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Enhanced predictive value of post-treatment lymphocyte-based immunoinflammatory biomarkers for cancer therapy-related cardiac dysfunction in anthracycline-treated breast cancer patients. 蒽环类药物治疗的乳腺癌患者治疗后淋巴细胞免疫炎症生物标志物对癌症治疗相关心功能障碍的预测价值增强
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-21 DOI: 10.1186/s40959-026-00458-2
Shilan Zhang, Heying Yin, SenSen Zhang, Jiachun Xia, Yanan Pang, Lei Hou
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引用次数: 0
Electrocardiographic predictors of major adverse cardiovascular events in immune checkpoint inhibitor-associated myocarditis. 免疫检查点抑制剂相关心肌炎主要不良心血管事件的心电图预测因子。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-20 DOI: 10.1186/s40959-026-00455-5
Kanghao Zhou, Guangcheng Liu, Bin Zhang, Xiong Zhang, Wei Wu
{"title":"Electrocardiographic predictors of major adverse cardiovascular events in immune checkpoint inhibitor-associated myocarditis.","authors":"Kanghao Zhou, Guangcheng Liu, Bin Zhang, Xiong Zhang, Wei Wu","doi":"10.1186/s40959-026-00455-5","DOIUrl":"https://doi.org/10.1186/s40959-026-00455-5","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival in patients with monoclonal gammopathy of unknown significance after transcatheter aortic valve replacement: a global retrospective propensity-matched real-world analysis. 经导管主动脉瓣置换术后意义不明的单克隆γ病患者的生存率：一项全球回顾性倾向匹配的现实世界分析。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-20 DOI: 10.1186/s40959-026-00456-4
Lorenz Oelschläger, Dominik Rebafka, Christian Frerker, Thomas Stiermaier, Jan Morf, Jan Vorwerk, Anna Traub, Theo Leitner, Nikolas von Bubnoff, Cyrus Khandanpour, Ingo Eitel
{"title":"Survival in patients with monoclonal gammopathy of unknown significance after transcatheter aortic valve replacement: a global retrospective propensity-matched real-world analysis.","authors":"Lorenz Oelschläger, Dominik Rebafka, Christian Frerker, Thomas Stiermaier, Jan Morf, Jan Vorwerk, Anna Traub, Theo Leitner, Nikolas von Bubnoff, Cyrus Khandanpour, Ingo Eitel","doi":"10.1186/s40959-026-00456-4","DOIUrl":"10.1186/s40959-026-00456-4","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardioprotective strategies of ACEi/ARBs and beta-blockers against anthracycline-induced cardiotoxicity in pediatric cancer survivors: a systematic review. ACEi/ARBs和β受体阻滞剂对儿童癌症幸存者蒽环类药物引起的心脏毒性的心脏保护策略：一项系统综述
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-18 DOI: 10.1186/s40959-026-00447-5
Reza Sattarpour, Maryam Noori
{"title":"Cardioprotective strategies of ACEi/ARBs and beta-blockers against anthracycline-induced cardiotoxicity in pediatric cancer survivors: a systematic review.","authors":"Reza Sattarpour, Maryam Noori","doi":"10.1186/s40959-026-00447-5","DOIUrl":"https://doi.org/10.1186/s40959-026-00447-5","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of cardiotoxicity assessed with CZT-ERNA in patients undergoing contemporary cancer therapy: a 12-year real-world experience. 在接受当代癌症治疗的患者中，用CZT-ERNA评估心脏毒性的发生率：一项12年的真实世界经验。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-17 DOI: 10.1186/s40959-026-00457-3
Johan Erik Larsson, Marc Østergaard Nielsen, Bo Zerahn
{"title":"Incidence of cardiotoxicity assessed with CZT-ERNA in patients undergoing contemporary cancer therapy: a 12-year real-world experience.","authors":"Johan Erik Larsson, Marc Østergaard Nielsen, Bo Zerahn","doi":"10.1186/s40959-026-00457-3","DOIUrl":"https://doi.org/10.1186/s40959-026-00457-3","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of patients with systemic light chain amyloidosis treated with DVD front-line therapy. 全身性轻链淀粉样变性患者接受DVD一线治疗的结果。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-14 DOI: 10.1186/s40959-026-00446-6
Jinghua Wang, Mengyuan Li, Pengjun Liao, Jiaqi Tan, Lingji Zeng, Shengcai Liu, Ping Wu, Piaorong Zeng, Jianyu Weng, Xin Du, Liye Zhong, Peilong Lai
{"title":"Outcomes of patients with systemic light chain amyloidosis treated with DVD front-line therapy.","authors":"Jinghua Wang, Mengyuan Li, Pengjun Liao, Jiaqi Tan, Lingji Zeng, Shengcai Liu, Ping Wu, Piaorong Zeng, Jianyu Weng, Xin Du, Liye Zhong, Peilong Lai","doi":"10.1186/s40959-026-00446-6","DOIUrl":"10.1186/s40959-026-00446-6","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"34"},"PeriodicalIF":3.2,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue. 奥沙利铂引起的小鼠心脏毒性与心脏组织能量代谢的变化有关。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-13 DOI: 10.1186/s40959-026-00453-7
Junwei Du, Leland C Sudlow, Kiana Shahverdi, Haiying Zhou, Megan S Michie, Thomas H Schindler, Joshua D Mitchell, Shamim Mollah, Mikhail Y Berezin

Oxaliplatin is a platinum-based alkylating chemotherapeutic agent used for cancer treatment. At high cumulative dosage, the negative effect of oxaliplatin on the heart becomes evident and is linked to a growing number of clinical reports. The aim of this study was to determine how chronic oxaliplatin treatment causes the changes in energy-related metabolic activity in the heart that leads to cardiotoxicity and heart damage in mice. C57BL/6 male mice were treated with a human equivalent dosage of intraperitoneal oxaliplatin (0 and 10 mg/kg) once a week for eight weeks. During the treatment, mice were followed with ECG, histology and RNA sequencing of the heart. We identified that oxaliplatin induces strong changes in the heart and affects the heart's energy-related metabolic profile. Histological post-mortem evaluation identified focal myocardial necrosis infiltrated with a small number of associated neutrophils. Accumulated doses of oxaliplatin led to significant changes in gene expression related to energy related metabolic pathways including fatty acid (FA) oxidation and glycolysis leading to the glycolysis switch. Our study can be used for the development of diagnostic methods to detect oxaliplatin-induced cardiotoxicity at an early stage and identifying therapeutic methods to minimize heart failure.

奥沙利铂是一种以铂为基础的烷基化化疗药物，用于癌症治疗。在高累积剂量下，奥沙利铂对心脏的负面影响变得明显，并且与越来越多的临床报告有关。本研究的目的是确定慢性奥沙利铂治疗如何引起小鼠心脏能量相关代谢活动的变化，从而导致心脏毒性和心脏损伤。C57BL/6雄性小鼠按人等量腹腔注射奥沙利铂（0和10 mg/kg），每周1次，连续8周。在治疗期间，对小鼠进行心电图、心脏组织学和RNA测序。我们发现奥沙利铂诱导心脏发生强烈的变化，并影响心脏的能量相关代谢谱。死后组织学检查发现局灶性心肌坏死伴少量相关中性粒细胞浸润。累积剂量的奥沙利铂导致与能量相关的代谢途径相关的基因表达发生显著变化，包括脂肪酸（FA）氧化和糖酵解，导致糖酵解开关。我们的研究可用于开发诊断方法，在早期阶段检测奥沙利铂引起的心脏毒性，并确定治疗方法，以尽量减少心力衰竭。
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引用次数: 0
Associations of cardiovascular-kidney-metabolic syndrome stages with long-term mortality among US cancer survivors: a prospective cohort study. 美国癌症幸存者心血管-肾脏代谢综合征分期与长期死亡率的关系：一项前瞻性队列研究
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-11 DOI: 10.1186/s40959-026-00450-w
Yangyang Zheng, Ting Li, Jinghai Song
{"title":"Associations of cardiovascular-kidney-metabolic syndrome stages with long-term mortality among US cancer survivors: a prospective cohort study.","authors":"Yangyang Zheng, Ting Li, Jinghai Song","doi":"10.1186/s40959-026-00450-w","DOIUrl":"10.1186/s40959-026-00450-w","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"33"},"PeriodicalIF":3.2,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular signaling proteins as predictors of the cardiac effects of doxorubicin treatment in children with acute lymphoblastic leukemia. 心血管信号蛋白作为急性淋巴细胞白血病儿童阿霉素治疗对心脏影响的预测因子。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-10 DOI: 10.1186/s40959-026-00454-6
Steven E Lipshultz, Holly M Smith, Stephen E Sallan, Douglas B Sawyer

Background: Cardiac signaling proteins sensitive to changes in cardiac status may help predict the cardiac effects of doxorubicin in children with acute lymphoblastic leukemia (ALL). We determined the relationship between these proteins and biomarkers of cardiac injury and echocardiographic characteristics.

Methods: Cardiotrophin-1 (CT-1), interleukin-6 (IL-6), neuregulin-1 (NRG-1), and vascular endothelial growth factor (VEGF) concentrations were measured in 83 children on Dana-Farber Cancer Institute ALL Protocol 95 - 01 before, during (T1: 0-50 days, T2: 51-100 days, T3: 151-300 days), and after treatment and compared to existing data for cardiac troponin-T (cTnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), and echocardiograms.

Results: Compared to baseline, mean IL-6 concentrations were lower during doxorubicin treatment (P < 0.01 for all) and after (P = 0.03). Mean NRG-1 and CT-1 concentrations were significantly lower beginning at T2 and thereafter (P < 0.001 for all). Mean VEGF concentrations were significantly elevated from baseline at all on-treatment time points (P ≤ 0.02 for all). Lower odds of abnormal cTnT were marginally associated with increased NRG-1. Higher odds of abnormal NT-proBNP were associated with CT-1 concentrations (P = 0.03) and marginally associated with increased IL-6 and NRG-1 concentrations. Increased hsCRP concentrations were associated with increased IL-6, NRG-1, and CT-1 (P < 0.001 for all). No echocardiographic measurements were associated with signaling proteins.

Conclusions: Decreased concentrations CT-1 and NRG-1 during doxorubicin treatment may increase cardiomyocyte death. Changes in IL-6 and VEGF suggest doxorubicin-related inflammation and angiogenesis. These markers may help identify children at greatest risk of long-term adverse outcomes.

背景：对心脏状态变化敏感的心脏信号蛋白可能有助于预测阿霉素对急性淋巴细胞白血病（ALL）儿童的心脏影响。我们确定了这些蛋白与心脏损伤生物标志物和超声心动图特征之间的关系。方法：对83例接受丹娜法伯癌症研究所ALL方案95 - 01治疗前、治疗期间（T1: 0-50天，T2: 51-100天，T3: 151-300天）和治疗后的儿童进行心肌营养因子-1 （CT-1）、白细胞介素-6 （IL-6）、神经调节因子-1 （NRG-1）和血管内皮生长因子（VEGF）浓度测定，并与现有的心肌肌钙蛋白-t （cTnT）、n端前脑利钠肽（NT-proBNP）、高敏c反应蛋白（hsCRP）和超声心动图数据进行比较。结果：与基线相比，阿霉素治疗期间平均IL-6浓度降低(P结论：阿霉素治疗期间降低的CT-1和NRG-1浓度可能增加心肌细胞死亡。IL-6和VEGF的变化提示阿霉素相关炎症和血管生成。这些标记可能有助于识别长期不良后果风险最大的儿童。
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引用次数: 0
The impact of cardiac amyloidosis on patients with multiple myeloma: a systematic review and meta-analysis. 心脏淀粉样变对多发性骨髓瘤患者的影响：一项系统综述和荟萃分析。
IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardio-oncology
Pub Date : 2026-02-10 DOI: 10.1186/s40959-025-00435-1
Giuseppina Novo, Francesco Stabile, Daniela Di Lisi, Cristina Madaudo, Sebastian Jaramillo, Francesco Damiani, Christian Orilia, Massimiliano Camilli, Sergio Buccheri, Peter van Der Meer, Alfredo Ruggero Galassi, Alexander R Lyon
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引用次数: 0
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