Pub Date : 2025-12-10DOI: 10.1016/j.chom.2025.11.006
Daniela Ramírez-Sánchez, Detlef Weigel
In this issue of Cell Host & Microbe, Xu and colleagues investigate host pH modulation as a microbiome-mediated defense mechanism. Pseudomonas strains can protect wheat against the pathogenic fungus Fusarium graminearum by counteracting alkalinization of the host environment by the fungus, although other Pseudomonas strains support the fungus by further alkalinization.
{"title":"Pseudomonas can make or break a happy phyllosphere microbiota","authors":"Daniela Ramírez-Sánchez, Detlef Weigel","doi":"10.1016/j.chom.2025.11.006","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.006","url":null,"abstract":"In this issue of Cell Host & Microbe, Xu and colleagues investigate host pH modulation as a microbiome-mediated defense mechanism. Pseudomonas strains can protect wheat against the pathogenic fungus Fusarium graminearum by counteracting alkalinization of the host environment by the fungus, although other Pseudomonas strains support the fungus by further alkalinization.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"11 1","pages":"2004-2007"},"PeriodicalIF":30.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.chom.2025.11.003
Maren Ziegler, Claudia Pogoreutz
Microbial symbioses enable animals to colonize the most extreme habitats on Earth. The study by Wei et al.1 in this issue of Cell Host & Microbe elucidates how intricate molecular adaptations of a coral host and its newly discovered microbial symbionts underpin their entwined lives in the deep sea.
{"title":"Microbes help corals conquer the deep sea","authors":"Maren Ziegler, Claudia Pogoreutz","doi":"10.1016/j.chom.2025.11.003","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.003","url":null,"abstract":"Microbial symbioses enable animals to colonize the most extreme habitats on Earth. The study by Wei et al.<span><span><sup>1</sup></span></span> in this issue of <em>Cell Host & Microbe</em> elucidates how intricate molecular adaptations of a coral host and its newly discovered microbial symbionts underpin their entwined lives in the deep sea.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"148 1","pages":"2001-2002"},"PeriodicalIF":30.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.chom.2025.10.017
Richard A. Insel, John B. Jarman, Pedro J. Torres, Stephen Van Dien, Stephanie J. Culler, Willem M. de Vos
An early-life microbiota with increased Bifidobacterium and human milk oligosaccharide (HMO) utilization genes has been linked to decreased risk of childhood allergic disease. As infant microbiomes increasingly have reduced Bifidobacterium, we examine early-life dysbiosis and interventions that potentially prevent or reverse this dysbiotic state, thus mitigating noncommunicable diseases.
{"title":"Restoring a gut Bifidobacterium community in early infancy","authors":"Richard A. Insel, John B. Jarman, Pedro J. Torres, Stephen Van Dien, Stephanie J. Culler, Willem M. de Vos","doi":"10.1016/j.chom.2025.10.017","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.017","url":null,"abstract":"An early-life microbiota with increased <em>Bifidobacterium</em> and human milk oligosaccharide (HMO) utilization genes has been linked to decreased risk of childhood allergic disease. As infant microbiomes increasingly have reduced <em>Bifidobacterium</em>, we examine early-life dysbiosis and interventions that potentially prevent or reverse this dysbiotic state, thus mitigating noncommunicable diseases.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"37 1","pages":"2012-2016"},"PeriodicalIF":30.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.chom.2025.11.012
Chrishan M. Fernando, Nicole D. Marino
Across all domains of life, immune systems rely on nucleotide-based signaling molecules to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg, and colleagues identify and characterize diverse families of viral two-histidine phosphodiesterase enzymes that degrade these immune signals, each with distinct substrate specificities.
{"title":"Viral enzymes degrade to evade","authors":"Chrishan M. Fernando, Nicole D. Marino","doi":"10.1016/j.chom.2025.11.012","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.012","url":null,"abstract":"Across all domains of life, immune systems rely on nucleotide-based signaling molecules to activate defense responses. In a recent <em>Cell Host & Microbe</em> study, Doherty, Nomburg, and colleagues identify and characterize diverse families of viral two-histidine phosphodiesterase enzymes that degrade these immune signals, each with distinct substrate specificities.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"16 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.chom.2025.11.005
Frances Pitsillides, Hassan Salem
In a recent publication in Science, Nishino et al.1 reveal the evolutionary co-option of an auditory structure into a newly identified type of symbiotic organ. This organ, found on the hindlegs of female stinkbugs, houses fungi that act as defensive symbionts by protecting eggs from parasitism by wasps.
{"title":"An earful of fungi: Hearing organ repurposed for symbiosis","authors":"Frances Pitsillides, Hassan Salem","doi":"10.1016/j.chom.2025.11.005","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.005","url":null,"abstract":"In a recent publication in <em>Science</em>, Nishino et al.<span><span><sup>1</sup></span></span> reveal the evolutionary co-option of an auditory structure into a newly identified type of symbiotic organ. This organ, found on the hindlegs of female stinkbugs, houses fungi that act as defensive symbionts by protecting eggs from parasitism by wasps.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"34 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chom.2025.11.009
Anna P. Zagieboylo, Ran Mo, Bentley Lim, Andrew L. Goodman
The gut microbiome, comprising hundreds of individual species, is a complex and dynamic host-associated microbial community. However, how microbes interact within populations of the same species is largely unexplored. Using single-cell approaches, we discover that the human gut microbe Bacteroides thetaiotaomicron forms distinct sub-populations in the gut environment, which can be distinguished using N-hydroxysuccinimide (NHS) ester probes. This heterogeneity results from a locus encoding two secreted effector proteins and a cognate immunity factor. At the population level, this locus is among the most significantly upregulated across the B. thetaiotaomicron transcriptome in response to gut colonization; at the single-cell level, its variable expression leads to heterogeneity within the population. Sub-populations form in response to these effectors, exhibit distinct gene expression programs, and remain stable over time. Together, these findings demonstrate that prominent gut commensals establish population heterogeneity by producing and responding to secreted effector proteins.
{"title":"A commensal bacterium secretes effector proteins to establish population heterogeneity in the gut","authors":"Anna P. Zagieboylo, Ran Mo, Bentley Lim, Andrew L. Goodman","doi":"10.1016/j.chom.2025.11.009","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.009","url":null,"abstract":"The gut microbiome, comprising hundreds of individual species, is a complex and dynamic host-associated microbial community. However, how microbes interact within populations of the same species is largely unexplored. Using single-cell approaches, we discover that the human gut microbe <em>Bacteroides thetaiotaomicron</em> forms distinct sub-populations in the gut environment, which can be distinguished using <em>N</em>-hydroxysuccinimide (NHS) ester probes. This heterogeneity results from a locus encoding two secreted effector proteins and a cognate immunity factor. At the population level, this locus is among the most significantly upregulated across the <em>B. thetaiotaomicron</em> transcriptome in response to gut colonization; at the single-cell level, its variable expression leads to heterogeneity within the population. Sub-populations form in response to these effectors, exhibit distinct gene expression programs, and remain stable over time. Together, these findings demonstrate that prominent gut commensals establish population heterogeneity by producing and responding to secreted effector proteins.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"25 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145651405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chom.2025.11.008
Estefany Y. Reyes, Jae Yong, Devon T. DiPalma, Jonathan L. Messerschmidt, Miranda Lumbreras, Hana H. Hendi, Danira R. Mukhamedyarova, Emily C. Troutman, Emily J. Wert, Mari L. Shinohara
Cryptococcus, a neurotropic fungus classified as a critical-priority pathogen by the World Health Organization (WHO), causes cryptococcal meningoencephalitis (CM), the second leading cause of death in HIV/AIDS patients. Despite its clinical importance, host brain responses during CM remain poorly understood. In a mouse systemic infection model, Cryptococcus infiltrates the brain within a day. However, full activation of microglia and recruitment of leukocytes takes 14 days, a delay not observed in brain infections caused by Candida albicans. Microglia exhibit limited ability to directly detect Cryptococcus, and their activation depends on interferon (IFN)-γ from Th1 cells. Therefore, adaptive immunity (Th1 responses) precedes innate immune responses (microglial activation) in the brain during CM. Moreover, microglia-derived osteopontin (OPN/Spp1) exacerbates CM by altering peripheral immunity and increasing fungal loads in peripheral organs. These findings reveal a uniquely slow host cellular response to Cryptococcus brain infiltration, allowing the fungus an extended window to establish the infection.
{"title":"Cryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control","authors":"Estefany Y. Reyes, Jae Yong, Devon T. DiPalma, Jonathan L. Messerschmidt, Miranda Lumbreras, Hana H. Hendi, Danira R. Mukhamedyarova, Emily C. Troutman, Emily J. Wert, Mari L. Shinohara","doi":"10.1016/j.chom.2025.11.008","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.008","url":null,"abstract":"<em>Cryptococcus</em>, a neurotropic fungus classified as a critical-priority pathogen by the World Health Organization (WHO), causes cryptococcal meningoencephalitis (CM), the second leading cause of death in HIV/AIDS patients. Despite its clinical importance, host brain responses during CM remain poorly understood. In a mouse systemic infection model, <em>Cryptococcus</em> infiltrates the brain within a day. However, full activation of microglia and recruitment of leukocytes takes 14 days, a delay not observed in brain infections caused by <em>Candida albicans</em>. Microglia exhibit limited ability to directly detect <em>Cryptococcus</em>, and their activation depends on interferon (IFN)-γ from Th1 cells. Therefore, adaptive immunity (Th1 responses) precedes innate immune responses (microglial activation) in the brain during CM. Moreover, microglia-derived osteopontin (OPN/<em>Spp1</em>) exacerbates CM by altering peripheral immunity and increasing fungal loads in peripheral organs. These findings reveal a uniquely slow host cellular response to <em>Cryptococcus</em> brain infiltration, allowing the fungus an extended window to establish the infection.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"1 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145651400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chom.2025.11.004
Rui Liu, Yue Zhang, Siyi Ge, Jennifer Y. Cho, Nathaniel C. Esteves, Jun Zhu, Ansel Hsiao
The amount or type of dietary macronutrients dramatically changes the microbiota and physicochemical environment of the gut. Because the microbiota plays key roles in pathogen susceptibility, macronutrients could impact infection outcomes. We show that dietary protein sources differentially restrict colonization of Vibrio cholerae (V. cholerae) as well as impact pathogen-dependent changes in microbiota composition. Specifically, dietary proteins, notably casein, alter levels of the V. cholerae central flagellar regulator, FlrA, which controls expression of the type VI secretion system (T6SS), a key mediator of intra-bacterial competition. Resultant decreases in T6SS lead to a competitive disadvantage for V. cholerae against human commensal Escherichia coli, as well as changes in the abundance and composition of a model human gut microbiota. Mutations in FlrA restore V. cholerae T6SS expression and abrogate diet-dependent impacts on V. cholerae infection. These findings suggest dietary interventions for restricting V. cholerae and highlight the importance of diet in pathogen-commensal interactions.
{"title":"Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota","authors":"Rui Liu, Yue Zhang, Siyi Ge, Jennifer Y. Cho, Nathaniel C. Esteves, Jun Zhu, Ansel Hsiao","doi":"10.1016/j.chom.2025.11.004","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.004","url":null,"abstract":"The amount or type of dietary macronutrients dramatically changes the microbiota and physicochemical environment of the gut. Because the microbiota plays key roles in pathogen susceptibility, macronutrients could impact infection outcomes. We show that dietary protein sources differentially restrict colonization of <em>Vibrio cholerae</em> (<em>V. cholerae</em>) as well as impact pathogen-dependent changes in microbiota composition. Specifically, dietary proteins, notably casein, alter levels of the <em>V. cholerae</em> central flagellar regulator, FlrA, which controls expression of the type VI secretion system (T6SS), a key mediator of intra-bacterial competition. Resultant decreases in T6SS lead to a competitive disadvantage for <em>V. cholerae</em> against human commensal <em>Escherichia coli</em>, as well as changes in the abundance and composition of a model human gut microbiota. Mutations in FlrA restore <em>V. cholerae</em> T6SS expression and abrogate diet-dependent impacts on <em>V. cholerae</em> infection. These findings suggest dietary interventions for restricting <em>V. cholerae</em> and highlight the importance of diet in pathogen-commensal interactions.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"126 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145651038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chom.2025.11.007
Cody G. Cole, Zhenrun J. Zhang, Shravan R. Dommaraju, Qiwen Dong, Rosemary L. Pope, Sophie S. Son, Emma J. McSpadden, Che K. Woodson, Huaiying Lin, Nicholas P. Dylla, Ashley M. Sidebottom, Anitha Sundararajan, Douglas A. Mitchell, Eric G. Pamer
{"title":"Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance","authors":"Cody G. Cole, Zhenrun J. Zhang, Shravan R. Dommaraju, Qiwen Dong, Rosemary L. Pope, Sophie S. Son, Emma J. McSpadden, Che K. Woodson, Huaiying Lin, Nicholas P. Dylla, Ashley M. Sidebottom, Anitha Sundararajan, Douglas A. Mitchell, Eric G. Pamer","doi":"10.1016/j.chom.2025.11.007","DOIUrl":"https://doi.org/10.1016/j.chom.2025.11.007","url":null,"abstract":"","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"9 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：