Pub Date : 2025-11-26DOI: 10.1016/j.chom.2025.11.002
Kine Eide Kvitne, Celeste Allaband, Jennifer C. Onuora, Daniela Perry, Simone Zuffa, Lucas Patel, Vincent Charron-Lamoureux, Ipsita Mohanty, Kristija Sejane, Abubaker Patan, Abdullah Al Mahmud, Tahmeed Ahmed, Diego G. Bassani, Antonio González, Davidson H. Hamer, Rashidul Haque, Benjamin Ho, Md Iqbal Hossain, Mohammad Shahidul Islam, Daniel McDonald, Rob Knight
Early life is a critical period for immune and metabolic development, but these patterns remain underexplored in populations from low- and middle-income countries. Here, we profile the microbiome and metabolome of 55 Bangladeshi mother-infant dyads over the first 6 months of life. Importantly, we observe an increase in microbially derived bile amidates and N-acyl lipids with age in conjunction with reads matching the bile salt hydrolase/transferase (bsh) gene. Although microbial source tracking confirms maternal fecal seeding, a substantial environmental contribution is also highlighted. Differences in infant fecal metabolic profiles are associated with delivery mode, maternal milk composition, household assets, and household-level water treatment. Cesarean section (C-section) delivery and untreated drinking water are linked to transient metabolic differences, including increases in bile amidates, N-acyl lipids, and other host-microbe co-metabolic products, including acylcarnitines. Multi-omics analysis reveals specific microbial-metabolite relationships, highlighting how early environmental and maternal living circumstances influence gut metabolic development through the microbiome.
{"title":"Environmental and maternal imprints on infant gut metabolic development","authors":"Kine Eide Kvitne, Celeste Allaband, Jennifer C. Onuora, Daniela Perry, Simone Zuffa, Lucas Patel, Vincent Charron-Lamoureux, Ipsita Mohanty, Kristija Sejane, Abubaker Patan, Abdullah Al Mahmud, Tahmeed Ahmed, Diego G. Bassani, Antonio González, Davidson H. Hamer, Rashidul Haque, Benjamin Ho, Md Iqbal Hossain, Mohammad Shahidul Islam, Daniel McDonald, Rob Knight","doi":"10.1016/j.chom.2025.11.002","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.002","url":null,"abstract":"Early life is a critical period for immune and metabolic development, but these patterns remain underexplored in populations from low- and middle-income countries. Here, we profile the microbiome and metabolome of 55 Bangladeshi mother-infant dyads over the first 6 months of life. Importantly, we observe an increase in microbially derived bile amidates and <em>N</em>-acyl lipids with age in conjunction with reads matching the bile salt hydrolase/transferase (<em>bsh</em>) gene. Although microbial source tracking confirms maternal fecal seeding, a substantial environmental contribution is also highlighted. Differences in infant fecal metabolic profiles are associated with delivery mode, maternal milk composition, household assets, and household-level water treatment. Cesarean section (C-section) delivery and untreated drinking water are linked to transient metabolic differences, including increases in bile amidates, <em>N</em>-acyl lipids, and other host-microbe co-metabolic products, including acylcarnitines. Multi-omics analysis reveals specific microbial-metabolite relationships, highlighting how early environmental and maternal living circumstances influence gut metabolic development through the microbiome.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"97 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145600179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.chom.2025.10.019
Gulistan Agirman, Michael N.B. Quicho, Kaden K. Connelley, Xiaobei Zhang, Jonathan B. Lynch, Sung Min Ha, Heidi M. Schmidt, Ezgi Özcan, Angela X. Liang, Kristie B. Yu, In Sook Ahn, Cheng Qian, Jorge Paramo, Shenwei Zhang, Adriana Espinoza, Peter J. Turnbaugh, Thomas Q. de Aguiar Vallim, Xia Yang, Arpana Church, Elaine Y. Hsiao
Metabolic disorders are associated with gut microbiome imbalance, which can have additional physiological effects. The microbial metabolite imidazole propionate (ImP) is elevated in type 2 diabetes and has been linked to exacerbated metabolic dysfunctions. Here, we show that bacteria-produced ImP can enter the bloodstream and modulate brain activity and behavior. Elevated circulating ImP reaches the brain, leading to altered neuronal gene expression in the hypothalamus, disrupted GABAergic/glutamatergic signaling, and stress-related behaviors. Similarly, colonization with ImP-producing Eggerthella lenta elevates behavioral and molecular stress features. In a mouse model of type 2 diabetes, the gut microbiome shows greater capacity to generate ImP, leading to elevated systemic levels associated with heightened stress responses. In humans, higher ImP levels are associated with reduced hypothalamic reactivity to food cues, impaired stress coping, and increased emotional eating. Overall, these findings establish ImP as a microbial metabolite that links gut dysbiosis to altered hypothalamic function and stress in metabolic disease.
{"title":"The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors","authors":"Gulistan Agirman, Michael N.B. Quicho, Kaden K. Connelley, Xiaobei Zhang, Jonathan B. Lynch, Sung Min Ha, Heidi M. Schmidt, Ezgi Özcan, Angela X. Liang, Kristie B. Yu, In Sook Ahn, Cheng Qian, Jorge Paramo, Shenwei Zhang, Adriana Espinoza, Peter J. Turnbaugh, Thomas Q. de Aguiar Vallim, Xia Yang, Arpana Church, Elaine Y. Hsiao","doi":"10.1016/j.chom.2025.10.019","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.019","url":null,"abstract":"Metabolic disorders are associated with gut microbiome imbalance, which can have additional physiological effects. The microbial metabolite imidazole propionate (ImP) is elevated in type 2 diabetes and has been linked to exacerbated metabolic dysfunctions. Here, we show that bacteria-produced ImP can enter the bloodstream and modulate brain activity and behavior. Elevated circulating ImP reaches the brain, leading to altered neuronal gene expression in the hypothalamus, disrupted GABAergic/glutamatergic signaling, and stress-related behaviors. Similarly, colonization with ImP-producing <em>Eggerthella lenta</em> elevates behavioral and molecular stress features. In a mouse model of type 2 diabetes, the gut microbiome shows greater capacity to generate ImP, leading to elevated systemic levels associated with heightened stress responses. In humans, higher ImP levels are associated with reduced hypothalamic reactivity to food cues, impaired stress coping, and increased emotional eating. Overall, these findings establish ImP as a microbial metabolite that links gut dysbiosis to altered hypothalamic function and stress in metabolic disease.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"24 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.chom.2025.10.018
Erin E. Doherty, Jason Nomburg, Benjamin A. Adler, Santiago Lopez, Kendall Hsieh, Nathan Price, Nurashau Blount, Jennifer A. Doudna
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase (PDE)-mediated oligonucleotide cleavage for immune evasion, a strategy whose diversity has not yet been explored. Here, we use a canonical 2H PDE (2H PDE) structure-based search of prokaryotic and eukaryotic viral sequences to identify an exceptional diversity of 2H PDEs across the virome, including enzymes not detectable with sequence search methods alone. Despite active site conservation, biochemical experiments reveal remarkable substrate specificity of these PDEs that corresponds to variations in the core 2H fold. This nuanced specificity allows 2H PDEs to selectively degrade oligonucleotide messengers to avoid interfering with host nucleotide signaling. Together, these findings nominate viral 2H PDEs as key regulators of CDN signaling across the tree of life.
{"title":"Divergent viral phosphodiesterases for immune signaling evasion","authors":"Erin E. Doherty, Jason Nomburg, Benjamin A. Adler, Santiago Lopez, Kendall Hsieh, Nathan Price, Nurashau Blount, Jennifer A. Doudna","doi":"10.1016/j.chom.2025.10.018","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.018","url":null,"abstract":"Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase (PDE)-mediated oligonucleotide cleavage for immune evasion, a strategy whose diversity has not yet been explored. Here, we use a canonical 2H PDE (2H PDE) structure-based search of prokaryotic and eukaryotic viral sequences to identify an exceptional diversity of 2H PDEs across the virome, including enzymes not detectable with sequence search methods alone. Despite active site conservation, biochemical experiments reveal remarkable substrate specificity of these PDEs that corresponds to variations in the core 2H fold. This nuanced specificity allows 2H PDEs to selectively degrade oligonucleotide messengers to avoid interfering with host nucleotide signaling. Together, these findings nominate viral 2H PDEs as key regulators of CDN signaling across the tree of life.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"1 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deep-sea coral ecosystems support biodiversity and nutrient cycling through interactions with symbionts. However, their molecular mechanisms remain unexplored. Here, hologenomic analyses of Bathypathes pseudoalternata are applied to uncover molecular adaptations underpinning host-symbiont interactions. Genomic evidence reveals that B. pseudoalternata exhibits adaptations in nutrient transport, immune response, and lysosomal digestion, reflecting its genomic adjustments for a stable symbiosis. Candidatus Nitrosopumilus bathypathes (78.43% ± 3.65%) is inferred to oxidize host-derived ammonia to synthesize amino acids and vitamins to provision the host. The presence of CRISPR-Cas and restriction-modification (R-M) systems suggests that Ca. Bathyplasma bathypathes and Ca. Thalassoplasma bathypathes (10.68% ± 2.99%) may protect the host from viral infections. Ca. Bathybacter bathypathes (8.39% ± 1.53%) is hypothesized to synthesize heme, lipoic acid, and glutathione, which serve dual functions as antioxidants and nutrients. These findings collectively provide insights into how the hologenome contributes to the survival of B. pseudoalternata in the extreme environment.
{"title":"Hologenomic insights into the molecular adaptation of deep-sea coral Bathypathes pseudoalternata","authors":"ZhanFei Wei, Yi Lan, LiHui Meng, Hao Wang, LiangWei Li, Yang Li, NanNan Zhang, Rui Lu, Zhen Cui, YaLi Song, YinZhao Wang, YuanNing Li, Zhen Yue, GuangYi Fan, QiYe Li, Ying Gu, ShanShan Liu, Pei-Yuan Qian, Liang Meng, ChangWei Shao","doi":"10.1016/j.chom.2025.10.020","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.020","url":null,"abstract":"Deep-sea coral ecosystems support biodiversity and nutrient cycling through interactions with symbionts. However, their molecular mechanisms remain unexplored. Here, hologenomic analyses of <em>Bathypathes pseudoalternata</em> are applied to uncover molecular adaptations underpinning host-symbiont interactions. Genomic evidence reveals that <em>B. pseudoalternata</em> exhibits adaptations in nutrient transport, immune response, and lysosomal digestion, reflecting its genomic adjustments for a stable symbiosis. <em>Candidatus</em> Nitrosopumilus bathypathes (78.43% ± 3.65%) is inferred to oxidize host-derived ammonia to synthesize amino acids and vitamins to provision the host. The presence of CRISPR-Cas and restriction-modification (R-M) systems suggests that <em>Ca.</em> Bathyplasma bathypathes and <em>Ca.</em> Thalassoplasma bathypathes (10.68% ± 2.99%) may protect the host from viral infections. <em>Ca.</em> Bathybacter bathypathes (8.39% ± 1.53%) is hypothesized to synthesize heme, lipoic acid, and glutathione, which serve dual functions as antioxidants and nutrients. These findings collectively provide insights into how the hologenome contributes to the survival of <em>B. pseudoalternata</em> in the extreme environment.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"238 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145554798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phyllosphere microbiota play crucial roles in supporting host performance. However, the dynamic changes of phyllosphere-associated microbiome during pathogen infections and their impacts on plant health remain unknown. Here, we found phyllosphere microbes can mitigate wheat Fusarium head blight (FHB), a severe disease caused by Fusarium graminearum (F. graminearum) pathogen that promotes infection by inducing host alkalinization. Using wheat head microbial community profiling and metatranscriptomics, we found Pseudomonas spp. significantly enriched on infected wheat heads. Through isolating 595 bacterial strains from infected wheat heads—including 196 Pseudomonas isolates—we identified certain enriched Pseudomonas isolates capable of producing organic acids that counteract pathogen-induced pH upshift. In vitro experiments confirm the selective promotion of specific host-acidifying Pseudomonas in wheat heads. Field trials confirmed that host-acidifying Pseudomonas strains effectively controlled FHB. These findings highlight the pivotal role of plant-beneficial microbes in host pH regulation and offer innovative avenues for sustainable plant disease control.
层球微生物群在支持宿主性能方面起着至关重要的作用。然而，在病原菌侵染过程中，叶层相关微生物群的动态变化及其对植物健康的影响尚不清楚。本研究发现，层球微生物可以减轻小麦赤霉病（Fusarium head blight， FHB），这是一种由小麦赤霉病（Fusarium graminearum， F. graminearum）病原菌引起的严重疾病，通过诱导宿主碱化来促进感染。利用小麦穗微生物群落分析和超转录组学分析，我们发现假单胞菌在感染的小麦穗上显著富集。通过从受感染的麦穗中分离出595株细菌——包括196株假单胞菌——我们鉴定出某些富集的假单胞菌能够产生有机酸，从而抵消病原体引起的pH值上升。体外实验证实了特定宿主酸化假单胞菌在小麦穗中的选择性促进作用。田间试验证实，酸化宿主假单胞菌菌株能有效控制FHB。这些发现突出了植物有益微生物在宿主pH调节中的关键作用，为植物病害的可持续控制提供了创新的途径。
{"title":"Keystone Pseudomonas species in the wheat phyllosphere microbiome mitigate Fusarium head blight by altering host pH","authors":"Yujiao Xu, Zhiyuan Wang, Jinmei Wu, Yang Yue, Yajun Ren, Yingying Pan, Jiajia Li, Chen Liu, Rainer Borriss, Xin Liu, Junqing Qiao, Yin-Won Lee, Huijun Wu, Francisco Dini-Andreote, Qirong Shen, Wu Xiong, Xuewen Gao, Roeland L. Berendsen, Qin Gu","doi":"10.1016/j.chom.2025.10.016","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.016","url":null,"abstract":"Phyllosphere microbiota play crucial roles in supporting host performance. However, the dynamic changes of phyllosphere-associated microbiome during pathogen infections and their impacts on plant health remain unknown. Here, we found phyllosphere microbes can mitigate wheat Fusarium head blight (FHB), a severe disease caused by <em>Fusarium graminearum</em> (<em>F. graminearum</em>) pathogen that promotes infection by inducing host alkalinization. Using wheat head microbial community profiling and metatranscriptomics, we found <em>Pseudomonas</em> spp. significantly enriched on infected wheat heads. Through isolating 595 bacterial strains from infected wheat heads—including 196 <em>Pseudomonas</em> isolates—we identified certain enriched <em>Pseudomonas</em> isolates capable of producing organic acids that counteract pathogen-induced pH upshift. <em>In vitro</em> experiments confirm the selective promotion of specific host-acidifying <em>Pseudomonas</em> in wheat heads. Field trials confirmed that host-acidifying <em>Pseudomonas</em> strains effectively controlled FHB. These findings highlight the pivotal role of plant-beneficial microbes in host pH regulation and offer innovative avenues for sustainable plant disease control.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"72 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145545797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.012
Shaun K. Morris, Karina A. Top
Children and adults experienced the COVID-19 pandemic differently. While the impact on children was significant, it was different from what had originally been expected. Here, we outline key developments and learnings from the COVID-19 pandemic’s effects on children and draw lessons for pandemic preparedness.
{"title":"The impact of COVID-19 on children and lessons for pandemic preparedness","authors":"Shaun K. Morris, Karina A. Top","doi":"10.1016/j.chom.2025.10.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.012","url":null,"abstract":"Children and adults experienced the COVID-19 pandemic differently. While the impact on children was significant, it was different from what had originally been expected. Here, we outline key developments and learnings from the COVID-19 pandemic’s effects on children and draw lessons for pandemic preparedness.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"11 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.013
Bette Korber, Will Fischer, James Theiler
The global response to COVID-19 during the pandemic resulted in an unprecedented view of viral evolution. Here, we discuss both the capacity of the scientific community to monitor viral evolution on a global scale in real time and the mutational mechanisms and selective forces that shaped the evolution of SARS-CoV-2.
{"title":"Real-time monitoring of SARS-CoV-2 evolution during the COVID-19 pandemic","authors":"Bette Korber, Will Fischer, James Theiler","doi":"10.1016/j.chom.2025.10.013","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.013","url":null,"abstract":"The global response to COVID-19 during the pandemic resulted in an unprecedented view of viral evolution. Here, we discuss both the capacity of the scientific community to monitor viral evolution on a global scale in real time and the mutational mechanisms and selective forces that shaped the evolution of SARS-CoV-2.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"51 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.006
Lei Song, Zhao-Qing Luo
Bacterial pathogens interfere with host cell signaling by inducing post-translational modifications. In this issue, Xu and colleagues report that the Shigella flexneri effector OspB catalyzes an unusual recombination reaction between pro-death members of the BCL-2 family, creating inactive chimeras that effectively block apoptosis of infected cells, thereby promoting bacterial virulence.
{"title":"Bacteria block host cell death by protein cut-and-paste","authors":"Lei Song, Zhao-Qing Luo","doi":"10.1016/j.chom.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.006","url":null,"abstract":"Bacterial pathogens interfere with host cell signaling by inducing post-translational modifications. In this issue, Xu and colleagues report that the <em>Shigella flexneri</em> effector OspB catalyzes an unusual recombination reaction between pro-death members of the BCL-2 family, creating inactive chimeras that effectively block apoptosis of infected cells, thereby promoting bacterial virulence.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"28 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.004
Lingfang Zhu, Xihui Shen
How do gut bacteria outcompete rivals in dense microbial ecosystems? In this issue of Cell Host & Microbe, Li et al.1 report a Bacteroides T6SS adaptor protein C-orchestrated co-secretion mechanism of T6SS effectors Bacteroides T6SS phosphatase effector A and Bacteroides T6SS amidase effector B in gut Bacteroidota, thereby revealing a conserved strategy for interbacterial competition and gut microbiota modulation.
{"title":"A duet of T6SS effectors","authors":"Lingfang Zhu, Xihui Shen","doi":"10.1016/j.chom.2025.10.004","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.004","url":null,"abstract":"How do gut bacteria outcompete rivals in dense microbial ecosystems? In this issue of <em>Cell Host & Microbe</em>, Li et al.<span><span><sup>1</sup></span></span> report a <em>Bacteroides</em> T6SS adaptor protein C-orchestrated co-secretion mechanism of T6SS effectors <em>Bacteroides</em> T6SS phosphatase effector A and <em>Bacteroides</em> T6SS amidase effector B in gut Bacteroidota, thereby revealing a conserved strategy for interbacterial competition and gut microbiota modulation.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"27 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.009
Colin D. Sempeck, Matthew R. Olm
Many microbiome analysis techniques can only detect the microbes present in the reference genome database used. In this issue of Cell Host & Microbe, Cha et al. establish an improved genome database of the human oral microbiome, which they use to discover a connection between periodontitis and an enigmatic bacterial phylum.
{"title":"Mapping the oral microbiome opens links to periodontitis","authors":"Colin D. Sempeck, Matthew R. Olm","doi":"10.1016/j.chom.2025.10.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.009","url":null,"abstract":"Many microbiome analysis techniques can only detect the microbes present in the reference genome database used. In this issue of <em>Cell Host & Microbe</em>, Cha et al. establish an improved genome database of the human oral microbiome, which they use to discover a connection between periodontitis and an enigmatic bacterial phylum.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"23 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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