Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.07.010
Ashley R. Wolf
Acinetobacter baumannii causes antimicrobial-resistant infections. Asymptomatic gut colonization increases infection risk, yet little is known about how A. baumanii persists. In this issue of Cell Host & Microbe, Ren and Clark et al. establish a murine model to define how amino acid metabolism shapes long-term A. baumannii colonization.
{"title":"A. baumannii’s nutrient tug-of-war","authors":"Ashley R. Wolf","doi":"10.1016/j.chom.2025.07.010","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.010","url":null,"abstract":"<em>Acinetobacter baumannii</em> causes antimicrobial-resistant infections. Asymptomatic gut colonization increases infection risk, yet little is known about how <em>A. baumanii</em> persists. In this issue of <em>Cell Host & Microbe</em>, Ren and Clark et al. establish a murine model to define how amino acid metabolism shapes long-term <em>A. baumannii</em> colonization.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"745 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.07.006
Xander C.L. Zuijdgeest, Farid El Kasmi
Transfer of NLR-type immune receptors to distantly related plant species to expand pathogen recognition has often been difficult due to restricted taxonomic functionality (RTF). In a recent Cell publication, Du and Alam et al. overcame RTF by co-transfer of sensor and helper NLRs, which was used as a functional immunity module across species.
{"title":"Breaking open the taxonomic boundaries of plant NLR immunity","authors":"Xander C.L. Zuijdgeest, Farid El Kasmi","doi":"10.1016/j.chom.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.006","url":null,"abstract":"Transfer of NLR-type immune receptors to distantly related plant species to expand pathogen recognition has often been difficult due to restricted taxonomic functionality (RTF). In a recent <em>Cell</em> publication, Du and Alam et al. overcame RTF by co-transfer of sensor and helper NLRs, which was used as a functional immunity module across species.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"185 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144824991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.06.016
Tatsuya Nobori
Plant immunity emerges as cells, normally dedicated to non-immune functions, transition their states through diverse mechanisms to engage in defense roles. This Forum explores the concept of plant immune cell states, their biological significance, and emerging approaches to study them, highlighting the complex cellular basis of plant-microbe interactions.
{"title":"Immune cell states: Critical building blocks of the plant immune system","authors":"Tatsuya Nobori","doi":"10.1016/j.chom.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.chom.2025.06.016","url":null,"abstract":"Plant immunity emerges as cells, normally dedicated to non-immune functions, transition their states through diverse mechanisms to engage in defense roles. This Forum explores the concept of plant immune cell states, their biological significance, and emerging approaches to study them, highlighting the complex cellular basis of plant-microbe interactions.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"20 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144824992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.05.027
Derek S. Lundberg, Joy Bergelson, Fabrice Roux, Detlef Weigel, Talia L. Karasov
Plant-microbe research offers many choices of model and strain and whether a field-first or lab-first approach is best. However, differences between laboratory studies, offering control and repeatability, versus field experiments, revealing ecological relevance and environmental effects, should not be seen as failure but motivate further inquiry and allow complementary discovery.
{"title":"Lab to field: Challenges and opportunities for plant biology","authors":"Derek S. Lundberg, Joy Bergelson, Fabrice Roux, Detlef Weigel, Talia L. Karasov","doi":"10.1016/j.chom.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.027","url":null,"abstract":"Plant-microbe research offers many choices of model and strain and whether a field-first or lab-first approach is best. However, differences between laboratory studies, offering control and repeatability, versus field experiments, revealing ecological relevance and environmental effects, should not be seen as failure but motivate further inquiry and allow complementary discovery.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"6 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144824908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.07.013
Seyed Majed Modaresi, Melis N. Anahtar, Aarti Krishnan
In a recent issue of Science Translational Medicine, Xie et al. introduce a host defense peptide-mimicking prodrug that activates selectively at acidic infection sites, clearing Gram-negative pathogens and biofilms without inducing resistance—advancing precision antibiotic therapy.
{"title":"Active on demand: A precision prodrug strategy against drug-resistant Gram-negative pathogens","authors":"Seyed Majed Modaresi, Melis N. Anahtar, Aarti Krishnan","doi":"10.1016/j.chom.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.013","url":null,"abstract":"In a recent issue of <em>Science Translational Medicine</em>, Xie et al. introduce a host defense peptide-mimicking prodrug that activates selectively at acidic infection sites, clearing Gram-negative pathogens and biofilms without inducing resistance—advancing precision antibiotic therapy.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"103 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.05.022
Menglu Hou, Guoyong Xu
The growth-defense trade-off describes a prevalent pattern where developing resistance traits compromises growth. In this Forum, we highlight the importance of inducible and specific resistance to safeguard growth in wild plant evolution and elite crop breeding, while discussing how the relationship between defense and growth extends beyond a simple trade-off.
{"title":"Growth-defense trade-off in plants: From hypothesis to principle to paradigm","authors":"Menglu Hou, Guoyong Xu","doi":"10.1016/j.chom.2025.05.022","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.022","url":null,"abstract":"The growth-defense trade-off describes a prevalent pattern where developing resistance traits compromises growth. In this Forum, we highlight the importance of inducible and specific resistance to safeguard growth in wild plant evolution and elite crop breeding, while discussing how the relationship between defense and growth extends beyond a simple trade-off.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"107 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.06.009
Xiaowei Zhang, Xinhang Tan, Ertao Wang
Plants continuously interact with diverse microbes. Forming essential symbiotic relationships promotes plant growth, while defending against harmful microbes prevents disease. Plants resist pathogens by detecting molecules released from microbes. Beneficial microbes distinguish themselves from harmful pathogens before establishing symbiosis by releasing molecules and suppressing plant defenses during the infection and colonization stages. Despite their distinct outcomes, symbiotic and immune responses lie on a continuum and share key features, including dynamic cellular remodeling, metabolite rearrangement, and the maintenance of defenses against pathogens. This review explores the regulatory networks governing these processes, highlighting the shared and unique molecular mechanisms underlying symbiotic and immune responses. Understanding how plants integrate environmental signals to balance symbiotic compatibility and defense will provide valuable insights into optimizing plant health and productivity in changing ecosystems.
{"title":"Networks of the symbiosis-immunity continuum in plants","authors":"Xiaowei Zhang, Xinhang Tan, Ertao Wang","doi":"10.1016/j.chom.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.06.009","url":null,"abstract":"Plants continuously interact with diverse microbes. Forming essential symbiotic relationships promotes plant growth, while defending against harmful microbes prevents disease. Plants resist pathogens by detecting molecules released from microbes. Beneficial microbes distinguish themselves from harmful pathogens before establishing symbiosis by releasing molecules and suppressing plant defenses during the infection and colonization stages. Despite their distinct outcomes, symbiotic and immune responses lie on a continuum and share key features, including dynamic cellular remodeling, metabolite rearrangement, and the maintenance of defenses against pathogens. This review explores the regulatory networks governing these processes, highlighting the shared and unique molecular mechanisms underlying symbiotic and immune responses. Understanding how plants integrate environmental signals to balance symbiotic compatibility and defense will provide valuable insights into optimizing plant health and productivity in changing ecosystems.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"26 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.05.028
Francisco Dini-Andreote
Terrestrial plants have ancient evolutionary relationships with microbes. Global change alters these interactions, with impacts on natural and agricultural ecosystems. This commentary outlines an overview of plant-microbe interactions and provides perspectives for advancing research directions toward effectively harnessing plant-microbe interactions to promote plant and ecosystem tolerance amid global change scenarios.
{"title":"Plant-microbe interactions amid global change","authors":"Francisco Dini-Andreote","doi":"10.1016/j.chom.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.chom.2025.05.028","url":null,"abstract":"Terrestrial plants have ancient evolutionary relationships with microbes. Global change alters these interactions, with impacts on natural and agricultural ecosystems. This commentary outlines an overview of plant-microbe interactions and provides perspectives for advancing research directions toward effectively harnessing plant-microbe interactions to promote plant and ecosystem tolerance amid global change scenarios.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"291 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.07.012
Aditi Bhat, Cara H. Haney
Microbiota provide diverse benefits to their hosts, including nutrient acquisition, stress tolerance, and disease resistance. However, the mechanisms by which plants coordinate intrinsic and extrinsic cues to shape microbial communities remain poorly understood. Receptor-like kinases (RLKs), one of the largest gene families in plants, are central to the perception of both exogenous and endogenous signals, including pathogens, mutualists, and plant physiology. Indeed, recent evidence has identified RLKs that regulate microbiome structure and function. This minireview focuses on how their quantity and ability to transduce diverse signals make RLKs strong candidates to coordinate plant physiology and immunity with the microbiome.
{"title":"The role of plant receptor-like kinases in sensing extrinsic and host-derived signals and shaping the microbiome","authors":"Aditi Bhat, Cara H. Haney","doi":"10.1016/j.chom.2025.07.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.012","url":null,"abstract":"Microbiota provide diverse benefits to their hosts, including nutrient acquisition, stress tolerance, and disease resistance. However, the mechanisms by which plants coordinate intrinsic and extrinsic cues to shape microbial communities remain poorly understood. Receptor-like kinases (RLKs), one of the largest gene families in plants, are central to the perception of both exogenous and endogenous signals, including pathogens, mutualists, and plant physiology. Indeed, recent evidence has identified RLKs that regulate microbiome structure and function. This minireview focuses on how their quantity and ability to transduce diverse signals make RLKs strong candidates to coordinate plant physiology and immunity with the microbiome.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"16 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1016/j.chom.2025.07.014
John E. Common, Rebecca P. Payne
Inborn errors of immunity disrupt host-microbe interactions. In this issue of Cell Host & Microbe, Che et al.1 examine DOCK8-deficient individuals undergoing stem cell transplantation and show that immune reconstitution rebalances the skin microbiome, underscoring the central role of immunity in shaping cutaneous microbial ecology.
{"title":"Microbial Makeover: Skin microbiome reset after stem cell transplantation","authors":"John E. Common, Rebecca P. Payne","doi":"10.1016/j.chom.2025.07.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.07.014","url":null,"abstract":"Inborn errors of immunity disrupt host-microbe interactions. In this issue of <em>Cell Host & Microbe</em>, Che et al.<span><span><sup>1</sup></span></span> examine DOCK8-deficient individuals undergoing stem cell transplantation and show that immune reconstitution rebalances the skin microbiome, underscoring the central role of immunity in shaping cutaneous microbial ecology.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"15 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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