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Photobiomodulation as a Potential Adjuvant Therapy to Improve Cochlear Implant Efficiency. 光生物调节作为一种潜在的辅助疗法,可提高人工耳蜗植入效率。
IF 1.8 Q2 SURGERY Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI: 10.1089/photob.2024.0097
So-Young Chang, Min Young Lee

Objective: Photobiomodulation (PBM) is a noninvasive therapeutic modality with widespread applications for modulating various biological processes. Although the exact mechanisms of action remain uncertain, PBM promotes homeostasis through diverse pathways, including reducing inflammation and enhancing tissue recovery. Hearing loss is irreversible in mammals due to the limited regenerative capacity of cochlear hair cells. Cochlear implants offer a solution by electrically stimulating the auditory nerve, bypassing damaged hair cells in individuals with severe hearing loss. However, postoperative inflammatory responses and cochlear nerve fiber damage can compromise implant efficacy. Materials and Methods: We investigated current strategies to minimize secondary cochlear damage after cochlear implantation and evaluated the potential of PBM as an adjuvant therapeutic approach. Results: The auditory cell protective effects of PBM could significantly enhance the performance of EAS devices in individuals with residual hearing. Further, postoperative CI is accompanied by an inflammatory response characterized by the upregulation of specific cytokines. Conclusion: Considering the neuroregenerative potential of PBM, its application as a neuroprotective strategy warrants further validation.

目的:光生物调节(PBM)是一种非侵入性治疗方式,可广泛应用于调节各种生物过程。尽管确切的作用机制仍不确定,但光生物调节可通过多种途径促进体内平衡,包括减少炎症和促进组织恢复。由于耳蜗毛细胞的再生能力有限,哺乳动物的听力损失是不可逆的。人工耳蜗通过电刺激听觉神经,绕过受损的毛细胞,为重度听力损失患者提供了一种解决方案。然而,术后炎症反应和耳蜗神经纤维损伤会影响植入效果。材料和方法:我们研究了当前最大限度减少人工耳蜗植入术后继发性耳蜗损伤的策略,并评估了 PBM 作为辅助治疗方法的潜力。结果PBM 的听觉细胞保护作用可显著提高 EAS 设备在残余听力患者中的性能。此外,术后 CI 还伴随着以特定细胞因子上调为特征的炎症反应。结论考虑到 PBM 的神经再生潜力,其作为神经保护策略的应用值得进一步验证。
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引用次数: 0
"Five-Step" Vaporization of the Prostate Using 180-W XPS Greenlight Laser in Patients with Benign Prostatic Hyperplasia of Large Volume: Improved Efficacy and Safety. 使用 180 瓦 XPS 绿光激光对体积较大的良性前列腺增生患者进行 "五步 "前列腺汽化治疗:提高疗效和安全性。
IF 1.8 Q2 SURGERY Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI: 10.1089/pho.2024.0056
Zhi-Hua Zhang, Fei Luo, Ya-Shen Wang, Jian Li

Objective: To evaluate the safety and efficacy of 180-W XPS Greenlight laser "Five-step" photoselective vaporization of the prostate (PVP) in patients with benign prostatic hyperplasia (BPH) with prostate volume (PV) > 80 mL. Background: In patients with BPH with large PV, PVP often results in bleeding, unclear visual field, additional damage, and insufficient tissue vaporization. Methods: This single-center, retrospective study enrolled patients with BPH with PV > 80 mL treated with the Five-step PVP or the Conventional PVP from January 2018 to June 2021. Comorbidities, high-risk habits, and operative parameters were analyzed and compared. The short-term functional outcomes and postoperative complications were recorded over the 24-month follow-up. Results: Two hundred eligible patients were divided into the Five-step PVP and Conventional PVP groups (n = 100 each). These groups showed no differences in comorbidities, living habits, baseline perioperative parameters, operative time, lasing time, or energy use. However, a higher energy density (3.95 [interquartile range (IQR) 3.37, 4.52] vs 3.68 [IQR 3.17, 4.20] kJ/mL) and energy-time ratio (7.23 [IQR 6.12, 8.52] vs 6.72 [IQR 5.51, 7.87] kj/min p = 0.034) were obtained in the Five-step PVP group. Subgroup analysis of patients with PV ≥120 mL showed similar results. The short-term functional outcomes were similar between the two study groups with significant improvement from baseline, but the total prostate-specific antigen levels at 1 and 6 months were lower in the Five-step PVP group. Further, incidences of intraoperative bleeding, bladder mucosa injury, postoperative hematuria, and urinary tract infection were lower in the Five-step PVP group. In the Conventional PVP group, four patients required conversion to transurethral resection of the prostate in surgery and two patients required retreatment during the 24-month follow-up. Conclusions: The 180-W XPS Greenlight laser Five-step PVP has advantages of less bleeding, high vaporization efficiency, and low rates of perioperative complications, and, therefore, it is a promising treatment to improve short-term functional outcomes for patients with BPH with large PV.

目的评估 180-W XPS Greenlight 激光 "五步 "前列腺光选择性汽化术(PVP)对前列腺体积(PV)大于 80 mL 的良性前列腺增生症(BPH)患者的安全性和有效性。背景:对于前列腺体积较大的良性前列腺增生症(BPH)患者,PVP 通常会导致出血、视野不清、额外损伤和组织汽化不充分。方法:这项单中心回顾性研究纳入了 2018 年 1 月至 2021 年 6 月期间接受五步 PVP 或常规 PVP 治疗的 PV > 80 mL 的良性前列腺增生症患者。对合并症、高危习惯和手术参数进行了分析和比较。记录了24个月随访期间的短期功能预后和术后并发症。结果200 名符合条件的患者被分为五步 PVP 组和传统 PVP 组(各 100 人)。两组患者在合并症、生活习惯、围手术期基线参数、手术时间、激光时间或能量使用方面均无差异。不过,五步 PVP 组的能量密度(3.95 [四分位间范围 (IQR) 3.37, 4.52] vs 3.68 [IQR 3.17, 4.20] kJ/mL)和能量-时间比(7.23 [IQR 6.12, 8.52] vs 6.72 [IQR 5.51, 7.87] kj/min p = 0.034)更高。对 PV≥120 mL 患者进行的分组分析显示了相似的结果。两组患者的短期功能结果相似,与基线相比均有显著改善,但五步前列腺电切术组在 1 个月和 6 个月时的总前列腺特异性抗原水平较低。此外,五步前列腺电切术组术中出血、膀胱粘膜损伤、术后血尿和尿路感染的发生率较低。在传统前列腺电切术组中,有四名患者在手术中需要转为经尿道前列腺切除术,两名患者在 24 个月的随访期间需要进行再治疗。结论180-W XPS Greenlight 激光五步前列腺汽化电切术具有出血少、汽化效率高、围术期并发症发生率低等优点,因此是一种有望改善前列腺增生伴大前列腺体积患者短期功能预后的治疗方法。
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引用次数: 0
The Effect of Photobiomodulation on Bone Mineral Density, Serum Vitamin D, and Bone Formation Markers in Individuals with Complete Spinal Cord Injuries with Osteoporosis. 光生物调节对完全性脊髓损伤伴骨质疏松症患者的骨矿物质密度、血清维生素 D 和骨形成标志物的影响。
IF 1.8 Q2 SURGERY Pub Date : 2024-11-01 Epub Date: 2024-10-02 DOI: 10.1089/photob.2023.0195
Esmaeil Mohammadzadeh, Aref Hosseinian Amiri, Reza Fekrazad, Rainer A Leitgeb, Winfried Mayr, Kamran Ezzati

Study design: A quasi-experimental study utilized a matched-pair design, administering photobiomodulation at four-sites on one side of the body and assigning control to the other side at corresponding sites. Objectives: This study aimed to assess photobiomodulation treatment effects on bone mineral density (BMD) measurement using dual-energy X-ray-absorptiometry in individuals with complete spinal cord injury (C.SCI) and osteoporosis. Methods: Eight patients received treatment at four-sites: forearm-mid-distal (MID), proximal-femur, distal-femur, and proximal-tibia, totaling 32 sites. Using an 830 nm gallium-aluminum-arsenide semiconductor laser irradiation was administered three times weekly for 8 weeks. Different doses (energy density) were determined depending on bone depth from skin surface, as assessed by sonography and adjusted through irradiation time to be 8, 10, and 12 J/cm2 for depths <1 cm, between 1 and 1.5 cm, and >1.5 cm, respectively, using 200 mW power to deliver the optimal isodose of laser at each depth of bone within each therapeutic site. BMD was measured at baseline, week 8 of treatment, and week 15 of follow-up. Serum 25-(OH)-vitamin D and bone formation markers including osteocalcin and bone-alkaline-phosphatase (B-ALP) were also assessed at baseline and week 8 of treatment. Results: Significant increases in BMD were noted in proximal-femur and forearm-MID at both week 8 and week 15. Serum 25-(OH)-vitamin D levels significantly increased after treatment. However, no notable changes were observed in distal-femur and proximal-tibia BMD or in osteocalcin and B-ALP levels. Conclusions: Photobiomodulation (830 nm) laser demonstrated efficacy in improving BMD at proximal-femur and forearm-MID in individuals with C.SCI. Moreover, the observed positive influence on vitamin D levels suggests a potential photobiomodulation role, warranting further investigation.

研究设计:准实验研究采用配对设计,在身体一侧的四个部位进行光生物调节,并在另一侧的相应部位进行对照。研究目的本研究旨在评估光生物调节治疗对完全性脊髓损伤(C.SCI)和骨质疏松症患者使用双能 X 射线吸收测量法测量骨矿密度(BMD)的影响。治疗方法八名患者接受了四个部位的治疗:前臂-中远端(MID)、近端-股骨、远端-股骨和近端-胫骨,共 32 个部位。使用 830 纳米镓铝砷化半导体激光器进行照射,每周三次,持续 8 周。根据超声波检查评估的距皮肤表面的骨深度确定不同的剂量(能量密度),并通过照射时间将深度为 1.5 厘米的骨深度分别调整为 8、10 和 12 J/cm2,使用 200 mW 功率在每个治疗部位的每个骨深度提供最佳等剂量激光。在基线、治疗第 8 周和随访第 15 周时测量 BMD。血清 25-(OH)-vitamin D 和骨形成标志物(包括骨钙素和骨碱性磷酸酶 (B-ALP))也在基线和治疗第 8 周时进行了评估。结果显示在治疗第 8 周和第 15 周时,近端-女性和前臂-MID 的 BMD 均有显著增加。治疗后,血清 25-(OH)-vitamin D 水平显著增加。但是,远端-股骨和近端-胫骨的 BMD 以及骨钙素和 B-ALP 水平均未出现明显变化。结论光生物调节(830 nm)激光在改善 C.SCI 患者的近端-股骨和前臂-MID 的 BMD 方面具有疗效。此外,观察到的对维生素 D 水平的积极影响表明,光生物调节具有潜在的作用,值得进一步研究。
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引用次数: 0
Green Synthesis of Au-Doped Tin Oxide Nanoparticles Using Teucrium Polium Extract with Potential Applications in Photodynamic Therapy. 利用柚木提取物绿色合成掺金氧化锡纳米粒子,在光动力疗法中的潜在应用
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1089/photob.2024.0052
Merat Karimi, Ehsan Sadeghi, Mostafa Zahedifar, Hamed Mirzaei, Majid Nejati, Michael R Hamblin

Objective: The green synthesis of Tin(IV) oxide (SnO2): Gold (Au) nanoparticles (NPs) using Teucrium polium medicinal plant extract was investigated, and the NPs were characterized and tested as photosensitizers to produce reactive oxygen species (ROS). Methods: The cytotoxic effect on C26 cells was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) technique. The results showed their toxicity in a dose-dependent manner. The green synthesis of SnO2:Au NPs was achieved for the first time using an extract of T. polium medicinal plant as a reducing and stabilizing agent. The produced NPs were examined for their application in photodynamic therapy (PDT) for cancer. Results: Methylene blue and anthracene were used to confirm that the photosensitizer could produce ROS when excited with UVA radiation. The anticancer activity of SnO2:Au was investigated in vitro using the C26 cell line and an MTT assay, showing that PDT with SnO2:Au NPs could inhibit cancer cell proliferation. Conclusions: The significant afterglow of the SnO2:Au NPs could cause the generation of ROS to continue several minutes after switching off the light source.

目的:研究了利用柚子药用植物提取物绿色合成氧化锡(IV)(SnO2)、金(Au)纳米粒子(NPs)的方法:金(Au)纳米粒子(NPs)的绿色合成进行了研究,并对其作为光敏剂产生活性氧(ROS)进行了表征和测试。研究方法采用 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑(MTT)技术研究了 NPs 对 C26 细胞的细胞毒性作用。结果表明,它们的毒性呈剂量依赖性。利用枸杞药用植物的提取物作为还原剂和稳定剂,首次实现了 SnO2:Au NPs 的绿色合成。研究了所制备的 NPs 在癌症光动力疗法(PDT)中的应用。结果显示用亚甲蓝和蒽证实了光敏剂在 UVA 辐射激发下能产生 ROS。使用 C26 细胞系和 MTT 试验对 SnO2:Au 的抗癌活性进行了体外研究,结果表明,使用 SnO2:Au NPs 进行光动力疗法可抑制癌细胞增殖。结论SnO2:Au NPs 的明显余辉可导致 ROS 的产生在光源关闭后持续数分钟。
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引用次数: 0
Underexplored Areas of Photobiomodulation in Oral Oncology: An Expert Analysis. 口腔肿瘤学中尚未充分开发的光生物调节领域:专家分析。
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 DOI: 10.1089/photob.2023.0155
Luiz Alcino Gueiros, Margherita Gobbo, Alan Roger Santos-Silva, Elisabetta Merigo, Wanessa Miranda-Silva, Eduardo Rodrigues Fregnani, Giulia Ottaviani, Elisa Kauark-Fontes, Rene-Jean Bensadoun, Praveen Arany

Objective: This study aimed to review the current body of literature on underexplored areas of photobiomodulation (PBM) for preventing and/or treating oral adverse events. Background: Recent studies suggest that PBM may offer potential benefits in managing cancer-related toxicities other than oral mucositis. Nevertheless, further research to establish conclusive evidence is still missing. Methods: A panel of specialists conducted a narrative review to evaluate the evidence on PBM therapy for oral mucositis, xerostomia, dysgeusia, dysphagia, and trismus/fibrosis. Each topic was reviewed by two specialists who discussed treatment rationale, summarized current evidence, evaluated risk/benefit ratio, and identified future research directions. Results: The current evidence suggests promising outcomes in nonroutine uses of PBM for xerostomia, dysgeusia, odynophagia, oral mucositis (extraoral PBM and the pediatric population), and trismus/fibrosis. However, the primary studies are often small and may have biases that require further evaluation, particularly regarding treatment safety. Conclusion: Despite the overall positive impression of PBM therapy for oral adverse events of cancer treatment, robust evidence from large multicentered studies is necessary to support its widespread clinical use.

研究目的本研究旨在回顾目前有关光生物调控 (PBM) 用于预防和/或治疗口腔不良事件的未充分探索领域的文献。背景:最近的研究表明,光生物调节疗法在控制癌症相关毒性反应(口腔粘膜炎除外)方面具有潜在的益处。然而,目前仍缺乏进一步的研究来确立确凿的证据。研究方法一个专家小组进行了叙述性综述,以评估 PBM 治疗口腔黏膜炎、口腔异物感、吞咽困难和咀嚼障碍/纤维化的证据。每个主题都由两名专家进行评审,他们讨论了治疗原理、总结了当前证据、评估了风险/效益比,并确定了未来的研究方向。结果:目前的证据表明,非日常使用 PBM 治疗口腔异物感、吞咽困难、吞咽困难、口腔粘膜炎(口外 PBM 和儿童人群)以及咀嚼肌痉挛/纤维化的效果很好。不过,主要研究的规模通常较小,可能存在偏差,需要进一步评估,尤其是在治疗安全性方面。结论:尽管PBM疗法在治疗癌症口腔不良反应方面给人的总体印象是积极的,但仍需要大型多中心研究的有力证据来支持其在临床上的广泛应用。
{"title":"Underexplored Areas of Photobiomodulation in Oral Oncology: An Expert Analysis.","authors":"Luiz Alcino Gueiros, Margherita Gobbo, Alan Roger Santos-Silva, Elisabetta Merigo, Wanessa Miranda-Silva, Eduardo Rodrigues Fregnani, Giulia Ottaviani, Elisa Kauark-Fontes, Rene-Jean Bensadoun, Praveen Arany","doi":"10.1089/photob.2023.0155","DOIUrl":"https://doi.org/10.1089/photob.2023.0155","url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study aimed to review the current body of literature on underexplored areas of photobiomodulation (PBM) for preventing and/or treating oral adverse events. <b><i>Background:</i></b> Recent studies suggest that PBM may offer potential benefits in managing cancer-related toxicities other than oral mucositis. Nevertheless, further research to establish conclusive evidence is still missing. <b><i>Methods:</i></b> A panel of specialists conducted a narrative review to evaluate the evidence on PBM therapy for oral mucositis, xerostomia, dysgeusia, dysphagia, and trismus/fibrosis. Each topic was reviewed by two specialists who discussed treatment rationale, summarized current evidence, evaluated risk/benefit ratio, and identified future research directions. <b><i>Results:</i></b> The current evidence suggests promising outcomes in nonroutine uses of PBM for xerostomia, dysgeusia, odynophagia, oral mucositis (extraoral PBM and the pediatric population), and trismus/fibrosis. However, the primary studies are often small and may have biases that require further evaluation, particularly regarding treatment safety. <b><i>Conclusion:</i></b> Despite the overall positive impression of PBM therapy for oral adverse events of cancer treatment, robust evidence from large multicentered studies is necessary to support its widespread clinical use.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 10","pages":"609-619"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental and Chitosan-Infused Adhesive with Dentin Pretreated with Femtosecond Laser, Methylene Blue-Activated Low-Level Laser, and Phosphoric Acid. 用飞秒激光、亚甲基蓝激活低强度激光和磷酸预处理牙本质的实验粘合剂和注入壳聚糖的粘合剂。
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI: 10.1089/pho.2024.0077
Fahad Alkhudhairy

Aim: To prepare experimental adhesive (EA) with 1% and without chitosan nanoparticles on dentin conditioned with a conventional technique phosphoric acid (PA) compared with two different contemporary techniques: photodynamic therapy (PDT) and femtosecond laser (FSL). Method: The methodology consisted of synthesis of EA and 1% chitosan-modified adhesive (CMA). Scanning electron microscopy, dentin adhesive interface assessment, energy-dispersive spectroscopy, shear bond strength (SBS), degree of conversion (DC), and bond failure were assessed. Teeth were selected, disinfected, and mounted in acrylic up to the cementoenamel junction. Occlusal enamel was removed and teeth were randomly allocated into groups and conditioned. These included Group 1: samples treated with PA; Group 2: specimens conditioned with methylene blue photosensitizer (MBP) activated by PDT; and Group 3: samples conditioned with FSL. Following different conditioning regimes, specimens were bonded using 1% CMA and EA. The composite buildup was followed by SBS testing and a bond failure assessment. DC was assessed for both EA and CMA. Analysis of variance and Tukey's post hoc test were used to compare the mean and standard deviation of SBS and DC in different experimental groups, with a significance level of p < 0.05. Results: Dentin pretreated with etch and rinse demonstrated the highest bond strength with 1% CMA. Dentin conditioned with MBP activated by PDT and bonded to EA showed the lowest bond scores. Overall SBS values of 1% CMA were better than EA irrespective of the conditioning regime of dentin. The DC was higher in EA adhesive. This was followed by DC in 1% CMA. DC in EA was found to be comparable with 1% CMA. Conclusions: PA remains the gold standard for dentin conditioning. The incorporation of 1% chitosan in adhesive improves SBS and results in no change in DC. The use of FSL in dentin conditioning can be used as an alternative approach as it results in SBS within acceptable limits. The study was approved by the ethical board of King Saud University.

目的:制备含 1%和不含壳聚糖纳米颗粒的牙本质实验粘合剂(EA),并将其与两种不同的现代技术:光动力疗法(PDT)和飞秒激光(FSL)进行比较。方法:方法包括合成 EA 和 1%壳聚糖改性粘合剂(CMA)。对扫描电子显微镜、牙本质粘接界面评估、能量色散光谱、剪切粘接强度(SBS)、转换度(DC)和粘接失败进行评估。选取牙齿,进行消毒,并将其安装在丙烯酸树脂中,直至牙本质釉质交界处。去除咬合面珐琅质,将牙齿随机分配到不同的组别并进行调节。其中包括:第 1 组:用 PA 处理的样本;第 2 组:用亚甲基蓝光敏剂 (MBP) 激活 PDT 调理的样本;第 3 组:用 FSL 调理的样本。在采用不同的调节机制后,使用 1% CMA 和 EA 对试样进行粘合。复合材料堆积后进行 SBS 测试和粘接失效评估。对 EA 和 CMA 都进行了 DC 评估。采用方差分析和 Tukey 后验法比较不同实验组中 SBS 和 DC 的平均值和标准偏差,显著性水平为 p <0.05。结果经蚀刻和冲洗预处理的牙本质与 1% CMA 的粘接强度最高。用 PDT 激活的 MBP 调理牙本质并与 EA 粘接后,粘接得分最低。无论牙本质的调节机制如何,1% CMA 的总体 SBS 值都优于 EA。EA 粘合剂的 DC 值较高。其次是 1%CMA。发现 EA 中的 DC 与 1%CMA相当。结论:PA 仍是牙本质调节的黄金标准。在粘合剂中加入 1%的壳聚糖可提高 SBS,但不会改变 DC。在牙本质调节中使用 FSL 可作为一种替代方法,因为它能使 SBS 在可接受的范围内。该研究已获得沙特国王大学伦理委员会的批准。
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引用次数: 0
Analysis of the Ultrasensitive C-Reactive Protein and Homocysteine Biomarkers after Photobiomodulation Therapy in Hormone Blocker-Treated Mastectomized Women: A Randomized, Blind, and Controlled Clinical Study. 激素阻断剂治疗的乳房切除妇女接受光生物调节疗法后的超敏 C 反应蛋白和同型半胱氨酸生物标志物分析:一项随机、盲法对照临床研究。
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 DOI: 10.1089/photob.2024.0071
Juliano Abreu Pacheco, Kelly Fernanda Molena, Eugenia Velludo Veiga

Main: The pharmacological treatment of cancer can lead to undesirable hemodynamic adverse effects. Laser therapy may promote hemodynamic balance in these patients. This study aimed to analyze the values of the biomarkers ultrasensitive C-reactive protein (PCR_us) and Homocysteine (HCy) after the use of intravascular laser irradiation of blood (ILIB) in mastectomized patients using hormonal blockers Tamoxifen and Aromatase Inhibitors. Methods: This was an experimental, placebo-controlled, randomized clinical trial with experimental (G1) and control (G2) groups. In G1, patients were irradiated with ILIB using a red laser at 660 nm on the carotid artery, while G2 received a placebo treatment. Blood collection for HCy and us-CRP biomarker evaluation was conducted monthly for 4 months. Statistical analysis was performed using R Studio 4.4.2 and JAMOVI, with a significance level of 5%. Results: A total of 21 patients participated in the study, with 12 in G1 and 9 in G2. There were no differences in age, systolic, diastolic blood pressure, and heart rate between the groups. The initial and final mean PCR_us levels for G1 were 6.8 and 3.8 mg/dL, and for HCy were 14.2 and 12.1 µmol/L, respectively. While for G2 initial and final mean PCR_us levels were 9.40 and 7.60 mg/dL, and for HCy were 14.33 and 16.69 µmol/L. There was no statistical difference for PCR_us. However, a significant difference between the groups (p < 0.05) for HCy in the 3rd and 4th months. Conclusion: During ILIB Therapy, there was a reduction in HCy, which may favor the improvement of cardiovascular function in these patients undergoing anticancer therapies.

主要内容:癌症的药物治疗可能会对血液动力学产生不良影响。激光疗法可促进这些患者的血液动力学平衡。本研究旨在分析使用激素阻断剂他莫昔芬和芳香化酶抑制剂的乳腺切除术患者使用血管内激光照射血液(ILIB)后的生物标志物超敏 C 反应蛋白(PCR_us)和同型半胱氨酸(HCy)的值。研究方法这是一项实验、安慰剂对照、随机临床试验,分为实验组(G1)和对照组(G2)。在 G1 组中,使用波长为 660 纳米的红色激光对患者的颈动脉进行 ILIB 照射,而 G2 组则接受安慰剂治疗。在为期 4 个月的时间里,每月采集血液进行 HCy 和 us-CRP 生物标志物评估。统计分析使用 R Studio 4.4.2 和 JAMOVI 进行,显著性水平为 5%。结果共有 21 名患者参与了研究,其中 G1 组 12 人,G2 组 9 人。两组患者的年龄、收缩压、舒张压和心率均无差异。G1 组的 PCR_us 初始和最终平均水平分别为 6.8 和 3.8 mg/dL,HCy 初始和最终平均水平分别为 14.2 和 12.1 µmol/L。而 G2 的 PCR_us 初始和最终平均水平分别为 9.40 和 7.60 mg/dL,HCy 为 14.33 和 16.69 µmol/L。PCR_us 没有统计学差异。但在第 3 个月和第 4 个月,各组间的 HCy 存在明显差异(p < 0.05)。结论在 ILIB 治疗期间,HCy 有所下降,这可能有利于正在接受抗癌治疗的患者改善心血管功能。
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引用次数: 0
The Effectiveness of Three Different Irrigant Activation Methods in the Elimination of Enterococcus faecalis from Root Canals. 三种不同灌洗剂活化方法在消除根管中粪肠球菌方面的效果。
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI: 10.1089/pho.2023.0189
Ozgur Genc Sen, Ali Erdemir

Background and Objective: Eliminating intracanal Enterococcus faecalis (E. faecalis) is challenging because of its ability to penetrate deep dentinal tubules and its high resistance to many chemicals. This study evaluated the effectiveness of conventional needle irrigation and three different irrigant activation methods in reducing E. faecalis. Methods: The root canals of extracted teeth were shaped, contaminated with E. faecalis, and incubated for three weeks. They were randomly allocated to four experimental groups of 15 teeth each according to the final irrigation method: group 1, conventional needle irrigation; group 2, passive ultrasonic (PU) irrigation; group 3, XP-endo Finisher (XPF); and group 4, laser-activated (LA) irrigation. Bacterial samples were taken and cultured before and after these final irrigation procedures. The colony-forming units were counted, and the bacterial reduction percentages of each group were calculated. The Kruskal-Wallis and Dunnet tests were used for statistical analysis. Results: All irrigant activation methods were significantly more effective than conventional needle irrigation. Although the LA group generated more negative samples than PU, there was no statistically significant difference between the LA and PU groups. LA was significantly more effective than the XPF, whereas PU and XPF were statistically similar. Conclusions: Within the limitations of this study, the final irrigation with LA and PU showed the best reductive effect on E. faecalis colonies. Considering that the LA group had more negative samples, it may be chosen as an alternative to enhance root canal disinfection, especially in difficult cases.

背景和目的:消灭牙槽骨内的粪肠球菌(E. faecalis)具有挑战性,因为它能够穿透深层牙本质小管,而且对许多化学物质具有很强的抵抗力。本研究评估了传统针头冲洗和三种不同冲洗剂激活方法在减少粪肠球菌方面的效果。方法:对拔牙的根管进行塑形,用粪大肠杆菌污染根管并培养三周。根据最终灌洗方法,将它们随机分配到四个实验组,每组 15 颗牙齿:第 1 组,传统针头灌洗;第 2 组,被动超声波(PU)灌洗;第 3 组,XP-endo Finisher(XPF);第 4 组,激光激活(LA)灌洗。在这些最终灌洗程序之前和之后采集细菌样本并进行培养。对菌落形成单位进行计数,并计算各组的细菌减少率。统计分析采用 Kruskal-Wallis 和 Dunnet 检验。结果所有灌流剂激活方法的效果都明显优于传统针头灌流法。虽然 LA 组比 PU 组产生更多的阴性样本,但 LA 组和 PU 组之间没有统计学意义上的显著差异。LA 明显比 XPF 更有效,而 PU 和 XPF 在统计学上相似。结论:在本研究的局限性范围内,LA 和 PU 的最终灌溉对粪大肠杆菌菌落的还原效果最好。考虑到 LA 组有更多的阴性样本,可以选择它作为加强根管消毒的替代方法,尤其是在疑难病例中。
{"title":"The Effectiveness of Three Different Irrigant Activation Methods in the Elimination of <i>Enterococcus faecalis</i> from Root Canals.","authors":"Ozgur Genc Sen, Ali Erdemir","doi":"10.1089/pho.2023.0189","DOIUrl":"10.1089/pho.2023.0189","url":null,"abstract":"<p><p><b><i>Background and Objective:</i></b> Eliminating intracanal <i>Enterococcus faecalis</i> (<i>E. faecalis</i>) is challenging because of its ability to penetrate deep dentinal tubules and its high resistance to many chemicals. This study evaluated the effectiveness of conventional needle irrigation and three different irrigant activation methods in reducing <i>E. faecalis</i>. <b><i>Methods:</i></b> The root canals of extracted teeth were shaped, contaminated with <i>E. faecalis</i>, and incubated for three weeks. They were randomly allocated to four experimental groups of 15 teeth each according to the final irrigation method: group 1, conventional needle irrigation; group 2, passive ultrasonic (PU) irrigation; group 3, XP-endo Finisher (XPF); and group 4, laser-activated (LA) irrigation. Bacterial samples were taken and cultured before and after these final irrigation procedures. The colony-forming units were counted, and the bacterial reduction percentages of each group were calculated. The Kruskal-Wallis and Dunnet tests were used for statistical analysis. <b><i>Results:</i></b> All irrigant activation methods were significantly more effective than conventional needle irrigation. Although the LA group generated more negative samples than PU, there was no statistically significant difference between the LA and PU groups. LA was significantly more effective than the XPF, whereas PU and XPF were statistically similar. <b><i>Conclusions:</i></b> Within the limitations of this study, the final irrigation with LA and PU showed the best reductive effect on <i>E. faecalis</i> colonies. Considering that the LA group had more negative samples, it may be chosen as an alternative to enhance root canal disinfection, especially in difficult cases.</p>","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":" ","pages":"628-633"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photobiomodulation Literature Watch December 2023. 2023 年 12 月光生物调制文献观察。
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 DOI: 10.1089/pho.2024.0087
James D Carroll
{"title":"Photobiomodulation Literature Watch December 2023.","authors":"James D Carroll","doi":"10.1089/pho.2024.0087","DOIUrl":"https://doi.org/10.1089/pho.2024.0087","url":null,"abstract":"","PeriodicalId":94169,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"42 10","pages":"660-662"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-Guided Nd:YAG Laser Intervention in the Orofacial Region: Report of a Case of Multi-Focal Venous Malformation. 超声引导下的 Nd:YAG 激光口面部介入治疗:多灶性静脉畸形病例报告。
IF 1.8 Q2 SURGERY Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI: 10.1089/photob.2024.0012
Jingchen Jia, Mingzhu Feng, Ping Wang, Jing Lv, Wenbin Wang, Bin Ma, Hongshi Li

Venous malformation is acongenital vascular system structure malformation caused by abnormal vascular endothelial cell morphology, which can occur in any tissue or organ of the oral and maxillofacial region. Laser treatment is currently a commonly used minimally invasive treatment. In this case, the patient with congenital multiple venous malformation was treated with Nd:YAG laser for the visible submucosal part, and the subcutaneous part under the chin tip was treated with ultrasound. The chin tip was treated with ultrasound guided by the chair to achieve the purpose of minimally invasive laser treatment. In this case's diagnosis and treatment process, we hope to provide a new idea for laser treatment of oromaxillofacial vein malformations.

静脉畸形是由血管内皮细胞形态异常引起的先天性血管系统结构畸形,可发生于口腔颌面部的任何组织或器官。激光治疗是目前常用的微创治疗方法。在本病例中,先天性多发性静脉畸形患者采用 Nd:YAG 激光治疗可见的粘膜下部分,并用超声波治疗颏尖下的皮下部分。在椅子的引导下用超声波治疗颏尖,达到了激光微创治疗的目的。通过本病例的诊断和治疗过程,我们希望能为口腔颌面部静脉畸形的激光治疗提供一种新的思路。
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Photobiomodulation, photomedicine, and laser surgery
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