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On our radar 在我们的雷达上
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-cover12
None Matt Blois, None Alex Scott
Flo Materials makes endlessly recyclable plastics Shoes, carpets, and packaging are each made from several types of plastic, which makes them hard to recycle. In addition, some types of plastic start to degrade after being repeatedly recycled. The start-up Flo Materials, founded in 2021, is trying to commercialize a group of vitrimer plastics called enamine covalent adaptive networks (ECANs). These can be recycled endlessly, even if they are combined with other materials. The company, which is located in Berkeley, California, says its recycling process, based on research from Lawrence Berkeley National Laboratory , breaks down the plastic to monomers that are just as good as virgin materials. It also removes colors, contaminants, and additives. Flo CEO Kezi Cheng says that like high- performance thermosetting polymers, such as epoxy or polyurethane foam, her company’s materials are resistant to heat and chemical degradation. The bonds that make thermoset materials strong also make
鞋子、地毯和包装都是由几种类型的塑料制成的,这使得它们很难回收。此外,某些类型的塑料在被反复回收后开始降解。初创公司Flo Materials成立于2021年,正试图将一组名为烯胺共价自适应网络(ECANs)的玻璃塑料商业化。即使它们与其他材料结合在一起,它们也可以无限循环利用。这家位于加州伯克利的公司表示,其回收过程是基于劳伦斯伯克利国家实验室的研究,将塑料分解成单体,就像原始材料一样好。它还能去除颜色、污染物和添加剂。Flo首席执行官程克子表示,与高性能热固性聚合物(如环氧树脂或聚氨酯泡沫)一样,她公司的材料具有耐热性和耐化学降解性。使热固性材料坚固的化学键也使
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引用次数: 0
Reactions 反应
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-reactions
NUCLEAR POWER Reactions ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2023, 101 (37), p 3November 13, 2023Cite this:C&EN 101, 37, 3Letters to the editorNuclear wasteA provocative editorial in every sense of the word (Sept. 18, 2023, page 2). Yes, we do have a looming disaster of our impact on the global climate, one that will remain well beyond our remaining lifetimes today. Yes, urgent action is required. However, I would like to suggest that conventional nuclear power is not the solution, or even close to it. There are several reasons. I shall stick with one, not the elephant in the room but the mastodon in the room: nuclear waste.Mitch Jacoby mentions permanent repositories. In their current form these are major environmental disasters waiting to happen. Why? The main reason is that even with the vitrification technologies of today, it is near impossible to understand the chemistry, the materials science, and the physics of these matrices in 100 years, 1,000 years, or 1 million years in the future. Evidence from Hanford and continuing efforts of its cleanup tell us much of what to expect to happen in these so-called permanent repositories.If we do go this route, they will need to remain permanently accessible for the continued reprocessing for several hundreds of thousands of years—potentially longer periods. Imagine what the person-hour rate would be in 500,000 years. Imagine how people will look back on the generation that created this waste. Of course, this assumes we do not develop technologies to deal with this waste in the future, which we well might; however, the waste still needs to be accessible. It is of course possible that this waste would undergo subduction into the mantle. A proper life-cycle analysis (ISO 144040), including the continuous waste reprocessing cycles for several thousands of years, would show it to be a very expensive energy source, indeed.Paul JonsenHarrogate, EnglandNowhere in “Can Small Modular Reactors Save Nuclear Energy?” was there a mention of how the waste from these reactors will be disposed of (Sept. 11, 2023, page 30). Maybe we should figure out what to do with the mountains of nuclear waste already created over the last 7 decades of nuclear power generation before we start generating more.Jim SchulteCicero, Illinois CorrectionsSept. 18, 2023, page 40: Newscripts has an incorrect print publication date. It was published in the Sept. 18, not Sept. 11, issue.Oct. 23, 2023, page 30: A quote in the cover story on cool-roof coatings incorrectly implies that Victoria Scarborough is affiliated with the Cool Roof Rating Council. She was instead pointing to the group as a resource.Oct. 30, 2023, page 14: A business news story about Roche’s acquisition of Telavant Holdings describes Roche incorrectly. The company is Swiss, not French.Oct. 30, 2023, page 28: The cover story on small-molecule drugs gives an incorrect affiliation for Matthew Disney. He is based at the Herbert Wertheim UF Scripps Instit
核能反应分享分享在facebook上推特上推特上链接在reddite电子邮件引用:C&EN, 2023,101 (37), p 32311月13日引用:C&EN, 101,37,3给编辑的信核废料一篇在任何意义上都具有挑衅意味的社论(2023年9月18日,第2页)。是的,我们确实有一场迫在眉睫的灾难,我们对全球气候的影响将远远超过我们今天的余生。是的,需要采取紧急行动。然而,我想说的是,传统的核能不是解决办法,甚至不是接近解决办法。有几个原因。我将坚持讲一个,不是房间里的大象,而是房间里的乳齿象:核废料。Mitch Jacoby提到了永久存储库。以目前的形式来看,这些都是即将发生的重大环境灾难。为什么?主要原因是,即使使用今天的玻璃化技术,也几乎不可能在100年、1000年或100万年后了解这些基质的化学、材料科学和物理学。来自汉福德的证据和持续的清理工作告诉我们,在这些所谓的永久储存库中会发生什么。如果我们真的走这条路,它们将需要在几十万年——可能更长——的时间里保持永久的可访问性,以便继续进行再处理。想象一下50万年后每小时的速度会是多少。想象一下,人们将如何回顾制造这种浪费的一代人。当然,这是假设我们将来不开发处理这些废物的技术,而我们很可能会这样做;然而,废物仍然需要是可获取的。当然,这些废物也有可能俯冲到地幔中。适当的生命周期分析(ISO 144040),包括持续数千年的废物再处理循环,将表明它确实是一种非常昂贵的能源。《小型模块化反应堆能拯救核能吗?》有没有提到如何处理这些反应堆产生的废料(2023年9月11日,第30页)。也许在我们开始生产更多的核废料之前,我们应该弄清楚如何处理过去70年核电产生的堆积如山的核废料。Jim SchulteCicero,伊利诺斯州惩教所2023年18日,第40页:Newscripts的印刷出版日期不正确。这篇文章发表在9月18日,而不是9月11日。2023年3月23日,第30页:封面故事中关于凉爽屋顶涂料的引用错误地暗示维多利亚·斯卡伯勒隶属于凉爽屋顶评级委员会。相反,她指出该组织是一种资源。2023年3月30日,第14页:一篇关于罗氏收购Telavant Holdings的商业新闻报道错误地描述了罗氏。这家公司是瑞士的,不是法国的。2023年3月30日,第28页:关于小分子药物的封面故事给了马修·迪斯尼一个错误的归属。他就职于佛罗里达大学赫伯特·韦特海姆UF斯克里普斯生物医学创新与技术研究所,而不是斯克里普斯研究所。下载
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引用次数: 0
EPA to rebuild endocrine disruptor program 环保署重建内分泌干扰物项目
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-polcon4
None Britt E. Erickson
After decades with little progress, the US Environmental Protection Agency plans to revamp an effort to evaluate pesticides for potential effects on estrogen, androgen, and thyroid hormones. The move follows a late-2022 lawsuit from environmental and farmworker groups and a scathing 2021 report from the EPA’s Office of Inspector General over endocrine disruptor testing delays. The EPA’s beleaguered Endocrine Disruptor Screening Program, created in 1998 to comply with changes to US food and drinking-water laws, has been on hiatus with no “effective internal controls in place since 2015,” according to the 2021 report. To get the program back on track, the EPA will request data from manufacturers for 30 pesticides that showed estrogen or androgen activity when agency scientists tested them with high-throughput assays and computational modeling , the agency announced Oct. 26. The 30 high-priority pesticides are part of a group of 403 pesticides that the EPA is reviewing
在几十年进展甚微之后,美国环境保护署计划重新评估农药对雌激素、雄激素和甲状腺激素的潜在影响。此前,环保和农场工人团体在2022年底提起诉讼,美国环保署监察长办公室在2021年发布了一份关于内分泌干扰物测试延误的严厉报告。根据2021年的报告,美国环保署于1998年为遵守美国食品和饮用水法律的变化而创建的内分泌干扰物筛查计划陷入困境,该计划一直处于中断状态,“自2015年以来没有有效的内部控制”。EPA于10月26日宣布,为了使该计划重回正轨,EPA将要求制造商提供30种农药的数据,这些农药在EPA科学家用高通量分析和计算模型对其进行测试时显示出雌激素或雄激素活性。这30种高优先级农药是美国环保署正在审查的403种农药中的一部分
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引用次数: 0
Blackrock invests in direct air capture 贝莱德投资于直接空气捕捉
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-buscon7
None Craig Bettenhausen
The investment firm BlackRock will put $550 million into a direct-air-capture (DAC) project being developed by a subsidiary of the oil and gas giant Occidental. Under the terms of the deal, BlackRock and Oxy will form a joint venture that will own Stratos, a DAC facility that Oxy is building in Texas. When the plant comes on-line in 2025, the firms expect it to remove 500,000 metric tons of carbon dioxide per year from the ambient air. In August, Oxy bought Carbon Engineering, the DAC technology provider for the project, for $1.1 billion.
投资公司贝莱德(BlackRock)将向石油和天然气巨头西方石油公司(Occidental)的一家子公司开发的直接空气捕捉(DAC)项目投入5.5亿美元。根据交易条款,贝莱德和Oxy将组建一家合资企业,拥有Oxy正在德克萨斯州建造的DAC设施Stratos。当工厂在2025年投入使用时,两家公司预计它每年将从环境空气中去除50万吨二氧化碳。今年8月,Oxy以11亿美元的价格收购了该项目的DAC技术提供商Carbon Engineering。
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引用次数: 0
Almac details expansion plans Almac详细介绍了扩展计划
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-buscon17
None Rick Mullin
Almac has published details of a $98 million investment program that will expand its pharmaceutical and diagnostic service units with manufacturing and laboratory assets at its headquarters in Craigavon, Northern Ireland. Plans include a 9,300 m 2 production facility supporting oral dosage drugs and a 3,700 m 2 development center with diagnostic kit manufacturing facilities. Alma, which has set a recruitment goal of 1,000 new staffers in Northern Ireland over 3 years, says this expansion will create more than 550 jobs.
Almac公布了一项9800万美元投资计划的细节,该计划将扩大其在北爱尔兰克雷加文总部的制药和诊断服务部门的生产和实验室资产。计划包括一个9300平方米的生产设施,用于支持口服剂量药物和一个3700平方米的开发中心,其中包括诊断试剂盒生产设施。Alma已经设定了3年内在北爱尔兰招聘1000名新员工的目标,该公司表示,此次扩张将创造550多个就业岗位。
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引用次数: 0
Ashland plans restructuring 亚什兰计划重组
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-buscon10
None Matt Blois
The chemical firm Ashland is scaling back production of the food and cosmetic ingredients carboxymethyl cellulose, methyl cellulose, and hydroxyethyl cellulose in response to low demand. The company also plans to sell its nutraceuticals business. Ashland recently announced that it will focus on industries in which it has the biggest technology advantage, such as ingredients for pharmaceuticals, personal care products, and coatings. The firm sold its adhesives business to Arkema for $1.65 billion in 2022 .
化工公司亚什兰正在缩减食品和化妆品原料羧甲基纤维素、甲基纤维素和羟乙基纤维素的生产,以应对低需求。该公司还计划出售其营养保健品业务。亚什兰最近宣布,它将把重点放在它拥有最大技术优势的行业,如制药原料、个人护理产品和涂料。该公司于2022年以16.5亿美元的价格将其粘合剂业务出售给阿科玛。
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引用次数: 0
Septerna Septerna
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-cover9
None Laurel Oldach
There are hundreds of G protein–coupled receptors (GPCRs) in the human genome, regulating just about every physiological system. While roughly a third of marketed drugs target a GPCR, many of the receptors have remained out of reach for drug hunters, in part because of challenges involved in studying them . After the heyday of GPCR-targeting drugs in the 1990s and early 2000s, few medicines targeting these proteins have been introduced. But new technologies may be poised to change that. A few years ago, chemistry Nobel laureate Robert J. Lefkowitz was working with scientists in his lab at Duke University in North Carolina to develop a new way to isolate enzymatically active GPCRs. Halfway around the world, at Monash University in Melbourne, Australia, the eminent pharmacology duo Patrick Sexton and Arthur Christopoulos was simultaneously developing techniques to modulate GPCR signaling using structure-based drug design. And in San Francisco, Jeffrey Finer, a
人类基因组中有数百个G蛋白偶联受体(gpcr),它们调节着几乎所有的生理系统。虽然大约有三分之一的上市药物靶向GPCR,但许多受体仍然是药物猎人无法触及的,部分原因是研究它们所涉及的挑战。在20世纪90年代和21世纪初gpcr靶向药物的鼎盛时期之后,很少有针对这些蛋白质的药物被引入。但新技术可能会改变这种状况。几年前,诺贝尔化学奖得主罗伯特·j·莱夫科维茨(Robert J. Lefkowitz)在北卡罗来纳州杜克大学(Duke University)的实验室里与科学家们合作,开发了一种分离酶活性gpcr的新方法。在地球的另一端,澳大利亚墨尔本的莫纳什大学,著名的药理学二人组Patrick Sexton和Arthur Christopoulos正在同时开发利用基于结构的药物设计来调节GPCR信号的技术。在旧金山,一位名叫杰弗里
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引用次数: 0
Goodyear, Visolis plan biobased isoprene 固特异,维索里斯计划生物基异戊二烯
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-buscon9
None Matt Blois
The Goodyear Tire & Rubber Company is working with the biomanufacturing firm Visolis to develop a process for producing biobased isoprene, a precursor for some types of synthetic rubber used to make tires. Isoprene is typically made as a by-product of oil refining. Visolis plans to make the chemical from lignocellulosic feedstock, which is inedible biomass. In 2007, Goodyear entered into a partnership with Genencor to produce isoprene enzymatically from plant sugars. The partners initially hoped to commercialize the product by 2013 but haven’t announced additional progress.
固特异轮胎橡胶公司正与生物制造公司Visolis合作开发一种生产生物基异戊二烯的工艺,异戊二烯是用于制造轮胎的某些合成橡胶的前体。异戊二烯通常是炼油的副产品。Visolis计划从木质纤维素原料中制造这种化学物质,这是一种不可食用的生物质。2007年,固特异与Genencor建立了合作伙伴关系,从植物糖中酶法生产异戊二烯。合作伙伴最初希望在2013年将该产品商业化,但尚未宣布进一步的进展。
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引用次数: 0
Clariant to purchase Lucas Meyer Cosmetics 科莱恩收购卢卡斯迈耶化妆品公司
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-buscon3
None Craig Bettenhausen
Clariant has agreed to buy the personal care ingredient maker Lucas Meyer Cosmetics from International Flavors & Fragrances (IFF) for $810 million. The deal also includes another ingredient brand, IBR, as well as 195 employees and six research and production sites around the world. Clariant CEO Conrad Keijzer said on an Oct. 30 call with analysts that IFF’s cosmetic ingredient business had a profit margin of almost 50% on sales of $100 million in 2022. The firm aims to increase sales to $180 million by 2028. IFF bought Lucas Meyer in 2015 for $305 million. But after its 2021 merger with DuPont’s nutrition and biosciences business, IFF has been restructuring to focus on nutrition, scent, and health-care markets. It sold a microbial control business to Lanxess last year and two specialty flavoring units to private equity firms earlier this year . On the call, Keijzer said cosmetic ingredients are “one
科莱恩同意以8.1亿美元的价格从国际香精香料公司(IFF)手中收购个人护理成分制造商Lucas Meyer Cosmetics。该交易还包括另一个配料品牌IBR,以及195名员工和全球6个研发和生产基地。科莱恩首席执行官Conrad Keijzer在10月30日与分析师的电话会议上表示,到2022年,IFF的化妆品成分业务销售额为1亿美元,利润率接近50%。该公司的目标是到2028年将销售额增加到1.8亿美元。IFF在2015年以3.05亿美元收购了卢卡斯·迈耶。但在2021年与杜邦的营养和生物科学业务合并后,IFF一直在进行重组,专注于营养、气味和医疗保健市场。去年,该公司将一项微生物控制业务出售给朗盛(Lanxess),并在今年早些时候将两家特种调味品部门出售给私募股权公司。在电话中,Keijzer说化妆品成分是“一种”
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引用次数: 0
Regulators, researchers develop AI safeguards 监管机构、研究人员开发人工智能防护措施
Pub Date : 2023-11-13 DOI: 10.1021/cen-10137-scicon1
None Laurel Oldach
Artificial intelligence and machine learning tools are already being used to power voice assistants and self-driving cars, determine what users see on the internet, and guide drug design and chemical syntheses. But there are concerns about their ability to push disinformation, compromise cybersecurity, and engineer harmful biological materials. Governments around the world hope to mitigate those risks without quashing progress in the problems that AI seems poised to solve. A recent executive order by US president Joe Biden announced measures to make AI systems safer, such as requiring their developers to search for ways that bad actors could exploit the tools. Shortly after the order’s announcement , government and corporation representatives gathered in the UK for a summit on the risks of AI; 28 countries signed a declaration that supports continuing development of the technology but calls for more research into its potential risks. Many parts of the chemical enterprise
人工智能和机器学习工具已被用于驱动语音助手和自动驾驶汽车,确定用户在互联网上看到的内容,以及指导药物设计和化学合成。但人们担心它们有能力传播虚假信息、破坏网络安全,以及制造有害的生物材料。世界各国政府都希望在不影响人工智能似乎准备解决的问题取得进展的情况下,减轻这些风险。美国总统乔·拜登(Joe Biden)最近发布了一项行政命令,宣布了使人工智能系统更安全的措施,比如要求它们的开发人员寻找恶意行为者利用这些工具的方式。在该命令宣布后不久,政府和企业代表聚集在英国,召开了一场关于人工智能风险的峰会;28个国家签署了一份声明,支持继续开发这项技术,但呼吁对其潜在风险进行更多研究。化工企业的许多部分
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引用次数: 0
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C&EN Global Enterprise
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