Pub Date : 2018-06-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.02.020
Wenying Zhao, Beizhen Xie
Objective To review the effects of controlled airtight environment on health and the health care functions of Auricularia auricular. Literature resource and selection The related research papers and reviews in this field published at home and abroad. Literature quotation Sixty-four published papers and reviews were cited. Literature synthesis The effects of controlled airtight environment, such as space station, on human health were analyzed, including on body bone metabolism, immune function, cardiovascular system, digestive system and gut microbiota. In addition, the health conditioning advantages and mechanism of using Auricularia auricula for the personnel in controlled airtight environment for protecting bone loss, immune-strengthening, anti-radiation, anti-hypoglycemia, anti-hypolipidemia, anti-thrombotic, relieving constipation, and modulating gut microbiota were also elaborated. Conclusions Auricularia auricula, as a kind of Chinese precious health food combining medicinal and food functions, is expected to improve the health and work efficiency of the personnel in controlled airtight environment by ingesting as supplementary food. It has broad application prospects for the personnel worked in controlled airtight environment. Key words: Environment, controlled; Auriculariaceae; Physiological functions; Gut microbiota
{"title":"Effects of controlled airtight environment on human health and the health care functions of Auricularia auricula","authors":"Wenying Zhao, Beizhen Xie","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.020","url":null,"abstract":"Objective \u0000To review the effects of controlled airtight environment on health and the health care functions of Auricularia auricular. \u0000 \u0000 \u0000Literature resource and selection \u0000The related research papers and reviews in this field published at home and abroad. \u0000 \u0000 \u0000Literature quotation \u0000Sixty-four published papers and reviews were cited. Literature synthesis The effects of controlled airtight environment, such as space station, on human health were analyzed, including on body bone metabolism, immune function, cardiovascular system, digestive system and gut microbiota. In addition, the health conditioning advantages and mechanism of using Auricularia auricula for the personnel in controlled airtight environment for protecting bone loss, immune-strengthening, anti-radiation, anti-hypoglycemia, anti-hypolipidemia, anti-thrombotic, relieving constipation, and modulating gut microbiota were also elaborated. \u0000 \u0000 \u0000Conclusions \u0000Auricularia auricula, as a kind of Chinese precious health food combining medicinal and food functions, is expected to improve the health and work efficiency of the personnel in controlled airtight environment by ingesting as supplementary food. It has broad application prospects for the personnel worked in controlled airtight environment. \u0000 \u0000 \u0000Key words: \u0000Environment, controlled; Auriculariaceae; Physiological functions; Gut microbiota","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86551589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.02.002
Ye Liu
Objective: To investigate whether the preconditioning of hyperbaric oxygen (HBO)can improve the tolerance of lower body negative pressure in pilots . Methods: Twenty healthy male fighter pilots were selected as subjects .The multiple HBO chamber was used and 3-time HBO exposure scheme was chosen .The chamber pressure was gradually increased to 2.5 atmospheres absolute （ATA） in 10 min and maintained for 65 min （with twice 30-min mask oxygen breathing and 5-min interval .Then the pressure was gradually reduced to 1.3 ATA in 10 min and returned to normal pressure in 5 min after staying for 5 min .Such 95-min test was undertaken once a day （set at 15:30--17:05） and repeated for 3 days .The lower body negative pressure tolerance was measured before and after HBO preconditioned and self-contrasted . Results: The cumulative stress index was significantly increased from(-1353.50±449 .95) to(-1843.50± 522 0.7) by 3 rounds HBO pretreatment （t =11.10，P<0.05） and it indicated that the lower body negative pressure tolerance had been improved . Conclusions: Hyperbaric oxygen preconditioning can improve the pilot’s lower body negative pressure tolerance
目的:探讨高压氧(HBO)预处理是否能提高飞行员下体负压耐受性。方法:二十岁健康男性战斗机飞行员被选为研究对象,使用多个HBO室和俄罗斯HBO暴露方案被选中,燃烧室压力逐渐增加到2.5大气绝对(ATA) 10分钟和维持65分钟(两次30分钟面具氧呼吸和5分钟间隔区间压力逐渐减少到1.3 ATA 10分钟和5分钟恢复正常压力假设待5分钟后95分钟测试一天进行一次(设置(15:30—17:05)，重复3天。测量HBO预处理前后下体负压耐受性，并进行自我对比。结果:经3轮HBO预处理，累计应激指数由(-1353.50±449 .95)显著提高至(-1843.50±522 . 0.7)(t =11.10,P<0.05)，提示下体负压耐受性得到改善。结论:高压氧预处理能提高飞行员下体负压耐受性
{"title":"Application of Hyperbaric Oxygen Preconditioning to Improve Pilot′s Lower Body Negative Pressure Tolerance","authors":"Ye Liu","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.002","url":null,"abstract":"\u0000 Objective: To investigate whether the preconditioning of hyperbaric oxygen (HBO)can improve the tolerance of lower body negative pressure in pilots . Methods: Twenty healthy male fighter pilots were selected as subjects .The multiple HBO chamber was used and 3-time HBO exposure scheme was chosen .The chamber pressure was gradually increased to 2.5 atmospheres absolute （ATA） in 10 min and maintained for 65 min （with twice 30-min mask oxygen breathing and 5-min interval .Then the pressure was gradually reduced to 1.3 ATA in 10 min and returned to normal pressure in 5 min after staying for 5 min .Such 95-min test was undertaken once a day （set at 15:30--17:05） and repeated for 3 days .The lower body negative pressure tolerance was measured before and after HBO preconditioned and self-contrasted . Results: The cumulative stress index was significantly increased from(-1353.50±449 .95) to(-1843.50± 522 0.7) by 3 rounds HBO pretreatment （t =11.10，P<0.05） and it indicated that the lower body negative pressure tolerance had been improved . Conclusions: Hyperbaric oxygen preconditioning can improve the pilot’s lower body negative pressure tolerance","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88766135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.02.006
Cuiling Zhang
{"title":"One case of accelerated ventricular autonomic rhythm diagnosed in the physical examination of candidates of Teenager Aviation School of Air Force","authors":"Cuiling Zhang","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.006","url":null,"abstract":"","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79942594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To analyze the dynamics response of head and neck to -Gx acceleration and to evaluate the stability of helmet by simulating the movement of head and neck under -Gx acceleration and measuring the mechanics parameters. Methods A swing pendulum was designed based on the head and neck of HYBRID III dummy. The body at the lower end of neck impacted the wave generator when the pendulum swing moved forward. The acceleration of impact, head response, force and torque at lower end of neck and helmet displacement were measured. The differences on dummy's head and neck dynamic response and the displacement of helmet were compared between the states of wearing helmet and wearing helmet mounted display. Results The duration of force and torque at the lower end of dummy′s head and neck was significantly longer than that of impact acceleration. As with the helmet, -Gx peak amplitude of the impact acceleration was (6.82±0.27) G and the pulse width was (42.63±1.04) ms, the peak amplitude and pulse width of head response acceleration was (5.66±0.16) G and (173.91±2.31) ms, the force and torque at lower end of neck was (390.37±10.98) N and (183.51±6.26) ms, (79.64±2.70) N·m and (164.17±1.53) ms respectively. The angular and linear displacement of the helmet relative to head was (13.16°±4.61°) and (21.51±10.58) mm respectively. There were statistically significant differences on pulse width of head response acceleration, force and torque at lower end of neck between the states of wearing helmet and wearing helmet mounted display (t=12.947, 3.105, 17.871, P<0.05). The experiment showed that helmet with display caused bigger displacement. There were statistically significant differences on the peak acceleration and pulse width between the impact and the head response both under the states of wearing helmet and wearing helmet mounted display (t=20.48-485.26, P<0.01). Conclusions The swing pendulum test method could basically reflect the dynamics response and motion features of head and neck to -Gx acceleration. The results have important significance on evaluating the safety of head and neck and stability of helmet. Key words: Acceleration; Head protective device; Neck; Dynamics response
{"title":"Dynamics response of head and neck to -Gx acceleration when wearing helmet","authors":"Xiaoyan Sun, Ming-lei Wu, Heqing Liu, Weiping Bu, Guang Zhao, Jinhuan Zhang, Jinwen Zhang, Lianyun Chen","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.005","url":null,"abstract":"Objective \u0000To analyze the dynamics response of head and neck to -Gx acceleration and to evaluate the stability of helmet by simulating the movement of head and neck under -Gx acceleration and measuring the mechanics parameters. \u0000 \u0000 \u0000Methods \u0000A swing pendulum was designed based on the head and neck of HYBRID III dummy. The body at the lower end of neck impacted the wave generator when the pendulum swing moved forward. The acceleration of impact, head response, force and torque at lower end of neck and helmet displacement were measured. The differences on dummy's head and neck dynamic response and the displacement of helmet were compared between the states of wearing helmet and wearing helmet mounted display. \u0000 \u0000 \u0000Results \u0000The duration of force and torque at the lower end of dummy′s head and neck was significantly longer than that of impact acceleration. As with the helmet, -Gx peak amplitude of the impact acceleration was (6.82±0.27) G and the pulse width was (42.63±1.04) ms, the peak amplitude and pulse width of head response acceleration was (5.66±0.16) G and (173.91±2.31) ms, the force and torque at lower end of neck was (390.37±10.98) N and (183.51±6.26) ms, (79.64±2.70) N·m and (164.17±1.53) ms respectively. The angular and linear displacement of the helmet relative to head was (13.16°±4.61°) and (21.51±10.58) mm respectively. There were statistically significant differences on pulse width of head response acceleration, force and torque at lower end of neck between the states of wearing helmet and wearing helmet mounted display (t=12.947, 3.105, 17.871, P<0.05). The experiment showed that helmet with display caused bigger displacement. There were statistically significant differences on the peak acceleration and pulse width between the impact and the head response both under the states of wearing helmet and wearing helmet mounted display (t=20.48-485.26, P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The swing pendulum test method could basically reflect the dynamics response and motion features of head and neck to -Gx acceleration. The results have important significance on evaluating the safety of head and neck and stability of helmet. \u0000 \u0000 \u0000Key words: \u0000Acceleration; Head protective device; Neck; Dynamics response","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81370750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.02.017
Yu-Ting Pan, Min Du, Yang Yang, Wenhao Li
{"title":"One case of high performance fighter pilot with incapability induced by altitude hypoxia","authors":"Yu-Ting Pan, Min Du, Yang Yang, Wenhao Li","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.017","url":null,"abstract":"","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78344652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.02.004
Hongdai Sun, Yawei Wang, Xue-Jin Huang, Yuanwen Zou
Objective To improve the vitro simulation of the human circulation system under acceleration environment by studying a membrane compliance cavity. Methods The vitro simulation of the human circulation system equipped with a membrane cavity wherein the air and liquid was separated by a silicone membrane (0.2 mm or 0.4 mm thick) in order to prevent the gas got into the system as soon as the simulated acceleration caused air-liquid interface tilt. The segmentation of air-liquid interface and deformation of silicone membranes were recorded by a high definition camera when 20 to 200 mmHg pressure applied to the cavity to simulate the acceleration effect. The compliance values at different pressures were calculated. Results ①No air was found in the closed liquid loop when cavity was pressured. The deformation of 0.2 mm membrane was larger than that of 0.4 mm membrane. ②The membrane compliance cavity showed viscoelasticity feature both in pressure loading and unloading processes. When the cyclic loading was up to 3 times the loading curve of 0.2 mm membrane compliance cavity was almost overlapped on its unloading curve, but they did not coincide for the 0.4 mm membrane. ③The simulation range of 0.2 mm silicone membrane was in 0-1.4 ml/mmHg under 20-200 mmHg test pressures, while 0-0.4 ml/mmHg for 0.4 mm silicone membrane. Conclusions The membrane compliance cavity has solved the problem of the air-liquid interface segmentation under the simulated acceleration environment. The simulation range of compliance meets the needs of the vitro simulation for human circulatory system. Key words: Acceleration physiology; Blood circulatory; Compliance; In vitro simulation; Silica membrane cavity; Pilots
{"title":"Experimental study of a membrane compliance cavity to improve vitro simulation of the human circulation system under acceleration environment","authors":"Hongdai Sun, Yawei Wang, Xue-Jin Huang, Yuanwen Zou","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.004","url":null,"abstract":"Objective \u0000To improve the vitro simulation of the human circulation system under acceleration environment by studying a membrane compliance cavity. \u0000 \u0000 \u0000Methods \u0000The vitro simulation of the human circulation system equipped with a membrane cavity wherein the air and liquid was separated by a silicone membrane (0.2 mm or 0.4 mm thick) in order to prevent the gas got into the system as soon as the simulated acceleration caused air-liquid interface tilt. The segmentation of air-liquid interface and deformation of silicone membranes were recorded by a high definition camera when 20 to 200 mmHg pressure applied to the cavity to simulate the acceleration effect. The compliance values at different pressures were calculated. \u0000 \u0000 \u0000Results \u0000①No air was found in the closed liquid loop when cavity was pressured. The deformation of 0.2 mm membrane was larger than that of 0.4 mm membrane. ②The membrane compliance cavity showed viscoelasticity feature both in pressure loading and unloading processes. When the cyclic loading was up to 3 times the loading curve of 0.2 mm membrane compliance cavity was almost overlapped on its unloading curve, but they did not coincide for the 0.4 mm membrane. ③The simulation range of 0.2 mm silicone membrane was in 0-1.4 ml/mmHg under 20-200 mmHg test pressures, while 0-0.4 ml/mmHg for 0.4 mm silicone membrane. \u0000 \u0000 \u0000Conclusions \u0000The membrane compliance cavity has solved the problem of the air-liquid interface segmentation under the simulated acceleration environment. The simulation range of compliance meets the needs of the vitro simulation for human circulatory system. \u0000 \u0000 \u0000Key words: \u0000Acceleration physiology; Blood circulatory; Compliance; In vitro simulation; Silica membrane cavity; Pilots","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.02.016
W. Peng, Huwei Li
{"title":"Analysis of murine density in Baiyun International Airport","authors":"W. Peng, Huwei Li","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.016","url":null,"abstract":"","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85460939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To observe the effect of simulated microgravity on lipopolysaccharide (LPS)-induced inflammatory cytokines release in human monocytic leukemia THP-1 cells. Methods The human′s THP-1 cells were chosen as the research objects and divided into control group and simulated weightlessness group. After being resuscitated and subcultured, the cells in simulated weightlessness group were treated by clinostat with the speed of 30 r/min and cultured in the 37℃ incubator. The control group was set up synchronously with the experimental conditions that were consistent with simulated weightlessness group but without clinostat treatment. Six bottles of cells for each group had been tested for 3 times. When the cells in simulated weightlessness group were cultured in the clinostat for 48 h, 3 bottles of cell for each group were centrifuged for 5 min with the speed of 1 000 r/min. Then the LPS cell was added to stimulate cells with the concentration of 1 μg/ml and the cultivation lasted for 8 h. The cells and the cultured medium were collected by centrifugation. The other 3 bottles of control group and simulated weightlessness group were added equivalent volume cultured medium with LPS. The cells and the cultured medium were collected by centrifugation 8 h later. The experiment was repeated for 3 times. The mRNA expression and the changes of the concentration of TNF-α, IL-6, IL-1β gathered under 4 experimental conditions were compared. Results ①Compared with those in the control group, the mRNA expressions of TNF-α, IL-6 and IL-1β were increased significantly in LPS group and simulated weightlessness + LPS group (q=11.63-50.24, P<0.05); mRNA expressions of TNF-α and IL-1β were increased significantly in simulated weightlessness group (q=5.56-3.44, P<0.05). Compared with LPS group, the mRNA expressions of TNF-α and IL-6, IL-1β were increased significantly in simulated weightlessness + LPS group (q=9.08-26.50, P<0.01). ②Compared with those in control group, the concentration of TNF-α, IL-6, IL-1β were increased significantly in LPS group and simulated weightlessness group (q=3.02-32.52, P<0.05); the concentrations of TNF-α, IL-6 and IL-1β were increased significantly in simulated weightlessness + LPS group (q=40.02-65.31, P<0.01). Compared with those in LPS group, the concentrations of TNF-α and IL-6, IL-1β were increased significantly in simulated weightlessness + LPS group (q=17.59-32.79, P<0.01). Conclusions Simulated weightlessness can significantly increase the secretion of inflammatory cytokines and aggravate the LPS-induced inflammatory reaction in THP-1 cells. Key words: Weightlessness simulated; Lipopolysaccharides; Gene expression; Cytokines
{"title":"Effect of simulated microgravity on lipopolysaccharide induced inflammatory cytokines release in human monocytic leukemia THP-1 cells","authors":"Ying Zhang, Jing-Chan Yao, Tingting Li, Jieping Li, Jingyu Wang, Min Yuan, Jiang Cheng","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.02.008","url":null,"abstract":"Objective \u0000To observe the effect of simulated microgravity on lipopolysaccharide (LPS)-induced inflammatory cytokines release in human monocytic leukemia THP-1 cells. \u0000 \u0000 \u0000Methods \u0000The human′s THP-1 cells were chosen as the research objects and divided into control group and simulated weightlessness group. After being resuscitated and subcultured, the cells in simulated weightlessness group were treated by clinostat with the speed of 30 r/min and cultured in the 37℃ incubator. The control group was set up synchronously with the experimental conditions that were consistent with simulated weightlessness group but without clinostat treatment. Six bottles of cells for each group had been tested for 3 times. When the cells in simulated weightlessness group were cultured in the clinostat for 48 h, 3 bottles of cell for each group were centrifuged for 5 min with the speed of 1 000 r/min. Then the LPS cell was added to stimulate cells with the concentration of 1 μg/ml and the cultivation lasted for 8 h. The cells and the cultured medium were collected by centrifugation. The other 3 bottles of control group and simulated weightlessness group were added equivalent volume cultured medium with LPS. The cells and the cultured medium were collected by centrifugation 8 h later. The experiment was repeated for 3 times. The mRNA expression and the changes of the concentration of TNF-α, IL-6, IL-1β gathered under 4 experimental conditions were compared. \u0000 \u0000 \u0000Results \u0000①Compared with those in the control group, the mRNA expressions of TNF-α, IL-6 and IL-1β were increased significantly in LPS group and simulated weightlessness + LPS group (q=11.63-50.24, P<0.05); mRNA expressions of TNF-α and IL-1β were increased significantly in simulated weightlessness group (q=5.56-3.44, P<0.05). Compared with LPS group, the mRNA expressions of TNF-α and IL-6, IL-1β were increased significantly in simulated weightlessness + LPS group (q=9.08-26.50, P<0.01). ②Compared with those in control group, the concentration of TNF-α, IL-6, IL-1β were increased significantly in LPS group and simulated weightlessness group (q=3.02-32.52, P<0.05); the concentrations of TNF-α, IL-6 and IL-1β were increased significantly in simulated weightlessness + LPS group (q=40.02-65.31, P<0.01). Compared with those in LPS group, the concentrations of TNF-α and IL-6, IL-1β were increased significantly in simulated weightlessness + LPS group (q=17.59-32.79, P<0.01). \u0000 \u0000 \u0000Conclusions \u0000Simulated weightlessness can significantly increase the secretion of inflammatory cytokines and aggravate the LPS-induced inflammatory reaction in THP-1 cells. \u0000 \u0000 \u0000Key words: \u0000Weightlessness simulated; Lipopolysaccharides; Gene expression; Cytokines","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89183088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.01.008
Xiafei Li, Man Zhou, Yanan Li, Yaxian Ba
{"title":"A misdiagnosed case of the pilot with impetigo","authors":"Xiafei Li, Man Zhou, Yanan Li, Yaxian Ba","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.01.008","url":null,"abstract":"","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82590773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-15DOI: 10.3760/CMA.J.ISSN.1007-6239.2018.01.009
Ying-tao Xie, Qiaolian Zhang, Xiaohui Zheng, W. Shi, Tian-Rang Liu
Objective To explore the effects of real-time shear wave elastography (SWE) on diagnosing benign and malignant thyroid nodules in pilots. Methods Fifty-two pilots were diagnosed as thyroid nodules (60 nodules) in 456th Hospital of People′s Liberation Army from May 2014 to May 2017. They were checked by real-time shear wave elastography and the Young's moduli of nodules and normal thyroid tissues were recorded. The Young's modulus of patients′ normal thyroid tissues was taken as control value and was compared to that of thyroid nodules. By referring to the pathological examination result as the gold stand, the receiver operating characteristic (ROC) curve was plotted to determine if the thyroid nodules were benign or malignant in SWE diagnosis. The area under the ROC curve (AUC) was compared to determine the best diagnostic boundary. Results Out of 52 cases of thyroid nodules, 43 cases (48 nodules) were benign lesions. The pathological types included nodular goiter (n=33) and adenomas (n=15). There were 9 cases of malignant lesions (12 nodules) including papillary carcinoma (n=10) and small papillary carcinoma (n=2). The maximum, average and minimum Young′s modulus values showed significant difference between control group and those with thyroid adenoma, nodular goiter and thyroid malignant tumor (F=258.19, 268.39, 421.84, P<0.01). The mean, maximum and minimum Young′s modulus values of malignant nodules were (58.68±9.27) kPa, (78.64±11.53) kPa and (38.51±5.81) kPa respectively, and were higher than those of benign thyroid nodules (41.48±5.69) kPa, (52.23±7.71) kPa, (31.51±2.47) kPa. The differences had statistical significance (t=8.16, 9.55, 6.44, P<0.01). The AUC corresponding to the maximum, average and minimum Young′s modulus value was 0.929, 0.863 and 0.798 respectively. The best diagnostic efficiency was at the maximum Young′s modulus in the nodule and its diagnostic threshold was 54.42 kPa. Conclusions The Young′s modulus of benign thyroid nodules is smaller than that of malignant nodules in pilots. Applying the maximum value of the Young′s modulus enables better diagnosis accuracy than using its average or minimum value in determining malignant thyroid nodules. The quantitative SWE is helpful for diagnosing benign and malignant thyroid nodules in pilots. Key words: Thyroid nodule; Ultrasonography; Shear wave elastography; Pilots
{"title":"Application of real-time shear wave elastography on the diagnosis of thyroid nodules in pilots","authors":"Ying-tao Xie, Qiaolian Zhang, Xiaohui Zheng, W. Shi, Tian-Rang Liu","doi":"10.3760/CMA.J.ISSN.1007-6239.2018.01.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2018.01.009","url":null,"abstract":"Objective \u0000To explore the effects of real-time shear wave elastography (SWE) on diagnosing benign and malignant thyroid nodules in pilots. \u0000 \u0000 \u0000Methods \u0000Fifty-two pilots were diagnosed as thyroid nodules (60 nodules) in 456th Hospital of People′s Liberation Army from May 2014 to May 2017. They were checked by real-time shear wave elastography and the Young's moduli of nodules and normal thyroid tissues were recorded. The Young's modulus of patients′ normal thyroid tissues was taken as control value and was compared to that of thyroid nodules. By referring to the pathological examination result as the gold stand, the receiver operating characteristic (ROC) curve was plotted to determine if the thyroid nodules were benign or malignant in SWE diagnosis. The area under the ROC curve (AUC) was compared to determine the best diagnostic boundary. \u0000 \u0000 \u0000Results \u0000Out of 52 cases of thyroid nodules, 43 cases (48 nodules) were benign lesions. The pathological types included nodular goiter (n=33) and adenomas (n=15). There were 9 cases of malignant lesions (12 nodules) including papillary carcinoma (n=10) and small papillary carcinoma (n=2). The maximum, average and minimum Young′s modulus values showed significant difference between control group and those with thyroid adenoma, nodular goiter and thyroid malignant tumor (F=258.19, 268.39, 421.84, P<0.01). The mean, maximum and minimum Young′s modulus values of malignant nodules were (58.68±9.27) kPa, (78.64±11.53) kPa and (38.51±5.81) kPa respectively, and were higher than those of benign thyroid nodules (41.48±5.69) kPa, (52.23±7.71) kPa, (31.51±2.47) kPa. The differences had statistical significance (t=8.16, 9.55, 6.44, P<0.01). The AUC corresponding to the maximum, average and minimum Young′s modulus value was 0.929, 0.863 and 0.798 respectively. The best diagnostic efficiency was at the maximum Young′s modulus in the nodule and its diagnostic threshold was 54.42 kPa. \u0000 \u0000 \u0000Conclusions \u0000The Young′s modulus of benign thyroid nodules is smaller than that of malignant nodules in pilots. Applying the maximum value of the Young′s modulus enables better diagnosis accuracy than using its average or minimum value in determining malignant thyroid nodules. The quantitative SWE is helpful for diagnosing benign and malignant thyroid nodules in pilots. \u0000 \u0000 \u0000Key words: \u0000Thyroid nodule; Ultrasonography; Shear wave elastography; Pilots","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83878071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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