Despite proven effectiveness, vaccine uptake in high-risk groups remains low due to access barriers, misinformation, and limited trial data. In this Forum, we discuss how targeted communication, optimized vaccine formulations, inclusive trials, and real-world effectiveness studies can help close protection gaps in vulnerable populations.
{"title":"Optimizing vaccine protection for high-risk populations","authors":"Thiago Cerqueira-Silva, Manoel Barral-Netto, Viviane Sampaio Boaventura","doi":"10.1016/j.chom.2025.10.014","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.014","url":null,"abstract":"Despite proven effectiveness, vaccine uptake in high-risk groups remains low due to access barriers, misinformation, and limited trial data. In this Forum, we discuss how targeted communication, optimized vaccine formulations, inclusive trials, and real-world effectiveness studies can help close protection gaps in vulnerable populations.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"139 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.007
Kei Sato
Pandemic preparedness is critical as we face potential threats of infectious diseases. Systems virology and collaborative/responsive science are key infrastructures that facilitated scientific advances during the SARS-CoV-2 pandemic. As discussed here, G2P-Japan and other consortia are examples of systems virology-based research collaborations that can guide future responses.
{"title":"Systems virology as a cornerstone for pandemic responsiveness: A G2P-Japan perspective","authors":"Kei Sato","doi":"10.1016/j.chom.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.007","url":null,"abstract":"Pandemic preparedness is critical as we face potential threats of infectious diseases. Systems virology and collaborative/responsive science are key infrastructures that facilitated scientific advances during the SARS-CoV-2 pandemic. As discussed here, G2P-Japan and other consortia are examples of systems virology-based research collaborations that can guide future responses.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"1 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.015
Hengcong Liu, Jiang Zhou, Weifeng Shi
Most emerging human infectious diseases are derived from animals, and monitoring such zoonoses is imperative to help prevent future outbreaks. In this Forum, we discuss the knowledge gaps in our current understanding of viral ecology, global disparities in virus discovery, and the applications of artificial intelligence in infectious disease monitoring.
{"title":"Monitoring zoonoses to prevent future outbreaks and pandemics","authors":"Hengcong Liu, Jiang Zhou, Weifeng Shi","doi":"10.1016/j.chom.2025.10.015","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.015","url":null,"abstract":"Most emerging human infectious diseases are derived from animals, and monitoring such zoonoses is imperative to help prevent future outbreaks. In this Forum, we discuss the knowledge gaps in our current understanding of viral ecology, global disparities in virus discovery, and the applications of artificial intelligence in infectious disease monitoring.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"54 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.003
Xinyi Gu, Bing Zhai
Due to the presence of gut microbiota, enteric pathogens such as Salmonella are rarely alone in their battleground with the host. In a recent study published in Nature, Jaswal et al. revealed that Candida albicans, a fungus frequently found in the gut, facilitates the intestinal colonization and infection of Salmonella.
{"title":"Triggering infection: When microbial pathogens are in cahoots","authors":"Xinyi Gu, Bing Zhai","doi":"10.1016/j.chom.2025.10.003","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.003","url":null,"abstract":"Due to the presence of gut microbiota, enteric pathogens such as <em>Salmonella</em> are rarely alone in their battleground with the host. In a recent study published in <em>Nature</em>, Jaswal et al. revealed that <em>Candida albicans</em>, a fungus frequently found in the gut, facilitates the intestinal colonization and infection of <em>Salmonella</em>.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"39 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.10.008
Chin-Hsien Lin, Wei-Li Wu
Motor complications in Parkinson’s disease (PD) are exacerbated by the pulsatile delivery of levodopa (L-DOPA). In this issue of Cell Host & Microbe, Padhi et al. engineer a microbiota-based therapeutic for sustained, non-fluctuating L-DOPA production, demonstrating therapeutic promise through stable dopamine signaling.
{"title":"Brain hacks: Engineering a microbial factory for Parkinson’s disease","authors":"Chin-Hsien Lin, Wei-Li Wu","doi":"10.1016/j.chom.2025.10.008","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.008","url":null,"abstract":"Motor complications in Parkinson’s disease (PD) are exacerbated by the pulsatile delivery of levodopa (L-DOPA). In this issue of <em>Cell Host & Microbe</em>, Padhi et al. engineer a microbiota-based therapeutic for sustained, non-fluctuating L-DOPA production, demonstrating therapeutic promise through stable dopamine signaling.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"368 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.09.013
Penny L. Moore, Shabir A. Madhi, Glenda Gray
The COVID-19 pandemic caused global disruption that reverberated across Africa and revealed deep systemic vulnerabilities. Nonetheless, the scientific response to SARS-CoV-2 catalyzed unprecedented global scientific collaboration, established new collaborative networks, and accelerated local capacity building across Africa. This legacy extends beyond COVID-19, informing responses to subsequent mpox and Ebola outbreaks, and establishes a framework to respond to future infectious disease threats in Africa.
{"title":"The Africa COVID-19 legacy—Improved vaccinology for pandemic preparedness","authors":"Penny L. Moore, Shabir A. Madhi, Glenda Gray","doi":"10.1016/j.chom.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.013","url":null,"abstract":"The COVID-19 pandemic caused global disruption that reverberated across Africa and revealed deep systemic vulnerabilities. Nonetheless, the scientific response to SARS-CoV-2 catalyzed unprecedented global scientific collaboration, established new collaborative networks, and accelerated local capacity building across Africa. This legacy extends beyond COVID-19, informing responses to subsequent mpox and Ebola outbreaks, and establishes a framework to respond to future infectious disease threats in Africa.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"107 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.chom.2025.09.019
Biao Wan, Muammar Mansor
Discovering new microbial metabolism is every microbiologist’s dream. Microorganisms that respire iron coupled to sulfide oxidation were considered a myth, incapable of competing against fast abiotic reactions. Recently, in Nature, Chen et al.1 combined creative cultivation setups with omic analyses to show that this metabolism is not only possible but also pervasive.
{"title":"Microbes that breathe iron and eat sulfur","authors":"Biao Wan, Muammar Mansor","doi":"10.1016/j.chom.2025.09.019","DOIUrl":"https://doi.org/10.1016/j.chom.2025.09.019","url":null,"abstract":"Discovering new microbial metabolism is every microbiologist’s dream. Microorganisms that respire iron coupled to sulfide oxidation were considered a myth, incapable of competing against fast abiotic reactions. Recently, in <em>Nature</em>, Chen et al.<span><span><sup>1</sup></span></span> combined creative cultivation setups with omic analyses to show that this metabolism is not only possible but also pervasive.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"138 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.chom.2025.10.010
Bahtiyar Yilmaz, Isabel Baertschi, Karin H.U. Meier, Constance Le Gac, Sebastian B.U. Jordi, Caitlin Black, Jiaqi Li, Anna K. Lindholm
Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high variability in consortial composition is largely compensated by similar metabolic functions across different taxa. However, the extent of compensation in lower diversity mouse models, and whether vivaria are metabolically equivalent, is unknown. We provide a searchable resource of microbiome composition variability across 51 murine vivaria and 12 wild mouse colonies worldwide, with vivarium-specific variants mapped according to predicted 3D structures for each microbial species. Our matched metabolomics data show that realized metabolic potential has relatively low variability, providing functional evidence for metabolic compensation. Additionally, variability is related to taxonomic composition rather than vivarium, revealing taxa-metabolite associations that are potentially relevant to phenotypic differences between vivaria. Collectively, this resource offers tools to strengthen microbiome studies and collaborative science.
{"title":"A global survey of taxa-metabolic associations across mouse microbiome communities","authors":"Bahtiyar Yilmaz, Isabel Baertschi, Karin H.U. Meier, Constance Le Gac, Sebastian B.U. Jordi, Caitlin Black, Jiaqi Li, Anna K. Lindholm","doi":"10.1016/j.chom.2025.10.010","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.010","url":null,"abstract":"Host-microbiota mutualism is rooted in the exchange of dietary and metabolic molecules. Microbial diversity broadens the metabolite pool, with each taxon contributing distinct compounds in varying proportions. In the human microbiome, high variability in consortial composition is largely compensated by similar metabolic functions across different taxa. However, the extent of compensation in lower diversity mouse models, and whether vivaria are metabolically equivalent, is unknown. We provide a searchable resource of microbiome composition variability across 51 murine vivaria and 12 wild mouse colonies worldwide, with vivarium-specific variants mapped according to predicted 3D structures for each microbial species. Our matched metabolomics data show that realized metabolic potential has relatively low variability, providing functional evidence for metabolic compensation. Additionally, variability is related to taxonomic composition rather than vivarium, revealing taxa-metabolite associations that are potentially relevant to phenotypic differences between vivaria. Collectively, this resource offers tools to strengthen microbiome studies and collaborative science.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"9 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.chom.2025.10.005
Piyush Padhi, Ahmed Abdalla, Benjamin Schneider, Nick Backes, Alyssa A. Otto, Ileia J. Scheibe, Jacob P. Thomas, Gargi Khadse, Manikandan Samidurai, Alexander K. Jochmans, Amanda George, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Aditya Mishra, Karin Allenspach, Jonathan Mochel, Gregory J. Phillips, Anumantha G. Kanthasamy
L-3,4-Dihydroxyphenylalanine (L-DOPA), synthesized from L-tyrosine, is a direct precursor to dopamine. L-DOPA is the gold-standard treatment for Parkinson’s disease (PD), given orally alongside decarboxylase inhibitors (e.g., benserazide) to enhance bioavailability. However, its chronic daily pulsatile-like delivery is associated with complications. Herein, we show the construction and in vivo efficacy of a programmable, titratable, genetically engineered E. coli Nissle 1917 system (EcNL-DOPA) that continuously synthesizes L-DOPA from L-tyrosine for systemic distribution. Oral administration of EcNL-DOPA with benserazide maintains therapeutic plasma L-DOPA concentrations and increases brain dopamine levels. EcNL-DOPA improves motor performance and limits depressive-like behaviors without adverse side effects in healthy mice, Parkinsonian mice, and canine models. Simulated physiological models from pharmacokinetic and pharmacodynamic studies in canines demonstrate the translational feasibility of this biotherapeutic system for potential human studies. This work lays the groundwork for EcNL-DOPA as a continuous, non-invasive microbial drug delivery platform for PD and chronic neurological diseases.
l -3,4-二羟基苯丙氨酸（L-DOPA）是由l -酪氨酸合成的，是多巴胺的直接前体。左旋多巴是帕金森病（PD）的金标准治疗方法，与脱羧酶抑制剂（如苯塞拉肼）一起口服，以提高生物利用度。然而，其慢性每日搏动样分娩与并发症有关。在此，我们展示了一个可编程、可滴定的基因工程大肠杆菌Nissle 1917系统（EcNL-DOPA）的构建和体内功效，该系统连续地从l -酪氨酸合成L-DOPA并进行全身分布。口服EcNL-DOPA与苯塞拉肼维持治疗血浆左旋多巴浓度并增加脑多巴胺水平。在健康小鼠、帕金森小鼠和犬类模型中，EcNL-DOPA可改善运动表现，限制抑郁样行为，且无不良副作用。通过对犬的药代动力学和药效学研究，模拟生理模型证明了这种生物治疗系统在人类研究中的可行性。这项工作为EcNL-DOPA作为PD和慢性神经系统疾病的连续、无创微生物给药平台奠定了基础。
{"title":"Bioengineered gut bacterium synthesizing levodopa alleviates motor deficits in models of Parkinson’s disease","authors":"Piyush Padhi, Ahmed Abdalla, Benjamin Schneider, Nick Backes, Alyssa A. Otto, Ileia J. Scheibe, Jacob P. Thomas, Gargi Khadse, Manikandan Samidurai, Alexander K. Jochmans, Amanda George, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Aditya Mishra, Karin Allenspach, Jonathan Mochel, Gregory J. Phillips, Anumantha G. Kanthasamy","doi":"10.1016/j.chom.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.chom.2025.10.005","url":null,"abstract":"L-3,4-Dihydroxyphenylalanine (L-DOPA), synthesized from L-tyrosine, is a direct precursor to dopamine. L-DOPA is the gold-standard treatment for Parkinson’s disease (PD), given orally alongside decarboxylase inhibitors (e.g., benserazide) to enhance bioavailability. However, its chronic daily pulsatile-like delivery is associated with complications. Herein, we show the construction and <em>in vivo</em> efficacy of a programmable, titratable, genetically engineered <em>E. coli</em> Nissle 1917 system (EcN<sub>L-DOPA</sub>) that continuously synthesizes L-DOPA from L-tyrosine for systemic distribution. Oral administration of EcN<sub>L-DOPA</sub> with benserazide maintains therapeutic plasma L-DOPA concentrations and increases brain dopamine levels. EcN<sub>L-DOPA</sub> improves motor performance and limits depressive-like behaviors without adverse side effects in healthy mice, Parkinsonian mice, and canine models. Simulated physiological models from pharmacokinetic and pharmacodynamic studies in canines demonstrate the translational feasibility of this biotherapeutic system for potential human studies. This work lays the groundwork for EcN<sub>L-DOPA</sub> as a continuous, non-invasive microbial drug delivery platform for PD and chronic neurological diseases.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"354 1","pages":""},"PeriodicalIF":30.3,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145397593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：