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The Organic Farmer Safety, Health & Life Questionnaire (OFSHLQ): A Tool for an Expanded Paradigm on Occupational Safety and Health. 有机农民安全、健康和生活问卷(OFSHLQ):职业安全与健康扩展范例的工具。
Pub Date : 2024-12-09 DOI: 10.1097/JOM.0000000000003299
Francisco Soto Mas, Yu-Yu Hsiao, Ming Ji, Shixi Zhao

Objective: Develop and validate a multidimensional tool consistent with an expanded occupational safety and health (OSH) paradigm.

Methods: Systematic development process; cross-sectional survey design for psychometric properties. Exploratory factor analyses (EFA) and reliability estimates on key theoretical constructs.

Results: The Organic Farmer Safety, Health & Life Questionnaire (OFSHLQ) is a population-specific, theory-based, multilevel tool that integrates work and life dimensions. The development process contributed to face and content validity. The EFA identified 11 scales with acceptable factor loadings. Reliability estimates across scales ranged from 0.58 to 0.92.

Discussion: OFSHLQ integrates traditional dimensions of OSH and other intrapersonal, interpersonal, and contextual factors that contribute to overall workers' health and well-being.

Conclusion: OFSHLQ constitutes a resource for traditional OSH surveillance and research, and is also consistent with an expanded paradigm of OSH.

目标:开发和验证符合扩展职业安全与健康(OSH)范例的多维工具。方法:系统开发流程;心理测量特性的横断面调查设计。探索性因子分析(EFA)和关键理论结构的可靠性估计。结果:有机农民安全、健康与生活问卷(OFSHLQ)是一种针对人群的、基于理论的、整合工作和生活维度的多层次工具。开发过程对外观效度和内容效度都有贡献。全民教育评估确定了11个可接受因子负荷的量表。各量表的信度估计范围从0.58到0.92。讨论:OFSHLQ整合了职业安全与健康的传统维度,以及其他有助于员工整体健康和福祉的个人、人际和环境因素。结论:OFSHLQ为传统的职业安全与卫生监测和研究提供了资源,也符合职业安全与卫生的扩展范例。
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引用次数: 0
The Beneficial Role of Participation in Decision-Making on Workers' Health and Commitment: A Cross-Sectional Study in Belgium's Health and Homecare Sector. 参与决策对工人健康和承诺的有益作用:比利时卫生和家庭护理部门的横断面研究。
Pub Date : 2024-12-09 DOI: 10.1097/JOM.0000000000003298
Bensliman Rachida, Mahieu Céline, Casini Annalisa

Objectives: To test the hypothesis of a beneficial role of worker participation in the decision-making process as a buffer against demanding work organisation on mental and physical health and commitment.

Methods: A cross-sectional study (N = 1134) was conducted among workers employed in the health and homecare sector. Multiple regressions and moderation analyses were performed to test whether worker participation in decision-making moderates the association between demanding work organisation and health and whether it directly predicts work commitment.

Results: As hypothesized, results show that demanding work organisation is negatively associated with the mental and physical health of workers and that participation in the decision-making moderates this negative association. Finally, participation in decision-making is directly related to work commitment.

Conclusions: Results are discussed in light of the recent evolution of work conditions in the health and homecare sector.

目的:检验工人参与决策过程的有益作用的假设,作为对要求工作组织对心理和身体健康和承诺的缓冲。方法:对在卫生和家庭护理部门工作的工人进行了横断面研究(N = 1134)。采用多元回归和调节分析来检验工人参与决策是否调节了要求高的工作组织与健康之间的关系,以及它是否直接预测了工作承诺。结果:正如假设的那样,结果表明,苛刻的工作组织与工人的心理和身体健康呈负相关,参与决策调节了这种负相关。最后,参与决策与工作承诺直接相关。结论:根据最近保健和家庭护理部门工作条件的变化讨论了结果。
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引用次数: 0
Association Between Male Menopause Severity and Presenteeism: A Cross-sectional Study. 男性更年期严重程度与出勤之间的关系:一项横断面研究。
Pub Date : 2024-12-03 DOI: 10.1097/JOM.0000000000003294
Hiroki Beppu, Makoto Okawara, Satoshi Yamashita, Seiichiro Tateishi, Shigeo Horie, Toshiyuki Yasui, Yoshihisa Fujino

Objective: This study explored the association between symptoms of male menopause and presenteeism among middle-aged men in Japan.

Methods: We conducted a cross-sectional survey among 3,795 men aged 40 to 59 years who were in current employment in Japan. Male menopause symptoms were assessed using the Aging Male Symptoms (AMS) scale. Presenteeism was measured with the Work Functioning Impairment Scale (WFun). Poisson regression analysis was conducted.

Results: The prevalence of presenteeism increased with increasing total AMS scale score (p for trend <0.001). Severe AMS scale group showed prevalence ratio of 11.81 (95% confidence interval: 9.45-14.74) compared to no symptoms group. Each subscale demonstrated a dose-response relationship when evaluated independently.

Conclusions: We identified a strong association between male menopause symptoms and presenteeism. Addressing these symptoms, particularly the psychological and physical symptoms, in the workplace could reduce presenteeism.

目的:本研究探讨日本中年男性更年期症状与出勤率的关系。方法:我们对3,795名年龄在40至59岁之间的日本在职男性进行了横断面调查。男性更年期症状评估采用老年男性症状(AMS)量表。出勤率采用工作功能障碍量表(WFun)进行测量。进行泊松回归分析。结果:出勤率随AMS总分的增加而增加(p为趋势)。结论:我们发现男性更年期症状与出勤率之间存在很强的关联。在工作场所解决这些症状,特别是心理和身体症状,可以减少出勤。
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引用次数: 0
Gaps in Workplace Injury Reporting Among Physicians to the United States Bureau of Labor Statistics. 向美国劳工统计局报告医生工作场所伤害的差距。
Pub Date : 2024-12-03 DOI: 10.1097/JOM.0000000000003295
Andrew T Gabrielson, Kristin Chrouser, M Susan Hallbeck, Tara Cohen, Claudia Corwin

Objective: To identify gaps in nonfatal injury and illness (NII) reporting between physicians and other occupations.

Methods: Bureau of Labor Statistics data (2011-2019) were analyzed, comparing annualized NII incidence rates using incidence rate ratios (IRR), with physicians as the reference.

Results: Between 2011-2019, physicians reported significantly lower NII rates compared to high-hazard non-medical occupations (IRR 17.2-70.8, all p < 0.01) and most low-hazard non-medical occupations (IRR 1.2-6.3, all p < 0.01), except lawyers. NII rates among physicians were also lower than those in non-physician medical occupations (IRR 1.4-27.6, all p < 0.01). In 2020, relative NII rates between physicians and non-physician medical occupations decreased but returned to pre-pandemic levels by 2021.

Conclusions: Physicians report significantly lower NII rates than other occupations, likely due to underreporting or undercounting, highlighting a potential gap in occupational injury data.

目的:确定医师和其他职业在非致命性伤害和疾病(NII)报告方面的差距。方法:分析美国劳工统计局(Bureau of Labor Statistics) 2011-2019年数据,以医师为参考,采用发病率比(IRR)比较年化NII发病率。结果:2011-2019年期间,除律师外,医生报告的NII率显著低于高风险非医疗职业(IRR 17.2-70.8,均p < 0.01)和大多数低风险非医疗职业(IRR 1.2-6.3,均p < 0.01)。医师的NII率也低于非医师医疗职业(IRR 1.4 ~ 27.6, p < 0.01)。2020年,医生和非医生医疗职业之间的相对NII比率下降,但到2021年恢复到大流行前的水平。结论:医生报告的NII率明显低于其他职业,可能是由于少报或少计,突出了职业伤害数据的潜在差距。
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引用次数: 0
Mental Health Support for First Responders Provided Outside of California's Workers' Compensation System. 在加州工人赔偿制度之外为急救人员提供的心理健康支持。
Pub Date : 2024-12-02 DOI: 10.1097/JOM.0000000000003293
Denise D Quigley, Nabeel Qureshi, Michael Dworsky, Lisa S Meredith

Objective: Concern about psychiatric injuries for first responders has grown. We examine alternatives to workers' compensation (WC).

Method: We conducted 15 interviews across 5 California departments contracted with non-WC mental health (MH) providers. We performed content analysis.

Results: MH support outside of WC most often was a dedicated contract with outside MH providers for assessment, diagnosis, and treatment. Departments had formal financing mechanisms with union and city support designating funding for MH care. Frustration and past WC experiences drove the desire for WC alternatives. First responders reported high levels of stigma associated with MH care. Compared to WC, these alternatives allowed more comprehensive services to injured workers along with ease of accessing care, expediting the healing process.

Conclusion: Contracting culturally competent MH providers outside of WC for first responders has potential and needs formal evaluation.

目的:对急救人员精神损伤的关注越来越多。我们研究了工人补偿(WC)的替代方案。方法:我们在加州5个与非wc心理健康(MH)提供者签约的部门进行了15次访谈。我们进行了内容分析。结果:卫生院以外的卫生保健支持通常是与外部卫生保健提供者签订专门的合同,以进行评估、诊断和治疗。各部门有正式的筹资机制,有工会和市政府的支持,指定医院护理的资金。挫折和过去的WC经历促使人们渴望WC的替代品。急救人员报告说,与MH护理相关的耻辱感很高。与WC相比,这些替代方案可以为受伤工人提供更全面的服务,同时易于获得护理,加快愈合过程。结论:在医院外签约文化上有能力的医院提供者作为第一响应者是有潜力的,需要正式的评估。
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引用次数: 0
A Longitudinal Study on the Impact of Working From Home During the COVID-19 Pandemic: Self-Rated General Health, Stress, and Work-Family and Family-Work Conflict-Are There Gender and Parental Status Differences? 关于 COVID 19 大流行期间在家工作的影响的纵向研究:自我评定的总体健康状况、压力以及工作-家庭和家庭-工作冲突--是否存在性别和父母地位差异?
Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1097/JOM.0000000000003237
Melissa Graham, Victoria Weale, Katrina A Lambert, Natasha Kinsman, Rwth Stuckey, Jodi Oakman

Objective: The aim of the study is to examine the impact of working from home during the COVID-19 pandemic on general health, stress, work-family, and family-work conflict over-time and identify differences by gender and parental status.

Methods: Trajectory analyses described outcomes over time. Multinomial logistic regression relates the effects of gender, children, and the interaction between them, on group membership based on the latent class growth analyses.

Results: Not all trajectories followed the expected cubic pattern. Females had less family-work conflict (high/low: OR = 0.29, 95% CI: 0.17-0.66; moderate/low OR = 0.37, 95% CI: 0.20-0.67). Children increased the odds of family-work conflict (high/low: OR = 8.48, 95% CI: 3.38-21.25; moderate/low OR = 2.98, 95% CI: 1.63-5.43). Work-family conflict was worse for those with children (high-to-moderate decline/low-stable: OR = 2.59, 95% CI 1.25-5.41).

Conclusions: Work from home has implications for health and well-being of employees with differences based on gender and parental status for stress, work-family, and family-work conflict.

目的研究在 COVID-19 大流行期间在家工作(WFH)对总体健康、压力、工作-家庭和家庭-工作冲突的影响,并确定不同性别和父母状况的差异:方法:轨迹分析描述了随时间变化的结果。根据潜类增长分析,多项式逻辑回归将性别、子女以及它们之间的交互作用与群体成员资格的影响联系起来:并非所有轨迹都遵循预期的立方模式。女性的家庭工作冲突较少(高/低:OR 0.29 95%CI 0.17-0.66;中/低 OR 0.37 95%CI 0.20-0.67)。子女增加了家庭工作冲突的几率(高/低:OR 8.48 95%CI 3.38-21.25;中/低 OR 2.98 95%CI 1.63-5.43)。有子女者的工作与家庭冲突更严重(高至中度下降/低度稳定:OR 2.59 95%CI 1.25-5.41):全职家庭对员工的健康和幸福有影响,不同性别和父母身份的员工在压力、工作-家庭和家庭-工作冲突方面存在差异。
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引用次数: 0
COVID-19 Risk Assessment Among Vulnerable Small Business Owners in El Paso County, Texas. COVID-19 德克萨斯州埃尔帕索县弱势小企业主的风险评估。
Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1097/JOM.0000000000003227
Sadie H Conway, Denise Vasquez, Kristina D Mena, Louis D Brown, Soyoung Kwon, Janelle Rios

Background: Our objective was to deliver actionable, worksite-specific COVID-19 risk assessments and mitigation strategies tailored to vulnerable workers in one of the highest-risk areas in the US.

Methods: Four trained, bilingual (English/Spanish) community health workers (CHWs) recruited small businesses (ie, ≤20 employees) across various industries and executed novel on-site infectious disease risk assessment surveys of at least one employer and one employee.

Results: Of 102 participating businesses (95% Hispanic-owned), 96% were characterized as "high risk" or "very high risk" for disease transmission. All businesses reported implementing at least one practice to reduce disease transmission; however, almost half of businesses lacked at least 13 of the 17 controls identified to mitigate risk.

Conclusions: Tailored, culturally sensitive outreach led by CHWs identified and educated businesses on critical hazards, and these methods may be transferable to similar communities.

背景:我们的目标是为美国高风险地区的弱势工人提供可操作的、针对工作场所的 COVID-19 风险评估和缓解策略:方法: 四名训练有素的双语(英语/西班牙语)社区保健员(CHWs)招募了各行各业的小型企业(即员工人数少于 20 人),并对至少一名雇主和一名员工进行了新颖的现场传染病风险评估调查:在 102 家参与调查的企业(95% 为西班牙裔企业)中,96% 的企业被定性为疾病传播的 "高风险 "或 "极高风险 "企业。所有企业都报告说至少实施了一种减少疾病传播的做法;然而,几乎有一半的企业至少缺乏 17 项控制措施中的 13 项来降低风险:由社区保健工作者领导的有针对性、对文化敏感的外联活动识别并教育了企业的关键危害,这些方法可能适用于类似的社区。
{"title":"COVID-19 Risk Assessment Among Vulnerable Small Business Owners in El Paso County, Texas.","authors":"Sadie H Conway, Denise Vasquez, Kristina D Mena, Louis D Brown, Soyoung Kwon, Janelle Rios","doi":"10.1097/JOM.0000000000003227","DOIUrl":"10.1097/JOM.0000000000003227","url":null,"abstract":"<p><strong>Background: </strong>Our objective was to deliver actionable, worksite-specific COVID-19 risk assessments and mitigation strategies tailored to vulnerable workers in one of the highest-risk areas in the US.</p><p><strong>Methods: </strong>Four trained, bilingual (English/Spanish) community health workers (CHWs) recruited small businesses (ie, ≤20 employees) across various industries and executed novel on-site infectious disease risk assessment surveys of at least one employer and one employee.</p><p><strong>Results: </strong>Of 102 participating businesses (95% Hispanic-owned), 96% were characterized as \"high risk\" or \"very high risk\" for disease transmission. All businesses reported implementing at least one practice to reduce disease transmission; however, almost half of businesses lacked at least 13 of the 17 controls identified to mitigate risk.</p><p><strong>Conclusions: </strong>Tailored, culturally sensitive outreach led by CHWs identified and educated businesses on critical hazards, and these methods may be transferable to similar communities.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":"987-992"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Who's Behind the Wheel? Work and Health Backgrounds of New Transit Bus Operators. 谁在驾驶?新公交巴士运营商的工作和健康背景。
Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1097/JOM.0000000000003235
Ryan Olson, Stacy A Stoffregen, Talya N Bauer, Brad Wipfli, W Kent Anger, Todd Bodner, Peter Graven, Andrew W McHill, Courtney Donovan

Objective: Investigate new bus operators' ( N = 293) occupational and health backgrounds to inform how transit authorities can support their future health and job success.

Methods: New bus operators completed surveys and direct measurements that addressed demographics, work history, and 10 health risk factors.

Results: Participants averaged 42.76 years of age and were predominantly male (73.5%). Many (45.7%) came from minority backgrounds and most (66.3%) had no prior commercial driving experience. Transportation and material moving occupations were operators' most common prior jobs followed by protective service, and sales and related occupations. Study-specific criteria classified operators as having low (49.5%), medium (37.9%), and high (12.6%) health risk levels.

Conclusions: About half of the sample had medium-to-high health risks and most lacked commercial driving experience. Such information may help employers proactively support new bus operators' health and job success.

目标:调查新公交车驾驶员(n = 293)的职业和健康背景:调查新公交车驾驶员(n = 293)的职业和健康背景,为公交公司如何支持他们未来的健康和工作成功提供信息:方法:新公交车驾驶员填写调查问卷,并对人口统计学、工作历史和 10 个健康风险因素进行直接测量:参与者平均年龄为 42.76 岁,以男性为主(73.5%)。许多人(45.7%)来自少数民族,大多数人(66.3%)以前没有商业驾驶经验。驾驶员以前最常见的工作是运输和材料搬运,其次是保护服务和销售及相关职业。研究的具体标准将驾驶员的健康风险水平分为低(49.5%)、中(37.9%)和高(12.6%):结论:大约一半的样本具有中到高的健康风险,大多数人缺乏商业驾驶经验。这些信息可帮助雇主积极支持新巴士驾驶员的健康和工作成功。
{"title":"Who's Behind the Wheel? Work and Health Backgrounds of New Transit Bus Operators.","authors":"Ryan Olson, Stacy A Stoffregen, Talya N Bauer, Brad Wipfli, W Kent Anger, Todd Bodner, Peter Graven, Andrew W McHill, Courtney Donovan","doi":"10.1097/JOM.0000000000003235","DOIUrl":"10.1097/JOM.0000000000003235","url":null,"abstract":"<p><strong>Objective: </strong>Investigate new bus operators' ( N = 293) occupational and health backgrounds to inform how transit authorities can support their future health and job success.</p><p><strong>Methods: </strong>New bus operators completed surveys and direct measurements that addressed demographics, work history, and 10 health risk factors.</p><p><strong>Results: </strong>Participants averaged 42.76 years of age and were predominantly male (73.5%). Many (45.7%) came from minority backgrounds and most (66.3%) had no prior commercial driving experience. Transportation and material moving occupations were operators' most common prior jobs followed by protective service, and sales and related occupations. Study-specific criteria classified operators as having low (49.5%), medium (37.9%), and high (12.6%) health risk levels.</p><p><strong>Conclusions: </strong>About half of the sample had medium-to-high health risks and most lacked commercial driving experience. Such information may help employers proactively support new bus operators' health and job success.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":"1022-1029"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Physical Work Environment During Work From Home and Sleep During the COVID-19 Pandemic: A Prospective Cohort Study in Japan. COVID-19 大流行期间在家工作期间的物理工作环境与睡眠之间的关系:日本前瞻性队列研究。
Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI: 10.1097/JOM.0000000000003216
Keiki Hirashima, Makoto Okawara, Seiichiro Tateishi, Hisashi Eguchi, Mayumi Tsuji, Akira Ogami, Koji Mori, Shinya Matsuda, Yoshihisa Fujino

Objective: The work environment during work from home (WFH) may have a negative impact on workers' health. We investigated the effects of the physical work environment during WFH on sleep.

Methods: We conducted a 1-year cohort study of 2099 Japanese WFH workers. We used eight questions about the physical work environment during WFH as independent variables and the Athens Insomnia Scale as the dependent variable. We performed multilevel logistic regression with residence as a random effect.

Results: With the exception of one item, nonconformity with recommendations for the physical work environment during WFH was significantly associated with sleep problems. Further, the number of nonconformities and sleep problems showed a graded relationship.

Conclusion: An inappropriate physical work environment during WFH may be associated with sleep problems.

目的在家工作(WFH)期间的工作环境可能会对工人的健康产生负面影响。我们研究了在家工作期间的物理工作环境对睡眠的影响:我们对 2099 名日本在家工作的工人进行了为期一年的队列研究。我们将有关全职工作期间物理工作环境的八个问题作为自变量,将雅典失眠量表作为因变量。我们以居住地为随机效应进行了多层次逻辑回归:结果:除一个项目外,在全职工作期间不遵守物理工作环境建议与睡眠问题密切相关。此外,不符合建议的次数与睡眠问题之间存在分级关系:结论:全职工作期间不适当的物理工作环境可能与睡眠问题有关。
{"title":"Association Between Physical Work Environment During Work From Home and Sleep During the COVID-19 Pandemic: A Prospective Cohort Study in Japan.","authors":"Keiki Hirashima, Makoto Okawara, Seiichiro Tateishi, Hisashi Eguchi, Mayumi Tsuji, Akira Ogami, Koji Mori, Shinya Matsuda, Yoshihisa Fujino","doi":"10.1097/JOM.0000000000003216","DOIUrl":"10.1097/JOM.0000000000003216","url":null,"abstract":"<p><strong>Objective: </strong>The work environment during work from home (WFH) may have a negative impact on workers' health. We investigated the effects of the physical work environment during WFH on sleep.</p><p><strong>Methods: </strong>We conducted a 1-year cohort study of 2099 Japanese WFH workers. We used eight questions about the physical work environment during WFH as independent variables and the Athens Insomnia Scale as the dependent variable. We performed multilevel logistic regression with residence as a random effect.</p><p><strong>Results: </strong>With the exception of one item, nonconformity with recommendations for the physical work environment during WFH was significantly associated with sleep problems. Further, the number of nonconformities and sleep problems showed a graded relationship.</p><p><strong>Conclusion: </strong>An inappropriate physical work environment during WFH may be associated with sleep problems.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":"956-961"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational Exposure to 50 ppm Isoflurane Impairs Sperm Parameters in Mice. 职业暴露于 50 ppm 异氟醚会损害小鼠的精子参数。
Pub Date : 2024-12-01 Epub Date: 2024-09-04 DOI: 10.1097/JOM.0000000000003218
Marina Zanin, Antonio Sergio Varela Junior, Izani Bonel Acosta, Edenara Anastacio da Silva, Maria Eduarda Bicca Dode, Martielo Ivan Gehrcke, Mariana Gobbo Braz, Carine Dahl Corcini

Objectives: The aims of the study are to assess the effect of occupational exposure to isoflurane on the sperm quality of mice and to investigate whether cessation of exposure can restore seminal quality.

Methods: Mice were exposed to 50 ppm of isoflurane for 5 hours per day over a 30-day period. Following this exposure, they were euthanized at predetermined postexposure intervals, and their sperm samples were analyzed for kinetics and viability parameters.

Results: Occupational exposure to isoflurane can adversely affect sperm at 50 ppm, a concentration deemed safe by international occupational health conventions in some countries. These effects are marked by oxidative stress, mitochondrial dysfunction, and genomic damage, alongside alterations in sperm kinetics and acrosomal integrity. Furthermore, cessation of exposure does not guarantee restoration of cellular quality.

Conclusions: Isoflurane at 50 ppm, previously deemed safe by some countries, impairs sperm kinetics and viability, potentially directing the spermatogenic process toward infertility and apoptosis.

研究目的评估职业暴露于异氟醚对小鼠精子质量的影响,并研究停止暴露能否恢复精子质量:小鼠每天暴露于 50 ppm 的异氟醚中 5 小时,为期 30 天。方法:将小鼠暴露于 50 ppm 异氟醚中,每天暴露 5 小时,持续 30 天。暴露后,在预定的暴露间隔时间内对小鼠实施安乐死,并对小鼠的精子样本进行动力学和活力参数分析:结果:职业暴露于异氟醚会对精子产生不利影响,浓度为百万分之 50,一些国家的国际职业健康公约认为这一浓度是安全的。这些影响主要表现为氧化应激、线粒体功能障碍和基因组损伤,以及精子动力学和顶体完整性的改变。此外,停止接触也不能保证细胞质量的恢复:结论:50ppm的异氟醚以前被一些国家认为是安全的,但它会损害精子动力学和活力,有可能导致精子生成过程出现不育和凋亡。
{"title":"Occupational Exposure to 50 ppm Isoflurane Impairs Sperm Parameters in Mice.","authors":"Marina Zanin, Antonio Sergio Varela Junior, Izani Bonel Acosta, Edenara Anastacio da Silva, Maria Eduarda Bicca Dode, Martielo Ivan Gehrcke, Mariana Gobbo Braz, Carine Dahl Corcini","doi":"10.1097/JOM.0000000000003218","DOIUrl":"10.1097/JOM.0000000000003218","url":null,"abstract":"<p><strong>Objectives: </strong>The aims of the study are to assess the effect of occupational exposure to isoflurane on the sperm quality of mice and to investigate whether cessation of exposure can restore seminal quality.</p><p><strong>Methods: </strong>Mice were exposed to 50 ppm of isoflurane for 5 hours per day over a 30-day period. Following this exposure, they were euthanized at predetermined postexposure intervals, and their sperm samples were analyzed for kinetics and viability parameters.</p><p><strong>Results: </strong>Occupational exposure to isoflurane can adversely affect sperm at 50 ppm, a concentration deemed safe by international occupational health conventions in some countries. These effects are marked by oxidative stress, mitochondrial dysfunction, and genomic damage, alongside alterations in sperm kinetics and acrosomal integrity. Furthermore, cessation of exposure does not guarantee restoration of cellular quality.</p><p><strong>Conclusions: </strong>Isoflurane at 50 ppm, previously deemed safe by some countries, impairs sperm kinetics and viability, potentially directing the spermatogenic process toward infertility and apoptosis.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":"978-986"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of occupational and environmental medicine
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