Pub Date : 2026-01-15DOI: 10.1186/s40959-025-00424-4
Abdelrahman El-Helbawy, Sara T Zaki, Fouad Hanna, Mohamed Bassiouni, Khaled O Yaseen, Amany H Ali, Oliver M Farid
{"title":"Cardioprotective effect of diabetic medication on cancer patients undergoing proven cardiotoxic chemotherapy: a systematic review and meta-analysis.","authors":"Abdelrahman El-Helbawy, Sara T Zaki, Fouad Hanna, Mohamed Bassiouni, Khaled O Yaseen, Amany H Ali, Oliver M Farid","doi":"10.1186/s40959-025-00424-4","DOIUrl":"10.1186/s40959-025-00424-4","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"14"},"PeriodicalIF":3.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1186/s40959-025-00442-2
Alexander Jp Fulton, Mun Cheang, Maria Ta Wetscherek, Paul Cacciottolo, Jean E Abraham
{"title":"Abemaciclib-induced myocarditis in early breast cancer: a case report.","authors":"Alexander Jp Fulton, Mun Cheang, Maria Ta Wetscherek, Paul Cacciottolo, Jean E Abraham","doi":"10.1186/s40959-025-00442-2","DOIUrl":"https://doi.org/10.1186/s40959-025-00442-2","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1186/s40959-025-00438-y
Linquan Mu, Yi Zhou, Songpu Li, Feng Liu
{"title":"Multiple trait association analysis revealed common genetic loci between lung cancer and heart failure.","authors":"Linquan Mu, Yi Zhou, Songpu Li, Feng Liu","doi":"10.1186/s40959-025-00438-y","DOIUrl":"10.1186/s40959-025-00438-y","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"25"},"PeriodicalIF":3.2,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Among Asian, Native Hawaiian, and Pacific Islanders (ANHPI) in the United States, cancer and cardiovascular disease are the leading causes of death. Colorectal cancer (CRC) is the third most common cancer among ANHPIs, with improving survival rates. However, the risk of cardiovascular disease (CVD) events among ANHPI CRC survivors is unknown, especially within disaggregated ANHPI race and ethnicity groups.
Methods: We estimated the risk of CVD events among ANHPI CRC survivors within the SEER-Medicare database. Composite CVD, heart failure, ischemic heart disease, and stroke/transient ischemic attack were identified using International Classification of Diseases (ICD) diagnostic codes. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for CVD events among ANHPI regional subgroups.
Results: Compared to non-Hispanic White (NHW) CRC survivors, the risk of composite CVD was lower among East and Southeast Asian CRC survivors at > 1 years after initial cancer diagnosis. The risk of composite CVD, heart failure, and ischemic heart disease were lower among East and Southeast Asians for follow-up > 5 years. When compared to East Asians, NHW and Southeast Asian CRC survivors had a higher risk of composite CVD, heart failure, and ischemic heart disease where South Asians had a higher risk of ischemic heart disease.
Conclusions: Within the disaggregated ANHPI race and ethnicity groups of CRC survivors, our results support heterogeneity of incident CVD events. Further research is needed to develop public health interventions to address the disparities in CVD risk, especially among the high-risk groups of South Asian and Southeast Asian CRC survivors.
{"title":"Risk of incident cardiovascular disease events among older Asian, Native Hawaiian, and Pacific Islander colorectal cancer survivors in the United States: a cohort study.","authors":"Timothy Nguyen, Chun-Pin Esther Chang, Randa Tao, Kuangyu Liu, Zuo-Feng Zhang, Mia Hashibe","doi":"10.1186/s40959-025-00440-4","DOIUrl":"10.1186/s40959-025-00440-4","url":null,"abstract":"<p><strong>Background: </strong>Among Asian, Native Hawaiian, and Pacific Islanders (ANHPI) in the United States, cancer and cardiovascular disease are the leading causes of death. Colorectal cancer (CRC) is the third most common cancer among ANHPIs, with improving survival rates. However, the risk of cardiovascular disease (CVD) events among ANHPI CRC survivors is unknown, especially within disaggregated ANHPI race and ethnicity groups.</p><p><strong>Methods: </strong>We estimated the risk of CVD events among ANHPI CRC survivors within the SEER-Medicare database. Composite CVD, heart failure, ischemic heart disease, and stroke/transient ischemic attack were identified using International Classification of Diseases (ICD) diagnostic codes. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for CVD events among ANHPI regional subgroups.</p><p><strong>Results: </strong>Compared to non-Hispanic White (NHW) CRC survivors, the risk of composite CVD was lower among East and Southeast Asian CRC survivors at > 1 years after initial cancer diagnosis. The risk of composite CVD, heart failure, and ischemic heart disease were lower among East and Southeast Asians for follow-up > 5 years. When compared to East Asians, NHW and Southeast Asian CRC survivors had a higher risk of composite CVD, heart failure, and ischemic heart disease where South Asians had a higher risk of ischemic heart disease.</p><p><strong>Conclusions: </strong>Within the disaggregated ANHPI race and ethnicity groups of CRC survivors, our results support heterogeneity of incident CVD events. Further research is needed to develop public health interventions to address the disparities in CVD risk, especially among the high-risk groups of South Asian and Southeast Asian CRC survivors.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"23"},"PeriodicalIF":3.2,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1186/s40959-025-00425-3
Johnny Huang, Rex Lam, Alice Pozza, Hadeel Hassan, Jane E Schneiderman, Paul C Nathan, Luc Mertens, Barbara Cifra
Anthracycline chemotherapy is commonly used to treat cancer in both adult and pediatric patients. While effective, anthracycline treatment is associated with a high risk of cardiotoxicity, often manifesting as a decline in left ventricular function, resulting in long term cardiovascular complications. Aerobic exercise has been studied extensively for its cardioprotective benefits in patients with anthracycline-induced cardiac dysfunction; however, the role of resistance training remains unexplored and controversial due to historical concerns regarding safety. This systematic review examined the existing literature on the effects and safety of resistance training in pediatric and adult cancer patients treated with anthracyclines. A two-part screening process was completed in Covidence (2025), starting with the screening of titles and abstracts, followed by the full-text screening. Eight studies, all incorporating AR-T were reviewed. The findings suggest that AR-T is safe and well-tolerated, with no evidence indicating that resistance training exacerbates cardiac dysfunction. No studies included exclusively pediatric or adolescent patients, limiting the generalizability of the findings to these populations. Randomized controlled trials focused solely on resistance training are needed to inform future clinical guidelines.
{"title":"Evaluating the safety and cardiac impact of resistance training in anthracycline-treated patients: a systematic review.","authors":"Johnny Huang, Rex Lam, Alice Pozza, Hadeel Hassan, Jane E Schneiderman, Paul C Nathan, Luc Mertens, Barbara Cifra","doi":"10.1186/s40959-025-00425-3","DOIUrl":"10.1186/s40959-025-00425-3","url":null,"abstract":"<p><p>Anthracycline chemotherapy is commonly used to treat cancer in both adult and pediatric patients. While effective, anthracycline treatment is associated with a high risk of cardiotoxicity, often manifesting as a decline in left ventricular function, resulting in long term cardiovascular complications. Aerobic exercise has been studied extensively for its cardioprotective benefits in patients with anthracycline-induced cardiac dysfunction; however, the role of resistance training remains unexplored and controversial due to historical concerns regarding safety. This systematic review examined the existing literature on the effects and safety of resistance training in pediatric and adult cancer patients treated with anthracyclines. A two-part screening process was completed in Covidence (2025), starting with the screening of titles and abstracts, followed by the full-text screening. Eight studies, all incorporating AR-T were reviewed. The findings suggest that AR-T is safe and well-tolerated, with no evidence indicating that resistance training exacerbates cardiac dysfunction. No studies included exclusively pediatric or adolescent patients, limiting the generalizability of the findings to these populations. Randomized controlled trials focused solely on resistance training are needed to inform future clinical guidelines.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"24"},"PeriodicalIF":3.2,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1186/s40959-025-00432-4
Jannek Brauer, Sebastian W Romann, Christian Stengele, Lukas F Entenmann, Daniel Finke, Hugo A Katus, Evangelos Giannitsis, Norbert Frey, Lorenz H Lehmann
{"title":"Prevalence of obstructive coronary artery disease in asymptomatic cancer patients with elevated troponin levels.","authors":"Jannek Brauer, Sebastian W Romann, Christian Stengele, Lukas F Entenmann, Daniel Finke, Hugo A Katus, Evangelos Giannitsis, Norbert Frey, Lorenz H Lehmann","doi":"10.1186/s40959-025-00432-4","DOIUrl":"10.1186/s40959-025-00432-4","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"15"},"PeriodicalIF":3.2,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1186/s40959-026-00444-8
Ahmed Basuoni, Khalid Al-Baimani, Fatma AlKindi, Waleed Dawelbeit, Rawan AlHarrasi, Hadil Al-Sharqi, Nadiya AlKindi, Amany Hany Mohamed Kamel
{"title":"The ROOT-CTRCD study: exploring the relationship of oral health to cancer therapy-related cardiac dysfunction in HER2-positive breast cancer patients.","authors":"Ahmed Basuoni, Khalid Al-Baimani, Fatma AlKindi, Waleed Dawelbeit, Rawan AlHarrasi, Hadil Al-Sharqi, Nadiya AlKindi, Amany Hany Mohamed Kamel","doi":"10.1186/s40959-026-00444-8","DOIUrl":"10.1186/s40959-026-00444-8","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"16"},"PeriodicalIF":3.2,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1186/s40959-025-00441-3
Vibhuti Arya, Lana Mackic, Sara M Telles Langdon, David Y C Cheung, Paris R Haasbeek, Skyler Eastman, Lauren Castagna, Scott Grandy, Stefan S Heinze, Danielle Desautels, Vallerie Gordon, Jeffrey Graham, Susan Green, Debjani Grenier, Christina A Kim, Maclean Thiessen, Marshall Pitz, Davinder S Jassal
{"title":"Can flaxseed \"milk\" prevent anthracycline mediated cardiotoxicity in women with breast cancer (CANFLAX-BC)?","authors":"Vibhuti Arya, Lana Mackic, Sara M Telles Langdon, David Y C Cheung, Paris R Haasbeek, Skyler Eastman, Lauren Castagna, Scott Grandy, Stefan S Heinze, Danielle Desautels, Vallerie Gordon, Jeffrey Graham, Susan Green, Debjani Grenier, Christina A Kim, Maclean Thiessen, Marshall Pitz, Davinder S Jassal","doi":"10.1186/s40959-025-00441-3","DOIUrl":"10.1186/s40959-025-00441-3","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":" ","pages":"20"},"PeriodicalIF":3.2,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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