中华航空航天医学杂志最新文献

{"title":"The application of minimally invasive endoscopic surgery to cure the flying personnel with intractable upper urinary tract stones","authors":"Jian-ye Li, Heqing Guo, Bin Sun, Jianchang Wang, Haibo Sheng, Gaobiao Zhou, D. Mu","doi":"10.3760/CMA.J.ISSN.1007-6239.2016.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2016.02.008","url":null,"abstract":"Objective \u0000To evaluate the therapeutic effect of minimally invasive endoscopic surgery in the treatment of intractable upper urinary tract stones for flying personnel. \u0000 \u0000 \u0000Methods \u0000We retrospectively analyzed the clinical records of pilots who accepted minimally invasive endoscopic surgery for intractable upper urinary tract stones at our hospital from June 2006 to October 2014. \u0000 \u0000 \u0000Results \u0000All patients are male, aging from 24 to 50 yr. There were 13 cases of ureteral calculus and 13 cases of renal calculus. The CT scan showed that the long diameter of the stones ranged from 0.2 to 0.8 cm. All ureteral calculus patients were hospitalized because of renal colic. Renal calculus patients' stones were found in routine health examination and there were no flank pain, urinary irritation symptoms and hematuria. Ureteral calculus patients were cured by ureteroscopic lithotripsy and recovered. Ten renal calculus patients were cured simply by flexible ureteroscopy. One renal calculus patient was cured simply by percutaneous nephrostolithotomy and 2 were cured by flexible ureteroscopy combine percutaneous nephrostolithotomy. All patients were qualified for flying after the surgeries. \u0000 \u0000 \u0000Conclusions \u0000The minimally invasive endoscopic surgery can cure the intractable upper urinary tract stones of flying personnel effectively and safely. The proper treatment would avoid flying personnel's grounding and enable them to continue their flight career. \u0000 \u0000 \u0000Key words: \u0000Endoscopy; Urinary calculi; Surgical procedures, minimally; Lithotripsy; Aircrews","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"44 1","pages":"112-115"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78138670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of reverse operation in simulated carrier aircraft landing on mental workload","authors":"Wenbin Li, Jin Ma, Xiao-ping Xie, Rong Li, Yuting Su, Yao-ming Chang","doi":"10.3760/CMA.J.ISSN.1007-6239.2016.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2016.01.003","url":null,"abstract":"Objective \u0000To compare the subjects' scores of National Aeronautics and Space Administration-task load index (NASA-TLX), the indexes of ECG and performance between the reverse target tracking task and the ordinary target tracking task which simply simulate\"reverse operation\"of carrier aircraft landing, and to preliminarily investigate the effect of\"reverse operation\"on pilot's mental workload and its influence factors. \u0000 \u0000 \u0000Methods \u0000Twenty-five young male subjects accomplished the reverse and the ordinary target tracking tasks with two degrees of difficulty. ECG signals were recorded during the resting period before the task, periods of each task and the resting period after the task. Each subjects filled in NASA-TLX scale after the completion of each task and had a score feedback for each task. The scores of NASA-TLX and the indexes of performance were analyzed by analysis of variance (ANOVA) in 2×2 factorial design. The indexes of ECG were analyzed by Friedman M test and the multiple comparisons were carried out by LSD-t test. \u0000 \u0000 \u0000Results \u0000The scores of NASA-TLX and the average tracking distance of the reverse target tracking task were higher than those of the ordinary target tracking task (F=21.70, 16.14, P<0.05) and the highest appeared in the reverse dual task (F=6.67, P<0.05). HR also had the corresponding change (χ2=34.87, P<0.05), but the indexes of HRV had no significant differences. \u0000 \u0000 \u0000Conclusions \u0000Mental workload of the reverse operation task is higher than that of the ordinary operation task if the other conditions are the same. The reverse operation impacts mental workload severer when more information processing is required. Mental demand, physical demand and frustration level are the major influence factors of causing high mental workload in reverse operations. \u0000 \u0000 \u0000Key words: \u0000Workload; Cognition; Habituation, psychophysiologic; Work capacity evaluation; Electrocardiography","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"54 1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91224582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Rosuvastatin Calcium on insulin resistance of the flying personnel with metabolic syndrome","authors":"Hui-Ting Lei","doi":"10.3760/CMA.J.ISSN.1007-6239.2016.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2016.01.004","url":null,"abstract":"Objective \u0000To investigate the effects of Rosuvastatin Calcium on insulin resistance (IR) in the flying personnel with metabolic syndrome (MS). \u0000 \u0000 \u0000Methods \u0000Sixty-five cases of flying personnel with metabolic syndrome were assigned to group A (32 cases) and group B (33 cases) according to double blind and control method. Group A was administered with Rosuvastatin Calcium (10 mg/d) while group B was ingested by placebo (10 mg/d) with dinner. Homeostasis model assessment insulin resistance index (HOMA-IR) and drug adverse reactions of 2 groups were observed and compared before and 4 weeks after the treatment. \u0000 \u0000 \u0000Results \u0000There was no significant difference in the level of HOMA-IR, fasting insulin (FINS) and fasting blood glucose (FBG) between group A and group B before treatment (P>0.05). After 4-week treatment, HOMA-IR, FINS and FBG of group A was significantly lower than that of group B (t=2.895-3.231, P 0.05). There was significant difference of HOMA-IR, FBG in each group after treatment (t=4.228-8.846, P 0.05). FINS and FBG were positively correlated with HOMA-IR (r=0.436-0.982, P 0.05). Flying personnel of group A and group B were well tolerated to the treatments of Rosuvastatin Calcium. Glutamic-pyruvic transaminase, creatinine and creatine kinase had no significant difference by the treatment (P>0.05). \u0000 \u0000 \u0000Conclusions \u0000Rosuvastatin Calcium could improve IR in the flying personnel with MS. It is suggested that healthy lifestyle should be build and Rosuvastatin Calcium would be taken for the flying personnel with MS to effectively improve their IR if necessary. \u0000 \u0000 \u0000Key words: \u0000Insulin; Metabolic syndrome X; Rosuvastatin calcium; Flying personnel","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"5 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81210234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three cases of flying personnel with apical hypertrophy cardiomyopathy and literature review","authors":"Jieyong Li, Jun Wang, Xiangshang Xue, Dong-Jing Wang","doi":"10.3760/CMA.J.ISSN.1007-6239.2016.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2016.01.007","url":null,"abstract":"Objective \u0000To discuss the influence of apical hypertrophy cardiomyopathy (AHCM) on the flying personnel's and the evaluation principle of aeromedicine. \u0000 \u0000 \u0000Methods \u0000The clinical AHCM data, including diagnosis, therapy and prognosis of three pilots were analyzed and related literatures were reviewed. \u0000 \u0000 \u0000Results \u0000Three flying personnel cases were without clinical symptoms but were diagnosed as AHCM according to abnormal electrocardiogram and echocardiogram in physical examination. In 24-year follow-up of case 1 the ECG showed T wave inversion upon V3, V4 leads and the amplitude raised from 0.4 mV to 0.9 mV, the thickness of apex cordis increased from 12 mm to 19 mm. But he had safe flight for 19 000 h. Case 2 showed T wave inversion upon V3-V5 leads and the amplitude changed from 0.5 mV to 1.4 mV, the thickness of apex cordis varied from 12 mm to 24 mm in 22-year follow-up. He had safe flight for 20 000 h. Nine-year follow-up was taken for case 3 that also appeared T wave inversion on V5 lead, amplitude changed from 0.2 mV to 0.6 mV and the thickness of apex cordis increased from 12 mm to 17 mm. He had safe flight for 1 000 h. \u0000 \u0000 \u0000Conclusions \u0000Early diagnosis of AHCM will benefit to take the clinical follow-up for flying personnel. Due to the good prognosis the qualification could be issued to the flying personnel with AHCM but must be with strict supervision. The individual evaluation is also suggested. \u0000 \u0000 \u0000Key words: \u0000Cardiomyopathy, hypertrophic; Eligibility determination; Rstricted flying; Aircrews","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"1 1","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89486981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the evaluation and assessment system for the construction of medical selection system of Air Force flying cadets","authors":"Xinwei Ma, Zhi-gang Jiao","doi":"10.3760/CMA.J.ISSN.1007-6239.2016.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2016.01.008","url":null,"abstract":"Objective \u0000To establish the evaluation and assessment system for the construction of medical selection system of Air Force flying cadets and to provide references for improving the theory of Air Force cadets selection system and the work efficiency of medical service organization. \u0000 \u0000 \u0000Methods \u0000The assessment essential indexes were screened and defined by literature review, on site investigation and systemic analysis, and the evaluation index system framework was built then. With the principle of compromising the composition of the specialists and their familiarity with medical selection of military flying cadets, 22 specialists, including 19 senior professionals and 3 official staffs, were selected to complete questionnaire and analytic hierarchy process (AHP). Three rounds of questionnaire investigation were carried out in accordance with the rule of Delphi consultation and each round lasted for 25 to 35 d. The framework of index system of medical selection system of Air Force flying cadets was revised upon specialists' feedback and scores and the evaluation and assessment system and weight of index at each level of the system were determined. \u0000 \u0000 \u0000Results \u0000①One hundred and thirty-nine questionnaires were issued. The recovery rate was 90.65% and the available rate was 89.68%. Since middle and late 1980s, China's medical selection system of military flying cadets has developed rapidly, but such inefficiencies as low management efficiency, imperfect system, unreasonable specialist team composition and outdated equipment were still there. ②The recovery rate of 3 rounds questionnaire was 90.9%, 95.0% and 94.7% respectively and the harmonious coefficient was 0.543, 0.706 and 0.799. The specialists' feedbacks showed unisonous reliability (χ2=39.08, 50.82, 57.53, P<0.01). ③The determined construction of medical selection system of Air Force flying cadets included 5 primary indexes, 13 secondary indexes and 35 third class indexes. The primary indexes were the organization construction, system construction, team construction, equipment construction and business construction correspondingly with the weight of 0.162, 0.172, 0.400, 0.184 and 0.082. The final weight of index passed the coincidence test (CR<0.1). \u0000 \u0000 \u0000Conclusions \u0000This study builds an index system to evaluate the construction of medical selection system of Air Force flying cadets. The result of this study can provide the theoretical support and reference to the evaluation of the construction of medical selection system of Air Force flying cadets. \u0000 \u0000 \u0000Key words: \u0000Personnel selection; Organizations; Evaluation studies; Military personnel; Flying cadets","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"103 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89734821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation on vestibular autonomic reaction of fighter pilots by 3D vestibular trainer","authors":"Tao Jiang, Junling Wang, Wen Dong, Feng Shao, Fan Feng","doi":"10.3760/CMA.J.ISSN.1007-6239.2016.01.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2016.01.013","url":null,"abstract":"","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"55 1","pages":"60-62"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77290147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of hyperlipemia and metabolic diseases for navy pilots","authors":"Jiaxing Zhou","doi":"10.3760/CMA.J.ISSN.1007-6239.2015.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2015.02.005","url":null,"abstract":"Objective \u0000To make a survey on blood lipid levels and blood lipid abnormality classification of the navy pilots who transit to high performance fighter, to analyze the correlation to hyperuricemia (HUA), fatty liver and body mass index (BMI) excess, and to provide the basis for pilot health maintenance. \u0000 \u0000 \u0000Methods \u0000The blood lipid data of 128 navy pilots who transit to high performance fighter were retrospectively analyzed. Pilots were divided into hyperlipidemia and ortholiposis groups by blood fat level. The morbilities of hyperuricemia, fatty liver and BMI excess were compared between groups. \u0000 \u0000 \u0000Results \u0000In selected pilots, hyperlipidemia was accounted for 23.44% (30/128), in which hypertriglyceridemia (HTG), hypercholesteremia, low high-density lipoprotein cholesterolemia (LHDL-C) and combined hyperlipidemia (CHL) was respectively accounted for 14.06% (18/128), 7.03% (9/128), 1.56% (2/128) and 0.78% (1/128). In hyperlipidemia group, 70.00% pilots (21/30) showed BMI excess and 63.33% pilots (19/30) were diagnosed as fatty liver, those were significantly higher than that of ortholiposis group (χ2=15.755, 39.409, P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The morbility of hyperlipidemia in the navy pilots is high and closely correlated with BMI excess and fatty liver. It's suggested to strengthen the prevention of hyperlipidemia in navy transit pilots and to validate intervention as necessary in order to prolong pilot's career and ensure flight safety. \u0000 \u0000 \u0000Key words: \u0000Hyperlipidemia; Body mass index; Fatty liver; Hyperuricemia; Pilots","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"149 1","pages":"103-107"},"PeriodicalIF":0.0,"publicationDate":"2015-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75710149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential diagnosis of coronary heart disease in aircrews and medical evaluation","authors":"Jun Zheng, Xiaoguang Xiao, Heng Zhang, Jing Liu, Li Cui, Cong-chun Huang, Xian-rong Xu","doi":"10.3760/CMA.J.ISSN.1007-6239.2015.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2015.02.002","url":null,"abstract":"Objective \u0000To further determine the clinical checking procedure of coronary heart disease (CHD) in aircrews, and investigate possibility of the flying qualification for the military aircrew with CHD who has been cured. \u0000 \u0000 \u0000Methods \u0000Treadmill exercise test, coronary computed tomography angiography (CTA), single photon emission computed tomography (SPECT) myocardial perfusion imaging and coronary angiography were performed in 134 aircrews who were suspected with CHD, and their availability of the CHD diagnosis was evaluated. By following-up 8 flying qualified aircrews whose CHD had been cured, the flying adaptability was evaluated. \u0000 \u0000 \u0000Results \u0000The sensitivity of treadmill exercise test, coronary CTA, SPECT myocardial angiography and coronary angiography, was 66.7%, 88.9%, 50.0% and 94.4%, the specificity was 67.6%, 89.3%, 94.1% and 100.0%, the positive predictive value was 14.3%, 57.1%, 66.7% and 100.0%, and the negative predictive value was 96.2%, 98.0%, 88.9% and 95.2%, respectively. Eight flying qualified aircrew with CHD had returned to flying for 24-72 months and flied 40-150 h per year. Their state of illness was in stabilization and had a good flying adaptability. \u0000 \u0000 \u0000Conclusions \u0000Treadmill exercise test and coronary CTA can be used as effective methods to screen and exclude CHD in aircrew. Coronary angiography can be the method of finally diagnosing CHD. CHD cured aircrews who fly such airplane as transports and helicopters can be issued conditional qualification for the safety. \u0000 \u0000 \u0000Key words: \u0000Coronary disease; Diagnosis; Eligibility determination; Aircrews","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"2 1","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"2015-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76719247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases of pilots with amiodarone-induced thyroid dysfunction and literature review","authors":"Caizhe Yang, Yajing Yu, Xian-rong Xu, Jun Zheng, Hongjin Liu, Zhao-jun Fu, Li Cui, Xiaohong Guan","doi":"10.3760/CMA.J.ISSN.1007-6239.2015.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2015.02.007","url":null,"abstract":"Objective \u0000To summarize the clinic feature, diagnosis, treatment, and prognosis of amiodarone-induced thyroid dysfunction in the pilots with arrhythmia and gather the experiences on treatment and aviation medical assessment. \u0000 \u0000 \u0000Methods \u0000Retrospective analysis was done on the process of 2 cases with amiodarone induced abnormal thyroid function in pilots with atrial fibrillation and on the literatures to summary the clinic feature, diagnosis, treatment, and prognosis were reviewed. \u0000 \u0000 \u0000Results \u0000Case 1 had taken amiodarone for 7 months and low T3 syndrome was diagnosed 1 month later. Two years later, he took amiodarone again for 1 month and was induced type 2 thyrotoxicosis iodine. After he stopped taking amiodarone for 3 months his thyroid function returned to normal. Case 2 was diagnosed iodine induced hypothyroidism after intermittent taking amiodarone for 9 years. The patient changed to the treatment with 75 μg levothyroxine daily for 5 months and his thyroid function was in normal. By 2-year levothyroxine treatment his thyroid function completely recovered. Aviation medical assessment of two pilots is temporary dlisqualified as arrhythmias. \u0000 \u0000 \u0000Conclusions \u0000The thyroid related examination is necessary before taking amiodarone. In the treatment of amiodarone, or after withdrawal for 6-9 months or even longer, the regular follow-up is suggested, especially for the patients with thyroid diseases history and with risk factors. Amiodarone-induced abnormal thyroid function could be treated. The aviation medical assessment should be concerned arrhythmias and thyroid function. \u0000 \u0000 \u0000Key words: \u0000Amiodarone; Thyrotoxicosis; Hypothyroidism; Diagnosis; Treatment outcome; Pilots","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"33 1","pages":"113-118"},"PeriodicalIF":0.0,"publicationDate":"2015-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90331544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of astrocyte and microglia on spinal cord injury of the rabbits in decompression sickness","authors":"Cui-cui Wang, Xiaohong Liu, Yong-cheng Cao, L. Bi","doi":"10.3760/CMA.J.ISSN.1007-6239.2015.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-6239.2015.02.013","url":null,"abstract":"Objective \u0000To investigate the effects of astrocyte and microglia on spinal cord injury of the rabbits in decompression sickness (DCS). \u0000 \u0000 \u0000Methods \u0000Twenty-one healthy adult male New Zealand rabbits were averagely divided into 3 groups according to random number table: control group, safety relief group and DCS group. Experimental animals were placed in the pressure cabin. Safety relief group model referred to the Chinese Navy diving decompression tables when decompression applied. In DCS group, the pressure equably was increased to 0.8 MPa (absolute pressure) within 5 min by compressed air, maintained for 60 min and then equably decompressed to normal pressure within 5 min. The change of pathology morphology in the spinal cord of thoracolumbar vertebra was observed by light microscope. The expression of tumor necrosis factor-α (TNF-α) and Glial Fibrillary Acidic Protein (GFAP) mRNA were measured by real-time polymerase chain reaction (real-time PCR) and the expression of TNF-α, GFAP, ionized calcium binding adapter molecule 1 (IBA1) protein was measured by immunohistochemistry method. \u0000 \u0000 \u0000Results \u0000There were some cavity formations on white matter of spinal cord in DCS group. The relative expression of TNF-α mRNA was higher in DCS (6.28±1.73) than that in control group (1.00±0.14) and in safety relief group (1.34±0.42) (P<0.01). The relative expression of GFAP mRNA was higher in DCS (7.39±2.04) than in that control group (1.02±0.26) and in safety relief group (1.63±0.90) (P<0.01). The expression of TNF-α protein was significantly higher in DCS group (24.14±2.61) than that in control group (6.71±1.25) and in safety relief group (8.28±1.11) (P<0.01). The expression of GFAP protein was also significantly higher in DCS (18.20±4.38) than that in control group (4.30±2.70) and in safety relief group (6.20±2.92) (P<0.01). The expression of IBA1 protein was also significantly higher in DCS (21.53±1.37) than that in control group (5.94±0.36) and in safety relief group (6.69±0.81) (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The astrocyte and microglia may play a key role in pathophysiology of spinal cord injury. They are activated in the early stage of DCS and accompanied with massive release of TNF-α, which causes excessive inflammation reaction and induces the spinal cord injury finally. \u0000 \u0000 \u0000Key words: \u0000Decompression sickness; Spinal cord injuries; Astrocytes; Microglia; Tumor necrosis factor-alpha","PeriodicalId":9904,"journal":{"name":"Chinese Journal of Aerospace Medicine","volume":"94 1","pages":"135-139"},"PeriodicalIF":0.0,"publicationDate":"2015-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78595359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}