{"title":"Ads","authors":"","doi":"10.1021/cen-10136-ads","DOIUrl":"https://doi.org/10.1021/cen-10136-ads","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"2 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136105702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-acsnews2
None Sara Cottle
Teams of chemical scientists from AbbVie and Enanta Pharmaceuticals, Honeywell, Incyte, Merck & Co., Vertex Pharmaceuticals, and ViiV Healthcare received 2023 Heroes of Chemistry Awards at a banquet in Alexandria, Virginia, on Oct. 12. The researchers were recognized for advancements in a number of areas: treating chronic hepatitis C, creating non-ozone-depleting greenhouse gas alternatives, developing a versatile treatment for rare blood cancers and graft-versus-host disease, designing a general anesthesia drug with reduced side effects, coming up with drugs that target and correct genetic abnormalities that cause cystic fibrosis, and improving HIV treatment. Now in its 27th year, the Heroes of Chemistry Awards recognizes scientists whose use of chemistry acts as a service to society. The award is based on three criteria: technical merit, commercial impact, and benefit to humankind. It is the American Chemical Society’s most prestigious distinction for industrial chemists and is supported by ACS’s Board Committee on Corporation
{"title":"ACS celebrates its 2023 Heroes of Chemistry","authors":"None Sara Cottle","doi":"10.1021/cen-10136-acsnews2","DOIUrl":"https://doi.org/10.1021/cen-10136-acsnews2","url":null,"abstract":"Teams of chemical scientists from AbbVie and Enanta Pharmaceuticals, Honeywell, Incyte, Merck & Co., Vertex Pharmaceuticals, and ViiV Healthcare received 2023 Heroes of Chemistry Awards at a banquet in Alexandria, Virginia, on Oct. 12. The researchers were recognized for advancements in a number of areas: treating chronic hepatitis C, creating non-ozone-depleting greenhouse gas alternatives, developing a versatile treatment for rare blood cancers and graft-versus-host disease, designing a general anesthesia drug with reduced side effects, coming up with drugs that target and correct genetic abnormalities that cause cystic fibrosis, and improving HIV treatment. Now in its 27th year, the Heroes of Chemistry Awards recognizes scientists whose use of chemistry acts as a service to society. The award is based on three criteria: technical merit, commercial impact, and benefit to humankind. It is the American Chemical Society’s most prestigious distinction for industrial chemists and is supported by ACS’s Board Committee on Corporation","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-buscon17
None Laura Howes
In the first time the regulator has acted against an active pharmaceutical ingredient cartel, the European Commission has fined five companies for price-fixing for the antispasmodic butylscopolamine. Alkaloids of Australia, Alkaloids Corporation, Boehringer Ingelheim, Linnea, and Transo-Pharm will have to pay a total of $14.2 million. A sixth firm, C 2 Pharma, was not fined because it revealed the price-fixing to the commission. All six admitted their involvement and agreed to settle the case. A seventh firm, Alchem, did not settle; the investigation in that case is ongoing.
{"title":"EU fines drug companies for price fixing","authors":"None Laura Howes","doi":"10.1021/cen-10136-buscon17","DOIUrl":"https://doi.org/10.1021/cen-10136-buscon17","url":null,"abstract":"In the first time the regulator has acted against an active pharmaceutical ingredient cartel, the European Commission has fined five companies for price-fixing for the antispasmodic butylscopolamine. Alkaloids of Australia, Alkaloids Corporation, Boehringer Ingelheim, Linnea, and Transo-Pharm will have to pay a total of $14.2 million. A sixth firm, C 2 Pharma, was not fined because it revealed the price-fixing to the commission. All six admitted their involvement and agreed to settle the case. A seventh firm, Alchem, did not settle; the investigation in that case is ongoing.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"49 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
At one stage, small-molecule drugs seemed at risk of going out of fashion, as industry began to favor biotherapeutics. But over the past 10 years, small molecules have made it clear that they aren’t going away. New classes of molecules, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, have people excited. So do technologies, such as machine learning and generative artificial intelligence, that are helping drive drug discovery. Today, drug hunters have more ambition to go after difficult targets and to use novel chemistry. And that makes it an exciting time for chemists. Last year, sales of the 10 top-selling drugs were split 40:60 between small molecules and larger, more complicated biologics, according to Drug Discovery and Development . But those numbers are skewed by the huge cost of some biologic blockbusters. On a global scale, around 90% of all drugs sold are small molecules, according to a Medicine in
在一个阶段，小分子药物似乎有过时的危险，因为工业界开始青睐生物治疗药物。但在过去的10年里，小分子已经清楚地表明它们不会消失。新的分子种类，如靶向蛋白水解嵌合体(PROTACs)和分子胶，让人们兴奋不已。机器学习和生成式人工智能等有助于推动药物发现的技术也是如此。今天，药物猎人有更大的野心去追求困难的目标，并使用新的化学物质。这对化学家来说是一个激动人心的时刻。据药物发现与开发公司(Drug Discovery and Development)称，去年10大畅销药物的销量在小分子和更大、更复杂的生物制剂之间的比例为40:60。但是这些数字被一些生物大片的巨大成本所扭曲。据《医学》杂志报道，在全球范围内，销售的所有药物中约有90%是小分子药物
{"title":"Is this a golden age of small-molecule drug discovery?","authors":"None Laura Howes","doi":"10.1021/cen-10136-cover","DOIUrl":"https://doi.org/10.1021/cen-10136-cover","url":null,"abstract":"At one stage, small-molecule drugs seemed at risk of going out of fashion, as industry began to favor biotherapeutics. But over the past 10 years, small molecules have made it clear that they aren’t going away. New classes of molecules, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, have people excited. So do technologies, such as machine learning and generative artificial intelligence, that are helping drive drug discovery. Today, drug hunters have more ambition to go after difficult targets and to use novel chemistry. And that makes it an exciting time for chemists. Last year, sales of the 10 top-selling drugs were split 40:60 between small molecules and larger, more complicated biologics, according to Drug Discovery and Development . But those numbers are skewed by the huge cost of some biologic blockbusters. On a global scale, around 90% of all drugs sold are small molecules, according to a Medicine in","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-comment
None Michelle Cummings, chair, ACS Committee on Chemists with Dis
Recently, I had the privilege of visiting the Renwick Gallery of the Smithsonian American Art Museum in Washington, DC. In the gallery, there are several pieces by modern artists that illustrate loss, grief, and hardship in recent US history, including the impact of racial conflicts and COVID-19. Through their art, each artist conveyed to me their sadness, frustration, and anger about their personal experiences. I found myself thinking about how that relates to people with disabilities and their feelings about lack of accessibility to so many things in society. Their emotions about their need to fight to unlock tools that help bring equity parallel the struggles expressed by the artists in the Renwick Gallery. But it doesn’t need to be like this; society can choose a different path to make the world more accessible. The tools for an inclusive future The vision of the American Chemical Society Committee on Chemists
{"title":"Making chemistry accessible to all","authors":"None Michelle Cummings, chair, ACS Committee on Chemists with Dis","doi":"10.1021/cen-10136-comment","DOIUrl":"https://doi.org/10.1021/cen-10136-comment","url":null,"abstract":"Recently, I had the privilege of visiting the Renwick Gallery of the Smithsonian American Art Museum in Washington, DC. In the gallery, there are several pieces by modern artists that illustrate loss, grief, and hardship in recent US history, including the impact of racial conflicts and COVID-19. Through their art, each artist conveyed to me their sadness, frustration, and anger about their personal experiences. I found myself thinking about how that relates to people with disabilities and their feelings about lack of accessibility to so many things in society. Their emotions about their need to fight to unlock tools that help bring equity parallel the struggles expressed by the artists in the Renwick Gallery. But it doesn’t need to be like this; society can choose a different path to make the world more accessible. The tools for an inclusive future The vision of the American Chemical Society Committee on Chemists","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"5 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-buscon2
None Matt Blois
China’s commerce ministry has put the world’s battery industry on notice by restricting the export of some graphite materials that are used to make anodes for lithium-ion batteries. The move is calling attention to China’s dominance of the market and providing a push to establish graphite processing outside the country. Graphite anodes can be produced from synthetic graphite—made by heating petroleum coke—or from mined graphite flakes. Graphite flakes must be milled into spherical particles and then coated with carbon. Both forms are mixed with binders to create a battery anode . Starting in December, companies in China will have to get permission to export some forms of natural and synthetic graphite materials that are used to make anodes. Over 60% of the world’s mined graphite and nearly half of synthetic graphite is produced in China, according to the US Geological Survey. The country also dominates processing steps further down the
{"title":"China restricts battery graphite exports","authors":"None Matt Blois","doi":"10.1021/cen-10136-buscon2","DOIUrl":"https://doi.org/10.1021/cen-10136-buscon2","url":null,"abstract":"China’s commerce ministry has put the world’s battery industry on notice by restricting the export of some graphite materials that are used to make anodes for lithium-ion batteries. The move is calling attention to China’s dominance of the market and providing a push to establish graphite processing outside the country. Graphite anodes can be produced from synthetic graphite—made by heating petroleum coke—or from mined graphite flakes. Graphite flakes must be milled into spherical particles and then coated with carbon. Both forms are mixed with binders to create a battery anode . Starting in December, companies in China will have to get permission to export some forms of natural and synthetic graphite materials that are used to make anodes. Over 60% of the world’s mined graphite and nearly half of synthetic graphite is produced in China, according to the US Geological Survey. The country also dominates processing steps further down the","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-scicon4
None Bethany Halford
{"title":"16-carbon ring is doubly antiaromatic","authors":"None Bethany Halford","doi":"10.1021/cen-10136-scicon4","DOIUrl":"https://doi.org/10.1021/cen-10136-scicon4","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136070261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-feature2
None Alex Tullo
The petrochemical industry is entering a rough period. A building boom of massive new complexes over the past decade—particularly in the US and China—has left the sector with the greatest overabundance of production capacity in decades. Struggling to find a market for the surplus, chemical producers will see lower prices and profits. Some, particularly in Europe and East Asia, where operating costs are high, will likely rack up losses. Compounding the overcapacity problem will be a slowdown that may be an enduring fixture in the world economy as China cools from the robust growth of the past 2 decades. In addition, the industry must grapple with increased, and often costly, sustainability demands with no guarantee that its green investments will pay off. Those were takeaways from the inaugural World Chemical Forum, held last month in downtown Houston. The conference was organized by Chemical Market Analytics by OPIS, a chemical consulting
{"title":"Fallow days loom for petrochemical firms","authors":"None Alex Tullo","doi":"10.1021/cen-10136-feature2","DOIUrl":"https://doi.org/10.1021/cen-10136-feature2","url":null,"abstract":"The petrochemical industry is entering a rough period. A building boom of massive new complexes over the past decade—particularly in the US and China—has left the sector with the greatest overabundance of production capacity in decades. Struggling to find a market for the surplus, chemical producers will see lower prices and profits. Some, particularly in Europe and East Asia, where operating costs are high, will likely rack up losses. Compounding the overcapacity problem will be a slowdown that may be an enduring fixture in the world economy as China cools from the robust growth of the past 2 decades. In addition, the industry must grapple with increased, and often costly, sustainability demands with no guarantee that its green investments will pay off. Those were takeaways from the inaugural World Chemical Forum, held last month in downtown Houston. The conference was organized by Chemical Market Analytics by OPIS, a chemical consulting","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-buscon8
None Matt Blois
The battery recycler Ascend Elements will work with the fluorine chemical firm Koura—whose parent company, Orbia, has invested in Ascend—to commercialize technology for recycling graphite anode material in batteries. Some battery recycling processes can recover graphite, but Ascend claims that the product isn’t usually pure enough for batteries. Graphite has received less attention from recyclers because it’s less valuable than cathode metals like cobalt, lithium, and nickel. Orbia is also working with Ascend to recycle fluorine chemicals in batteries.
{"title":"Ascend and Koura to recycle battery graphite","authors":"None Matt Blois","doi":"10.1021/cen-10136-buscon8","DOIUrl":"https://doi.org/10.1021/cen-10136-buscon8","url":null,"abstract":"The battery recycler Ascend Elements will work with the fluorine chemical firm Koura—whose parent company, Orbia, has invested in Ascend—to commercialize technology for recycling graphite anode material in batteries. Some battery recycling processes can recover graphite, but Ascend claims that the product isn’t usually pure enough for batteries. Graphite has received less attention from recyclers because it’s less valuable than cathode metals like cobalt, lithium, and nickel. Orbia is also working with Ascend to recycle fluorine chemicals in batteries.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"26 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1021/cen-10136-buscon7
None Alex Tullo
The Brazilian petrochemical maker Braskem has formed a partnership with Northwestern University to develop a platform, based on coelectrolysis, to make chemicals from carbon dioxide emissions. The project will be led by Northwestern chemistry professor Ted Sargent and research assistant professor Ke Xie. Sargent’s group previously worked out a route to acetic acid that began with the electrolysis of CO 2 and water into carbon monoxide. Braskem has a similar agreement with the University of Illinois. It is also partnering with the start-up New Iridium on an approach to making chemicals from CO 2 using photocatalysis.
{"title":"Braskem teams up with Northwestern","authors":"None Alex Tullo","doi":"10.1021/cen-10136-buscon7","DOIUrl":"https://doi.org/10.1021/cen-10136-buscon7","url":null,"abstract":"The Brazilian petrochemical maker Braskem has formed a partnership with Northwestern University to develop a platform, based on coelectrolysis, to make chemicals from carbon dioxide emissions. The project will be led by Northwestern chemistry professor Ted Sargent and research assistant professor Ke Xie. Sargent’s group previously worked out a route to acetic acid that began with the electrolysis of CO 2 and water into carbon monoxide. Braskem has a similar agreement with the University of Illinois. It is also partnering with the start-up New Iridium on an approach to making chemicals from CO 2 using photocatalysis.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"111 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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