Pub Date : 2024-03-30DOI: 10.33696/nanotechnol.5.049
O. Amin, I. Shehata, H. Kamel, N. Elbokle
Aim: The aim of the study was to assess the stability after early loading of nano coated hydroxyapatite implants in posterior maxilla. Methodology: This study was conducted on nine patients with at least a missing one maxillary posterior tooth. Ten Nano-coated hydroxyapatite implants (ETIII NH implant by Hiossen) were inserted in nine patients, and then subjected to early loading according to the secondary stability readings taken by Osstell®. Implant stability was measured at the time of implant insertion (T0), 4 (T1), 6 (T1 modified), weeks, and 4 months (T2) post-operative. Cone-beam computed tomography (CBCT) was performed in all patients before starting the treatment. Nine implants healed well except for one implant that failed due to infection. Results: Secondary stability results after 6 weeks of implant incretion were sufficient enough for implant loading, there was significant difference (F= 12.642, DF 3, P value <0.001) among T0, T1, T1 modified, and T2. Conclusion: Nano-coated hydroxyapatite implants are of good choice in posterior maxilla and they can be early loaded.
{"title":"Assessment of Stability of Early Loaded Nano Coated Hydroxyapatite Implants in Posterior Maxilla","authors":"O. Amin, I. Shehata, H. Kamel, N. Elbokle","doi":"10.33696/nanotechnol.5.049","DOIUrl":"https://doi.org/10.33696/nanotechnol.5.049","url":null,"abstract":"Aim: The aim of the study was to assess the stability after early loading of nano coated hydroxyapatite implants in posterior maxilla.\u0000\u0000Methodology: This study was conducted on nine patients with at least a missing one maxillary posterior tooth. Ten Nano-coated hydroxyapatite implants (ETIII NH implant by Hiossen) were inserted in nine patients, and then subjected to early loading according to the secondary stability readings taken by Osstell®. Implant stability was measured at the time of implant insertion (T0), 4 (T1), 6 (T1 modified), weeks, and 4 months (T2) post-operative. Cone-beam computed tomography (CBCT) was performed in all patients before starting the treatment. Nine implants healed well except for one implant that failed due to infection.\u0000\u0000Results: Secondary stability results after 6 weeks of implant incretion were sufficient enough for implant loading, there was significant difference (F= 12.642, DF 3, P value <0.001) among T0, T1, T1 modified, and T2. \u0000\u0000Conclusion: Nano-coated hydroxyapatite implants are of good choice in posterior maxilla and they can be early loaded.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"32 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.33696/nanotechnol.4.045
Samia M. Ibrahim, Ahmed F. Al-Hossainy, Hazim M. Ali, Mohamed Abd El Aal, Nasser Farhan
Fabrication of dye thin films is accomplished through physical vapor deposition with a thickness of 150 ± 5 nm. Kinetically, the reduction of permanganate ion as a multi-equivalent oxidant by acriflavine hydrochloride (ACFH) in a neutral medium has been studied spectrophotometrically. In the presence of a pseudo-first-order reaction, the experimental results suggest fractional first-order kinetics in [ACFH] and a first-order dependency in [MnO4-]. The spectroscopic identification of intermediate species involving complexes of Mn (V) coordination has been examined along with a unique nitro-derivative-ACF (NDACF) synthesis. Based on the estimated activation values, which are in great agreement with the kinetic data obtained, oxidation reaction mechanism was postulated and described. The data exactly determine that ΔEgOpt the amount decreases from 1.566 eV for [ACFH]TF to 1.36 eV for [NDACF]TF for isolated molecules in the gaseous state utilizing TD-DFT model, HOMO and LUMO calculation. The improvements in kinetical and optical properties were achieved, and it is promising to use [NDACF]TF as solar cell application.
{"title":"Oxidation and TD-DFT of Toxic Acriflavine Hydrochloride Dye by Potassium Permanganate in Neutral Media: Kinetics and Removal of Dyes from Wastewater","authors":"Samia M. Ibrahim, Ahmed F. Al-Hossainy, Hazim M. Ali, Mohamed Abd El Aal, Nasser Farhan","doi":"10.33696/nanotechnol.4.045","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.045","url":null,"abstract":"Fabrication of dye thin films is accomplished through physical vapor deposition with a thickness of 150 ± 5 nm. Kinetically, the reduction of permanganate ion as a multi-equivalent oxidant by acriflavine hydrochloride (ACFH) in a neutral medium has been studied spectrophotometrically. In the presence of a pseudo-first-order reaction, the experimental results suggest fractional first-order kinetics in [ACFH] and a first-order dependency in [MnO4-]. The spectroscopic identification of intermediate species involving complexes of Mn (V) coordination has been examined along with a unique nitro-derivative-ACF (NDACF) synthesis. Based on the estimated activation values, which are in great agreement with the kinetic data obtained, oxidation reaction mechanism was postulated and described. The data exactly determine that ΔEgOpt the amount decreases from 1.566 eV for [ACFH]TF to 1.36 eV for [NDACF]TF for isolated molecules in the gaseous state utilizing TD-DFT model, HOMO and LUMO calculation. The improvements in kinetical and optical properties were achieved, and it is promising to use [NDACF]TF as solar cell application.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135535440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.33696/nanotechnol.4.044
A. Koutinas, Theano Petsi, Sissy Panitsa, M. Kanellaki
This commentary shows the development of a new optical biosensor, based on cell immobilization of Pseudomonas Fluorescens HK44, in nano and micro-tubular cellulose (TC) and a mixture of carbohydrate nanotubes (CHNTs) and carbohydrate micro-tubes (CHMTs). Methodology follows, this biocatalyst can be industrialized with the use of a single tank immobilized cell bioreactor (ICB). A techno-economic analysis was conducted within the framework of it by designing a process flow sheet with mass and energy balance. According to its case study, the investment is 227,800 euros, and the daily production cost is 1434 euros, with a maximum daily added value of 25,000 euros. The discussion revealed that novel research proposals and a novel study concept are being developed in the field of biosensors. The results are supported by papers published on ICB area development. The problem that leads to this commentary is industrialization of ICB, in the case of a simple biosensor development using immobilized cells and it is the objective.
{"title":"Immobilized Cell Bioreactor Industrialization in the Development of an Innovative Optical Biosensor Technology","authors":"A. Koutinas, Theano Petsi, Sissy Panitsa, M. Kanellaki","doi":"10.33696/nanotechnol.4.044","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.044","url":null,"abstract":"This commentary shows the development of a new optical biosensor, based on cell immobilization of Pseudomonas Fluorescens HK44, in nano and micro-tubular cellulose (TC) and a mixture of carbohydrate nanotubes (CHNTs) and carbohydrate micro-tubes (CHMTs). Methodology follows, this biocatalyst can be industrialized with the use of a single tank immobilized cell bioreactor (ICB). A techno-economic analysis was conducted within the framework of it by designing a process flow sheet with mass and energy balance. According to its case study, the investment is 227,800 euros, and the daily production cost is 1434 euros, with a maximum daily added value of 25,000 euros. The discussion revealed that novel research proposals and a novel study concept are being developed in the field of biosensors. The results are supported by papers published on ICB area development. The problem that leads to this commentary is industrialization of ICB, in the case of a simple biosensor development using immobilized cells and it is the objective.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76638851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.33696/nanotechnol.4.042
J. Chen, A. L. Vishart, S. Sauer, K. Mikkelsen
This presentation considers theoretical investigations of dye-sensitized solar cells (DSSC). Theoretical methods were applied to investigate the interactions between titanium dioxide nanoparticles and sensitizers. The ONIOM model was used to obtain the geometries of different conformers of dye molecules with TiO2 and their binding energies. TD-DFT calculations were carried out to obtain the absorption spectra and the relative orbital energy levels of sensitizers and TiO2. The electronic couplings between different sensitizers and TiO2 were calculated using the fragment charge difference method. The redox potentials of the sensitizers are calculated to complete the full working cycle of a DSSC. We observed that the -COOH group is not the only possible binding site, and the sensitizers are more likely to be adsorbed horizontally on the TiO2 surface instead of being perpendicular to the surface having the -COOH group as a linker. The TiO2 nanoparticle was found to have minor influence on the absorptions of the sensitizers with the spectra shift smaller than 0.2 eV. TiO2 has more influence on the absorptions of softer and larger molecules because the interactions between sensitizers and TiO2 twist the conjugated chromophore structures. Compared to the neutral form, the deprotonated anion conformers of the sensitizers have larger binding energy and lower LUMO level against conduction band of TiO2. The gap between the LUMO of sensitizers and conduction band edge of TiO2 might indicate the coupling strength between the sensitizers and TiO2. Several binding groups have shown promising properties for interacting with the TiO2 nanoparticle and generally deprotonated anion forms of the dyes were strongly bonded to the TiO2 nanoparticle. The model and associated calculated results provide close agreement with experimental data and give crucial atomistic information of the relevant processes in dye-sensitized solar cells.
{"title":"Theoretical Investigations of Dye-Sensitized Solar Cells","authors":"J. Chen, A. L. Vishart, S. Sauer, K. Mikkelsen","doi":"10.33696/nanotechnol.4.042","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.042","url":null,"abstract":"This presentation considers theoretical investigations of dye-sensitized solar cells (DSSC). Theoretical methods were applied to investigate the interactions between titanium dioxide nanoparticles and sensitizers. The ONIOM model was used to obtain the geometries of different conformers of dye molecules with TiO2 and their binding energies. TD-DFT calculations were carried out to obtain the absorption spectra and the relative orbital energy levels of sensitizers and TiO2. The electronic couplings between different sensitizers and TiO2 were calculated using the fragment charge difference method. The redox potentials of the sensitizers are calculated to complete the full working cycle of a DSSC. We observed that the -COOH group is not the only possible binding site, and the sensitizers are more likely to be adsorbed horizontally on the TiO2 surface instead of being perpendicular to the surface having the -COOH group as a linker. The TiO2 nanoparticle was found to have minor influence on the absorptions of the sensitizers with the spectra shift smaller than 0.2 eV. TiO2 has more influence on the absorptions of softer and larger molecules because the interactions between sensitizers and TiO2 twist the conjugated chromophore structures. Compared to the neutral form, the deprotonated anion conformers of the sensitizers have larger binding energy and lower LUMO level against conduction band of TiO2. The gap between the LUMO of sensitizers and conduction band edge of TiO2 might indicate the coupling strength between the sensitizers and TiO2. Several binding groups have shown promising properties for interacting with the TiO2 nanoparticle and generally deprotonated anion forms of the dyes were strongly bonded to the TiO2 nanoparticle. The model and associated calculated results provide close agreement with experimental data and give crucial atomistic information of the relevant processes in dye-sensitized solar cells.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90545077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-18DOI: 10.33696/nanotechnol.4.041
Eui Jin, Yeong-Jin Chung
Chung's equations-II, -III, and -IV were applied to evaluate the fire risk and fire risk ratings of flame retardants. As an example, a wood specimen coated with a flame retardant was selected and tested using a cone calorimeter according to the ISO 5660-1 standard. The external heat flux was fixed to 50 kW/m2. Fire performance index-III used three variables to evaluate the initial fire risk: the time to ignition, first peak heat release rate, and first peak smoke release rate. Fire growth index-III was calculated using the first peak heat release rate, peak smoke production rate, and time to reach the first peak smoke production rate. This index is a standardized fire hazard category with poly(methyl methacrylate) as the reference material. The fire risk rating index, fire risk index-IV, is expressed as the value obtained by dividing the fire growth index-III by fire performance index-III. In this study, the methodology for fire risk rating evaluation is discussed.
{"title":"Fire Risk Rating Assessment for Wood Specimens Coated with Flame Retardant","authors":"Eui Jin, Yeong-Jin Chung","doi":"10.33696/nanotechnol.4.041","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.041","url":null,"abstract":"Chung's equations-II, -III, and -IV were applied to evaluate the fire risk and fire risk ratings of flame retardants. As an example, a wood specimen coated with a flame retardant was selected and tested using a cone calorimeter according to the ISO 5660-1 standard. The external heat flux was fixed to 50 kW/m2. Fire performance index-III used three variables to evaluate the initial fire risk: the time to ignition, first peak heat release rate, and first peak smoke release rate. Fire growth index-III was calculated using the first peak heat release rate, peak smoke production rate, and time to reach the first peak smoke production rate. This index is a standardized fire hazard category with poly(methyl methacrylate) as the reference material. The fire risk rating index, fire risk index-IV, is expressed as the value obtained by dividing the fire growth index-III by fire performance index-III. In this study, the methodology for fire risk rating evaluation is discussed.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86602384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.33696/nanotechnol.4.039
Soufiane Abdelghani-Idrissi, M.BA. Freville, A. Colin
Multi-phasic electrochemical systems such as electrolyzers or metal-air batteries are intimately linked to energy transition and are at the heart of new scientific advances and modern industrial development. The presence of gas phases, inherent to the processes, directly impacts the performance and stability of the systems. In this study, we propose different ways to improve the dynamics of bubble evacuation, through forced convection (flow systems), and natural convection (electrode design and cell geometry). By analyzing the links between the electrochemical kinetics and active surface electrode variations, we show that forced convection is an excellent way to decrease the overall energy cost and reduce the harmful impact of gas bubbles. Regarding natural evacuation, adapted electrode or cell designs also allow to improve performances, without adding external hydraulic circuit.
{"title":"Natural and Forced Convection in Multi-Phasic Electrochemical Systems","authors":"Soufiane Abdelghani-Idrissi, M.BA. Freville, A. Colin","doi":"10.33696/nanotechnol.4.039","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.039","url":null,"abstract":"Multi-phasic electrochemical systems such as electrolyzers or metal-air batteries are intimately linked to energy transition and are at the heart of new scientific advances and modern industrial development. The presence of gas phases, inherent to the processes, directly impacts the performance and stability of the systems. In this study, we propose different ways to improve the dynamics of bubble evacuation, through forced convection (flow systems), and natural convection (electrode design and cell geometry). By analyzing the links between the electrochemical kinetics and active surface electrode variations, we show that forced convection is an excellent way to decrease the overall energy cost and reduce the harmful impact of gas bubbles. Regarding natural evacuation, adapted electrode or cell designs also allow to improve performances, without adding external hydraulic circuit.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75803406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.33696/nanotechnol.4.038
Li Yan
In recent years, DNA has emerged as a powerful tool in the field of nanotechnology. The DNA origami technique is largely responsible for this, revolutionizing nanofabrication due to its controllability, precision, and ability to leverage DNA’s unique properties. The technique consists of folding a long, single-stranded DNA (called a scaffold strand) by binding it with shorter staple strands to create almost any shape desired. With a desired structure in mind, researchers can design and assemble scaffold and staple strands using computer software like Cadnano or Tiamat. This is possible because of the Watson-Crick base pairing of DNA strands, which allows for programmable self-assembly of DNA nanostructures and therefore, the synthesis of arbitrary 2D and 3D shapes. Because DNA is a biomolecule,the nanostructures are also biocompatible and can be employed in biological applications including drug delivery. DNA origami nanostructures are not only limited to biological applications; they have also found uses in nanophotonics, plasmonics, and electronics. However, DNA origami still faces many challenges before it can be widely adopted. One such challenge is ensuring stability, and thus guaranteeing the performance of the DNA origami, in the presence of heat, nuclease in organic bodies, and chaotropic agents. This warrants the question: what methodologies can be employed to best stabilize DNA origami structures? This paper further focuses on two methods: covalently binding various molecules by cross-linking and non-binding encapsulation. Detailed analysis and comparison between various molecules used to bind and coat DNA nanostructures is used to evaluate performance and applicability of each method. In the end an oligolysines coating cross-linked with glutaraldehyde was found to have the strongest biological stability, thymine cross-linking had the strongest thermal stability, a silica coating had the best stability against the largest number of factors, and both graphene and Al3O2 coatings had the best mechanical stability.
{"title":"A Comprehensive Review of DNA Origami Stabilization Techniques","authors":"Li Yan","doi":"10.33696/nanotechnol.4.038","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.038","url":null,"abstract":"In recent years, DNA has emerged as a powerful tool in the field of nanotechnology. The DNA origami technique is largely responsible for this, revolutionizing nanofabrication due to its controllability, precision, and ability to leverage DNA’s unique properties. The technique consists of folding a long, single-stranded DNA (called a scaffold strand) by binding it with shorter staple strands to create almost any shape desired. With a desired structure in mind, researchers can design and assemble scaffold and staple strands using computer software like Cadnano or Tiamat. This is possible because of the Watson-Crick base pairing of DNA strands, which allows for programmable self-assembly of DNA nanostructures and therefore, the synthesis of arbitrary 2D and 3D shapes. Because DNA is a biomolecule,the nanostructures are also biocompatible and can be employed in biological applications including drug delivery. DNA origami nanostructures are not only limited to biological applications; they have also found uses in nanophotonics, plasmonics, and electronics. However, DNA origami still faces many challenges before it can be widely adopted. One such challenge is ensuring stability, and thus guaranteeing the performance of the DNA origami, in the presence of heat, nuclease in organic bodies, and chaotropic agents. This warrants the question: what methodologies can be employed to best stabilize DNA origami structures? This paper further focuses on two methods: covalently binding various molecules by cross-linking and non-binding encapsulation. Detailed analysis and comparison between various molecules used to bind and coat DNA nanostructures is used to evaluate performance and applicability of each method. In the end an oligolysines coating cross-linked with glutaraldehyde was found to have the strongest biological stability, thymine cross-linking had the strongest thermal stability, a silica coating had the best stability against the largest number of factors, and both graphene and Al3O2 coatings had the best mechanical stability.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84326158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-18DOI: 10.33696/nanotechnol.4.037
Lobna M. Abdel-Aziz, Ahmed S Abdelkhalek, Alyaa Antar, Emad H. Abdelraziq, Emad A. Farghaly, Emad M. Elsayed, Emad Y. Metwally, Ammar Y. Khalil, Ammar T. Khalifa, M. Sebaiy
In this literature review, we will introduce pharmacology in addition to most of the up-to-date reported methods that have been developed for determination of important oral hypoglycemic drugs which are metformin and glimepiride in their pure forms, combined forms with other drugs, combined forms with degradation products, and in biological samples.
{"title":"The Methods of Analysis for Determination of Metformin and Glimepiride in Different Matrices","authors":"Lobna M. Abdel-Aziz, Ahmed S Abdelkhalek, Alyaa Antar, Emad H. Abdelraziq, Emad A. Farghaly, Emad M. Elsayed, Emad Y. Metwally, Ammar Y. Khalil, Ammar T. Khalifa, M. Sebaiy","doi":"10.33696/nanotechnol.4.037","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.037","url":null,"abstract":"In this literature review, we will introduce pharmacology in addition to most of the up-to-date reported methods that have been developed for determination of important oral hypoglycemic drugs which are metformin and glimepiride in their pure forms, combined forms with other drugs, combined forms with degradation products, and in biological samples.","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74135063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.33696/nanotechnol.4.043
Oksana Fihurka, Stephen Aradi, Vasyl Sava, Juan Sanchez-Ramos
A major obstacle to fulfilling the therapeutic promise of gene therapies for hereditary brain diseases, such as Huntington' Disease (HD), is the requirement for viral vectors and/or an invasive delivery system (stereotaxic injection into brain or infusion into the intrathecal space). HD is an autosomal dominant neurodegenerative disease for which several clinical trials have demonstrated gene-lowering effects following intrathecal administration. These technical limitations have given impetus to the development of alternative non-invasive delivery systems for gene therapy of brain diseases. The overall objective of this review is to discuss the key features in the design of nanocarriers for intranasal administration of gene-therapy for HD, focusing primarily on our series of published work on the use of nanocarriers for gene therapy. Design and development of nanocarriers packaged with gene-lowering agents represents a significant advance towards non-invasive nose-to-brain delivery of gene therapy for HD and other hereditary brain disorders.
{"title":"Key Features in the Design and Function of Nanocarriers for Intranasal Administration of Gene Therapy in Huntington Disease.","authors":"Oksana Fihurka, Stephen Aradi, Vasyl Sava, Juan Sanchez-Ramos","doi":"10.33696/nanotechnol.4.043","DOIUrl":"https://doi.org/10.33696/nanotechnol.4.043","url":null,"abstract":"<p><p>A major obstacle to fulfilling the therapeutic promise of gene therapies for hereditary brain diseases, such as Huntington' Disease (HD), is the requirement for viral vectors and/or an invasive delivery system (stereotaxic injection into brain or infusion into the intrathecal space). HD is an autosomal dominant neurodegenerative disease for which several clinical trials have demonstrated gene-lowering effects following intrathecal administration. These technical limitations have given impetus to the development of alternative non-invasive delivery systems for gene therapy of brain diseases. The overall objective of this review is to discuss the key features in the design of nanocarriers for intranasal administration of gene-therapy for HD, focusing primarily on our series of published work on the use of nanocarriers for gene therapy. Design and development of nanocarriers packaged with gene-lowering agents represents a significant advance towards non-invasive nose-to-brain delivery of gene therapy for HD and other hereditary brain disorders.</p>","PeriodicalId":94095,"journal":{"name":"Journal of nanotechnology and nanomaterials","volume":"4 2","pages":"55-69"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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