Deep Stacking Learning for Categorizing Non-Small Cell Lung Cancer.","authors":"Xinchao Wu, Jieqiong Wang, Shibiao Wan","doi":"10.1002/aisy.202500635","DOIUrl":"10.1002/aisy.202500635","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) comprises the largest subtype of lung cancer with the most cases. Lung adenocarcinoma and lung squamous cell carcinoma are two NSCLC subtypes that pose challenges for accurate diagnosis using conventional methods, including histological examination and imaging, which can be slow and inconclusive. To address these concerns, RPSLearner is proposed, which combines random projection (RP) for dimensionality reduction and stacking ensemble learning to accurately predict lung cancer subtypes. Specifically, multiple independent RP matrices are first generated to project the high-dimensional RNA-seq data into a lower-dimensional space, whose features are subsequently concatenated. After that, the concatenated RP features are fed into a stack of diverse base classifiers, and integrated the predictions from base models via a deep linear layer network. Benchmarking tests on 1 333 NSCLC patients demonstrated that RPSLearner outperformed state-of-the-art approaches for lung cancer subtype classification. Specifically, RPSLearner efficiently preserved sample-to-sample distances even after significant dimension reduction, and the meta-model in RPSLearner yielded consistently higher scores than individual base models. In addition, the feature fusion method outperformed conventional score ensemble methods. We believe RPSLearner is a promising model for downstream lung cancer clinical diagnosis, and it holds the potential to be extended to subtyping of other types of cancer.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiyuan He, Peng Chen, Xinye Wang, Yuxiang Chen, Tao Sun
The postoperative rehabilitation of ankle fractures, particularly in the home setting, has a crucial influence on the recovery of lower limb function. To enhance the portability, real-time performance, and safety of postoperative remote rehabilitation training, this study proposes a novel robot-assisted remote rehabilitation system tailored for postoperative ankle fracture patients. Based on a distributed system architecture, the hardware system enables modular decomposition and facilitates wireless control of the lower controller. The total weight of the robotic system is 2.634 kg. By combining a deep learning algorithm with an interpolation fitting method, the time delay in interaction force signals during remote communication is predicted and compensated. The control frequency is elevated to 100 Hz with a maximum normalized root mean square error of 10.89%, ensuring the precision and continuity of the robot control system. Additionally, a full-cycle rehabilitation training strategy based on adaptive admittance control with system stiffness identification is proposed, encompassing passive, active–passive, isotonic, and active activities of daily living trainings. Experimental results indicate that the robotic system can execute the training strategies at each phase with high accuracy and safety, and the proposed adaptive control strategy has better compliance than fixed parameter admittance control and fuzzy admittance control methods.
{"title":"A Robot-Assisted Remote Rehabilitation System for Ankle Fractures Based on Predictive Force and Full-Cycle Training Strategy","authors":"Zhiyuan He, Peng Chen, Xinye Wang, Yuxiang Chen, Tao Sun","doi":"10.1002/aisy.202500420","DOIUrl":"https://doi.org/10.1002/aisy.202500420","url":null,"abstract":"<p>The postoperative rehabilitation of ankle fractures, particularly in the home setting, has a crucial influence on the recovery of lower limb function. To enhance the portability, real-time performance, and safety of postoperative remote rehabilitation training, this study proposes a novel robot-assisted remote rehabilitation system tailored for postoperative ankle fracture patients. Based on a distributed system architecture, the hardware system enables modular decomposition and facilitates wireless control of the lower controller. The total weight of the robotic system is 2.634 kg. By combining a deep learning algorithm with an interpolation fitting method, the time delay in interaction force signals during remote communication is predicted and compensated. The control frequency is elevated to 100 Hz with a maximum normalized root mean square error of 10.89%, ensuring the precision and continuity of the robot control system. Additionally, a full-cycle rehabilitation training strategy based on adaptive admittance control with system stiffness identification is proposed, encompassing passive, active–passive, isotonic, and active activities of daily living trainings. Experimental results indicate that the robotic system can execute the training strategies at each phase with high accuracy and safety, and the proposed adaptive control strategy has better compliance than fixed parameter admittance control and fuzzy admittance control methods.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"8 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202500420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Petrš, Ryota Kobayashi, Fuda van Diggelen, Hiroyuki Nabae, Koichi Suzumori, Dario Floreano
Tensegrity Robotics
This research presents tensegrity articulated joints with actuation that combine thin pneumatic artificial muscles and energy-restoring elastics, both integrated into the tensile network. It uses a tensegrity spine-inspired topology, further refined through a multi-objective, constraint-based evolutionary algorithm. The method was validated by designing and fabricating two types of joints, which were tested in a quadruped robot and gripper application. More details can be found in the Research Article by Jan Petrš and co-workers (Doi: 10.1002/aisy.202500310).