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Artificial Intelligence-Driven Smart Scan: A Rapid, Automatic Approach for Comprehensive Imaging and Spectroscopy for Fast Compositional Analysis 人工智能驱动的智能扫描:用于快速成分分析的综合成像和光谱分析的快速自动方法
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-17 DOI: 10.1002/aisy.202300745
Pavel Potocek, Cigdem Ozsoy-Keskinbora, Philipp Müller, Thorsten Wieczorek, Maurice Peemen, Philipp Slusallek, Bert Freitag

Nanomaterial properties and functionalities are influenced by their shape, size, and chemical composition. The importance of these parameters highlights the need for a statistically robust analysis of a large particle population, necessitating automation. This study introduces a neural network-empowered smart scan technique that achieves a relative increase in speed compared to traditional energy-dispersive X-ray spectroscopy (EDX) mapping. The main advantage is that it reduces the required dose, decreasing potential damage to the sample by avoiding unnecessary exposure. It holds potential use in other multimodal scanning transmission electron microscopy or scanning-based imaging approaches. In the first example, identifying particles in a matrix with a trained neural network reduces the acquisition time by two orders of magnitude. This acceleration enables a statistical compositional analysis of thousands of particles in less than 1 h. Similar improvements are observed for atomic resolution. The discrete positions of atoms identified by the trained network allow for selective EDX sampling at these centers, thereby identifying the atomic species of the column with much-reduced sampling. Consequently, a lower sampling dose is required, enabling mapping of more delicate materials with high lateral resolution and at a high statistical confidence interval. Even though manual training is still required, this approach greatly benefits repetitive quality control tasks.

纳米材料的特性和功能受其形状、尺寸和化学成分的影响。这些参数的重要性凸显了对大量粒子群进行稳健统计分析的必要性,因此必须实现自动化。本研究介绍了一种神经网络驱动的智能扫描技术,与传统的能量色散 X 射线光谱(EDX)绘图相比,该技术的速度相对提高。其主要优点是减少了所需剂量,避免了不必要的曝光,从而降低了对样品的潜在损害。它在其他多模态扫描透射电子显微镜或基于扫描的成像方法中也有潜在用途。在第一个例子中,利用训练有素的神经网络识别矩阵中的颗粒可将采集时间缩短两个数量级。在原子分辨率方面也有类似的改进。通过训练有素的网络识别原子的离散位置,可以在这些中心进行选择性 EDX 取样,从而在大大减少取样的情况下识别柱中的原子种类。因此,所需的取样剂量更低,从而能够以高横向分辨率和高统计置信区间绘制更精细的材料。尽管仍需要人工培训,但这种方法对重复性质量控制任务大有裨益。
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引用次数: 0
Simple Data Transformations for Mitigating the Syntactic Similarity to Improve Sentence Embeddings at Supervised Contrastive Learning 通过简单的数据转换减轻句法相似性,在监督对比学习中改善句子嵌入效果
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-15 DOI: 10.1002/aisy.202300717
Minji Kim, Whanhee Cho, Soohyeong Kim, Yong Suk Choi

Contrastive learning of sentence representations has achieved great improvements in several natural language processing tasks. However, the supervised contrastive learning model trained on the natural language inference (NLI) dataset is insufficient to elucidate the semantics of sentences since it is prone to make a prediction based on heuristics. Herein, by using the ParsEVAL and the word overlap metric, it is shown that sentence pairs in the NLI dataset have strong syntactic similarity and propose a framework to compensate for this problem in two aspects. 1) Apply simple syntactic transformations to the hypothesis and 2) expand the objective to SupCon Loss to leverage variants of sentences. The method is evaluated on semantic textual similarity (STS) tasks and transfer tasks. The proposed methods improve the performance of the BERT-based baseline in STS Benchmark and SICK Relatedness by 1.48% and 2.2%. Furthermore, the model achieves 82.65% on the HANS benchmark dataset, to the best of our knowledge, which is a state-of-the-art performance demonstrating that our approach is effective in grasping semantics without heuristics in the NLI dataset at supervised contrastive learning. The code is available at https://github.com/whnhch/Break-the-Similarity.

句子表征的对比学习在多项自然语言处理任务中取得了巨大进步。然而,在自然语言推理(NLI)数据集上训练的监督对比学习模型不足以阐明句子的语义,因为它容易根据启发式方法做出预测。本文通过使用 ParsEVAL 和单词重叠度量,证明了 NLI 数据集中的句子对具有很强的句法相似性,并从两个方面提出了弥补这一问题的框架。1) 对假设进行简单的句法转换;2) 将目标扩展为 SupCon Loss,以利用句子的变体。该方法在语义文本相似性(STS)任务和转移任务中进行了评估。在 STS Benchmark 和 SICK Relatedness 中,所提出的方法将基于 BERT 的基线性能提高了 1.48% 和 2.2%。此外,据我们所知,该模型在 HANS 基准数据集上的性能达到了 82.65%,这是目前最先进的性能,表明我们的方法在 NLI 数据集的有监督对比学习中无需启发式方法就能有效地掌握语义。代码见 https://github.com/whnhch/Break-the-Similarity。
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引用次数: 0
A Novel Shape Memory Alloy Modular Robot with Spatially Stable Structure 具有空间稳定结构的新型形状记忆合金模块化机器人
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-15 DOI: 10.1002/aisy.202400091
Junlong Xiao, Michael Yu Wang, Chao Chen

Soft robots exhibit significant flexibility but normally lack stability owing to their inherent low stiffness. Current solutions for achieving variable stiffness or implementing lock mechanisms tend to involve complex structures. Additionally, passive solutions like bistable and multistate mechanisms lack spatial stable characteristics. This study presents a novel shape memory alloy (SMA) modular robot with spatially stable structure, by utilizing gooseneck as the backbone. This is the first time that a concept of spatially stable structure is proposed. When the power is off, the robot can still maintain its current posture in three-dimensional space and resist external disturbance. The SMA spring and gooseneck are characterized, elucidating the mechanism behind achieving spatial stability. Then, a controller based on the inverse kinematics is designed, and validated by experiments. The results demonstrate the structural stability of the robot. Specifically, it can withstand a maximum external force of 2.5 N (0.0875 Nm) when bent at an angle of 20° without consuming energy. Moreover, with the assistance of the SMA spring, this resistance capacity surpasses 5 N (0.175 Nm).

软体机器人具有极大的灵活性,但由于其固有的低刚度,通常缺乏稳定性。目前实现可变刚度或实施锁定机制的解决方案往往涉及复杂的结构。此外,双稳态和多态机制等被动解决方案缺乏空间稳定特性。本研究利用鹅颈作为骨架,提出了一种具有空间稳定结构的新型形状记忆合金(SMA)模块化机器人。这是首次提出空间稳定结构的概念。当电源关闭时,机器人仍能在三维空间中保持当前姿态,抵御外界干扰。本文对 SMA 弹簧和鹅颈进行了描述,阐明了实现空间稳定的机理。然后,设计了基于逆运动学的控制器,并通过实验进行了验证。实验结果证明了机器人的结构稳定性。具体来说,当机器人弯曲 20° 角时,它可以承受 2.5 牛(0.0875 牛米)的最大外力,而不会消耗能量。此外,在 SMA 弹簧的辅助下,这种抵抗能力超过了 5 牛顿(0.175 牛米)。
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引用次数: 0
Optimized Magnetically Docked Ingestible Capsules for Non-Invasive Refilling of Implantable Devices 用于植入式设备非侵入性填充的优化磁性对接可吞食胶囊
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-09 DOI: 10.1002/aisy.202400125
Hind Al-Haddad, Daniele Guarnera, Izadyar Tamadon, Lorenzo Arrico, Giulia Ballardini, Francesco Mariottini, Alessio Cucini, Simone Ricciardi, Fabio Vistoli, Maria Isabella Rotondo, Daniela Campani, Xuyang Ren, Gastone Ciuti, Benjamin Terry, Veronica Iacovacci, Leonardo Ricotti

Automated drug delivery systems (ADDS) improve chronic disease management by enhancing adherence and reducing patient burden, particularly in conditions like type 1 diabetes, through intraperitoneal insulin delivery. However, periodic invasive refilling of the reservoir is needed in such a class of implantable devices. In previous work, an implantable ADDS with a capsule docking system is introduced for non-invasive reservoir refilling. Yet, it encounters reliability issues in manufacturing, sealing, and docking design and lacks evidence on intestinal tissue compression effects and chronic in vivo data. This work proposes an optimization of the different components featuring this ADDS. The ingestible capsule is designed, developed, and tested following ISO 13485, exhibiting high insulin stability and optimal sealing for six days in harsh gastrointestinal-like conditions. A magnetic docking system is optimized, ensuring reliable and stable capsule docking at a clinically relevant distance of 5.92 mm. Histological tests on human intestinal tissues confirm safe capsule compression during docking. Bench tests demonstrate that the integrated mechatronic system effectively docks capsules at various peristalsis-mimicking velocities. A six-week in vivo test on porcine models demonstrates chronic safety and provides hints on fibrotic reactions. These results pave the way for the further evolution of implantable ADDS.

自动给药系统(ADDS)通过腹腔注射胰岛素,提高了患者的依从性,减轻了患者的负担,从而改善了慢性疾病的管理,尤其是对 1 型糖尿病患者而言。然而,这类植入式设备需要定期对储液器进行侵入性加注。在以前的工作中,曾介绍过一种带有胶囊对接系统的植入式 ADDS,可实现无创储液器再充液。然而,它在制造、密封和对接设计方面遇到了可靠性问题,而且缺乏有关肠道组织压缩效应的证据和慢性体内数据。这项研究提出了对该 ADDS 不同组件的优化方案。按照 ISO 13485 标准设计、开发和测试了可食用胶囊,其胰岛素稳定性高,在类似胃肠道的苛刻条件下可保持六天的最佳密封性。磁性对接系统经过优化,可确保在 5.92 毫米的临床相关距离内可靠、稳定地对接胶囊。对人体肠道组织的组织学测试证实,在对接过程中胶囊的压缩是安全的。工作台测试表明,集成机电一体化系统可在各种蠕动模拟速度下有效对接胶囊。在猪模型上进行的为期六周的体内试验证明了其长期安全性,并提供了有关纤维化反应的提示。这些结果为植入式 ADDS 的进一步发展铺平了道路。
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引用次数: 0
A Review on the Form and Complexity of Human–Robot Interaction in the Evolution of Autonomous Surgery 自主手术发展过程中人机互动的形式与复杂性综述
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-09 DOI: 10.1002/aisy.202400197
Tangyou Liu, Jiaole Wang, Shing Wong, Andrew Razjigaev, Susann Beier, Shuhua Peng, Thanh Nho Do, Shuang Song, Dewei Chu, Chun Hui Wang, Nigel H. Lovell, Liao Wu

As robotics and intelligence increasingly integrate into surgery, the pivotal role of human–robot interaction (HRI) in surgical procedures and outcomes becomes evident. However, debate rages over whether increasing robot autonomy will result in less human involvement. Some scholars assert that autonomy will reduce human participation, whereas others contend it will result in more complex interactions. To reveal the role of HRI in the evolution of autonomous surgery, this review systematically explores the HRI of robotic surgery with various levels of autonomy. The HRI is examined from both robotic science and clinical practice perspectives, incorporating relevant case studies. Two key components, intention detection and situation awareness, are especially concerned with a brief description of the interfaces and control strategies they rely on. Additional insights are drawn from analogous technologies in aviation, industrial robotics, and autonomous vehicles. The analysis suggests that HRI complexity tends to increase as the robot transitions from no autonomy to conditional autonomy and is predicted to subsequently decrease with a substantial shift in the interaction form when moving toward full autonomy. It is concluded by highlighting challenges from technical and clinical perspectives and delineating research trends in this rapidly evolving field.

随着机器人技术和智能技术越来越多地融入外科手术,人机互动(HRI)在手术过程和结果中的关键作用变得显而易见。然而,关于机器人自主性的提高是否会导致人类参与减少的争论仍在激烈进行。一些学者认为,自主性会减少人类的参与,而另一些学者则认为,自主性会带来更复杂的互动。为了揭示人机交互在自主外科手术发展过程中的作用,本综述系统地探讨了具有不同自主水平的机器人外科手术的人机交互。本综述从机器人科学和临床实践两个角度,并结合相关案例研究,对人机交互界面进行了探讨。其中特别关注意图检测和情境感知这两个关键部分,并简要介绍了它们所依赖的界面和控制策略。此外,还从航空、工业机器人和自动驾驶汽车等领域的类似技术中汲取了更多启示。分析表明,当机器人从无自主过渡到有条件自主时,人机交互的复杂性往往会增加,而在向完全自主过渡时,随着交互形式的重大转变,复杂性预计会随之降低。最后,报告从技术和临床角度强调了所面临的挑战,并勾勒出这一快速发展领域的研究趋势。
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引用次数: 0
Enhancing Longitudinal Flight Performance of Drones through the Coupling of Wings Morphing and Deflection of Aerodynamic Surfaces 通过机翼变形和空气动力表面偏转的耦合增强无人机的纵向飞行性能
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-09 DOI: 10.1002/aisy.202300709
Junming Zhang, Yubin Liu, Liang Gao, Yanhe Zhu, Xizhe Zang, Hegao Cai, Jie Zhao

In nature, gliding birds frequently execute intricate flight maneuvers such as aerial somersaults, perched landings, and swift descents, enabling them to navigate obstacles or hunt prey. It is evident that birds rely on different wing–tail configurations to accomplish a wide range of aerial maneuvers. For traditional fixed-wing unmanned aerial vehicles (UAVs), pitch control primarily comes from the tail's elevators, while adjusting flight lift and drag involves deploying wing flaps. Although these designs ensure reliable flight, they compromise the drones’ maneuverability to maintain longitudinal stability. Therefore, the study introduces a biomimetic morphing wing UAV, and presents a pitch control strategy that simultaneously engages morphing wings, ailerons, and tail elevators. The pull-up maneuver tests indicate that the proposed control method results in a pitch rate that is approximately 2.5 times greater than when using only the elevator control. A closed-loop control system for the drone is also established. The closed-loop flight experiment, which tracks a 45° pitch angle, demonstrates the effectiveness of the proposed coupled control method in adjusting the flight attitude. In addition, during cruising, the UAV employs three configurations, straight wing, forward-swept wing, and back-swept wing, to cater to different mission objectives and augment its flight capabilities.

在自然界中,滑翔鸟类经常执行复杂的飞行动作,如空中翻筋斗、栖息着陆和迅速下降,使它们能够穿越障碍物或捕食猎物。显然,鸟类依靠不同的翼尾配置来完成各种空中机动。对于传统的固定翼无人飞行器(UAV)来说,俯仰控制主要来自尾部的升降舵,而调整飞行升力和阻力则需要展开襟翼。虽然这些设计能确保飞行的可靠性,但却影响了无人机保持纵向稳定性的机动性。因此,本研究引入了仿生物变形翼无人机,并提出了一种同时使用变形翼、副翼和尾部升降舵的俯仰控制策略。拉升机动测试表明,所提出的控制方法可使俯仰率比仅使用升降舵控制时提高约 2.5 倍。此外,还建立了无人机闭环控制系统。闭环飞行实验跟踪了 45° 的俯仰角,证明了所提出的耦合控制方法在调整飞行姿态方面的有效性。此外,在巡航过程中,无人机采用了直翼、前掠翼和后掠翼三种配置,以满足不同的任务目标并增强其飞行能力。
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引用次数: 0
A Flexible, Architected Soft Robotic Actuator for Motorized Extensional Motion 用于电动伸展运动的灵活、结构化软机器人致动器
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-08 DOI: 10.1002/aisy.202300866
Taekyoung Kim, Pranav Kaarthik, Ryan L. Truby

To advance the design space of electrically-driven soft actuators, a flexible, architected soft robotic actuator is presented for motor-driven extensional motion. The actuator comprises a 3D printed, cylindrical handed shearing auxetic (HSA) structure and a deformable, internal rubber bellows shaft. The actuator linearly extends upon applying torque from a servo motor; the rubber bellows shaft is stretchable but resistant to torsional deflection, allowing it to transmit torque from the servo motor to the other end of the HSA. The high flexibility of the HSA and rubber bellows shaft enable the actuator to adaptively extend even when bent. The actuator's two components and its performance are mechanically characterized. Actuation strains of 45% elongation and a maximum blocked pushing force of about 8 N are demonstrated. The actuator's capabilities are showcased in two separate demonstrations: a crawling robot and a sensorized artificial muscle that integrates a microfluidic, liquid metal strain sensor. The architected material design approach for a robust, motor-driven soft actuator provides several unique features—including a compact form factor and ease of use—over other motorized soft robotic actuators based on HSA assemblies or cable tendon mechanisms.

为了拓展电驱动软致动器的设计空间,本文介绍了一种用于电机驱动伸展运动的灵活、结构化软机器人致动器。该致动器包括一个 3D 打印的圆柱形手动剪切辅助(HSA)结构和一个可变形的内部橡胶波纹管轴。当伺服电机施加扭矩时,致动器可线性伸展;橡胶波纹管轴可伸展,但不易扭转变形,使其能够将伺服电机的扭矩传递到 HSA 的另一端。HSA 和橡胶波纹管轴的高弹性使推杆即使在弯曲时也能自适应伸展。推杆的两个组件及其性能均具有机械特性。结果表明,致动器的伸长应变为 45%,最大阻挡推力约为 8 N。致动器的功能在两个独立的演示中得到了展示:爬行机器人和集成了微流体液态金属应变传感器的传感人造肌肉。与其他基于 HSA 组件或缆索腱机制的电动软机器人致动器相比,用于坚固耐用的电机驱动软致动器的结构化材料设计方法具有多个独特功能,包括外形紧凑和易于使用。
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引用次数: 0
Morphology Classification of Live Unstained Human Sperm Using Ensemble Deep Learning 利用集合深度学习对未染色人类活精子进行形态学分类
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-08 DOI: 10.1002/aisy.202400141
Sahar Shahali, Mubasshir Murshed, Lindsay Spencer, Ozlem Tunc, Ludmila Pisarevski, Jason Conceicao, Robert McLachlan, Moira K. O’Bryan, Klaus Ackermann, Deirdre Zander-Fox, Adrian Neild, Reza Nosrati

Sperm morphology analysis is crucial in infertility diagnosis and treatment. However, current clinical analytical methods use either chemical stains that render cells unusable for treatment or rely on subjective manual inspection. Here, an ensemble deep-learning model is presented for classification of live, unstained human sperm using whole-cell morphology. This model achieves an accuracy and precision of 94% benchmarked against the consensus of three andrology scientists who classified the images independently. The model loses less than a 12% prediction performance even when image resolution is reduced by over sixfold. This ensures compatibility across varied clinical imaging setups. This model also provides a high certainty and robust classification of challenging images, which divided the experts. By providing a consistent, automated approach for classifying live, unstained cells using quantitative data, this model offers promising future opportunities for enhancing clinical sperm selection practices and reducing day-to-day variability in clinics.

精子形态分析对不孕症的诊断和治疗至关重要。然而,目前的临床分析方法要么使用化学染色剂使细胞无法用于治疗,要么依赖主观的人工检查。本文介绍了一种集合深度学习模型,用于利用全细胞形态学对未染色的人类活精子进行分类。该模型的准确率和精确度均达到 94%,并以三位独立对图像进行分类的男性学科学家的共识为基准。即使图像分辨率降低六倍以上,该模型的预测性能损失也不到 12%。这确保了各种临床成像设置的兼容性。该模型还能对专家们意见不一的具有挑战性的图像进行高确定性和稳健的分类。该模型提供了一种使用定量数据对未染色活细胞进行分类的一致、自动化方法,为加强临床精子选择实践和减少诊所的日常变异性提供了大有可为的机会。
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引用次数: 0
Pushing with Soft Robotic Arms via Deep Reinforcement Learning 通过深度强化学习实现软机械臂推举
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-08 DOI: 10.1002/aisy.202300899
Carlo Alessi, Diego Bianchi, Gianni Stano, Matteo Cianchetti, Egidio Falotico
<p>Soft robots can adaptively interact with unstructured environments. However, nonlinear soft material properties challenge modeling and control. Learning-based controllers that leverage efficient mechanical models are promising for solving complex interaction tasks. This article develops a closed-loop pose/force controller for a dexterous soft manipulator enabling dynamic pushing tasks using deep reinforcement learning. Force tests investigate the mechanical properties of a soft robot module, resulting in orthogonal forces of <span></span><math> <semantics> <mrow> <mn>9</mn> <mo>−</mo> <mn>13</mn> </mrow> <annotation>$9 - 13$</annotation> </semantics></math> N. Then, the policy is trained in simulation leveraging a dynamic Cosserat rod model of the soft robot. Domain randomization mitigate the sim-to-real gap while careful reward engineering induced pose and force control even without explicit force inputs. Despite the approximate simulation, the sim-to-real transfer achieved an average reaching distance of <span></span><math> <semantics> <mrow> <mn>34</mn> <mo>±</mo> <mn>14</mn> </mrow> <annotation>$34 pm 14$</annotation> </semantics></math> mm (<span></span><math> <semantics> <mrow> <mn>8.1</mn> <mo>%</mo> <mi>L</mi> <mo>±</mo> <mn>3.4</mn> <mo>%</mo> <mi>L</mi> </mrow> <annotation>$ L pm L$</annotation> </semantics></math>), an average orientation error of <span></span><math> <semantics> <mrow> <mn>0.40</mn> <mo>±</mo> <mn>0.29</mn> </mrow> <annotation>$0.40 pm 0.29$</annotation> </semantics></math> rad (<span></span><math> <semantics> <mrow> <mrow> <mn>23</mn> </mrow> <mo>°</mo> <mo>±</mo> <mrow> <mn>17</mn> </mrow> <mo>°</mo> </mrow> <annotation>$left(23right)^{circ} pm left(17right)^{circ}$</annotation> </semantics></math>) and applied pushing forces up to <span></span><math> <semantics> <mn>3</mn> <annotation>$3$</annotation> </semantics></math> N. Such performance is reasonable for the intended assistive tasks of the manipulator. The exper
软体机器人可以自适应地与非结构化环境互动。然而,非线性软材料特性对建模和控制提出了挑战。利用高效机械模型的学习型控制器有望解决复杂的交互任务。本文为灵巧的软机械手开发了一种闭环姿势/力控制器,利用深度强化学习实现动态推动任务。力测试研究了软体机器人模块的机械特性,得出了 N 的正交力。然后,利用软体机器人的动态 Cosserat 杆模型对策略进行仿真训练。域随机化减轻了模拟与实际之间的差距,同时,即使没有明确的力输入,精心设计的奖励工程也能诱导姿势和力控制。尽管是近似模拟,但模拟到实际的转换实现了平均达毫米()的伸手距离,平均方位误差为弧度(),施加的推力高达 N。对于机械手的预期辅助任务来说,这样的性能是合理的。实验发现,与环境互动的软体机器人表现出扭转和平衡运动。虽然没有明确强制执行,但它们来自机械手的机械智能。这些结果证明了通过强化学习进行软机器人操纵的潜力。
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引用次数: 0
Super-Resolution of Histopathological Frozen Sections via Deep Learning Preserving Tissue Structure 通过深度学习实现组织病理学冷冻切片的超分辨率,保留组织结构
IF 6.8 Q1 AUTOMATION & CONTROL SYSTEMS Pub Date : 2024-07-08 DOI: 10.1002/aisy.202300672
Elad Yoshai, Gil Goldinger, Miki Haifler, Natan T. Shaked

Histopathology plays a pivotal role in medical diagnostics. In contrast to preparing permanent sections for histopathology, a time-consuming process, preparing frozen sections is significantly faster and can be performed during surgery, where the sample scanning time should be optimized. Super-resolution techniques allow imaging of histopathalogical samples in lower magnification, thus sparing scanning time. Herein, a new approach is presented to super-resolution of histopathological frozen sections, with focus on achieving better distortion measures, rather than pursuing photorealistic images that may compromise critical diagnostic information. Our deep-learning architecture focuses on learning the error between interpolated images and real images; thereby generating high-resolution images while preserving critical image details, which reduces the risk of diagnostic misinterpretation. This is done by leveraging the loss functions in the frequency domain and assigning higher weights to the reconstruction of complex, high-frequency components. In comparison with existing methods, significant improvements are obtained in terms of distortion metrics, improving the pathologist's clinical decisions. This approach has a great potential to provide faster frozen-section imaging, with less scanning, speeding up intraoperative decisions, while preserving the high-resolution details in the imaged sample.

组织病理学在医学诊断中起着举足轻重的作用。与制作组织病理学永久切片这一耗时的过程相比,制作冷冻切片要快得多,而且可以在手术过程中进行,从而优化样本扫描时间。超分辨率技术能以较低的放大率对组织病理学样本进行成像,从而节省扫描时间。本文提出了一种组织病理学冰冻切片超分辨率的新方法,重点是实现更好的失真测量,而不是追求可能会损害关键诊断信息的逼真图像。我们的深度学习架构侧重于学习插值图像与真实图像之间的误差,从而在生成高分辨率图像的同时保留关键图像细节,降低诊断误读的风险。这是通过利用频域中的损失函数并为复杂的高频成分重建分配更高的权重来实现的。与现有方法相比,该方法在失真指标方面取得了显著改善,从而提高了病理学家的临床决策水平。这种方法在提供更快的冷冻切片成像、减少扫描次数、加快术中决策、同时保留成像样本的高分辨率细节方面具有巨大潜力。
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Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)
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