Pub Date : 2025-08-14DOI: 10.1016/j.oor.2025.100760
Krishnasamy Nitya , Yash Merchant , Somdipto Das , Sameep S. Shetty
The status of margins in OSCC is a critical prognostic factor that is known to influence local recurrence and overall survival outcomes. Positive or close surgical margins substantially increase the risk of locoregional failure, necessitating revision and adjuvant therapy that may adversely impact patients’ quality of life. Conventional intraoperative techniques of assessment of margins such as visual inspection, palpation, and selective frozen section analysis, have inherent limitations. These include subjectivity, sampling errors, and procedural delays. Narrow Band Imaging (NBI) is an innovative, non-contact, non-invasive optical imaging modality that enhances visualisation of the mucosal and submucosal microvasculature by employing filtered light at specific wavelengths. NBI enables more accurate delineation of tumour margins by accentuating vascular patterns associated with neoplastic transformation. This short correspondence discusses the fundamental principles, intraoperative applications, clinical advantages, and prospects of NBI as a valuable adjunct to conventional methods for margin assessment.
{"title":"Use of Narrow Band Imaging (NBI) as a non-invasive adjunct for margin assessment in oral squamous cell carcinoma (OSCC)","authors":"Krishnasamy Nitya , Yash Merchant , Somdipto Das , Sameep S. Shetty","doi":"10.1016/j.oor.2025.100760","DOIUrl":"10.1016/j.oor.2025.100760","url":null,"abstract":"<div><div>The status of margins in OSCC is a critical prognostic factor that is known to influence local recurrence and overall survival outcomes. Positive or close surgical margins substantially increase the risk of locoregional failure, necessitating revision and adjuvant therapy that may adversely impact patients’ quality of life. Conventional intraoperative techniques of assessment of margins such as visual inspection, palpation, and selective frozen section analysis, have inherent limitations. These include subjectivity, sampling errors, and procedural delays. Narrow Band Imaging (NBI) is an innovative, non-contact, non-invasive optical imaging modality that enhances visualisation of the mucosal and submucosal microvasculature by employing filtered light at specific wavelengths. NBI enables more accurate delineation of tumour margins by accentuating vascular patterns associated with neoplastic transformation. This short correspondence discusses the fundamental principles, intraoperative applications, clinical advantages, and prospects of NBI as a valuable adjunct to conventional methods for margin assessment.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"15 ","pages":"Article 100760"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-07DOI: 10.1016/j.oor.2025.100763
Sharfunnisa S.H.
{"title":"Comprehensive nutritional index: A novel prognostic and quality of life tool in nasopharyngeal carcinoma care","authors":"Sharfunnisa S.H.","doi":"10.1016/j.oor.2025.100763","DOIUrl":"10.1016/j.oor.2025.100763","url":null,"abstract":"","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"15 ","pages":"Article 100763"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-06DOI: 10.1016/j.oor.2025.100764
Jessica Sonal Monteiro , Sowmya M. Kumar , Yash P. Merchant , Anand Ramanathan , José Alcides Almeida de Arruda , Eleni Georgakopoulou , Charles E. Anyanechi , Darshana Devadiga , Nitya Krishnasamy , Sameep Shetty
Oral squamous cell carcinoma (OSCC) is a complex and insidious disease, often presenting with subtle symptoms that can be challenging to diagnose in its early stages. The oral cavity, comprising various heterogeneous subsites, poses a unique challenge in identifying malignant transformations due to its complex anatomy and the potential for asymptomatic presentations. The difficulty in distinguishing oral potentially malignant disorders or malignant lesions from benign ones through visual inspection alone highlights the need for heightened clinical vigilance. Despite the advances in medical knowledge and technology, oral cancer continues to have a poor prognosis when diagnosed at an advanced stage. This is partly due to the delayed recognition of early warning signs or “red flags,” which include persistent lesions, non-healing ulcers, unexplained lumps and other harbingers of disease. A comprehensive search of the existing literature was conducted using PubMed, Scopus and Web of Science databases, focusing on studies and reviews related to the early detection and diagnosis of OSCC. The literature reveals a consistent theme: the early detection of OSCC depends on the clinician's meticulous attention to subtle lesions, increased patient awareness, and the screening of individuals at high risk. This review aims to elucidate the early symptoms of oral cancer, highlighting the critical red flags that should prompt immediate diagnostic workup. By improving the recognition of these early signs, we can potentially reduce the morbidity and mortality associated with oral cancer, ensuring better outcomes for patients.
口腔鳞状细胞癌（OSCC）是一种复杂而隐匿的疾病，通常表现为早期难以诊断的微妙症状。口腔由各种异质亚位组成，由于其复杂的解剖结构和潜在的无症状表现，在识别恶性转化方面提出了独特的挑战。仅通过视觉检查就难以区分口腔潜在的恶性疾病或恶性病变与良性病变，这突出了提高临床警惕的必要性。尽管医学知识和技术不断进步，但口腔癌在晚期诊断时预后仍然很差。这在一定程度上是由于早期预警信号或“危险信号”的识别延迟，这些信号包括持续的病变、无法愈合的溃疡、无法解释的肿块和其他疾病的前兆。利用PubMed、Scopus和Web of Science数据库全面检索现有文献，重点检索与OSCC早期发现和诊断相关的研究和综述。文献揭示了一个一致的主题：OSCC的早期发现取决于临床医生对细微病变的细致关注，提高患者的意识，以及对高危个体的筛查。本综述旨在阐明口腔癌的早期症状，强调应立即进行诊断检查的关键危险信号。通过提高对这些早期症状的认识，我们可以潜在地降低与口腔癌相关的发病率和死亡率，确保患者获得更好的结果。
{"title":"Red flags of oral cancer: Unravelling the early symptoms – A literature review","authors":"Jessica Sonal Monteiro , Sowmya M. Kumar , Yash P. Merchant , Anand Ramanathan , José Alcides Almeida de Arruda , Eleni Georgakopoulou , Charles E. Anyanechi , Darshana Devadiga , Nitya Krishnasamy , Sameep Shetty","doi":"10.1016/j.oor.2025.100764","DOIUrl":"10.1016/j.oor.2025.100764","url":null,"abstract":"<div><div>Oral squamous cell carcinoma (OSCC) is a complex and insidious disease, often presenting with subtle symptoms that can be challenging to diagnose in its early stages. The oral cavity, comprising various heterogeneous subsites, poses a unique challenge in identifying malignant transformations due to its complex anatomy and the potential for asymptomatic presentations. The difficulty in distinguishing oral potentially malignant disorders or malignant lesions from benign ones through visual inspection alone highlights the need for heightened clinical vigilance. Despite the advances in medical knowledge and technology, oral cancer continues to have a poor prognosis when diagnosed at an advanced stage. This is partly due to the delayed recognition of early warning signs or “red flags,” which include persistent lesions, non-healing ulcers, unexplained lumps and other harbingers of disease. A comprehensive search of the existing literature was conducted using PubMed, Scopus and Web of Science databases, focusing on studies and reviews related to the early detection and diagnosis of OSCC. The literature reveals a consistent theme: the early detection of OSCC depends on the clinician's meticulous attention to subtle lesions, increased patient awareness, and the screening of individuals at high risk. This review aims to elucidate the early symptoms of oral cancer, highlighting the critical red flags that should prompt immediate diagnostic workup. By improving the recognition of these early signs, we can potentially reduce the morbidity and mortality associated with oral cancer, ensuring better outcomes for patients.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"15 ","pages":"Article 100764"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-05DOI: 10.1016/j.oor.2025.100761
Darren P. Reynolds , Samantha J. Tordesillas , Ashlie Denison , Abigail Legg
Background
The Community Head and Neck Team (CHANT) is an award winning multi-disciplinary team provided by Guy's and St. Thomas' NHS Foundation Trust, supporting patients across South East London post-treatment for head and neck cancer. In 2022, CHANT was expanded to include a dedicated psychology service. This study aimed to audit all psychology referrals to date, evaluate patient reported outcome measures, and explore patient feedback to inform future service development.
Methods
A retrospective audit of head and neck cancer patients who were referred to the CHANT Psychology Service between September 2022 and February 2025 was conducted. Routine clinical outcomes were analysed at assessment and at discharge from the service, and additional qualitative and quantitative analyses were conducted using patient feedback forms from those who completed therapy.
Results
A total of 247 referrals were received (56.7 % male; mean age = 59.1 years). Primary reasons for referral included adjustment difficulties (44.1 %), low mood (28.7 %), and anxiety regarding health (18.6 %) amongst others. Statistically significant reductions in symptoms of low mood and anxiety, improved HRQoL, and reduced psychological inflexibility were observed. Patient feedback was overwhelmingly positive indicating psychological support was valued and beneficial.
Conclusion
To our knowledge, the CHANT Psychology Service is the only dedicated community-based head and neck cancer psychology service in the UK. Audit and evaluation findings highlight the need for such a service and suggest it is both effective and acceptable in terms of its current service delivery. Ongoing data collection will support further evaluation and guide future development.
{"title":"Implementing an embedded psychology service within a multi-disciplinary community head and neck cancer team: preliminary service evaluation and clinical audit of referrals from the first two years","authors":"Darren P. Reynolds , Samantha J. Tordesillas , Ashlie Denison , Abigail Legg","doi":"10.1016/j.oor.2025.100761","DOIUrl":"10.1016/j.oor.2025.100761","url":null,"abstract":"<div><h3>Background</h3><div>The Community Head and Neck Team (CHANT) is an award winning multi-disciplinary team provided by Guy's and St. Thomas' NHS Foundation Trust, supporting patients across South East London post-treatment for head and neck cancer. In 2022, CHANT was expanded to include a dedicated psychology service. This study aimed to audit all psychology referrals to date, evaluate patient reported outcome measures, and explore patient feedback to inform future service development.</div></div><div><h3>Methods</h3><div>A retrospective audit of head and neck cancer patients who were referred to the CHANT Psychology Service between September 2022 and February 2025 was conducted. Routine clinical outcomes were analysed at assessment and at discharge from the service, and additional qualitative and quantitative analyses were conducted using patient feedback forms from those who completed therapy.</div></div><div><h3>Results</h3><div>A total of 247 referrals were received (56.7 % male; mean age = 59.1 years). Primary reasons for referral included adjustment difficulties (44.1 %), low mood (28.7 %), and anxiety regarding health (18.6 %) amongst others. Statistically significant reductions in symptoms of low mood and anxiety, improved HRQoL, and reduced psychological inflexibility were observed. Patient feedback was overwhelmingly positive indicating psychological support was valued and beneficial.</div></div><div><h3>Conclusion</h3><div>To our knowledge, the CHANT Psychology Service is the only dedicated community-based head and neck cancer psychology service in the UK. Audit and evaluation findings highlight the need for such a service and suggest it is both effective and acceptable in terms of its current service delivery. Ongoing data collection will support further evaluation and guide future development.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"15 ","pages":"Article 100761"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-11DOI: 10.1016/j.oor.2025.100759
Zahra Farivar , Hamid Salehiniya , Leili Alizadeh
Background
Oral mucositis (OM) is a common and debilitating complication of cancer treatments, particularly chemotherapy and radiotherapy. It significantly impacts patients’ quality of life, increases healthcare costs, and can interrupt or delay cancer therapy. This systematic review aimed to evaluate the effectiveness of various oral care interventions in the prevention and management of OM in patients undergoing anticancer treatments.
Methods
A systematic literature search was conducted in PubMed, Web of Science, and Scopus databases, adhering to PRISMA guidelines. Eligible studies included clinical trials and cohort studies published between January 2000 and June 2025. The quality of included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools.
Results
Out of 2542 records screened, 48 studies met the inclusion criteria. Among these, 16 studies evaluated professional oral health care (POHC), 16 assessed chlorhexidine rinses, 6 focused on patient education, 6 examined sodium bicarbonate rinses, and 4 studied saline rinses. POHC and patient education consistently demonstrated beneficial effects, with over 75 % of studies in these categories reporting significant reductions in OM incidence and severity. Chlorhexidine and saline rinses showed mixed or limited results: only 38 % of chlorhexidine studies and 25 % of saline studies reported a measurable benefit. Risk of bias was rated as low to moderate in most studies, with 14 studies rated as high quality.
Conclusion
This review highlights the effectiveness of structured oral care interventions particularly POHC and patient education in mitigating OM among cancer patients. These findings support the integration of evidence-based oral care protocols into routine oncology practice and emphasize the need for standardized clinical guidelines to enhance patient outcomes and quality of life.
背景：口腔黏膜炎（OM）是一种常见的癌症治疗并发症，尤其是化疗和放疗。它会显著影响患者的生活质量，增加医疗保健费用，并可能中断或延迟癌症治疗。本系统综述旨在评估各种口腔护理干预措施在接受抗癌治疗的患者中预防和管理OM的有效性。方法按照PRISMA指南，在PubMed、Web of Science和Scopus数据库中进行系统的文献检索。符合条件的研究包括2000年1月至2025年6月间发表的临床试验和队列研究。采用乔安娜布里格斯研究所（JBI）关键评估工具评估纳入研究的质量。结果在筛选的2542份记录中，有48项研究符合纳入标准。其中，16项研究评估了专业口腔卫生保健（POHC）， 16项评估了氯己定冲洗，6项关注患者教育，6项研究了碳酸氢钠冲洗，4项研究了生理盐水冲洗。POHC和患者教育一直显示出有益的效果，在这些类别的研究中，超过75%的研究报告OM发病率和严重程度显著降低。洗必泰和生理盐水冲洗显示混合或有限的结果：只有38%的洗必泰研究和25%的生理盐水研究报告了可测量的益处。在大多数研究中，偏倚风险被评为低至中等，有14项研究被评为高质量。结论本综述强调了结构化口腔护理干预，特别是POHC和患者教育在减轻癌症患者OM方面的有效性。这些发现支持将循证口腔护理方案整合到常规肿瘤学实践中，并强调需要标准化的临床指南来提高患者的预后和生活质量。
{"title":"Oral care interventions for the prevention and management of anticancer therapy–induced oral mucositis: A systematic review","authors":"Zahra Farivar , Hamid Salehiniya , Leili Alizadeh","doi":"10.1016/j.oor.2025.100759","DOIUrl":"10.1016/j.oor.2025.100759","url":null,"abstract":"<div><h3>Background</h3><div>Oral mucositis (OM) is a common and debilitating complication of cancer treatments, particularly chemotherapy and radiotherapy. It significantly impacts patients’ quality of life, increases healthcare costs, and can interrupt or delay cancer therapy. This systematic review aimed to evaluate the effectiveness of various oral care interventions in the prevention and management of OM in patients undergoing anticancer treatments.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted in PubMed, Web of Science, and Scopus databases, adhering to PRISMA guidelines. Eligible studies included clinical trials and cohort studies published between January 2000 and June 2025. The quality of included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools.</div></div><div><h3>Results</h3><div>Out of 2542 records screened, 48 studies met the inclusion criteria. Among these, 16 studies evaluated professional oral health care (POHC), 16 assessed chlorhexidine rinses, 6 focused on patient education, 6 examined sodium bicarbonate rinses, and 4 studied saline rinses. POHC and patient education consistently demonstrated beneficial effects, with over 75 % of studies in these categories reporting significant reductions in OM incidence and severity. Chlorhexidine and saline rinses showed mixed or limited results: only 38 % of chlorhexidine studies and 25 % of saline studies reported a measurable benefit. Risk of bias was rated as low to moderate in most studies, with 14 studies rated as high quality.</div></div><div><h3>Conclusion</h3><div>This review highlights the effectiveness of structured oral care interventions particularly POHC and patient education in mitigating OM among cancer patients. These findings support the integration of evidence-based oral care protocols into routine oncology practice and emphasize the need for standardized clinical guidelines to enhance patient outcomes and quality of life.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"15 ","pages":"Article 100759"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-18DOI: 10.1016/j.oor.2025.100755
Jan Horackiewicz , Matthew Donachie , Nichola Philp , Marta Chmielecka , Mohd Afiq Mohd Slim , Rhona Hurley , Catriona M. Douglas
Introduction
Incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising and is increasingly associated with human papillomavirus (HPV) infection, which makes up approximately 50 % of OPSCC cases in the UK. Patients presenting with HPV-positive OPSCC have better overall survival (OS) and prognosis. A significant proportion of these still have poor survival outcomes and identification of these patients remains a challenge. This study aims to investigate the predictive value of albumin, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammation index (SIII) for overall survival in OPSCC.
Methods
Seven hundred and twenty-eight patients were extracted from the West of Scotland Cancer Network database and met inclusion criteria with available blood markers at diagnosis. ROC curve analysis was constructed with respect to age, albumin and systemic inflammatory markers to determine diagnostic cut-offs, which were used to stratify subsequent Kaplan-Meier analyses. Univariate and multivariate analysis was carried out with respect to all baseline characteristics.
Results
Patients with lowered albumin, LMR and raised NLR, PLR and SIII presented with poorer OS over time as well as median survival times. HPV-negative patients presented with significantly poorer survival outcomes as compared to HPV-positive. Only albumin ≥35.5 g/L (HR = 0.683, 95 %CI 0.538–0.868) and NLR≥4.0 (HR = 1.416, 95 %CI 1.031–1.946) were found to be independent prognostic factors in patients with OPSCC.
Conclusion
Serum albumin and NLR represent valuable predictors of survival in OPSCC regardless of HPV status. A universal, diagnostic NLR cut-off remains unknown. Systemic inflammatory markers may be a helpful adjunct when assessing patients during MDT.
口咽鳞状细胞癌（OPSCC）的发病率正在上升，并且越来越多地与人乳头瘤病毒（HPV）感染相关，在英国，HPV感染约占OPSCC病例的50%。hpv阳性的OPSCC患者有更好的总生存期（OS）和预后。其中很大一部分患者的生存结果仍然很差，对这些患者的识别仍然是一个挑战。本研究旨在探讨白蛋白、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）、全身免疫炎症指数（SIII）对OPSCC总生存期的预测价值。方法从苏格兰西部癌症网络数据库中提取728例符合诊断时可用血液标志物纳入标准的患者。根据年龄、白蛋白和全身炎症标志物构建ROC曲线分析，以确定诊断截止点，并将其用于分层后续的Kaplan-Meier分析。对所有基线特征进行单因素和多因素分析。结果白蛋白、LMR降低，NLR、PLR和SIII升高的患者随着时间的推移出现较差的OS和中位生存时间。与hpv阳性患者相比，hpv阴性患者的生存结果明显较差。只有白蛋白≥35.5 g/L （HR = 0.683, 95% CI 0.538 ~ 0.868）和NLR≥4.0 （HR = 1.416, 95% CI 1.031 ~ 1.946）是OPSCC患者的独立预后因素。结论血清白蛋白和NLR是有价值的预测OPSCC存活的指标，与HPV状态无关。一个普遍的、诊断性的NLR分界点仍然未知。在MDT期间评估患者时，全身性炎症标志物可能是一个有用的辅助工具。
{"title":"Prognostic significance of systemic inflammatory markers in oropharyngeal squamous cell carcinoma","authors":"Jan Horackiewicz , Matthew Donachie , Nichola Philp , Marta Chmielecka , Mohd Afiq Mohd Slim , Rhona Hurley , Catriona M. Douglas","doi":"10.1016/j.oor.2025.100755","DOIUrl":"10.1016/j.oor.2025.100755","url":null,"abstract":"<div><h3>Introduction</h3><div>Incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising and is increasingly associated with human papillomavirus (HPV) infection, which makes up approximately 50 % of OPSCC cases in the UK. Patients presenting with HPV-positive OPSCC have better overall survival (OS) and prognosis. A significant proportion of these still have poor survival outcomes and identification of these patients remains a challenge. This study aims to investigate the predictive value of albumin, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammation index (SIII) for overall survival in OPSCC.</div></div><div><h3>Methods</h3><div>Seven hundred and twenty-eight patients were extracted from the West of Scotland Cancer Network database and met inclusion criteria with available blood markers at diagnosis. ROC curve analysis was constructed with respect to age, albumin and systemic inflammatory markers to determine diagnostic cut-offs, which were used to stratify subsequent Kaplan-Meier analyses. Univariate and multivariate analysis was carried out with respect to all baseline characteristics.</div></div><div><h3>Results</h3><div>Patients with lowered albumin, LMR and raised NLR, PLR and SIII presented with poorer OS over time as well as median survival times. HPV-negative patients presented with significantly poorer survival outcomes as compared to HPV-positive. Only albumin ≥35.5 g/L (HR = 0.683, 95 %CI 0.538–0.868) and NLR≥4.0 (HR = 1.416, 95 %CI 1.031–1.946) were found to be independent prognostic factors in patients with OPSCC.</div></div><div><h3>Conclusion</h3><div>Serum albumin and NLR represent valuable predictors of survival in OPSCC regardless of HPV status. A universal, diagnostic NLR cut-off remains unknown. Systemic inflammatory markers may be a helpful adjunct when assessing patients during MDT.</div></div>","PeriodicalId":94378,"journal":{"name":"Oral Oncology Reports","volume":"15 ","pages":"Article 100755"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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