Pub Date : 2023-06-15DOI: 10.51580/2023-2.2710-1185.12
А.S. Abseyt, N. Yelibayeva, G. Abdikarim, Zh.S. Abseyt, Duman Fatih
This article presents the results of the quantitative determination of fatty acids and vitamins, contained in Acanthophyllum pungens plants, belonging to the Caryophyllaceae family growing in Khantagi, located near the city of Kentau, Turkestan region. As a result of gas chromatography of fatty acids, obtained as a result of studies of plant materials, it has been found that Acanthophyllum pungens contains 87% of unsaturated fatty acids, and 13% of saturated fatty acids. Saturated fatty acids: myristic, palmitic, stearic, pentadecanoic acids, while unsaturated fatty acids: palmitic, oleic, linoleic, and linolenic acids. As a result of quantitative analysis, it has turned out that oleic and linoleic acids are contained in large quantities, and the content of linolenic acid is much lower. It has been established that the plant Acanthophyllum pungens contains water-soluble B3-nicotinic acid, B5-pantothenic acid, B9-folic acid and vitamins A, C, E. It has also been found that the relatively high content of vitamin B5 (pantothenic acid), and the content of vitamins B6, B1, B2 and D are absent altogether. The phytochemical studies of the aboveground part of the Acanthophyllum pungens plant collected during the budding phase have been carried out in accordance with the methodological recommendations of the State Pharmacopoeia of the Republic of Kazakhstan. Using Clarus-600 gas chromatography, the amount of fatty acids (high-carbon acids) contained in the Acanthophyllum pungens plant has been determined. A qualitative analysis has been carried out by paper chromatography (PC) and gas-liquid chromatography (GC). A certain amount of vitamins and fatty acids of the Acanthophyllum pungens plant has been recommended for the first time.
{"title":"DETERMINATION OF FATTY ACIDS AND VITAMINS IN THE ACANTHOPHYLLUM PUNGENS PLANT COMPOSITION","authors":"А.S. Abseyt, N. Yelibayeva, G. Abdikarim, Zh.S. Abseyt, Duman Fatih","doi":"10.51580/2023-2.2710-1185.12","DOIUrl":"https://doi.org/10.51580/2023-2.2710-1185.12","url":null,"abstract":"This article presents the results of the quantitative determination of fatty acids and vitamins, contained in Acanthophyllum pungens plants, belonging to the Caryophyllaceae family growing in Khantagi, located near the city of Kentau, Turkestan region. As a result of gas chromatography of fatty acids, obtained as a result of studies of plant materials, it has been found that Acanthophyllum pungens contains 87% of unsaturated fatty acids, and 13% of saturated fatty acids. Saturated fatty acids: myristic, palmitic, stearic, pentadecanoic acids, while unsaturated fatty acids: palmitic, oleic, linoleic, and linolenic acids. As a result of quantitative analysis, it has turned out that oleic and linoleic acids are contained in large quantities, and the content of linolenic acid is much lower. It has been established that the plant Acanthophyllum pungens contains water-soluble B3-nicotinic acid, B5-pantothenic acid, B9-folic acid and vitamins A, C, E. It has also been found that the relatively high content of vitamin B5 (pantothenic acid), and the content of vitamins B6, B1, B2 and D are absent altogether. The phytochemical studies of the aboveground part of the Acanthophyllum pungens plant collected during the budding phase have been carried out in accordance with the methodological recommendations of the State Pharmacopoeia of the Republic of Kazakhstan. Using Clarus-600 gas chromatography, the amount of fatty acids (high-carbon acids) contained in the Acanthophyllum pungens plant has been determined. A qualitative analysis has been carried out by paper chromatography (PC) and gas-liquid chromatography (GC). A certain amount of vitamins and fatty acids of the Acanthophyllum pungens plant has been recommended for the first time.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79539339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.51580/2023-2.2710-1185.10
A. Dyuryagina, A. Lutsenko
The rapid progress of water-dispersion paints from the water-diluted group is due to a number of their advantages over other paint and varnishes from the category of environmentally friendly. The formulations of paintwork materials are dominated by aqueous dispersions of acrylic copolymers, acrylic styrole copolymers, homo- and copolymers of vinyl acetate. One of the main methods of targeted regulation of the properties of polymer composite materials and coatings is the use of surfactants (surfactants). As a result of adsorption phenomena, their physical interaction with the surface of dispersed particles and substrate, associations with film-forming molecules can significantly change the deformation-strength, insulating, adhesive, coloristic and other properties of paint coatings. The purpose of the work is a reasonable choice of polymer surfactants for obtaining water-dispersion acrylic coatings with a given set of properties. This determines the relevance of research. Objects. Film former - acrylic polymer, inorganic pigment - rutile-shaped titanium dioxide, modifying additives - polyestersiloxane copolymer (PES) and sodium polyacrylate (PAN), aqueous solvent. Conclusion. Analysis of the state and current trends in paint and varnish materials indicates the prospects of using water-dispersion acrylic compositions. The study of the physical and chemical regularities of processes involving surfactants, developed both in the volume of film-forming and at the interphase boundaries of its interface with pigment and air, is an important prerequisite for the formation of scientifically based approaches, when obtaining effective protective and decorative properties of coatings of water-dispersion compositions.
{"title":"CURRENT STATE OF PROTECTIVE AND DECORATIVE PROPERTIES OF WATER-DISPERSION ACRYLIC COMPOSITIONS","authors":"A. Dyuryagina, A. Lutsenko","doi":"10.51580/2023-2.2710-1185.10","DOIUrl":"https://doi.org/10.51580/2023-2.2710-1185.10","url":null,"abstract":"The rapid progress of water-dispersion paints from the water-diluted group is due to a number of their advantages over other paint and varnishes from the category of environmentally friendly. The formulations of paintwork materials are dominated by aqueous dispersions of acrylic copolymers, acrylic styrole copolymers, homo- and copolymers of vinyl acetate. One of the main methods of targeted regulation of the properties of polymer composite materials and coatings is the use of surfactants (surfactants). As a result of adsorption phenomena, their physical interaction with the surface of dispersed particles and substrate, associations with film-forming molecules can significantly change the deformation-strength, insulating, adhesive, coloristic and other properties of paint coatings. The purpose of the work is a reasonable choice of polymer surfactants for obtaining water-dispersion acrylic coatings with a given set of properties. This determines the relevance of research. Objects. Film former - acrylic polymer, inorganic pigment - rutile-shaped titanium dioxide, modifying additives - polyestersiloxane copolymer (PES) and sodium polyacrylate (PAN), aqueous solvent. Conclusion. Analysis of the state and current trends in paint and varnish materials indicates the prospects of using water-dispersion acrylic compositions. The study of the physical and chemical regularities of processes involving surfactants, developed both in the volume of film-forming and at the interphase boundaries of its interface with pigment and air, is an important prerequisite for the formation of scientifically based approaches, when obtaining effective protective and decorative properties of coatings of water-dispersion compositions.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89334249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.51580/2023-2.2710-1185.11
А.С. Kadirbayeva, А. Bayeshov, А. Zharmenov, М. Turlybekova
One of the most important sources of renewable energy worldwide is the use of solar energy, which is developing rapidly, and solar power plants are becoming part of the energy infrastructure of many countries. In this regard, titanium dioxide, which has photovoltaic properties, and is used in the conversion of solar energy into electrical energy, is widely used. Purpose is to develop a method for attaching nanostructured titanium dioxide, stable in aqueous solutions, to the surface of a metal titanium plate. Objects. The mechanism of titanium dioxide formation on the titanium surface has been studied by removing the potentiodynamic polarization curves of the anode-cathode cycle, and conducting electrolysis under the potentiostatic conditions. It is established that during anodic polarization, its oxides are formed on the surface of the titanium electrode in the solutions of sodium hydroxide (alkaline medium) and potassium sulfate (neutral medium). Results. The curves of the anode-cathode polarization of a titanium electrode in a solution of potassium sulfate with the concentration of 100 g/l have shown that an anode current appears in the region of the potentials +0.2 V. Conclusion. It has been shown that during anodic polarization of titanium in the solutions of sodium hydroxide and potassium sulfate, an oxide film forms on its surface. It is determined that the formation of a titanium dioxide film occurs at a very low rate under the conditions of transpassivation.
{"title":"DEVELOPMENT OF A METHOD FOR OBTAINING A THIN TIO2 FILM WITH THE PHOTOELECTRIC PROPERTIES BY THE ELECTROCHEMICAL METHOD","authors":"А.С. Kadirbayeva, А. Bayeshov, А. Zharmenov, М. Turlybekova","doi":"10.51580/2023-2.2710-1185.11","DOIUrl":"https://doi.org/10.51580/2023-2.2710-1185.11","url":null,"abstract":"One of the most important sources of renewable energy worldwide is the use of solar energy, which is developing rapidly, and solar power plants are becoming part of the energy infrastructure of many countries. In this regard, titanium dioxide, which has photovoltaic properties, and is used in the conversion of solar energy into electrical energy, is widely used. Purpose is to develop a method for attaching nanostructured titanium dioxide, stable in aqueous solutions, to the surface of a metal titanium plate. Objects. The mechanism of titanium dioxide formation on the titanium surface has been studied by removing the potentiodynamic polarization curves of the anode-cathode cycle, and conducting electrolysis under the potentiostatic conditions. It is established that during anodic polarization, its oxides are formed on the surface of the titanium electrode in the solutions of sodium hydroxide (alkaline medium) and potassium sulfate (neutral medium). Results. The curves of the anode-cathode polarization of a titanium electrode in a solution of potassium sulfate with the concentration of 100 g/l have shown that an anode current appears in the region of the potentials +0.2 V. Conclusion. It has been shown that during anodic polarization of titanium in the solutions of sodium hydroxide and potassium sulfate, an oxide film forms on its surface. It is determined that the formation of a titanium dioxide film occurs at a very low rate under the conditions of transpassivation.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79776317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.06
Macromolecules with crown ether groups are a fundamentally new type of sorbents whose active centers are ligands that retain electrical neutrality in the process of simultaneous binding of cations, anions, or organic compounds. The purpose of this work is to create new selective sorbents based on diaminodicyclohexylcrown ethers and to study their complexing properties with respect to alkali metal ions. Methodology. To study the composition and properties of the products of the synthesis of crown ether-containing sorbents, chemical and physicochemical methods of analysis were used: infrared spectroscopy, atomic absorption spectrophotometry. Results and discussion. Chemical grafting of cycloaliphatic crown ethers onto a macroporous chloromethylated copolymer of styrene and divinylbenzene has been carried out. Under the chosen conditions, when using diaminodicyclohexyl-18-crown-6, polycrown ethers were obtained with a content of crown ether grains of 1.42 mmol/g, when using diaminodicyclohexyl-24-crown-8, the content of macrocyclic groups was 1.24 mmol/g. The extraction of alkali metals under static conditions by grafted sorbents based on various macrocycles has been studied. The high values of the distribution coefficients of alkali metals (Na+, K+, Cs+) by the synthesized sorbents in an acidic medium are shown. The following selectivity series were found for the sorbent with diaminodicyclohexyl-18-crown-6 fragments: K+ ˃ Cs + ˃ Na+, and for the sorbent with diaminodicyclohexyl-24-crown-8 fragments: Cs+ ˃ K+ ˃ Na+ metals. Conclusion. The efficiency of extracting metal ions from aqueous solutions containing Crown esters is affected by the presence of amino groups. It is known that the amino group promotes the formation of a polymer that swells in water. It was noted that the use of sorbents based on polymers that swell in water when metal salts are removed from the aqueous medium leads to an increase in the sorption capacity of sorbents by facilitating the access of metal ions in water to the active areas of the immobilized sorbent.
{"title":"SELECTIVE SORBENTS BASED ON DIAMINODICYCLOHEXYLCROWN ETHERS","authors":"","doi":"10.51580/2023-1.2710-1185.06","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.06","url":null,"abstract":"Macromolecules with crown ether groups are a fundamentally new type of sorbents whose active centers are ligands that retain electrical neutrality in the process of simultaneous binding of cations, anions, or organic compounds. The purpose of this work is to create new selective sorbents based on diaminodicyclohexylcrown ethers and to study their complexing properties with respect to alkali metal ions. Methodology. To study the composition and properties of the products of the synthesis of crown ether-containing sorbents, chemical and physicochemical methods of analysis were used: infrared spectroscopy, atomic absorption spectrophotometry. Results and discussion. Chemical grafting of cycloaliphatic crown ethers onto a macroporous chloromethylated copolymer of styrene and divinylbenzene has been carried out. Under the chosen conditions, when using diaminodicyclohexyl-18-crown-6, polycrown ethers were obtained with a content of crown ether grains of 1.42 mmol/g, when using diaminodicyclohexyl-24-crown-8, the content of macrocyclic groups was 1.24 mmol/g. The extraction of alkali metals under static conditions by grafted sorbents based on various macrocycles has been studied. The high values of the distribution coefficients of alkali metals (Na+, K+, Cs+) by the synthesized sorbents in an acidic medium are shown. The following selectivity series were found for the sorbent with diaminodicyclohexyl-18-crown-6 fragments: K+ ˃ Cs + ˃ Na+, and for the sorbent with diaminodicyclohexyl-24-crown-8 fragments: Cs+ ˃ K+ ˃ Na+ metals. Conclusion. The efficiency of extracting metal ions from aqueous solutions containing Crown esters is affected by the presence of amino groups. It is known that the amino group promotes the formation of a polymer that swells in water. It was noted that the use of sorbents based on polymers that swell in water when metal salts are removed from the aqueous medium leads to an increase in the sorption capacity of sorbents by facilitating the access of metal ions in water to the active areas of the immobilized sorbent.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90299095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.04
R. Nurdillayeva, Sh. Dauletuly, A. Bayeshov
One of the urgent problems of electrochemistry is the reuse of production waste of a relatively expensive metal – titanium, which is in great demand in mechanical, aircraft engineering, medicine, and nanotechnology. The purpose of this work is to study the abnormal cathodic and transpassive anodic dissolution behavior of a titanium electrode in an aqueous hydrofluoric acid solution. Methodology. The anode and cathode spaces are separated by an anion exchange membrane. As a result of the electrochemical dissolution of titanium Ti4+ ions are formed in the anode space, and Ti3+ ions are formed in the cathode space due to the chemical dissolution of titanium. The influence of the main electrochemical parameters on the titanium dissolution process in the anode and cathode spaces has been studied. Results and discussions. The current efficiency of titanium anodic dissolution slowly increased with increasing current density, and its maximum value (82.5%) was observed at a current density of 800 A/m2. With an increase in the concentration of hydrogen fluoride, the current efficiency rapidly increased, and its maximum value at a current density of 200 A/m2 was determined at a concentration of 0.6 mol/l and was equal to 78.1%. Titanium dissolves forming Ti3+ ions along with Ti4+ ions in the anode space with an increase in the electrolyte temperature. The current efficiency of Ti4+ ions decreases while sharply increasing for Ti3+ ions. Conclusion. The optimal conditions for transpassive anodic and anomalous cathodic dissolution of a titanium electrode in an aqueous solution of hydrofluoric acid and the kinetic parameters of the electrode process are determined.
钛是一种相对昂贵的金属，在机械、航空工程、医学和纳米技术等领域都有很大的需求，其生产废料的再利用是电化学领域的一个紧迫问题。本研究的目的是研究钛电极在氢氟酸水溶液中的异常阴极和透阳极溶解行为。方法。阳极和阴极空间由阴离子交换膜隔开。由于钛的电化学溶解在阳极空间形成Ti4+离子，由于钛的化学溶解在阴极空间形成Ti3+离子。研究了主要电化学参数对钛在阳极和阴极空间溶解过程的影响。结果和讨论。钛阳极溶解的电流效率随着电流密度的增加而缓慢增加，在电流密度为800 a /m2时达到最大值(82.5%)。随着氟化氢浓度的增加，电流效率迅速提高，在浓度为0.6 mol/l时，电流密度为200 a /m2时电流效率达到最大值，为78.1%。随着电解液温度的升高，钛在阳极空间中溶解形成Ti3+离子和Ti4+离子。Ti4+离子的电流效率降低，Ti3+离子的电流效率急剧提高。结论。确定了钛电极在氢氟酸水溶液中通过阳极和异常阴极溶解的最佳条件以及电极过程的动力学参数。
{"title":"Transpassive and abnormal dissolution of titanium electrodes in hydrofluoric acid aqueous solution","authors":"R. Nurdillayeva, Sh. Dauletuly, A. Bayeshov","doi":"10.51580/2023-1.2710-1185.04","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.04","url":null,"abstract":"One of the urgent problems of electrochemistry is the reuse of production waste of a relatively expensive metal – titanium, which is in great demand in mechanical, aircraft engineering, medicine, and nanotechnology. The purpose of this work is to study the abnormal cathodic and transpassive anodic dissolution behavior of a titanium electrode in an aqueous hydrofluoric acid solution. Methodology. The anode and cathode spaces are separated by an anion exchange membrane. As a result of the electrochemical dissolution of titanium Ti4+ ions are formed in the anode space, and Ti3+ ions are formed in the cathode space due to the chemical dissolution of titanium. The influence of the main electrochemical parameters on the titanium dissolution process in the anode and cathode spaces has been studied. Results and discussions. The current efficiency of titanium anodic dissolution slowly increased with increasing current density, and its maximum value (82.5%) was observed at a current density of 800 A/m2. With an increase in the concentration of hydrogen fluoride, the current efficiency rapidly increased, and its maximum value at a current density of 200 A/m2 was determined at a concentration of 0.6 mol/l and was equal to 78.1%. Titanium dissolves forming Ti3+ ions along with Ti4+ ions in the anode space with an increase in the electrolyte temperature. The current efficiency of Ti4+ ions decreases while sharply increasing for Ti3+ ions. Conclusion. The optimal conditions for transpassive anodic and anomalous cathodic dissolution of a titanium electrode in an aqueous solution of hydrofluoric acid and the kinetic parameters of the electrode process are determined.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75895647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.02
E. S. Sycheva, D. Markina, M. Mukanova, L. Boltayeva, O. Seilkhanov
Particular attention in the cultivation of industrial and agricultural crops is paid to the fight against pathogenic fungi, which not only lead to significant yield losses, but they are also dangerous to humans. The aim of this work is the synthesis of biologically active compounds in the series of aromatic dithiocarbamic acids based on N-(4-methoxyphenyl)acetamide and N-phenylacetamide and the study of their antifungal and antibacterial activities. Results and discussion. Biologically active aromatic sodium dithiocarbamates were synthesized by the reaction of amines (N-(4-methoxyphenyl)acetamide and N-phenylacetamide) with carbon disulfide in the presence of NaOH in ethanol at a temperature of 25°C in 78 and 85% yields. Thioanhydrides were synthesized by the acylation of sodium acetyl(4-methoxyphenyl)carbamodithioate and sodium acetyl(phenyl)carbamodithioate with acid chlorides (benzoic, 3,4-dimethoxybenzoic, 2-bromobenzoic, and 4-nitrobenzoic) in chloroform at a temperature of 25°C. The corresponding derivatives of aromatic thioanhydrides of dithiocarbamic acids were obtained in 49-88% yields. The structure of the synthesized compounds was established on the basis of elemental analysis data, IR spectra, 1Н and 13С NMR spectroscopy. Antifungal and bactericidal properties of the synthesized compounds were studied against phytopathogenic fungi and Fusarium oxysporum and Pectobacterium carotovorum bacteria. Conclusion. According to the test results, it was revealed that sodium acetyl(4-methoxyphenyl)carbamodithioate at a concentration of 0.4% has a high fungicidal activity and completely inhibits the growth of the Fusarium oxysporum phytopathogen. The maximum zone of inhibition (18 mm) of Pectobacterium carotovorum bacteria was at a concentration of 0.4%.
{"title":"SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-(4-METHOXYPHENYL)ACETAMIDE AND N-PHENYLACETAMIDE DERIVATIVES","authors":"E. S. Sycheva, D. Markina, M. Mukanova, L. Boltayeva, O. Seilkhanov","doi":"10.51580/2023-1.2710-1185.02","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.02","url":null,"abstract":"Particular attention in the cultivation of industrial and agricultural crops is paid to the fight against pathogenic fungi, which not only lead to significant yield losses, but they are also dangerous to humans. The aim of this work is the synthesis of biologically active compounds in the series of aromatic dithiocarbamic acids based on N-(4-methoxyphenyl)acetamide and N-phenylacetamide and the study of their antifungal and antibacterial activities. Results and discussion. Biologically active aromatic sodium dithiocarbamates were synthesized by the reaction of amines (N-(4-methoxyphenyl)acetamide and N-phenylacetamide) with carbon disulfide in the presence of NaOH in ethanol at a temperature of 25°C in 78 and 85% yields. Thioanhydrides were synthesized by the acylation of sodium acetyl(4-methoxyphenyl)carbamodithioate and sodium acetyl(phenyl)carbamodithioate with acid chlorides (benzoic, 3,4-dimethoxybenzoic, 2-bromobenzoic, and 4-nitrobenzoic) in chloroform at a temperature of 25°C. The corresponding derivatives of aromatic thioanhydrides of dithiocarbamic acids were obtained in 49-88% yields. The structure of the synthesized compounds was established on the basis of elemental analysis data, IR spectra, 1Н and 13С NMR spectroscopy. Antifungal and bactericidal properties of the synthesized compounds were studied against phytopathogenic fungi and Fusarium oxysporum and Pectobacterium carotovorum bacteria. Conclusion. According to the test results, it was revealed that sodium acetyl(4-methoxyphenyl)carbamodithioate at a concentration of 0.4% has a high fungicidal activity and completely inhibits the growth of the Fusarium oxysporum phytopathogen. The maximum zone of inhibition (18 mm) of Pectobacterium carotovorum bacteria was at a concentration of 0.4%.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77168964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.01
G.K. Mukusheva, N.N. Toigambekova, N. G. Bazarnova, A.R. Zhasymbekova, V. Potkin, A.S. Mazhitov, M.S. Nurmaganbetova
The appearance of severe acute respiratory syndrome (SARS-CoV-2) created a pandemic in 212 countries, resulting in over 27 million of infections and about 900.000 deaths worldwide. SARS-CoV-2 has a capability to encode cysteine proteases. The goals is to consider the optimal methods of Mpro proteases for the development of anti-SARS-CoV-2 drugs. Methods. The structure of the synthesized compounds was established by 1H and 13C NMR, IR, and UV. A detail of quantum molecular descriptors of the title compounds such as Ionization Potential (IP) and Electron Affinities (EA), Hardness (η), Softness (S), Electronegativity (μ), Electrophilic Index (ω), Electron Donating Power (ω-), Electron Accepting Power (ω+) and Energy Gap (Eg) has been calculated. Pharmacokinetic properties of the title compounds and their bioactivity were investigated. In the following, a molecular docking study was carried out to screen for effective available compound, which may work as a strong inhibitor for the SARS-CoV-2 main protease Mpro. Results and discussion alkaloid derivatives, such as (R)- (6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl adamantane-1-carboxylate, (R)- (6- methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl 5-(p-tolyl)isoxazole-3-carboxylate were obtained in 91% and 86% yields, respectively. received. The total polar surface area of natural alkaloid derivatives was observed in the range of 42.31 - 77.70 Å. Conclusion. The binding energy between SARS-CoV-2 core protease Mpro and natural alkaloid derivatives showed good binding affinity. Therefore, the studied derivatives of natural alkaloids can be used against SARS-CoV-2 main Mpro protease.
{"title":"SYNTHESIS AND INVESTIGATION OF THE DERIVATIVES OF QUININE ALKALOID AS POTENTIAL INHIBITORS OF THE MAIN PROTEASE SARS-COV-2 Mpro","authors":"G.K. Mukusheva, N.N. Toigambekova, N. G. Bazarnova, A.R. Zhasymbekova, V. Potkin, A.S. Mazhitov, M.S. Nurmaganbetova","doi":"10.51580/2023-1.2710-1185.01","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.01","url":null,"abstract":"The appearance of severe acute respiratory syndrome (SARS-CoV-2) created a pandemic in 212 countries, resulting in over 27 million of infections and about 900.000 deaths worldwide. SARS-CoV-2 has a capability to encode cysteine proteases. The goals is to consider the optimal methods of Mpro proteases for the development of anti-SARS-CoV-2 drugs. Methods. The structure of the synthesized compounds was established by 1H and 13C NMR, IR, and UV. A detail of quantum molecular descriptors of the title compounds such as Ionization Potential (IP) and Electron Affinities (EA), Hardness (η), Softness (S), Electronegativity (μ), Electrophilic Index (ω), Electron Donating Power (ω-), Electron Accepting Power (ω+) and Energy Gap (Eg) has been calculated. Pharmacokinetic properties of the title compounds and their bioactivity were investigated. In the following, a molecular docking study was carried out to screen for effective available compound, which may work as a strong inhibitor for the SARS-CoV-2 main protease Mpro. Results and discussion alkaloid derivatives, such as (R)- (6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl adamantane-1-carboxylate, (R)- (6- methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl 5-(p-tolyl)isoxazole-3-carboxylate were obtained in 91% and 86% yields, respectively. received. The total polar surface area of natural alkaloid derivatives was observed in the range of 42.31 - 77.70 Å. Conclusion. The binding energy between SARS-CoV-2 core protease Mpro and natural alkaloid derivatives showed good binding affinity. Therefore, the studied derivatives of natural alkaloids can be used against SARS-CoV-2 main Mpro protease.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75107960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.03
O. Kaupbai, K. Maldybayev, T. Kan, M. Kiyatova, S. Kokhmetova, A. Kurbatov, F. Malchik
The membrane/separator is an important part of electrochemical energy storage devices such as supercapacitors and batteries. However, the transport processes that limit the rate capability of the charge/discharge are more pronounced for supercapacitors, which can be charged in seconds, unlike batteries; therefore, a more detailed selection of the material and porosity of the membranes is required for them. The paper shows a method for estimation of the contribution of additional membrane resistance by the cyclic voltammetry. As a result of a comparative analysis of 4 membranes: cellulose based separator TF4050 and VL100 (Nippon Kodoshi Corporation, Japan); filter paper - blue ribbon "OOO Melior XXI" (filter); filter based on polyvinylidene fluoride (PVdF) (Durapore® Membrane Filter) it was determined that the membrane based on PVdF has the least additional resistance in a concentrated solution of LiCl, while in concentrated solution of NaClO4 the least additional resistance has TF4050. In general, for preliminary electrochemical studies, the possibility of using not specialized membranes under certain conditions has been shown.
{"title":"COMPARISON AND SELECTION OF MEMBRANE MATERIAL FOR SUPERCAPACITORS BASED ON AQUEOUS ELECTROLYTES","authors":"O. Kaupbai, K. Maldybayev, T. Kan, M. Kiyatova, S. Kokhmetova, A. Kurbatov, F. Malchik","doi":"10.51580/2023-1.2710-1185.03","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.03","url":null,"abstract":"The membrane/separator is an important part of electrochemical energy storage devices such as supercapacitors and batteries. However, the transport processes that limit the rate capability of the charge/discharge are more pronounced for supercapacitors, which can be charged in seconds, unlike batteries; therefore, a more detailed selection of the material and porosity of the membranes is required for them. The paper shows a method for estimation of the contribution of additional membrane resistance by the cyclic voltammetry. As a result of a comparative analysis of 4 membranes: cellulose based separator TF4050 and VL100 (Nippon Kodoshi Corporation, Japan); filter paper - blue ribbon \"OOO Melior XXI\" (filter); filter based on polyvinylidene fluoride (PVdF) (Durapore® Membrane Filter) it was determined that the membrane based on PVdF has the least additional resistance in a concentrated solution of LiCl, while in concentrated solution of NaClO4 the least additional resistance has TF4050. In general, for preliminary electrochemical studies, the possibility of using not specialized membranes under certain conditions has been shown.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80938368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.08
N.S. Murzakassymova, M. A. Gavrilenko, N. Bektenov, R.M. Kudaibergenova, E.A. Baybazarova
The sorption capacity of modified activated carbon is investigated; the possibility of creating a sorbent for iron (II, III) in water bodies with a purified water yield of up to 0.01 mg/l is shown. A sulfogroup was used as a modifier and a complexing agent. To date, thousands of sorbents are produced with various matrix materials, functional groupings, ways of fixing them, containers, mechanical properties, granulation and other characteristics. The choice of the optimal sorbent depends on the task assigned to the researcher. To a large extent, the choice of a sorbent is determined by the nature of the micro–component - the form of existence of this component in solution, the size and charge of an ion or molecule, the ability of this form to react with functional groups or directly with the surface of the sorbent. When choosing a sorbent, it is necessary to take into account the concentration mode. Thus, after sorption extraction under static conditions, the sorbent concentrate should be easily separated from the mother liquor; when used in dynamic mode, it is undesirable to use strongly swelling sorbents, as well as too small fractions of sorbents. In combined techniques, where the first step is concentration, and the second is quality control of purified water, spectroscopic methods such as spectrophotometry, atomic absorption spectroscopy (AAS), atomic emission spectroscopy with inductively coupled plasma (NPP-ISP), mass spectrometry with inductively coupled plasma (MS-ISP) can act, the possibility of rapid and quantitative elution of elements. The development of express and simple methods of water purification from heavy metals, in particular, from the widespread iron (II, III) cation in natural and drinking waters is an important task of analytical chemistry. This is due to the high prevalence of iron in environmental objects and the biomedical effect of an excess of its ions on the human body.
{"title":"SORPTION PURIFICATION OF WATER FROM HEAVY METAL IONS USING SULFOUGL","authors":"N.S. Murzakassymova, M. A. Gavrilenko, N. Bektenov, R.M. Kudaibergenova, E.A. Baybazarova","doi":"10.51580/2023-1.2710-1185.08","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.08","url":null,"abstract":"The sorption capacity of modified activated carbon is investigated; the possibility of creating a sorbent for iron (II, III) in water bodies with a purified water yield of up to 0.01 mg/l is shown. A sulfogroup was used as a modifier and a complexing agent. To date, thousands of sorbents are produced with various matrix materials, functional groupings, ways of fixing them, containers, mechanical properties, granulation and other characteristics. The choice of the optimal sorbent depends on the task assigned to the researcher. To a large extent, the choice of a sorbent is determined by the nature of the micro–component - the form of existence of this component in solution, the size and charge of an ion or molecule, the ability of this form to react with functional groups or directly with the surface of the sorbent. When choosing a sorbent, it is necessary to take into account the concentration mode. Thus, after sorption extraction under static conditions, the sorbent concentrate should be easily separated from the mother liquor; when used in dynamic mode, it is undesirable to use strongly swelling sorbents, as well as too small fractions of sorbents. In combined techniques, where the first step is concentration, and the second is quality control of purified water, spectroscopic methods such as spectrophotometry, atomic absorption spectroscopy (AAS), atomic emission spectroscopy with inductively coupled plasma (NPP-ISP), mass spectrometry with inductively coupled plasma (MS-ISP) can act, the possibility of rapid and quantitative elution of elements. The development of express and simple methods of water purification from heavy metals, in particular, from the widespread iron (II, III) cation in natural and drinking waters is an important task of analytical chemistry. This is due to the high prevalence of iron in environmental objects and the biomedical effect of an excess of its ions on the human body.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81680620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.51580/2023-1.2710-1185.07
U. Jussipbekov, R. Chernyakova, R. Kaiynbayeva, G. Sultanbayeva, I.A. Kuksina, N. Kozhabekova
Calcium chloride is a popular product for oil/oil, gas, chemical, chemical-pharmaceutical, forest, construction and other industries. The aim of this work is to synthesize calcium chloride from low-quality limestone, to calculate the material balance of the process of its production and to study the possibility of using CaCI2 in the oil industry. Methodology: Infrared spectra were filmed on an infrared spectrophotometer in the spectral region 225-4000 cm-1. The basic hydrochloric acid method is selected for producing calcium chloride from technical lime. The synthesis and purification of the CaCI2 solution were carried out according to a known method. Results and discussion. Experiments have shown that calcium chloride enhances the anti-corrosion properties of a seawater well-killing fluid. The highest degree of protection (89.83%) was observed at 35% CaCI2 concentration due to chemical composition. Introducing CaCI2 into wastewater increases its mineralization and overall hardness, resulting in the formation of a more aggressive environment and an increased corrosion rate. Conclusions: A feasibility study of the process of obtaining pure calcium chloride from technical raw materials was carried out, the material balance of this process was calculated, and it was shown that the cost of the resulting CaCl2 does not exceed the cost of 1 ton of pure CaCl2 on the market of services.
{"title":"SYNTHESIS OF CALCIUM CHLORIDE FROM TECHNICAL LIME","authors":"U. Jussipbekov, R. Chernyakova, R. Kaiynbayeva, G. Sultanbayeva, I.A. Kuksina, N. Kozhabekova","doi":"10.51580/2023-1.2710-1185.07","DOIUrl":"https://doi.org/10.51580/2023-1.2710-1185.07","url":null,"abstract":"Calcium chloride is a popular product for oil/oil, gas, chemical, chemical-pharmaceutical, forest, construction and other industries. The aim of this work is to synthesize calcium chloride from low-quality limestone, to calculate the material balance of the process of its production and to study the possibility of using CaCI2 in the oil industry. Methodology: Infrared spectra were filmed on an infrared spectrophotometer in the spectral region 225-4000 cm-1. The basic hydrochloric acid method is selected for producing calcium chloride from technical lime. The synthesis and purification of the CaCI2 solution were carried out according to a known method. Results and discussion. Experiments have shown that calcium chloride enhances the anti-corrosion properties of a seawater well-killing fluid. The highest degree of protection (89.83%) was observed at 35% CaCI2 concentration due to chemical composition. Introducing CaCI2 into wastewater increases its mineralization and overall hardness, resulting in the formation of a more aggressive environment and an increased corrosion rate. Conclusions: A feasibility study of the process of obtaining pure calcium chloride from technical raw materials was carried out, the material balance of this process was calculated, and it was shown that the cost of the resulting CaCl2 does not exceed the cost of 1 ton of pure CaCl2 on the market of services.","PeriodicalId":9856,"journal":{"name":"Chemical Journal of Kazakhstan","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83353223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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