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Er:YAG Laser and Hemolasertherapy: Bone and Gingiva Gain-Case Report. Er:YAG 激光和血液疗法:骨骼和牙龈增生--病例报告。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-05-17 DOI: 10.1089/pho.2023.0138
Fatima Zanin, Gabriela Silva, Eric Mayer-Santos, Ana Paula Brugnera, Ariane Sardop, Aldo Brugnera

Background: Modern dentistry has increasingly valued conservative and biologically less invasive clinical practices, seeking to preserve the patients' tissues and natural dental elements. Most extractions in the dental clinic are preceded by periodontal disease that presents bone and gingival tissue loss, compromising the aesthetics as well as the support of dental elements. Objectives: The clinical approach in these cases often involves bone exertion followed by the successful installation of osseointegrated implants. Material and Methods: In this study, a case of extensive periodontal involvement and mobility of dental elements was carried out in a minimally invasive way, using the Er:YAG laser for periodontal decontamination and the hemolasertherapy technique to regenerate adjacent tissues, totaling nine weeks of treatment. Results: Clinical and radiographical improvement of tissue health and complete preservation of dental elements were observed. Conclusion: The patient underwent a follow-up appointment 2 years after the start of treatment when it was still possible to verify the stability of the clinical condition and the tissue gains obtained.

背景:现代牙科越来越重视保守和生物微创临床实践,力求保护患者的组织和天然牙体。牙科诊所中的大多数拔牙手术都是在牙周病发生之前进行的,牙周病会导致牙槽骨和牙龈组织缺损,从而影响美观和牙齿的支撑力。目标:这些病例的临床治疗方法通常包括骨质疏松,然后成功安装骨结合种植体。材料和方法:本研究采用微创方式对一例牙周广泛受累、牙体活动度大的病例进行了治疗,使用 Er:YAG 激光进行牙周净化,并使用血液激光治疗技术使邻近组织再生,共进行了九周的治疗。治疗结果从临床和放射学角度看,组织健康得到了改善,牙体成分得到了完全保存。结论:该患者在治疗开始两年后接受了复诊,当时仍能验证临床状况的稳定性和获得的组织增益。
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引用次数: 0
Fractional and Microablative CO2 LASER and Radiofrequency in the Treatment of Genitourinary Syndrome of Menopause: A Descriptive Study. 治疗更年期泌尿生殖系统综合征的点阵和微烧蚀二氧化碳激光及射频疗法:描述性研究。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-06-18 DOI: 10.1089/pho.2023.0110
Maria Cristina Caceres Nogueira, Ana Maria Homem de Mello Bianchi-Ferraro, Madalena Leonor Pereira Campos, Carla Dias Oliveira, Marair Gracio Ferreira Sartori, Zsuzsanna Ilona Katalin de Jármy Di Bella, Angela Flavia Logullo, Neila Maria Gois Speck

Objectives: This study aimed to evaluate the vagina clinically, cytologically, and histologically before and after treating genitourinary syndrome of menopause (GSM) with fractional microablative carbon dioxide LASER (CO2L), radiofrequency (RF), and estrogen vaginal cream (CT). Methods: Women with moderate-to-severe symptoms of GSM, denoted by a GSM Visual analog scale (VAS) score of >4, were eligible for this study. The patients were randomized into treatment groups. In the energy groups, three vulvovaginal applications were administered monthly. The CT group used 0.5 mg vaginal estriol cream for 14 consecutive days, followed by twice a week for 4 months. The follow-up visits occurred 120 days after the beginning of the treatments. The same parameters obtained at the first visit were re-evaluated: GSM VAS score, Incontinence Quality of Life Questionnaire (I-QOL), gynecological examination determining Vaginal Health Index (VHI), vaginal smear for Vaginal Maturation Value (VMV), and vaginal biopsy. Results: Seventy-one women were included, 48 completed the study and provided adequate samples for analysis (CO2L [21 patients], RF [15 patients], and CT [12 patients]). GSM symptoms, I-QOL, and VHI significantly improved after all proposed treatments, with no significant differences between them. VMV did not change after any treatment; however, only 22.9% of the patients presented with cytological atrophy before treatment. Histological vaginal atrophy was identified in 6 (12.5%) pretreated vaginal samples. After the intervention, all histological parameters were normalized, no tissue damage was observed, and no major clinical complications were observed. Conclusion: CO2L and RF seem to be good alternatives to CT for GSM treatment, with no tissue damage.

研究目的本研究旨在从临床、细胞学和组织学角度对使用点阵微烧蚀二氧化碳激光(CO2L)、射频(RF)和雌激素阴道霜(CT)治疗更年期泌尿生殖系统综合征(GSM)前后的阴道进行评估。治疗方法有中度至重度 GSM 症状(GSM 视觉模拟量表(VAS)评分大于 4 分)的妇女有资格参加这项研究。患者被随机分为不同的治疗组。能量组每月使用三次外阴阴道用药。CT 组连续 14 天使用 0.5 毫克阴道雌三醇霜,之后每周两次,持续 4 个月。治疗开始 120 天后进行随访。对首次就诊时获得的相同参数进行了重新评估:GSM VAS评分、尿失禁生活质量问卷(I-QOL)、确定阴道健康指数(VHI)的妇科检查、阴道成熟值(VMV)阴道涂片和阴道活检。结果:共纳入 71 名妇女,48 人完成了研究并提供了足够的样本进行分析(CO2L [21 名患者]、RF [15 名患者] 和 CT [12 名患者])。在所有建议的治疗后,GSM 症状、I-QOL 和 VHI 均有明显改善,且无显著差异。VMV在任何治疗后都没有变化;然而,只有22.9%的患者在治疗前出现细胞学萎缩。在 6 份(12.5%)治疗前的阴道样本中发现了组织学上的阴道萎缩。干预后,所有组织学参数均恢复正常,未观察到组织损伤,也未观察到重大临床并发症。结论CO2L和RF似乎是CT治疗GSM的良好替代品,且无组织损伤。
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引用次数: 0
Minimally Invasive Semiconductor Laser Surgery Combined with 5-ALA Photodynamic Therapy for a Chronic Hyperplastic Candidiasis Patient Who Is Ineffective to Antifungal Therapy. 微创半导体激光手术结合 5-ALA 光动力疗法治疗对抗真菌疗法无效的慢性增生性念珠菌病患者。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1089/photob.2023.0174
Feng Wang, Gang Zhou, Jing Zhang

Background: Chronic hyperplastic candidiasis (CHC) is a chronic oral mucosal infection caused by Candida, which has potential for malignant transformation. Diagnosing CHC can be challenging due to its various manifestations. In addition, fungal treatments often prove to be ineffective, highlighting the urgent need for a new safe and efficient treatment approach. Given the potential of CHC to transform into malignancy, it is crucial to emphasize dynamic monitoring and follow-up after treatment. Objective: We attempted to investigate the effect of semiconductor laser pretreatment combined with 5-amino-levulinic acid (5-ALA) photodynamic therapy (PDT) for CHC. Methods: We presented the successful treatment of CHC with mild dysplasia in a 30-year-old man using semiconductor laser and 5-ALA PDT after antifungal therapy proved ineffective. Toluidine blue staining, autofluorescence imaging, and DNA image cytometry were combined to dynamically monitor the progress of the disease. Results: We have obtained positive outcomes with the use of laser combined with PDT treatment. The patients experienced only mild adverse reactions after the treatment, and there was no indication of recurrence or malignant transformation during the subsequent follow-up period, as observed through various auxiliary examinations. Conclusions: This case report suggests that semiconductor laser surgery combined with PDT could be a promising treatment option for patients with CHC who do not respond to antifungal therapy. In addition, the use of combined noninvasive examinations might provide a more accurate assessment of malignant transformation in patients with CHC.

背景:慢性增生性念珠菌病(CHC)是由念珠菌引起的慢性口腔黏膜感染,有恶变的可能。由于慢性增生性念珠菌病的表现多种多样,因此诊断该病非常困难。此外,真菌治疗往往无效,因此迫切需要一种新的安全高效的治疗方法。鉴于 CHC 有可能转化为恶性肿瘤,因此强调治疗后的动态监测和随访至关重要。研究目的我们尝试研究半导体激光预处理联合 5- 氨基乙酰丙酸(5-ALA)光动力疗法(PDT)治疗 CHC 的效果。方法:我们介绍了在抗真菌治疗无效后,使用半导体激光和 5-ALA 光动力疗法成功治疗一名 30 岁男性轻度发育不良的 CHC 的病例。结合甲苯胺蓝染色、自发荧光成像和 DNA 图像细胞仪来动态监测疾病的进展。结果:我们使用激光联合光导疗法取得了良好的疗效。患者在治疗后仅出现轻微不良反应,在随后的随访期间,通过各种辅助检查也未发现复发或恶变迹象。结论:本病例报告表明,对于抗真菌治疗无效的 CHC 患者,半导体激光手术联合光动力疗法是一种很有前景的治疗方案。此外,联合使用非侵入性检查可更准确地评估 CHC 患者的恶性转化情况。
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引用次数: 0
Response to: Photobiomodulation in the Treatment of Dysgeusia in Patients with Long COVID: Comment. 回应:光生物调节治疗长COVID患者的发音障碍:评论。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-05-09 DOI: 10.1089/pho.2024.0040
Hinpetch Daungsupawong, Viroj Wiwanitkit
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引用次数: 0
The Application of PBM Therapy in Patients Subjected to Oral GVHD: A Review. PBM疗法在口腔GVHD患者中的应用:综述。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-06-20 DOI: 10.1089/pho.2023.0153
Dongqi Liu, Xiao Luo, Yin Jing, Tingting Wu, Fangchun Chen

Background: Oral graft-versus-host disease (GVHD) is characterized by mucosal lesions, salivary gland dysfunction etc., accompanied by pain and oral dysfunction. The efficacy of photobiomodulation (PBM) in managing pain and inflammation has been demonstrated. PBM has been applied in oral GVHD and is regarded as a potent adjunctive therapy. Objective: To review the application of PBM for oral GVHD and summarize its biological mechanisms and recommended parameters. Materials and Methods: The article provides an overview of the therapeutic effects of PBM in oral GVHD cases. It analyzes the biological mechanisms from different aspects and explores the potential prospects of PBM, and appropriate parameters and frequency for GVHD are recommended. Conclusions: The efficacy of PBM in oral GVHD has been demonstrated through symptom alleviation and function improvement. It is recommended as an adjuvant therapy for oral GVHD. However, further research is required to explore optimal devices, parameters, and potential complications associated with using PBM in oral GVHD.

背景:口腔移植物抗宿主病(GVHD)的特点是粘膜病变、唾液腺功能障碍等,并伴有疼痛和口腔功能障碍。光生物调节(PBM)在控制疼痛和炎症方面的疗效已得到证实。光生物调节已被应用于口腔 GVHD,并被视为一种有效的辅助疗法。目的:回顾 PBM 在口腔 GVHD 中的应用,总结其生物学机制和推荐参数。材料与方法:文章概述了 PBM 在口腔 GVHD 病例中的治疗效果。文章从不同方面分析了其生物学机制,探讨了 PBM 的潜在前景,并推荐了 GVHD 的适当参数和频率。结论PBM对口腔GVHD的疗效已通过症状缓解和功能改善得到证实。建议将其作为口腔 GVHD 的辅助疗法。不过,还需要进一步研究探讨在口腔 GVHD 中使用 PBM 的最佳设备、参数和潜在并发症。
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引用次数: 0
Root Regeneration with Photobiomodulation of an Upper Lateral Incisor Associated with Root Resorption Due to an Impacted Maxillary Canine: A Case Report. 用光生物调节技术使一颗因上颌犬齿受撞击而导致牙根吸收的上侧切牙牙根再生:病例报告。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1089/photob.2023.0150
Yax Cuellar, Sergio Andrés Velásquez, Angela Domínguez

Objective: To present a case report of maxillary lateral incisor root regeneration after severe root resorption, treated with photobiomodulation (PBM). Background: Impacted maxillary canines often come with the risk of maxillary lateral incisor root resorption, which is widely recognized as the predominant adverse effect in these situations. This progressive process of root resorption is currently irreversible, with no known way to reverse it. Materials and methods: A male patient was 14 years old. Radiographically it was observed that canine 23 is impacting against the root of 22 producing signs of root resorption and having a less than 1:1 crown-to-root ratio with mobility grade 1. From the beginning of the treatment, PBM-assisted orthodontics was proposed. To address the patient's dental concerns, the treatment plan outlined the extraction of the deciduous upper left canine tooth leaving the lateral as long as possible in the mouth. During each appointment, PBM was applied with a diode laser. The wavelength was 810 nm, Ap = 0.2 W, 4.4 J, 22 sec every 21 days, 13 applications in total (57.2J), with a 400 μm inactive surgical tip, in a scanning movement, 1 mm from the mucosa while moving following the vestibular surface of the upper left lateral and canine roots. Results: After 12 months, the 22 had root neoformation and complete closure of the apex with vitality. Conclusions: PBM with an 810 nm diode laser in this clinical case promoted root regeneration of an upper lateral incisor, with severe root resorption, owing to an impacted maxillary canine while still vital.

目的:报告一例上颌侧切牙牙根严重吸收后的牙根再生病例,采用光生物调制(PBM)治疗。背景:被撞击的上颌犬齿通常会伴随着上颌侧切牙牙根吸收的风险,这已被广泛认为是这些情况下最主要的不良反应。这种渐进的牙根吸收过程目前是不可逆的,也没有已知的逆转方法。材料和方法一名男性患者,14 岁。X光片显示,23号犬牙与22号牙根相撞,出现牙根吸收迹象,牙冠与牙根的比例小于1:1,活动度为1级。从治疗一开始,就建议采用 PBM 辅助正畸。为了解决患者的牙齿问题,治疗计划概述了拔除左上犬齿的落叶,尽可能将侧齿留在口腔内。每次就诊时,都会使用二极管激光器进行 PBM 治疗。波长为 810 nm,Ap = 0.2 W,4.4 J,每 21 天使用一次,每次 22 秒,共使用 13 次(57.2 J),使用 400 μm 非活动手术尖,以扫描运动的方式,距离粘膜 1 mm,同时沿着左上侧齿和犬齿根的前庭表面移动。结果:12 个月后,22 根牙根新生,根尖完全闭合,具有活力。结论在这个临床病例中,使用 810 nm 二极管激光进行 PBM 治疗,促进了一颗上侧切牙的牙根再生,这颗上侧切牙由于上颌犬齿的影响,牙根吸收严重,但仍具有活力。
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引用次数: 0
Comparative Effectiveness of Different Er:YAG Laser-Activated Irrigation Systems on Removing Calcium Hydroxide from Simulated Internal Root Resorption Cavities at Different Root Levels. 不同的 Er:YAG 激光激活灌洗系统对去除不同根水平模拟内根吸收龋洞中的氢氧化钙的效果比较。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-06-05 DOI: 10.1089/pho.2024.0057
Phu Yadanar Aung Myint, Satoshi Watanabe, Takashi Okiji

Objective: To investigate the effectiveness of Er:YAG laser-activated irrigation (LAI) with a short pulse duration for removing calcium hydroxide (CH) from simulated internal root resorption (IRR) cavities at three root levels. Background: Pulse duration is an important parameter during LAI, which ensures the efficiency of irradiation and the corresponding activation process. Short pulses in the range of a few microseconds enable rapid expansion and successive implosion of irrigants, resulting in distinct fluid movement. There have been few reports on CH removal efficacy from IRR cavities of different LAI systems, including those using short pulse duration. Methods: IRR cavities (1.6 mm diameter) were created at the apical, middle, and coronal root levels in 60 mandibular premolars and filled with a radiopaque CH paste. Samples were assigned to the following irrigation groups (n = 12, each): (1) LAI(P)-F, a prototype laser device that operates with short pulse duration (Morita Manufacturing) with a flat tip; (2) LAI(EA)-F, the ErwinAdverl laser device (Morita Manufacturing) with a flat tip; (3) LAI(EA)-T, the ErwinAdverl laser device with a tapered tip; (4) PIPS-T, the Lightwalker laser device (Fotona) with a tapered tip; and (5) SI, the syringe irrigation group. The laser tips were fixed at the canal entrance. The remaining CH volume and surface area were assessed in IRR cavities using micro-computed tomography and scanning electron microscopy, respectively. Data were statistically analyzed utilizing one-way analysis of variance and Tukey's test at 5% significance level. Results: The LAI(P)-F and PIPS-T groups exhibited the highest CH removal rates at three different levels (p < 0.05). The LAI(EA)-F group had a significantly better efficacy of CH removal compared with the LAI(EA)-T group at the middle level (p < 0.05). Conclusion: The LAI(P)-F and PIPS-T groups demonstrated superior efficiency in removing CH from simulated IRR cavities.

目的研究短脉冲持续时间的 Er:YAG 激光激活灌洗 (LAI) 在三个牙根水平上去除模拟内根吸收 (IRR) 龋洞中氢氧化钙 (CH) 的效果。背景:脉冲持续时间是 LAI 过程中的一个重要参数,可确保照射效率和相应的活化过程。几微秒范围内的短脉冲可使灌洗剂快速膨胀和连续内爆,从而产生明显的液体运动。关于不同 LAI 系统(包括使用短脉冲持续时间的系统)IRR 腔的 CH 清除效果的报道很少。方法:在 60 颗下颌前磨牙的根尖、中部和冠状根水平创建 IRR 洞(直径 1.6 毫米),并用不透射线的 CH 糊剂填充。样本被分配到以下灌洗组(各组 n = 12):(1)LAI(P)-F,短脉冲持续时间运行的原型激光设备(森田制钢),平头;(2)LAI(EA)-F,ErwinAdverl激光设备(森田制钢),平头;(3)LAI(EA)-T,ErwinAdverl激光设备,锥形头;(4)PIPS-T,Lightwalker激光设备(Fotona),锥形头;(5)SI,注射器灌洗组。激光头固定在牙槽骨入口处。分别使用微型计算机断层扫描和扫描电子显微镜评估 IRR 腔内剩余 CH 的体积和表面积。数据采用单因素方差分析和 Tukey 检验进行统计分析,显著性水平为 5%。结果在三个不同水平上,LAI(P)-F 组和 PIPS-T 组的 CH 去除率最高(P < 0.05)。与 LAI(EA)-T 组相比,LAI(EA)-F 组在中间水平的 CH 清除率明显更高(P < 0.05)。结论LAI(P)-F 组和 PIPS-T 组在去除模拟 IRR 龋齿中的 CH 方面表现出更高的效率。
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引用次数: 0
Effective Parameters for Orthodontic Tooth Movement Acceleration with Photobiomodulation: An Umbrella Review. 利用光生物调节加速正畸牙齿移动的有效参数:综述。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-06-05 DOI: 10.1089/pho.2024.0034
Angela Domínguez, Hernan Dario Muñoz-Alvear, Daniela Oviedo-Toro, Ximena Suárez-Quenguán, Esteban Lopez-Portilla

Objective: To answer this research question: What are the effective wavelength, power, and energy density parameters for achieving dental movement acceleration? Background Data: Photobiomodulation (PBM) has been clinically studied for its ability to accelerate dental movements in orthodontics. However, its effectiveness is dose dependent. Methods: The search was carried out in PubMed, SCOPUS, and ISI Web of Science. The quality of the included systematic reviews was performed using the AMSTAR 2 tool. The risk of bias was assessed using the ROBIS tool. Results: In total, 29 articles in PubMed, 75 in Scopus, and 61 in ISI Web of Science. Finally, only five systematic reviews were included. Conclusions: The results showed the range from 730 to 830 nm as the most effective range of wavelength to accelerate the orthodontic dental movement. A power range of 0.25-200 mW, with emphasis on the direct correlation between power, wavelength, and energy density. Energy density has not been adequately reported in the most randomized controlled clinical trials.

研究目的回答这一研究问题:实现牙齿运动加速的有效波长、功率和能量密度参数是什么?背景数据:临床研究表明,光生物调制(PBM)能够加速牙齿矫正中的牙齿移动。然而,其有效性与剂量有关。研究方法在 PubMed、SCOPUS 和 ISI Web of Science 上进行了搜索。使用 AMSTAR 2 工具对纳入的系统性综述进行质量评估。使用 ROBIS 工具评估偏倚风险。结果PubMed 共收录 29 篇文章,Scopus 共收录 75 篇文章,ISI Web of Science 共收录 61 篇文章。最后,仅纳入了 5 篇系统综述。结论结果表明,730 至 830 纳米波长范围是加速牙齿正畸运动最有效的波长范围。功率范围为 0.25-200 mW,重点是功率、波长和能量密度之间的直接相关性。大多数随机对照临床试验都没有充分报告能量密度。
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引用次数: 0
Successful Intentional Replantation of a Severely Compromised Tooth Using 3 Types of Phototherapy: A Case Report. 使用 3 种光疗成功为一颗严重受损的牙齿进行意向性再植:病例报告。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-05-03 DOI: 10.1089/photob.2023.0197
Alex Simon Chan, Andrew Jonathan Chan, Ambrose Chan, Patricia Armati

Background: Intentional replantation (IR) is an emerging and cost-effective last-resort treatment for persistent apical periodontitis. Adjunctive phototherapy for IR aims to improve the management of challenging cases by enhancing disinfection, stimulating healing and promoting regeneration. Objective: We report a novel phototherapy-assisted IR protocol conducted on a compromised lateral incisor with an extensive periapical infection (Ø > 10 mm) in a 68-year-old diabetic male. Methods: The IR protocol involved pre- and postoperative photobiomodulation (660 nm, 0.2 J/cm2, 60 sec/site), antimicrobial photodynamic therapy of the root surface (660 nm, 0.6 J/cm2, 30 sec, methylene blue photosensitizer), and Er:YAG root and socket debridement (2940 nm, 21 J/cm2, 30 sec). The total time from extraction to replantation was 14 min 35 sec. Results: The tooth at 3.5-year follow-up remained clinically functional with radiographic resolution of the infection indicating a successful reimplantation. Conclusions: This case report demonstrated that an adjunctive phototherapy IR protocol can effectively treat a compromised tooth with extensive periapical infection.

背景:有意再植(IR)是一种新兴的、经济有效的治疗顽固性根尖牙周炎的最后手段。针对 IR 的辅助光疗旨在通过加强消毒、刺激愈合和促进再生来改善对棘手病例的管理。目的:我们报告了一种新颖的光疗辅助 IR 方案,该方案针对的是一名 68 岁男性糖尿病患者的受损侧切牙,该患者患有广泛的根尖周炎(直径大于 10 毫米)。方法:红外线治疗方案包括术前和术后的光生物调节(660 纳米,0.2 焦耳/平方厘米,60 秒/部位)、牙根表面的抗菌光动力疗法(660 纳米,0.6 焦耳/平方厘米,30 秒,亚甲基蓝光敏剂)以及 Er:YAG 牙根和牙槽清创(2940 纳米,21 焦耳/平方厘米,30 秒)。从拔牙到重新种植的总时间为 14 分 35 秒。结果:该牙在 3.5 年的随访中仍保持临床功能,X 光片显示感染已消除,表明再植成功。结论:该病例报告表明,辅助光疗红外方案可以有效治疗受损牙齿的广泛根尖周炎。
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引用次数: 0
Photothermal Biostimulation of Platelet-Rich Plasma Improves Hand Rejuvenation Clinical Outcome: A Pilot Study. 富血小板血浆光热生物刺激改善手部年轻化临床效果:一项试点研究。
IF 1.8 Q2 SURGERY Pub Date : 2024-06-01 Epub Date: 2024-06-05 DOI: 10.1089/pho.2023.0192
Paloma Tejero García, Sheila Mota Antigua, Marta Ortega Zamorano, Rosa María de Lima Monteiro Saraiva, Hernán Pinto

Objective: This study aimed to evaluate physical skin changes and patients' subjective perception of treatment with photothermal bioactivated platelet-rich plasma (MCT Plasma) for hand rejuvenation. Background: Age-related changes in the dorsum of the hand include volume loss, dyschromia, and soft-tissue atrophy, which result in wrinkles and prominent deep structures. Methods: We conducted a prospective, single-center, randomized pilot study on 10 healthy female volunteers from 30 to 65 years with hand aging signs. Patients received two sessions of MCT Plasma on the treated hand and two sessions of standard platelet-rich plasma (PRP) on the control hand. Results were assessed through high-frequency ultrasonography, photographs, a patient satisfaction survey, patient perception of skin aspect, and patient perception of amelioration survey. Results: Ten women with a mean age of 57.5 years (standard deviation 10.5, range 31 - 67) were included, and seven (70%) completed the study. The treated hands' skin subepidermal low-echogenic band (SLEB) decreased from 20% to 60%, and 57.1% (n = 4) had better results than control. Twenty percent of patients were very satisfied with the results, 40% were satisfied, 40% were neutral, and none were unsatisfied or very unsatisfied. Patients perceived the skin of the treated hand (MCT Plasma) as "much better" (20%), "better" (60%), and "no changes" (20%) compared with the skin of the control hand (standard PRP). No treatment-related adverse events were reported during the study. Conclusions: Hands treated with MCT Plasma tended to have better outcomes in reducing SLEB compared with those treated with standard PRP. Patients were satisfied and the treatment was safe with no technical complications. However, further randomized controlled trials with larger sample sizes are mandatory to validate the extent of improvement provided by this device based on photothermal biomodulation.

研究目的本研究旨在评估光热生物活化富血小板血浆(MCT 血浆)治疗手部年轻化后皮肤的物理变化和患者的主观感受。研究背景手背与年龄有关的变化包括体积减小、色素沉着和软组织萎缩,从而产生皱纹和突出的深层结构。研究方法我们进行了一项前瞻性、单中心、随机试验研究,研究对象是 10 名 30 至 65 岁、有手部衰老迹象的健康女性志愿者。患者在接受治疗的手部接受两次 MCT 血浆治疗,在对照手部接受两次标准富血小板血浆治疗。结果通过高频超声波成像、照片、患者满意度调查、患者对皮肤方面的感知以及患者对改善情况的感知调查进行评估。结果:十名妇女的平均年龄为 57.5 岁(标准差 10.5,范围 31 - 67),其中七名(70%)完成了研究。接受治疗的手部皮肤表皮下低回声带(SLEB)从 20% 下降到 60%,57.1%(n = 4)的治疗效果优于对照组。20%的患者对治疗效果非常满意,40%表示满意,40%表示中性,没有患者表示不满意或非常不满意。与对照组手部皮肤(标准 PRP)相比,患者认为治疗过的手部皮肤(MCT 血浆)"好多了"(20%)、"更好了"(60%)和 "没有变化"(20%)。研究期间未报告与治疗相关的不良事件。研究结论与使用标准 PRP 治疗的手部相比,使用 MCT 血浆治疗的手部在减少 SLEB 方面有更好的效果。患者感到满意,而且治疗安全,无技术并发症。不过,要验证这种基于光热生物调制的设备所提供的改善程度,还必须进一步开展样本量更大的随机对照试验。
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Photobiomodulation, photomedicine, and laser surgery
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