Pavel Potocek, Cigdem Ozsoy-Keskinbora, Philipp Müller, Thorsten Wieczorek, Maurice Peemen, Philipp Slusallek, Bert Freitag
Nanomaterial properties and functionalities are influenced by their shape, size, and chemical composition. The importance of these parameters highlights the need for a statistically robust analysis of a large particle population, necessitating automation. This study introduces a neural network-empowered smart scan technique that achieves a relative increase in speed compared to traditional energy-dispersive X-ray spectroscopy (EDX) mapping. The main advantage is that it reduces the required dose, decreasing potential damage to the sample by avoiding unnecessary exposure. It holds potential use in other multimodal scanning transmission electron microscopy or scanning-based imaging approaches. In the first example, identifying particles in a matrix with a trained neural network reduces the acquisition time by two orders of magnitude. This acceleration enables a statistical compositional analysis of thousands of particles in less than 1 h. Similar improvements are observed for atomic resolution. The discrete positions of atoms identified by the trained network allow for selective EDX sampling at these centers, thereby identifying the atomic species of the column with much-reduced sampling. Consequently, a lower sampling dose is required, enabling mapping of more delicate materials with high lateral resolution and at a high statistical confidence interval. Even though manual training is still required, this approach greatly benefits repetitive quality control tasks.
纳米材料的特性和功能受其形状、尺寸和化学成分的影响。这些参数的重要性凸显了对大量粒子群进行稳健统计分析的必要性,因此必须实现自动化。本研究介绍了一种神经网络驱动的智能扫描技术,与传统的能量色散 X 射线光谱(EDX)绘图相比,该技术的速度相对提高。其主要优点是减少了所需剂量,避免了不必要的曝光,从而降低了对样品的潜在损害。它在其他多模态扫描透射电子显微镜或基于扫描的成像方法中也有潜在用途。在第一个例子中,利用训练有素的神经网络识别矩阵中的颗粒可将采集时间缩短两个数量级。在原子分辨率方面也有类似的改进。通过训练有素的网络识别原子的离散位置,可以在这些中心进行选择性 EDX 取样,从而在大大减少取样的情况下识别柱中的原子种类。因此,所需的取样剂量更低,从而能够以高横向分辨率和高统计置信区间绘制更精细的材料。尽管仍需要人工培训,但这种方法对重复性质量控制任务大有裨益。
{"title":"Artificial Intelligence-Driven Smart Scan: A Rapid, Automatic Approach for Comprehensive Imaging and Spectroscopy for Fast Compositional Analysis","authors":"Pavel Potocek, Cigdem Ozsoy-Keskinbora, Philipp Müller, Thorsten Wieczorek, Maurice Peemen, Philipp Slusallek, Bert Freitag","doi":"10.1002/aisy.202300745","DOIUrl":"10.1002/aisy.202300745","url":null,"abstract":"<p>Nanomaterial properties and functionalities are influenced by their shape, size, and chemical composition. The importance of these parameters highlights the need for a statistically robust analysis of a large particle population, necessitating automation. This study introduces a neural network-empowered smart scan technique that achieves a relative increase in speed compared to traditional energy-dispersive X-ray spectroscopy (EDX) mapping. The main advantage is that it reduces the required dose, decreasing potential damage to the sample by avoiding unnecessary exposure. It holds potential use in other multimodal scanning transmission electron microscopy or scanning-based imaging approaches. In the first example, identifying particles in a matrix with a trained neural network reduces the acquisition time by two orders of magnitude. This acceleration enables a statistical compositional analysis of thousands of particles in less than 1 h. Similar improvements are observed for atomic resolution. The discrete positions of atoms identified by the trained network allow for selective EDX sampling at these centers, thereby identifying the atomic species of the column with much-reduced sampling. Consequently, a lower sampling dose is required, enabling mapping of more delicate materials with high lateral resolution and at a high statistical confidence interval. Even though manual training is still required, this approach greatly benefits repetitive quality control tasks.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 8","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202300745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minji Kim, Whanhee Cho, Soohyeong Kim, Yong Suk Choi
Contrastive learning of sentence representations has achieved great improvements in several natural language processing tasks. However, the supervised contrastive learning model trained on the natural language inference (NLI) dataset is insufficient to elucidate the semantics of sentences since it is prone to make a prediction based on heuristics. Herein, by using the ParsEVAL and the word overlap metric, it is shown that sentence pairs in the NLI dataset have strong syntactic similarity and propose a framework to compensate for this problem in two aspects. 1) Apply simple syntactic transformations to the hypothesis and 2) expand the objective to SupCon Loss to leverage variants of sentences. The method is evaluated on semantic textual similarity (STS) tasks and transfer tasks. The proposed methods improve the performance of the BERT-based baseline in STS Benchmark and SICK Relatedness by 1.48% and 2.2%. Furthermore, the model achieves 82.65% on the HANS benchmark dataset, to the best of our knowledge, which is a state-of-the-art performance demonstrating that our approach is effective in grasping semantics without heuristics in the NLI dataset at supervised contrastive learning. The code is available at https://github.com/whnhch/Break-the-Similarity.
{"title":"Simple Data Transformations for Mitigating the Syntactic Similarity to Improve Sentence Embeddings at Supervised Contrastive Learning","authors":"Minji Kim, Whanhee Cho, Soohyeong Kim, Yong Suk Choi","doi":"10.1002/aisy.202300717","DOIUrl":"10.1002/aisy.202300717","url":null,"abstract":"<p>Contrastive learning of sentence representations has achieved great improvements in several natural language processing tasks. However, the supervised contrastive learning model trained on the natural language inference (NLI) dataset is insufficient to elucidate the semantics of sentences since it is prone to make a prediction based on heuristics. Herein, by using the ParsEVAL and the word overlap metric, it is shown that sentence pairs in the NLI dataset have strong syntactic similarity and propose a framework to compensate for this problem in two aspects. 1) Apply simple syntactic transformations to the hypothesis and 2) expand the objective to SupCon Loss to leverage variants of sentences. The method is evaluated on semantic textual similarity (STS) tasks and transfer tasks. The proposed methods improve the performance of the BERT-based baseline in STS Benchmark and SICK Relatedness by 1.48% and 2.2%. Furthermore, the model achieves 82.65% on the HANS benchmark dataset, to the best of our knowledge, which is a state-of-the-art performance demonstrating that our approach is effective in grasping semantics without heuristics in the NLI dataset at supervised contrastive learning. The code is available at https://github.com/whnhch/Break-the-Similarity.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 8","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202300717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soft robots exhibit significant flexibility but normally lack stability owing to their inherent low stiffness. Current solutions for achieving variable stiffness or implementing lock mechanisms tend to involve complex structures. Additionally, passive solutions like bistable and multistate mechanisms lack spatial stable characteristics. This study presents a novel shape memory alloy (SMA) modular robot with spatially stable structure, by utilizing gooseneck as the backbone. This is the first time that a concept of spatially stable structure is proposed. When the power is off, the robot can still maintain its current posture in three-dimensional space and resist external disturbance. The SMA spring and gooseneck are characterized, elucidating the mechanism behind achieving spatial stability. Then, a controller based on the inverse kinematics is designed, and validated by experiments. The results demonstrate the structural stability of the robot. Specifically, it can withstand a maximum external force of 2.5 N (0.0875 Nm) when bent at an angle of 20° without consuming energy. Moreover, with the assistance of the SMA spring, this resistance capacity surpasses 5 N (0.175 Nm).
软体机器人具有极大的灵活性,但由于其固有的低刚度,通常缺乏稳定性。目前实现可变刚度或实施锁定机制的解决方案往往涉及复杂的结构。此外,双稳态和多态机制等被动解决方案缺乏空间稳定特性。本研究利用鹅颈作为骨架,提出了一种具有空间稳定结构的新型形状记忆合金(SMA)模块化机器人。这是首次提出空间稳定结构的概念。当电源关闭时,机器人仍能在三维空间中保持当前姿态,抵御外界干扰。本文对 SMA 弹簧和鹅颈进行了描述,阐明了实现空间稳定的机理。然后,设计了基于逆运动学的控制器,并通过实验进行了验证。实验结果证明了机器人的结构稳定性。具体来说,当机器人弯曲 20° 角时,它可以承受 2.5 牛(0.0875 牛米)的最大外力,而不会消耗能量。此外,在 SMA 弹簧的辅助下,这种抵抗能力超过了 5 牛顿(0.175 牛米)。
{"title":"A Novel Shape Memory Alloy Modular Robot with Spatially Stable Structure","authors":"Junlong Xiao, Michael Yu Wang, Chao Chen","doi":"10.1002/aisy.202400091","DOIUrl":"10.1002/aisy.202400091","url":null,"abstract":"<p>Soft robots exhibit significant flexibility but normally lack stability owing to their inherent low stiffness. Current solutions for achieving variable stiffness or implementing lock mechanisms tend to involve complex structures. Additionally, passive solutions like bistable and multistate mechanisms lack spatial stable characteristics. This study presents a novel shape memory alloy (SMA) modular robot with spatially stable structure, by utilizing gooseneck as the backbone. This is the first time that a concept of spatially stable structure is proposed. When the power is off, the robot can still maintain its current posture in three-dimensional space and resist external disturbance. The SMA spring and gooseneck are characterized, elucidating the mechanism behind achieving spatial stability. Then, a controller based on the inverse kinematics is designed, and validated by experiments. The results demonstrate the structural stability of the robot. Specifically, it can withstand a maximum external force of 2.5 N (0.0875 Nm) when bent at an angle of 20° without consuming energy. Moreover, with the assistance of the SMA spring, this resistance capacity surpasses 5 N (0.175 Nm).</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 10","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202400091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hind Al-Haddad, Daniele Guarnera, Izadyar Tamadon, Lorenzo Arrico, Giulia Ballardini, Francesco Mariottini, Alessio Cucini, Simone Ricciardi, Fabio Vistoli, Maria Isabella Rotondo, Daniela Campani, Xuyang Ren, Gastone Ciuti, Benjamin Terry, Veronica Iacovacci, Leonardo Ricotti
Automated drug delivery systems (ADDS) improve chronic disease management by enhancing adherence and reducing patient burden, particularly in conditions like type 1 diabetes, through intraperitoneal insulin delivery. However, periodic invasive refilling of the reservoir is needed in such a class of implantable devices. In previous work, an implantable ADDS with a capsule docking system is introduced for non-invasive reservoir refilling. Yet, it encounters reliability issues in manufacturing, sealing, and docking design and lacks evidence on intestinal tissue compression effects and chronic in vivo data. This work proposes an optimization of the different components featuring this ADDS. The ingestible capsule is designed, developed, and tested following ISO 13485, exhibiting high insulin stability and optimal sealing for six days in harsh gastrointestinal-like conditions. A magnetic docking system is optimized, ensuring reliable and stable capsule docking at a clinically relevant distance of 5.92 mm. Histological tests on human intestinal tissues confirm safe capsule compression during docking. Bench tests demonstrate that the integrated mechatronic system effectively docks capsules at various peristalsis-mimicking velocities. A six-week in vivo test on porcine models demonstrates chronic safety and provides hints on fibrotic reactions. These results pave the way for the further evolution of implantable ADDS.
{"title":"Optimized Magnetically Docked Ingestible Capsules for Non-Invasive Refilling of Implantable Devices","authors":"Hind Al-Haddad, Daniele Guarnera, Izadyar Tamadon, Lorenzo Arrico, Giulia Ballardini, Francesco Mariottini, Alessio Cucini, Simone Ricciardi, Fabio Vistoli, Maria Isabella Rotondo, Daniela Campani, Xuyang Ren, Gastone Ciuti, Benjamin Terry, Veronica Iacovacci, Leonardo Ricotti","doi":"10.1002/aisy.202400125","DOIUrl":"10.1002/aisy.202400125","url":null,"abstract":"<p>Automated drug delivery systems (ADDS) improve chronic disease management by enhancing adherence and reducing patient burden, particularly in conditions like type 1 diabetes, through intraperitoneal insulin delivery. However, periodic invasive refilling of the reservoir is needed in such a class of implantable devices. In previous work, an implantable ADDS with a capsule docking system is introduced for non-invasive reservoir refilling. Yet, it encounters reliability issues in manufacturing, sealing, and docking design and lacks evidence on intestinal tissue compression effects and chronic in vivo data. This work proposes an optimization of the different components featuring this ADDS. The ingestible capsule is designed, developed, and tested following ISO 13485, exhibiting high insulin stability and optimal sealing for six days in harsh gastrointestinal-like conditions. A magnetic docking system is optimized, ensuring reliable and stable capsule docking at a clinically relevant distance of 5.92 mm. Histological tests on human intestinal tissues confirm safe capsule compression during docking. Bench tests demonstrate that the integrated mechatronic system effectively docks capsules at various peristalsis-mimicking velocities. A six-week in vivo test on porcine models demonstrates chronic safety and provides hints on fibrotic reactions. These results pave the way for the further evolution of implantable ADDS.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 11","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202400125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tangyou Liu, Jiaole Wang, Shing Wong, Andrew Razjigaev, Susann Beier, Shuhua Peng, Thanh Nho Do, Shuang Song, Dewei Chu, Chun Hui Wang, Nigel H. Lovell, Liao Wu
As robotics and intelligence increasingly integrate into surgery, the pivotal role of human–robot interaction (HRI) in surgical procedures and outcomes becomes evident. However, debate rages over whether increasing robot autonomy will result in less human involvement. Some scholars assert that autonomy will reduce human participation, whereas others contend it will result in more complex interactions. To reveal the role of HRI in the evolution of autonomous surgery, this review systematically explores the HRI of robotic surgery with various levels of autonomy. The HRI is examined from both robotic science and clinical practice perspectives, incorporating relevant case studies. Two key components, intention detection and situation awareness, are especially concerned with a brief description of the interfaces and control strategies they rely on. Additional insights are drawn from analogous technologies in aviation, industrial robotics, and autonomous vehicles. The analysis suggests that HRI complexity tends to increase as the robot transitions from no autonomy to conditional autonomy and is predicted to subsequently decrease with a substantial shift in the interaction form when moving toward full autonomy. It is concluded by highlighting challenges from technical and clinical perspectives and delineating research trends in this rapidly evolving field.
{"title":"A Review on the Form and Complexity of Human–Robot Interaction in the Evolution of Autonomous Surgery","authors":"Tangyou Liu, Jiaole Wang, Shing Wong, Andrew Razjigaev, Susann Beier, Shuhua Peng, Thanh Nho Do, Shuang Song, Dewei Chu, Chun Hui Wang, Nigel H. Lovell, Liao Wu","doi":"10.1002/aisy.202400197","DOIUrl":"10.1002/aisy.202400197","url":null,"abstract":"<p>As robotics and intelligence increasingly integrate into surgery, the pivotal role of human–robot interaction (HRI) in surgical procedures and outcomes becomes evident. However, debate rages over whether increasing robot autonomy will result in less human involvement. Some scholars assert that autonomy will reduce human participation, whereas others contend it will result in more complex interactions. To reveal the role of HRI in the evolution of autonomous surgery, this review systematically explores the HRI of robotic surgery with various levels of autonomy. The HRI is examined from both robotic science and clinical practice perspectives, incorporating relevant case studies. Two key components, intention detection and situation awareness, are especially concerned with a brief description of the interfaces and control strategies they rely on. Additional insights are drawn from analogous technologies in aviation, industrial robotics, and autonomous vehicles. The analysis suggests that HRI complexity tends to increase as the robot transitions from no autonomy to conditional autonomy and is predicted to subsequently decrease with a substantial shift in the interaction form when moving toward full autonomy. It is concluded by highlighting challenges from technical and clinical perspectives and delineating research trends in this rapidly evolving field.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 11","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202400197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In nature, gliding birds frequently execute intricate flight maneuvers such as aerial somersaults, perched landings, and swift descents, enabling them to navigate obstacles or hunt prey. It is evident that birds rely on different wing–tail configurations to accomplish a wide range of aerial maneuvers. For traditional fixed-wing unmanned aerial vehicles (UAVs), pitch control primarily comes from the tail's elevators, while adjusting flight lift and drag involves deploying wing flaps. Although these designs ensure reliable flight, they compromise the drones’ maneuverability to maintain longitudinal stability. Therefore, the study introduces a biomimetic morphing wing UAV, and presents a pitch control strategy that simultaneously engages morphing wings, ailerons, and tail elevators. The pull-up maneuver tests indicate that the proposed control method results in a pitch rate that is approximately 2.5 times greater than when using only the elevator control. A closed-loop control system for the drone is also established. The closed-loop flight experiment, which tracks a 45° pitch angle, demonstrates the effectiveness of the proposed coupled control method in adjusting the flight attitude. In addition, during cruising, the UAV employs three configurations, straight wing, forward-swept wing, and back-swept wing, to cater to different mission objectives and augment its flight capabilities.
{"title":"Enhancing Longitudinal Flight Performance of Drones through the Coupling of Wings Morphing and Deflection of Aerodynamic Surfaces","authors":"Junming Zhang, Yubin Liu, Liang Gao, Yanhe Zhu, Xizhe Zang, Hegao Cai, Jie Zhao","doi":"10.1002/aisy.202300709","DOIUrl":"10.1002/aisy.202300709","url":null,"abstract":"<p>In nature, gliding birds frequently execute intricate flight maneuvers such as aerial somersaults, perched landings, and swift descents, enabling them to navigate obstacles or hunt prey. It is evident that birds rely on different wing–tail configurations to accomplish a wide range of aerial maneuvers. For traditional fixed-wing unmanned aerial vehicles (UAVs), pitch control primarily comes from the tail's elevators, while adjusting flight lift and drag involves deploying wing flaps. Although these designs ensure reliable flight, they compromise the drones’ maneuverability to maintain longitudinal stability. Therefore, the study introduces a biomimetic morphing wing UAV, and presents a pitch control strategy that simultaneously engages morphing wings, ailerons, and tail elevators. The pull-up maneuver tests indicate that the proposed control method results in a pitch rate that is approximately 2.5 times greater than when using only the elevator control. A closed-loop control system for the drone is also established. The closed-loop flight experiment, which tracks a 45° pitch angle, demonstrates the effectiveness of the proposed coupled control method in adjusting the flight attitude. In addition, during cruising, the UAV employs three configurations, straight wing, forward-swept wing, and back-swept wing, to cater to different mission objectives and augment its flight capabilities.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 8","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202300709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To advance the design space of electrically-driven soft actuators, a flexible, architected soft robotic actuator is presented for motor-driven extensional motion. The actuator comprises a 3D printed, cylindrical handed shearing auxetic (HSA) structure and a deformable, internal rubber bellows shaft. The actuator linearly extends upon applying torque from a servo motor; the rubber bellows shaft is stretchable but resistant to torsional deflection, allowing it to transmit torque from the servo motor to the other end of the HSA. The high flexibility of the HSA and rubber bellows shaft enable the actuator to adaptively extend even when bent. The actuator's two components and its performance are mechanically characterized. Actuation strains of 45% elongation and a maximum blocked pushing force of about 8 N are demonstrated. The actuator's capabilities are showcased in two separate demonstrations: a crawling robot and a sensorized artificial muscle that integrates a microfluidic, liquid metal strain sensor. The architected material design approach for a robust, motor-driven soft actuator provides several unique features—including a compact form factor and ease of use—over other motorized soft robotic actuators based on HSA assemblies or cable tendon mechanisms.
{"title":"A Flexible, Architected Soft Robotic Actuator for Motorized Extensional Motion","authors":"Taekyoung Kim, Pranav Kaarthik, Ryan L. Truby","doi":"10.1002/aisy.202300866","DOIUrl":"10.1002/aisy.202300866","url":null,"abstract":"<p>To advance the design space of electrically-driven soft actuators, a flexible, architected soft robotic actuator is presented for motor-driven extensional motion. The actuator comprises a 3D printed, cylindrical handed shearing auxetic (HSA) structure and a deformable, internal rubber bellows shaft. The actuator linearly extends upon applying torque from a servo motor; the rubber bellows shaft is stretchable but resistant to torsional deflection, allowing it to transmit torque from the servo motor to the other end of the HSA. The high flexibility of the HSA and rubber bellows shaft enable the actuator to adaptively extend even when bent. The actuator's two components and its performance are mechanically characterized. Actuation strains of 45% elongation and a maximum blocked pushing force of about 8 N are demonstrated. The actuator's capabilities are showcased in two separate demonstrations: a crawling robot and a sensorized artificial muscle that integrates a microfluidic, liquid metal strain sensor. The architected material design approach for a robust, motor-driven soft actuator provides several unique features—including a compact form factor and ease of use—over other motorized soft robotic actuators based on HSA assemblies or cable tendon mechanisms.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 11","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202300866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Shahali, Mubasshir Murshed, Lindsay Spencer, Ozlem Tunc, Ludmila Pisarevski, Jason Conceicao, Robert McLachlan, Moira K. O’Bryan, Klaus Ackermann, Deirdre Zander-Fox, Adrian Neild, Reza Nosrati
Sperm morphology analysis is crucial in infertility diagnosis and treatment. However, current clinical analytical methods use either chemical stains that render cells unusable for treatment or rely on subjective manual inspection. Here, an ensemble deep-learning model is presented for classification of live, unstained human sperm using whole-cell morphology. This model achieves an accuracy and precision of 94% benchmarked against the consensus of three andrology scientists who classified the images independently. The model loses less than a 12% prediction performance even when image resolution is reduced by over sixfold. This ensures compatibility across varied clinical imaging setups. This model also provides a high certainty and robust classification of challenging images, which divided the experts. By providing a consistent, automated approach for classifying live, unstained cells using quantitative data, this model offers promising future opportunities for enhancing clinical sperm selection practices and reducing day-to-day variability in clinics.
{"title":"Morphology Classification of Live Unstained Human Sperm Using Ensemble Deep Learning","authors":"Sahar Shahali, Mubasshir Murshed, Lindsay Spencer, Ozlem Tunc, Ludmila Pisarevski, Jason Conceicao, Robert McLachlan, Moira K. O’Bryan, Klaus Ackermann, Deirdre Zander-Fox, Adrian Neild, Reza Nosrati","doi":"10.1002/aisy.202400141","DOIUrl":"10.1002/aisy.202400141","url":null,"abstract":"<p>Sperm morphology analysis is crucial in infertility diagnosis and treatment. However, current clinical analytical methods use either chemical stains that render cells unusable for treatment or rely on subjective manual inspection. Here, an ensemble deep-learning model is presented for classification of live, unstained human sperm using <i>whole-cell</i> morphology. This model achieves an accuracy and precision of 94% benchmarked against the consensus of three andrology scientists who classified the images independently. The model loses less than a 12% prediction performance even when image resolution is reduced by over sixfold. This ensures compatibility across varied clinical imaging setups. This model also provides a high certainty and robust classification of challenging images, which divided the experts. By providing a consistent, automated approach for classifying live, unstained cells using quantitative data, this model offers promising future opportunities for enhancing clinical sperm selection practices and reducing day-to-day variability in clinics.</p>","PeriodicalId":93858,"journal":{"name":"Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)","volume":"6 11","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aisy.202400141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlo Alessi, Diego Bianchi, Gianni Stano, Matteo Cianchetti, Egidio Falotico
<p>Soft robots can adaptively interact with unstructured environments. However, nonlinear soft material properties challenge modeling and control. Learning-based controllers that leverage efficient mechanical models are promising for solving complex interaction tasks. This article develops a closed-loop pose/force controller for a dexterous soft manipulator enabling dynamic pushing tasks using deep reinforcement learning. Force tests investigate the mechanical properties of a soft robot module, resulting in orthogonal forces of <span></span><math>