Pub Date : 2023-11-13DOI: 10.1021/cen-10137-scicon4
None Mark Peplow, special to C&EN
A team of researchers led by Mark Levin at the University of Chicago has unveiled a reaction that can perform a C-to-N swap in aromatic molecules that already contain a nitrogen atom, such as quinolines ( Nature 2023, DOI: 10.1038/s41586-023-06613-4 ). This approach, along with another that Levin’s lab unveiled in September, should enable medicinal chemists to make these single-atom substitutions in a swath of common molecules, easing efforts to generate analogs of drug candidates. “This is the problem that I started my lab to tackle,” Levin says. The method is the latest entrant to the growing field of skeletal editing , which aims to add, delete, or swap single atoms within a molecule’s backbone. Such alterations can have a profound effect on a molecule’s biological activity. Swapping out carbon in favor of nitrogen is a common tactic for boosting the potency of pharmaceuticals, but in practice these analogs often
{"title":"Skeletal edit swaps carbon for nitrogen","authors":"None Mark Peplow, special to C&EN","doi":"10.1021/cen-10137-scicon4","DOIUrl":"https://doi.org/10.1021/cen-10137-scicon4","url":null,"abstract":"A team of researchers led by Mark Levin at the University of Chicago has unveiled a reaction that can perform a C-to-N swap in aromatic molecules that already contain a nitrogen atom, such as quinolines ( Nature 2023, DOI: 10.1038/s41586-023-06613-4 ). This approach, along with another that Levin’s lab unveiled in September, should enable medicinal chemists to make these single-atom substitutions in a swath of common molecules, easing efforts to generate analogs of drug candidates. “This is the problem that I started my lab to tackle,” Levin says. The method is the latest entrant to the growing field of skeletal editing , which aims to add, delete, or swap single atoms within a molecule’s backbone. Such alterations can have a profound effect on a molecule’s biological activity. Swapping out carbon in favor of nitrogen is a common tactic for boosting the potency of pharmaceuticals, but in practice these analogs often","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"24 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-cover11
None Craig Bettenhausen
At a 2013 workshop held in a hotel at the Detroit airport, representatives from the Clean Energy Manufacturing Initiative of the US Department of Energy (DOE) asked a group of industry leaders how to reduce emissions from manufacturing carbon fiber—a strong and lightweight material used to replace steel and aluminum in airplanes, automobiles, and wind turbines. They all had the same response. “We need sustainable acrylonitrile,” they said, according to Corey Tyree, CEO and cofounder of Trillium Renewable Chemicals. Acrylonitrile is the raw material used to make carbon fiber. It’s also used as a feedstock for polymers such as nitrile rubber and acrylonitrile-butadiene-styrene, the plastic in Lego blocks. Conventional acrylonitrile is normally made from propylene, a petrochemical with a heavy carbon footprint. After the workshop, the DOE funded a project at the nonprofit Southern Research Institute to make biobased acrylonitrile. The team found a way, and Southern Research spun out
{"title":"Trillium Renewable Chemicals","authors":"None Craig Bettenhausen","doi":"10.1021/cen-10137-cover11","DOIUrl":"https://doi.org/10.1021/cen-10137-cover11","url":null,"abstract":"At a 2013 workshop held in a hotel at the Detroit airport, representatives from the Clean Energy Manufacturing Initiative of the US Department of Energy (DOE) asked a group of industry leaders how to reduce emissions from manufacturing carbon fiber—a strong and lightweight material used to replace steel and aluminum in airplanes, automobiles, and wind turbines. They all had the same response. “We need sustainable acrylonitrile,” they said, according to Corey Tyree, CEO and cofounder of Trillium Renewable Chemicals. Acrylonitrile is the raw material used to make carbon fiber. It’s also used as a feedstock for polymers such as nitrile rubber and acrylonitrile-butadiene-styrene, the plastic in Lego blocks. Conventional acrylonitrile is normally made from propylene, a petrochemical with a heavy carbon footprint. After the workshop, the DOE funded a project at the nonprofit Southern Research Institute to make biobased acrylonitrile. The team found a way, and Southern Research spun out","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"28 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-buscon4
None Gina Vitale
Drug designers try many different tricks to degrade badly behaving proteins. Much of the action in that space comes from companies developing small molecules like proteolysis targeting chimeras (PROTACs) , which degrade proteins that operate inside the cell. Gate Bioscience , a start-up backed by Versant Ventures that launched Nov. 1 with $60 million in series A funding, has set its sights on disease-causing proteins that are destined to end up outside the cell. The company’s name hints at the mechanism behind its small molecules, which work within a channel in a cell’s rough endoplasmic reticulum. For many extracellular proteins, getting through this channel is an important step on their path to exit the cell. Gate’s molecules bind in the channel, which prevents disease-causing proteins from escaping and allows good proteins to move freely through. Unable to leave, the stymied proteins are then degraded, according to Gate cofounder and CEO
{"title":"Gate launches to stop bad proteins at their source","authors":"None Gina Vitale","doi":"10.1021/cen-10137-buscon4","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon4","url":null,"abstract":"Drug designers try many different tricks to degrade badly behaving proteins. Much of the action in that space comes from companies developing small molecules like proteolysis targeting chimeras (PROTACs) , which degrade proteins that operate inside the cell. Gate Bioscience , a start-up backed by Versant Ventures that launched Nov. 1 with $60 million in series A funding, has set its sights on disease-causing proteins that are destined to end up outside the cell. The company’s name hints at the mechanism behind its small molecules, which work within a channel in a cell’s rough endoplasmic reticulum. For many extracellular proteins, getting through this channel is an important step on their path to exit the cell. Gate’s molecules bind in the channel, which prevents disease-causing proteins from escaping and allows good proteins to move freely through. Unable to leave, the stymied proteins are then degraded, according to Gate cofounder and CEO","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"28 15","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-buscon12
None Craig Bettenhausen
BASF has invested an undisclosed sum in the molecular biology start-up 3Helix. The firm makes specialized peptides that bind to damaged collagen molecules. 3Helix has so far commercialized its technology for medical imaging and diagnostic applications. BASF will gain exclusive rights to commercialize 3Helix’s platform for personal care applications, where a wide range of firms are building antiaging products around supporting or supplementing collagen in skin.
{"title":"BASF invests in collagen therapy","authors":"None Craig Bettenhausen","doi":"10.1021/cen-10137-buscon12","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon12","url":null,"abstract":"BASF has invested an undisclosed sum in the molecular biology start-up 3Helix. The firm makes specialized peptides that bind to damaged collagen molecules. 3Helix has so far commercialized its technology for medical imaging and diagnostic applications. BASF will gain exclusive rights to commercialize 3Helix’s platform for personal care applications, where a wide range of firms are building antiaging products around supporting or supplementing collagen in skin.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"28 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-cover6
None Alex Scott
Most of the world’s hydrogen is made unsustainably from methane or coal, and today most of it is used to produce petroleum-based fuels and chemicals. But the start-up H2Pro says hydrogen could also be key to slowing climate change if it is made without fossil fuels. This can be done by taking hydrogen out of water using renewable electricity. Scientists have long known how to extract hydrogen from water. But existing electrolyzers, the machines used to split water molecules , convert only about 70% of the electric energy they use into chemical energy, which is stored as hydrogen. H2Pro has devised a two-step process that generates hydrogen and oxygen in separate steps, ensuring they don’t mix. Hen Dotan, H2Pro’s cofounder and chief technology officer, says his company’s technology converts about 95% of the electricity it uses into chemical energy, a rate that would yield substantial financial savings at commercial scale.
{"title":"H2Pro","authors":"None Alex Scott","doi":"10.1021/cen-10137-cover6","DOIUrl":"https://doi.org/10.1021/cen-10137-cover6","url":null,"abstract":"Most of the world’s hydrogen is made unsustainably from methane or coal, and today most of it is used to produce petroleum-based fuels and chemicals. But the start-up H2Pro says hydrogen could also be key to slowing climate change if it is made without fossil fuels. This can be done by taking hydrogen out of water using renewable electricity. Scientists have long known how to extract hydrogen from water. But existing electrolyzers, the machines used to split water molecules , convert only about 70% of the electric energy they use into chemical energy, which is stored as hydrogen. H2Pro has devised a two-step process that generates hydrogen and oxygen in separate steps, ensuring they don’t mix. Hen Dotan, H2Pro’s cofounder and chief technology officer, says his company’s technology converts about 95% of the electricity it uses into chemical energy, a rate that would yield substantial financial savings at commercial scale.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"56 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-scicon2
None Brianna Barbu
Sometimes, conformity is a good thing. Particularly when it comes to stereochemistry. While stereocenters arise in mirror-image enantiomer pairs when left to their own devices, enantiomers can have very different biological activity. So synthetic and medicinal chemists would prefer to make only one of them at a time. Researchers from the Shanghai Institute of Organic Chemistry, led by Zhiwei Zuo , have now added a new reaction to the stereoselective toolbox. They have devised a clever method for turning mixtures of alcohol isomers into an enantiomerically pure product using a single catalyst ( Science 2023, DOI: 10.1126/science.adj0040 ). Once a mixture of stereoisomers is created, it’s very difficult to amend it without separating the isomers from each other and throwing out the unwanted one. Mixtures have higher entropy, which the universe prefers. And something called the principle of microscopic reversibility says that any mechanistic step that flips an unwanted enantiomer
{"title":"Single-catalyst stereoenrichment","authors":"None Brianna Barbu","doi":"10.1021/cen-10137-scicon2","DOIUrl":"https://doi.org/10.1021/cen-10137-scicon2","url":null,"abstract":"Sometimes, conformity is a good thing. Particularly when it comes to stereochemistry. While stereocenters arise in mirror-image enantiomer pairs when left to their own devices, enantiomers can have very different biological activity. So synthetic and medicinal chemists would prefer to make only one of them at a time. Researchers from the Shanghai Institute of Organic Chemistry, led by Zhiwei Zuo , have now added a new reaction to the stereoselective toolbox. They have devised a clever method for turning mixtures of alcohol isomers into an enantiomerically pure product using a single catalyst ( Science 2023, DOI: 10.1126/science.adj0040 ). Once a mixture of stereoisomers is created, it’s very difficult to amend it without separating the isomers from each other and throwing out the unwanted one. Mixtures have higher entropy, which the universe prefers. And something called the principle of microscopic reversibility says that any mechanistic step that flips an unwanted enantiomer","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"56 23","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-cover3
None Vanessa Zainzinger, special to C&EN
The multicolored feathers of a peacock, the brilliant blue wings of a morpho butterfly, and the metallic golden shell of a Chrysina beetle have one thing in common: they get their stunning color from biological nanostructures that have exactly the right spacing to reflect certain wavelengths of light. Scientists have long been interested in using this phenomenon to lend color to manufactured goods because traditional dyes and pigments require lots of water, energy, and harmful substances, such as heavy metals, aromatic amines, volatile organic compounds, and phthalates. In 2016, Ryan Pearson, then a materials chemistry PhD student at the University of Colorado Boulder, heard the apparel giant Nike present its dye problem at an industry workshop he attended. “Color was this huge environmental footprint for them,” he says. “And that’s kind of when it all clicked for me.” Structure-based colorants could offer an environmentally friendly option, but they have so
{"title":"Cypris Materials","authors":"None Vanessa Zainzinger, special to C&EN","doi":"10.1021/cen-10137-cover3","DOIUrl":"https://doi.org/10.1021/cen-10137-cover3","url":null,"abstract":"The multicolored feathers of a peacock, the brilliant blue wings of a morpho butterfly, and the metallic golden shell of a Chrysina beetle have one thing in common: they get their stunning color from biological nanostructures that have exactly the right spacing to reflect certain wavelengths of light. Scientists have long been interested in using this phenomenon to lend color to manufactured goods because traditional dyes and pigments require lots of water, energy, and harmful substances, such as heavy metals, aromatic amines, volatile organic compounds, and phthalates. In 2016, Ryan Pearson, then a materials chemistry PhD student at the University of Colorado Boulder, heard the apparel giant Nike present its dye problem at an industry workshop he attended. “Color was this huge environmental footprint for them,” he says. “And that’s kind of when it all clicked for me.” Structure-based colorants could offer an environmentally friendly option, but they have so","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"25 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-newscripts
None Bethany Halford
Holiday gift ideas Chemistry-themed goodies for the scientists in your life Playing cards Who needs the queen of hearts when you’ve got the queen of benzene? This chemistry-themed deck of cards features prominent chemists and molecular suits, $17.50 from the OneCreativeAcademic shop on Etsy. Pins These chemistry cat-themed pins are purrfect for decorating backpacks and book bags, $12.99 per 3 cm tall pin at the ItsKindaCatchyShoppe on Etsy. Magnets Stick important memos and papers to fridges and filing cabinets with these colorful flask-shaped tags backed with neodymium magnets, $9.75 for a set of 6 of the 1.75 cm tall magnets in rainbow colors from the yakitori store on Etsy. Embroidered cap Add molecular flair to your headwear with these embroidered caps from the embroideredchem shop on Etsy. Customize the molecule for $25 or choose from favorites like caffeine for $22. Whiskey glass Toast the evolution of the molecular model with
{"title":"Newscripts’ Holiday Gift Guide","authors":"None Bethany Halford","doi":"10.1021/cen-10137-newscripts","DOIUrl":"https://doi.org/10.1021/cen-10137-newscripts","url":null,"abstract":"Holiday gift ideas Chemistry-themed goodies for the scientists in your life Playing cards Who needs the queen of hearts when you’ve got the queen of benzene? This chemistry-themed deck of cards features prominent chemists and molecular suits, $17.50 from the OneCreativeAcademic shop on Etsy. Pins These chemistry cat-themed pins are purrfect for decorating backpacks and book bags, $12.99 per 3 cm tall pin at the ItsKindaCatchyShoppe on Etsy. Magnets Stick important memos and papers to fridges and filing cabinets with these colorful flask-shaped tags backed with neodymium magnets, $9.75 for a set of 6 of the 1.75 cm tall magnets in rainbow colors from the yakitori store on Etsy. Embroidered cap Add molecular flair to your headwear with these embroidered caps from the embroideredchem shop on Etsy. Customize the molecule for $25 or choose from favorites like caffeine for $22. Whiskey glass Toast the evolution of the molecular model with","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"27 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-buscon18
BUSINESS Business Roundup ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2023, 101 (37), p 13November 13, 2023Cite this:C&EN 101, 37, 13Abstract Braskem will supply Indorama subsidiary Oxiteno with ethylene made from renewable sources. Braskem says its biobased ethylene, which is derived from sugar cane and corn ethanol, has been certified under the International Sustainability and Carbon Certification scheme. Montinutra has raised $2.1 million for a demonstration plant in Vilppula, Finland, that will convert forestry waste products into biobased chemicals for binders, coatings, and other products. The firm says it can make chemicals from cellulose, hemicellulose, and lignin. OMV has formed a joint venture with the plastics recycler Interzero that plans to build a plant in Walldürn, Germany, capable of sorting up to 260,000 metric tons per year of mixed waste plastic. OMV will use sorted plastic waste from the plant as feedstock for making pyrolysis oil for new plastic production. Aclarity has raised $15.9 million in series A funding led by the water-focused venture capital fund Aqualateral. Aclarity isView: PDF | Full Text HTMLDownload PDF
商业商业综合报道共享于facebook twitter微信链接于reddite电子邮件C&EN, 2023,101 (37)， p 13 11月13日引用此:C&EN 101,37,13摘要布拉斯科姆将向Indorama子公司Oxiteno提供由可再生能源制成的乙烯。布拉斯科公司说，它的生物基乙烯是从甘蔗和玉米乙醇中提取的，已经通过了国际可持续发展和碳认证计划的认证。Montinutra已经为芬兰Vilppula的一家示范工厂筹集了210万美元，该工厂将把林业废弃物转化为生物基化学品，用于粘合剂、涂料和其他产品。该公司表示，它可以从纤维素、半纤维素和木质素中制造化学物质。OMV与塑料回收商Interzero成立了一家合资企业，计划在德国walld建立一家工厂，每年能够分拣多达26万吨的混合废塑料。OMV将使用从工厂中分类的塑料废物作为原料，生产用于新塑料生产的热解油。clarity在A轮融资中获得1590万美元，领投方是专注于水资源的风险投资基金Aqualateral。清晰度isView: PDF |全文html下载PDF
{"title":"Business Roundup","authors":"","doi":"10.1021/cen-10137-buscon18","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon18","url":null,"abstract":"BUSINESS Business Roundup ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2023, 101 (37), p 13November 13, 2023Cite this:C&EN 101, 37, 13Abstract Braskem will supply Indorama subsidiary Oxiteno with ethylene made from renewable sources. Braskem says its biobased ethylene, which is derived from sugar cane and corn ethanol, has been certified under the International Sustainability and Carbon Certification scheme. Montinutra has raised $2.1 million for a demonstration plant in Vilppula, Finland, that will convert forestry waste products into biobased chemicals for binders, coatings, and other products. The firm says it can make chemicals from cellulose, hemicellulose, and lignin. OMV has formed a joint venture with the plastics recycler Interzero that plans to build a plant in Walldürn, Germany, capable of sorting up to 260,000 metric tons per year of mixed waste plastic. OMV will use sorted plastic waste from the plant as feedstock for making pyrolysis oil for new plastic production. Aclarity has raised $15.9 million in series A funding led by the water-focused venture capital fund Aqualateral. Aclarity isView: PDF | Full Text HTMLDownload PDF","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"28 26","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1021/cen-10137-buscon14
None Laura Howes
Bristol Myers Squibb has purchased Orum Therapeutics’ protein degrader for treating acute myeloid leukemia or high-risk myelodyplastic syndromes. For an up-front payment of $100 million, BMS gets ORM-6151, a molecular-glue drug that is coupled to an antibody. The antibody helps the drug be delivered to cancer cells. There, the glue portion of ORM-6151 is released and marks the target protein GSPT1 for degradation, which ultimately kills the cancer cell.
{"title":"BMS buys Orum’s cancer drug","authors":"None Laura Howes","doi":"10.1021/cen-10137-buscon14","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon14","url":null,"abstract":"Bristol Myers Squibb has purchased Orum Therapeutics’ protein degrader for treating acute myeloid leukemia or high-risk myelodyplastic syndromes. For an up-front payment of $100 million, BMS gets ORM-6151, a molecular-glue drug that is coupled to an antibody. The antibody helps the drug be delivered to cancer cells. There, the glue portion of ORM-6151 is released and marks the target protein GSPT1 for degradation, which ultimately kills the cancer cell.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"28 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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