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American journal of Alzheimer's disease and other dementias最新文献

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Book Review: Love is Ageless: Stories about Alzheimer's Disease 书评:爱是永恒的:关于阿尔茨海默病的故事
Pub Date : 2003-07-01 DOI: 10.1177/153331750301800404
E. Stewart
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引用次数: 0
Book Review: Handbook of Dementia Caregiving: Evidence-Based Interventions for Family Caregivers; Innovative Interventions to Reduce Dementia Caregiver Distress: A Clinical Guide 书评:痴呆症护理手册:家庭照顾者的循证干预;创新干预措施,以减少痴呆症照顾者的痛苦:临床指南
Pub Date : 2003-05-01 DOI: 10.1177/153331750301800303
D. Kuhn
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引用次数: 0
New hope for an old disease 旧病有新希望
Pub Date : 2003-05-01 DOI: 10.1177/153331750301800301
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引用次数: 3
Scenes of Lee, Part Two 李的场景,第二部分
Pub Date : 2003-03-01 DOI: 10.1177/153331750301800212
Mary Donnarumma Sharnick
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引用次数: 0
Memory and medicines 记忆和药物
Pub Date : 2003-03-01 DOI: 10.1177/153331750301800201
C. Rowland
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引用次数: 0
Book Review: Alzheimer Solutions: A Personal Guide for Caregivers 书评:阿尔茨海默病解决方案:照顾者的个人指南
Pub Date : 2003-03-01 DOI: 10.1177/153331750301800203
L. Buettner
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引用次数: 0
Book Review: Drug Discovery and Development for Alzheimer's Disease 2000 书评:阿尔茨海默病的药物发现和开发,2000
Pub Date : 2003-03-01 DOI: 10.1177/153331750301800209
A. Popescu, C. Lippa
The mystery of Alzheimer’s disease (AD) appears to unravel in front of our eyes. Pathogenic mechanisms for AD have been explained, animal models have been created, target drugs that work in vitro and in transgenic animal models have been developed. Still, in humans, the implacable neurodegenerative process continues undisturbed, with a clocklike exactness. We have been unable so far to treat the disease other than symptomatically or delay the milestones such as institutionalization or loss of activities of daily living. However, Howard Fillit and Alan O’Connell embark on the difficult task of collecting data about currently known pathogenetic chains that can be targeted by therapeutic intervention. In a way, the quest for prevention and cure for AD is similar to the quest for immortality of the crusaders and King Arthur’s knights. The 29 chapters of the book are hypothetical 29 “sweet spots” where we could potentially hit this many-headed monster known as AD.
阿尔茨海默病(AD)的奥秘似乎就在我们眼前揭开。已经解释了阿尔茨海默病的致病机制,建立了动物模型,开发了在体外和转基因动物模型中起作用的靶向药物。然而,在人类中,不可避免的神经退行性过程继续不受干扰,像时钟一样精确。到目前为止,除了对症治疗之外,我们无法治疗这种疾病,也无法推迟制度化或丧失日常生活活动等里程碑。然而,Howard Fillit和Alan O 'Connell开始了一项艰巨的任务,即收集有关目前已知的可通过治疗干预靶向的致病链的数据。在某种程度上,对AD的预防和治疗的追求类似于对十字军和亚瑟王骑士永生的追求。这本书的29章是假设的29个“最佳点”,在那里我们可能会击中这个被称为AD的多头怪物。
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引用次数: 0
Book Review: Critical Advances in Reminiscence Work: From Theory to Application 书评:回顾工作的关键进展:从理论到应用
Pub Date : 2003-01-01 DOI: 10.1177/153331750301800103
M. Parker
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引用次数: 0
Decisions, Piaget, and King Lear 决定,皮亚杰,李尔王
Pub Date : 2003-01-01 DOI: 10.1177/153331750301800101
C. Rowland
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引用次数: 0
2002 Cumulative Author Index 2002年累积作者索引
Pub Date : 2003-01-01 DOI: 10.1177/153331750301800108
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引用次数: 0
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American journal of Alzheimer's disease and other dementias
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