Pub Date : 2023-11-13DOI: 10.1021/cen-10137-acsnews1
None Nina Notman, special to C&EN
On Oct. 23, the US Environmental Protection Agency announced the winners of this year’s Green Chemistry Challenge Awards during a ceremony at the National Academy of Sciences in Washington, DC. One academic researcher and five companies were recognized for efforts including transforming waste products into useful materials and creating greener industrial processes. “The Green Chemistry Challenge Awards demonstrate how sustainable alternatives in chemistry are flourishing and improve upon traditional methods,” Albert G. Horvath, American Chemical Society CEO, says in a press release . “Green chemistry can play a vital role in protecting human health and the environment by increasing efficiency, avoiding hazardous chemicals and preventing waste while improving the competitiveness of American companies,” Jennie Romer, deputy assistant administrator at the EPA Office of Chemical Safety and Pollution Prevention, says in the EPA’s press release . Richard Laine , a professor of materials science and engineering and macromolecular science and engineering
10月23日，在华盛顿国家科学院举行的颁奖典礼上，美国环境保护署宣布了今年绿色化学挑战奖的获奖者。一名学术研究人员和五家公司在将废物转化为有用材料和创造更环保的工业过程方面做出了努力。美国化学会首席执行官Albert G. Horvath在一次新闻发布会上说:“绿色化学挑战奖表明，化学领域的可持续替代方案正在蓬勃发展，并对传统方法进行了改进。”美国环保署化学品安全和污染预防办公室副助理署长珍妮·罗默在EPA的新闻发布会上说:“绿色化学可以提高效率，避免危险化学品，防止浪费，同时提高美国公司的竞争力，在保护人类健康和环境方面发挥至关重要的作用。”Richard Laine，材料科学与工程、高分子科学与工程教授
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Pub Date : 2023-11-13DOI: 10.1021/cen-10137-buscon16
None Laura Howes
Merck KGaA has signed a deal with the Chinese firm Jiangsu Hengrui Pharmaceuticals to bring to market two of Hengrui’s oncology drugs: HRS-1167, a PARP1 inhibitor, and SHR-A1904, an antibody-drug conjugate. For $169 million up front, Merck gets the rights to both drugs outside China. Merck says that the acquisition of HRS-1167 aligns with its in-house expertise in DNA damage response. The firm is exploring whether the inhibitor could be combined with other drugs for maximum effect.
{"title":"Merck KGaA expands oncology portfolio","authors":"None Laura Howes","doi":"10.1021/cen-10137-buscon16","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon16","url":null,"abstract":"Merck KGaA has signed a deal with the Chinese firm Jiangsu Hengrui Pharmaceuticals to bring to market two of Hengrui’s oncology drugs: HRS-1167, a PARP1 inhibitor, and SHR-A1904, an antibody-drug conjugate. For $169 million up front, Merck gets the rights to both drugs outside China. Merck says that the acquisition of HRS-1167 aligns with its in-house expertise in DNA damage response. The firm is exploring whether the inhibitor could be combined with other drugs for maximum effect.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"29 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-cover1
START-UPS C&EN’s 10 Start-Ups to WatchAiming for impact through entrepreneurship ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2023, 101 (37), pp 16–17November 13, 2023Cite this:C&EN 101, 37, 16-17(Credit: Kay Youn/Will Ludwig/C&EN)Figure1of1The standard career path for promising young chemists has long involved earning a PhD, honing skills further in a postdoctoral research position, and ultimately landing a job at a university, a national laboratory, or a multinational chemical firm. But there is an alternative route. Rather than trying to fill their curriculum vitae with as many peer-reviewed publications as possible, chemists from all over the world are using their skills to start new companies. Often, they’re motivated by the chance to slow climate change, combat pollution, or feed hungry people. Several of the founders in this year’s 10 Start-Ups to Watch fit this description.For Samantha Anderson, it was impossible to stand on the sidelines watching plastic pollution get worse. So while finishing a PhD at the Swiss Federal Institute of Technology, Lausanne (EPFL), she cofounded DePoly, a company that’s developing a better way to recycle polyethylene terephthalate.Similarly, after earning his PhD, Ryan Pearson went straight to Cyclotron Road, a fellowship program at Lawrence Berkeley National Laboratory that helps scientists turn their research into companies. That’s where Cypris Materials got off the ground. The company is developing new colorants that it hopes will reduce carbon emissions and pollution from coloring clothes, cars, and other products.Lately, C&EN’s pages have been filled with stories about start-ups founded by young chemists. A piece in July dug into Pivot Bio, a company trying to replace carbon-intensive synthetic fertilizers with microbes. The firm, now valued at more than $1 billion, was founded in 2011 by a pair of PhD candidates. A cover story in March featured Twelve, which hopes to make jet fuel out of carbon dioxide. That company took shape during Etosha Cave’s 2015 Activate Fellowship, a 2-year program that gives scientists funding and technical resources to turn themselves into founders.Not all companies in this year’s selection have stories like this. Some of them were founded by serial entrepreneurs with several companies under their belts. Others were catalyzed by government support or started by veterans from big companies who abandoned the security of incumbent firms to try something audacious.We considered hundreds of start-ups before settling on our finalists. They came from reader submissions, the pages of C&EN, and our reporters, who talked to chemists and entrepreneurs. Keep an eye on them. We’re excited to see what they do. Know about an interesting chemistry start-up? Nominate it for our 2024 feature at cenm.ag/startupnom. ContentsBelharra Therapeutics P.18Cypris Materials P.20DePoly P.22Elicit Plant P.24H2Pro P.26Halda Therapeutics P.28Mitra Chem P.30Septerna P.32Sublime Systems P.34Tr
C&EN十大值得关注的创业公司:通过创业实现影响力分享分享于facebook twitter微信链接于redditemail C&EN, 2023, 101 (37)， pp 16-17 2023年11月13日引用本文:C&EN 101, 37,16 -17长期以来，有前途的年轻化学家的标准职业道路包括获得博士学位，在博士后研究岗位上进一步磨练技能，最终在大学、国家实验室或跨国化学公司找到一份工作。但还有另一条路。来自世界各地的化学家不是试图用尽可能多的同行评议的出版物来填满他们的简历，而是利用他们的技能创办新公司。通常，他们的动机是有机会减缓气候变化，对抗污染，或养活饥饿的人。今年十大值得关注的初创企业中，有几位创始人符合这种描述。对萨曼莎·安德森(Samantha Anderson)来说，她不可能袖手旁观，眼睁睁地看着塑料污染日益恶化。因此，当她在瑞士洛桑联邦理工学院(EPFL)完成博士学位时，她与人共同创立了DePoly公司，该公司正在开发一种更好的回收聚对苯二甲酸乙二醇酯的方法。同样，在获得博士学位后，瑞安·皮尔森(Ryan Pearson)直接进入了劳伦斯伯克利国家实验室(Lawrence Berkeley National Laboratory)的回旋加速器之路(Cyclotron Road)，这是一个帮助科学家将研究成果转化为公司的奖学金项目。塞浦路斯材料公司就是在那里起步的。该公司正在开发新的着色剂，希望能减少衣服、汽车和其他产品染色过程中的碳排放和污染。最近，C&EN的页面上充斥着由年轻化学家创立的初创企业的故事。7月份的一篇文章深入研究了Pivot Bio公司，该公司试图用微生物取代碳密集型合成肥料。该公司于2011年由两位博士候选人创立，目前估值超过10亿美元。3月份的一篇封面故事介绍了Twelve公司，该公司希望用二氧化碳制造飞机燃料。这家公司是在埃托沙·凯夫2015年发起的“激活奖学金”项目中形成的，该项目为期两年，为科学家提供资金和技术资源，帮助他们成为创始人。并非所有入选今年榜单的公司都有这样的故事。其中一些是由连续创业家创立的，他们旗下有几家公司。其他一些则是由政府支持促成的，或者是由大公司的老员工创办的，他们放弃了现有公司的安全保障，去尝试一些大胆的东西。我们考虑了数百家初创企业，然后确定了最终入围企业。它们来自于读者的意见，C&EN的页面，以及我们的记者，他们与化学家和企业家交谈。盯紧他们。我们很期待他们能做些什么。知道一个有趣的化学创业公司吗?在cenm.ag/startupnom上提名它为我们2024年的专题。内容belharra Therapeutics p.18cypis Materials P.20DePoly P.22Elicit Plant P.24H2Pro P.26Halda Therapeutics P.28Mitra Chem P.30Septerna P.32Sublime Systems P.34Trillium Renewable Chemicals P.36On our radar P.38作者:Matt Blois项目经理:Michael sheehan作者:Craig Bettenhausen, Matt Blois, Britt E. Erickson, Bethany Halford, Laura Howes, Laurel Oldach, Mark Peplow, Alex Scott, Gina Vitale和Vanessa zainzinger编辑:马特·布洛伊斯和迈克尔·麦考伊创意总监:罗伯特·布莱森艺术总监:威廉·a·路德维希ui /UX导演:凯·扬web制片人:路易斯·a·卡瑞略，泰·a·菲诺基亚罗，詹妮弗·穆勒和谢默斯·墨菲制片编辑:艾莉森·埃利奥特，乔纳森·福尼，大卫·帕德汉姆，拉迪亚·帕特瓦瑞和悉尼·史密斯编辑:米歇尔·阿博伊特和萨布里娜·j·阿什威尔观众参与编辑:利亚姆·康伦下载PDF
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Pub Date : 2023-11-13DOI: 10.1021/cen-10137-cover8
None Matt Blois
By the beginning of 2020, the range of new electric cars had surpassed 330 km, up from 130 km a decade earlier. But drivers in the US were still pushing for more. “More range, more power, faster acceleration,” Vivas Kumar, then a principal with the battery material research firm Benchmark Mineral Intelligence, said in a talk at Stanford University that spring . “That’s the kind of attitude that drives Western automotive design decision-making.” To boost the capacity of their batteries, carmakers were increasing the amount of nickel they contained. Kumar, who previously managed Tesla’s battery material supply chain, predicted that they would continue to do so. But he warned that future shortages of nickel and cobalt could prove a roadblock for the industry. After the talk, a university administrator introduced Kumar to William Chueh, a materials scientist working on batteries at Stanford. Over the next several months, they brainstormed ways
到2020年初，新型电动汽车的续航里程已超过330公里，高于10年前的130公里。但美国的司机们仍在争取更多。当年春天，电池材料研究公司Benchmark Mineral Intelligence的负责人维瓦斯·库马尔(Vivas Kumar)在斯坦福大学(Stanford University)的一次演讲中说:“续航里程更长，动力更大，加速速度更快。”“正是这种态度推动了西方汽车设计决策。”为了提高电池的容量，汽车制造商增加了电池中镍的含量。库马尔曾管理过特斯拉的电池材料供应链，他预测特斯拉将继续这样做。但他警告称，未来镍和钴的短缺可能会成为该行业的障碍。讲座结束后，一位大学管理人员把库马尔介绍给了威廉·丘，他是斯坦福大学研究电池的材料科学家。在接下来的几个月里，他们集思广益
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Pub Date : 2023-11-13DOI: 10.1021/cen-10137-buscon6
None Matt Blois
Compass Minerals says it is pausing development of a lithium mine on Utah’s Great Salt Lake because of state regulations that the firm says introduce new obstacles for the project. Compass already extracts potassium, sodium, and magnesium from brine at the site. The company says that it’s hopeful future regulatory developments will make it easier to pursue lithium extraction. It is also seeking a partner for the project. Meanwhile, the battery materials firm EcoPro will work with the mining company Ioneer to develop a process for extracting lithium from clay at a mine Ioneer is developing in Nevada. If successful, EcoPro would develop a commercial-scale plant to refine lithium hydroxide from the clay. The US Department of Energy agreed in January to give Ioneer a $700 million loan to pay for on-site lithium processing as long as the project gets permits and meets other conditions. The company expects a permitting
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Pub Date : 2023-11-13DOI: 10.1021/cen-10137-comment2
None Angele Kwimi, chair, ACS Committee on Project SEED
Summer 2023 saw 333 high school students carry out in-person Project SEED research internships. An additional 13 students from across the US participated in eight Virtual Research Programs, allowing them to connect with mentors remotely. Since 1968, Project SEED has provided sustained research, learning, and growth opportunities for high school students with diverse identities and backgrounds to help them advance and enrich the chemical science enterprise. Project SEED appeals to a broad range of student populations. The self-reported races and ethnicities for the 2023 cohort were 32% Hispanic or Latino, 23% Asian, 20% Black, 20% White, 3% Middle Eastern or North African, and 2% Indigenous. A successful summer The 2023 in-person and Virtual Research Program students all engaged in centralized, online orientation sessions, which focused on laboratory and personal safety training, career exploration, and professional development. The online training program was developed and deployed by ACS staff in collaboration with
{"title":"Project SEED enhancements for the 2023 summer research program","authors":"None Angele Kwimi, chair, ACS Committee on Project SEED","doi":"10.1021/cen-10137-comment2","DOIUrl":"https://doi.org/10.1021/cen-10137-comment2","url":null,"abstract":"Summer 2023 saw 333 high school students carry out in-person Project SEED research internships. An additional 13 students from across the US participated in eight Virtual Research Programs, allowing them to connect with mentors remotely. Since 1968, Project SEED has provided sustained research, learning, and growth opportunities for high school students with diverse identities and backgrounds to help them advance and enrich the chemical science enterprise. Project SEED appeals to a broad range of student populations. The self-reported races and ethnicities for the 2023 cohort were 32% Hispanic or Latino, 23% Asian, 20% Black, 20% White, 3% Middle Eastern or North African, and 2% Indigenous. A successful summer The 2023 in-person and Virtual Research Program students all engaged in centralized, online orientation sessions, which focused on laboratory and personal safety training, career exploration, and professional development. The online training program was developed and deployed by ACS staff in collaboration with","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"55 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-scicon3
None Laura Howes
The team behind DeepMind’s protein structure prediction software AlphaFold announced Oct. 31 that it is expanding its model beyond proteins: ligands, nucleic acids, and posttranslational modifications will be included in the update. The announcement comes hot on the heels of a preprint describing a similar expansion to the RoseTTAFold model built by David Baker’s group at the University of Washington. Neither team has yet made its new software or code available to the broader scientific community. Modeling biomolecules, as well as the chemicals that can interact with them, has been a huge topic of research interest in recent years. One key application is in drug discovery, and established pharma companies and start-ups have been investing in the area. For example, in 2021, DeepMind CEO and cofounder Demis Hassabis launched Isomorphic Labs to design new medicines using AlphaFold models. But the rapid developments in computational protein structure modeling and design have
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Pub Date : 2023-10-30DOI: 10.1021/cen-10136-scicon1
None Bethany Halford
The molecular motif 1-azaspiro[3.3]heptane may look peculiar, with its two four-membered rings that share a single carbon. But the structure can behave like a mimic of piperidine, a popular heterocycle in many drugs. Until now, however, this molecular motif has been tough to make. Chemists led by Pavel K. Mykhailiuk at the Kyiv, Ukraine–based pharmaceutical chemical firm Enamine report a synthesis of monosubstituted 1-azaspiro[3.3]heptanes. The route expands the molecular toolbox for medicinal chemists looking to add diverse motifs to their molecules. 2-Azaspiro[3.3]heptanes have been popular piperidine mimics, or bioisosteres, since they were first proposed for this purpose in 2010. The motif has appeared in at least 100 research manuscripts, 500 patents, and 7,000 new compounds. But the isomeric 1-azaspiro[3.3]heptane has been rare because there was no modular route to make this motif with just one substituent. Mykhailiuk and colleagues decided to take up this challenge because of perceived demand from
分子基序1- azspiro[3.3]庚烷可能看起来很奇怪，因为它的两个四元环共用一个碳。但这种结构的行为类似于哌啶的模拟物，哌啶是许多药物中常见的杂环。然而，到目前为止，这种分子基序一直很难制造。位于乌克兰基辅的制药化学公司Enamine的Pavel K. Mykhailiuk领导的化学家们报告了一种单取代1-氮杂螺[3.3]庚烷的合成。这条路线扩大了药物化学家的分子工具箱，他们希望在分子中添加不同的基序。自2010年首次被提出用于此目的以来，2- azspiro[3.3]庚烷一直是流行的哌啶模拟物或生物异构体。该基序已经出现在至少100篇研究手稿、500项专利和7000种新化合物中。但是同分异构体1-氮杂螺[3.3]庚烷一直很少见，因为没有模块化的途径只用一个取代基来合成这个基序。Mykhailiuk和他的同事们决定接受这个挑战，因为他们感觉到来自
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Pub Date : 2023-10-30DOI: 10.1021/cen-10136-feature3
None Alex Tullo
{"title":"From the archives: The 1990s","authors":"None Alex Tullo","doi":"10.1021/cen-10136-feature3","DOIUrl":"https://doi.org/10.1021/cen-10136-feature3","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"81 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-feature1
None Samuel Lemonick, special to C&EN
{"title":"Why hasn’t Kristie Koski made tenure?","authors":"None Samuel Lemonick, special to C&EN","doi":"10.1021/cen-10136-feature1","DOIUrl":"https://doi.org/10.1021/cen-10136-feature1","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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