Chemical Engineering and Processing - Process Intensification最新文献_第2页

Numerical study on the flow and mixing characteristics of T-type micromixer with periodic 45° oblique helical groove 周期45°斜螺旋槽t型微混合器流动与混合特性的数值研究

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-30 DOI: 10.1016/j.cep.2026.110728

Xin Dong, Chong Dong, Ying Feng, Dongmao Yan, Jianwei Zhang

The mixing effect of a micromixer can be enhanced by the oblique helical flow, which is crucial for the application of passive micromixers in biopharmaceutical preparations. The T-type micromixer with periodic 45° oblique helical groove is proposed to improve the mixing performance. The effects of different Reynolds numbers and groove structure on vortex evolution and mixing performance of the micromixer is investigated by numerical simulation. The mixing performance of T-type micromixer with oblique helical groove is compared with conventional baffle and cylindrical obstacle mixers. The flow behavior, mixing uniformity, and pressure drop are analyzed. The results show that the stable annular vortices are induced by oblique helical groove, and the steady chaotic convection is formed at low Reynolds number (Re < 15). The Dean vortices superimpose in the same direction and scour the corners of the channel by the optimized four-wall helical groove, that the stagnant wake area effectively reduces. The mixing uniformity of T-type micromixer with oblique helical groove reaches 0.95 at Re = 15. The pressure drop and mixing uniformity of T-type micromixer with oblique helical groove are superior to the conventional micromixers. With the progressive flow transition mechanism, the energy utilization efficiency of the micromixer with oblique helical groove is effectively improved.

斜螺旋流可以增强微混合器的混合效果，这对于被动微混合器在生物制药制剂中的应用至关重要。为了提高混合性能，提出了带周期性45°斜螺旋槽的t型微混合器。通过数值模拟研究了不同雷诺数和沟槽结构对微混合器涡流演化和混合性能的影响。对斜螺旋槽t型微混合器的混合性能与常规挡板和圆柱障碍混合器进行了比较。对其流动特性、混合均匀性和压降进行了分析。结果表明：斜螺旋槽诱导出稳定的环形涡，低雷诺数（Re < 15）下形成稳定的混沌对流；迪安涡沿同一方向叠加，通过优化后的四壁螺旋槽冲刷通道转角，有效减小了滞流面积。斜螺旋槽t型微混合器在Re = 15时混合均匀性达到0.95。斜螺旋槽t型微混合器的压降和混合均匀性优于常规微混合器。斜螺旋槽微混合器采用进阶流动过渡机制，有效提高了其能量利用效率。

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引用次数: 0

Process intensification in co-production of plant and bacterial cellulose from citrus waste: A review 柑橘废弃物植物纤维素与细菌纤维素联产工艺强化研究进展

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-30 DOI: 10.1016/j.cep.2026.110730

Hanieh Ghorbani jafarbigloo, Alireza Chackoshian Khorasani

Bacterial cellulose (BC) offers remarkable properties such as biodegradability and biocompatibility, but its commercialization remains challenging due to high costs. A promising solution involves converting such as citrus waste (CW), into BC alongside other value-added products, enhancing sustainability and reducing expenses. While CW has been studied for plant cellulose extraction and limited BC production, existing reviews focus on pectin, polyphenols, or biofuels, neglecting combined plant cellulose and BC valorization. This review analyzes plant cellulose and BC production from CW, proposing an integrated approach. It evaluates physical, chemical, and biological extraction methods for plant cellulose, comparing efficiency and cost-effectiveness. For BC, key factors such as microbial strains, culture media, and process conditions are examined, with a performance comparison across methods. Challenges in scaling up production are also discussed. The study introduces a circular system: extracting plant cellulose as the primary product and converting residues into BC as a by-product. This dual approach improves sustainability, reduces fruit waste, and aligns with eco-economic goals—a gap unexplored in prior research. By optimizing waste utilization and lowering costs, this integrated model could advance bacterial and plant cellulose production while addressing environmental concerns.

细菌纤维素（BC）具有生物可降解性和生物相容性等显著特性，但由于成本高，其商业化仍具有挑战性。一个有希望的解决方案是将柑橘废弃物（CW）与其他增值产品一起转化为BC，从而提高可持续性并降低成本。虽然已经对植物纤维素提取和有限的BC生产进行了研究，但现有的综述主要集中在果胶、多酚或生物燃料上，而忽略了植物纤维素和BC的复合增值。本文对植物纤维素和BC的生产进行了分析，并提出了综合的方法。它评估了植物纤维素的物理、化学和生物提取方法，比较了效率和成本效益。对于BC，关键因素如微生物菌株、培养基和工艺条件进行了检查，并对不同方法进行了性能比较。还讨论了扩大生产的挑战。该研究介绍了一个循环系统：提取植物纤维素作为主要产品，将残留物转化为BC作为副产物。这种双重方法提高了可持续性，减少了水果浪费，并与生态经济目标保持一致-这是先前研究中未探索的空白。通过优化废物利用和降低成本，这种集成模型可以促进细菌和植物纤维素生产，同时解决环境问题。

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引用次数: 0

Enhancement of thin-film composite membrane properties and performance by using modified silicon dioxide for forward osmosis process 正渗透改性二氧化硅增强薄膜复合膜的性能

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-27 DOI: 10.1016/j.cep.2026.110726

Dhiyaa A. Hussein Al-Timimi , Maryam Y. Ghadhban , Afraa H. Kamel , Qusay F. Alsalhy , Amir Jangizehi , Seyed Abdollatif Hashemifard , Alireza Shakeri , Christoph Bantz , Michael Maskos , Sebastian Seiffert

The economic and environmental costs are one of the important factors to take into account before any membrane separation-based method is commercialized. Achieving this objective depends partially on the role that fabrication and operating factors play. For the water desalination purpose, we presented a methodical study for the construction of thin-film composite (TFC)-forward osmosis (FO) membranes. Meanwhile, the surface properties of the manufactured TFC membranes were inspected through a series of characterization methods. The influence of incorporating polyethyleneimine (PEI)-modified silicon dioxide (SiO₂) nanoparticles into the substrate, m-phenylenediamine (MPD) aqueous solution, and trimesoyl chloride (TMC) organic phase was analyzed. To optimize the FO membrane performance, the PES substrate porous structure were manipulated via the polymer concentration and fixed amount of modified SiO₂ nanoparticles. Likewise, the influence of membrane orientation, feed solution concentration, draw solute, and flow rate on the FO process were systematically investigated. The outcomes revealed that the modified NPs and the host polymer composition of the porous structure-substrate membrane significantly impacted the potential to customize the TFC-FO performance in terms of permeability and reverse salt flux. For substrate membrane with 16% PES and 0.7% modified nanoparticles (M1), the water flow enhanced by about 700% (reach 151.7 ±2.2 (liter/m² hr) LMH than the pristine membrane M0, which had a value of 20.1 ±3.1 LMH). Similarly, for AL-FS orientation, the water flux for the TFC1 (16% PES and 0.7% modified nanoparticles for substrate) membrane reported an enhancement by about 200% with about the same reverse salt flux (RSF), that reach 12.71 LMH and an RSF of 1.6 gMH, comparing with pristine membrane TFC0 (16% PES and without modified nanoparticles for substrate) that has just 3.9 LMH and RSF of 1.5 gMH. These results reveal an excellent potential for SiO₂-PEI on tailored membrane performance and considerably outperform those achieved by pure PES substrate membrane.

经济和环境成本是任何基于膜分离的方法商业化之前需要考虑的重要因素之一。实现这一目标部分取决于制造和操作因素所起的作用。为了实现海水淡化的目的，我们对薄膜复合(TFC)-正向渗透（FO）膜的构建进行了系统的研究。同时，通过一系列表征方法对制备的TFC膜的表面性能进行了检测。分析了在底物、间苯二胺（MPD）水溶液和三甲酰氯（TMC）有机相中掺入聚乙烯亚胺（PEI）修饰的二氧化硅（SiO₂）纳米颗粒对其性能的影响。为了优化FO膜的性能，通过聚合物浓度和一定量的改性sio2纳米颗粒来调控PES衬底的多孔结构。同样，系统地研究了膜取向、进料溶液浓度、提取溶质和流速对FO过程的影响。结果表明，改性的NPs和多孔结构-基质膜的宿主聚合物组成显著影响了TFC-FO在渗透性和反盐通量方面的定制性能。在基质膜中添加16% PES和0.7%修饰纳米颗粒（M1）时，其水流量比原始膜（20.1±3.1 LMH）提高了约700%（达到151.7±2.2 (l /m2 hr) LMH）。同样，对于AL-FS取向，与原始膜TFC0 （16% PES和未修饰底物纳米颗粒）相比，TFC1 （16% PES和0.7%修饰底物纳米颗粒）的水通量提高了约200%，其反盐通量（RSF）达到12.71 LMH， RSF为1.6 gMH，而原始膜TFC0 （16% PES和未修饰底物纳米颗粒）的水通量只有3.9 LMH， RSF为1.5 gMH。这些结果表明，SiO2-PEI在定制膜性能方面具有良好的潜力，并且大大优于纯PES衬底膜。

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引用次数: 0

Mechanochemical dephosphorization and ultrasound-intensified leaching of rare earths from low-thorium monazite ore 低钍独居石中稀土的机械化学脱磷及超声强化浸出

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-26 DOI: 10.1016/j.cep.2026.110723

Azadeh Khoshoei , Sachin Samarakone , Sasan Fazeli , Aurélien Bréant , Ahmed Bouajila , Daria C. Boffito

The recovery of rare earth elements (REEs) from monazite ore was studied using ultrasound-assisted leaching (UL) and compared with silent leaching (SL). The UL experiments were conducted using a 40-mm diameter Monel alloy horn at 20 kHz, with power densities of 142 - 232 W/L. SL with H₂SO₄ yielded <3% recovery for all REEs, whereas UL enhanced dissolution within 10 min, (8.5% Ce, 7.0% Nd, 8.8% La) via cavitation-induced particle breakdown, confirmed by Scanning Electron Microscopy (SEM). Using 62% H₂SO₄, optimization achieved maximum recoveries: 20.5% Ce, 17.2% Nd, 22.0% La, 16.3% Pr, and 17.9% Sm. Recovery increased with ultrasound power density up to 206 W/L (26.2% La) and decreased at higher values due to cavitation shielding and nuclei removal.

NaOH pretreatment via dry ball milling removed ⁓ 95% of phosphate with minimal REE loss. Among acids tested under SL (6 mol L^-1, 60 °C, 30 min), HNO₃ achieved > 95% recovery from phosphate-free monazite, compared to <10% for crude ore. Applying ultrasound to phosphate-free monazite accelerated leaching, yielding 55–92% recovery of Ce-Sm in 10 min and 72–94% after 30 min. Enhanced kinetics arising from improved ore disintegration, phosphate removal, and optimized acid conditions provide a rapid, scalable REEs recovery strategy.

研究了超声辅助浸出法（UL）从独居石矿石中回收稀土元素，并与无声浸出法（SL）进行了比较。UL实验采用直径40 mm的蒙奈尔合金喇叭，功率密度为142 ~ 232 W/L，工作频率为20 kHz。扫描电子显微镜（SEM）证实，与H₂SO₄混合的SL对所有稀土元素的回收率为<；3%，而UL通过空化诱导的颗粒击穿，在10 min内增强了（8.5% Ce, 7.0% Nd, 8.8% La）的溶解。使用62%的H₂SO₄优化后，Ce、Nd、La、Pr、Sm的回收率分别为20.5%、17.2%、22.0%、16.3%和17.9%。当超声功率密度达到206 W/L （26.2% La）时，回收率增加，而在更高的功率密度下，由于空化屏蔽和去核而降低。氢氧化钠预处理通过干球磨去除⁓95%的磷酸盐，稀土损失最小。在SL （6 mol L-1, 60°C, 30 min）条件下测试的酸中，HNO₃对无磷独居石的回收率为>； 95%，而对粗矿石的回收率为<；10%。将超声波应用于无磷独居石加速浸出，10 min内铈-钐的回收率为55-92%，30 min后回收率为72-94%。矿石崩解、磷酸盐去除和酸条件优化带来的动力学增强，提供了快速、可扩展的稀土回收策略。

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引用次数: 0

Hydrodynamic cavitation-assisted biodiesel production from waste oils: A scalable strategy with fuel quality enhancement 水动力空化辅助从废油生产生物柴油：提高燃料质量的可扩展策略

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-24 DOI: 10.1016/j.cep.2026.110721

Nirav Prajapati , Surendra Singh Kachhwaha , Pravin Kodgire , Rakesh Kumar Vij , Jeffrey S. Cross

Despite extensive research in biodiesel synthesis, there is a notable scarcity of pilot-scale studies that integrate hydrodynamic cavitation (HC), individually with mixed-alcohol transesterification, as well as high-free fatty acid (FFA) feedstock blends, along with experimentally validated property improvements and rigorous techno-economic analysis (TEA). This study reports, for the first time, the use of a 100-L pilot scale HC system incorporating a 32-hole orifice for biodiesel production from low-FFA waste cooking oil (WCO) evaluated through two distinct data sets: (i) high-FFA rice bran acid oil (RAO) blending using a two-step esterification followed by transesterification, and (ii) equimolar methanol-ethanol transesterification. The first run produced an FFA conversion of 96.87 ± 0.6 %, along with a biodiesel yield of 92.86 ± 0.5 % and an overall yield efficiency of 0.40 × 10^-3 kg/kJ, whereas the second run achieved a biodiesel yield of 93.52 ± 0.5 % and a yield efficiency of 0.76 × 10^-3 kg/kJ. Both runs demonstrated enhancements in the physicochemical properties of produced biodiesel with all measured values complying with ASTM D6751 and EN 14214 standards. TEA results indicated high profitability, evidenced by robust return on investment (ROI), internal rate of return (IRR), energy return on investment (EROI), and payback values, along with strong scalability for both data sets.

尽管在生物柴油合成方面进行了广泛的研究，但明显缺乏将流体动力空化（HC）单独与混合醇酯交换以及高游离脂肪酸（FFA）原料混合物结合起来的中试规模研究，以及经过实验验证的性能改进和严格的技术经济分析（TEA）。本研究首次报道了使用100 l中试规模HC系统（包含32孔孔）从低ffa废食用油（WCO）生产生物柴油，通过两个不同的数据集进行评估：(i)高ffa米糠酸油（RAO）混合使用两步酯化和酯交换，以及（ii）等摩尔甲醇-乙醇酯交换。第一次运行的FFA转化率为96.87±0.6%，生物柴油收率为92.86±0.5%，总产率为0.40 × 10-3 kg/kJ，而第二次运行的生物柴油收率为93.52±0.5%，产率为0.76 × 10-3 kg/kJ。两次运行都证明了生产的生物柴油的物理化学特性的增强，所有测量值都符合ASTM D6751和EN 14214标准。TEA结果表明高盈利能力，证明了强劲的投资回报率（ROI）、内部回报率（IRR）、能源投资回报率（EROI）和回报值，以及两个数据集的强大可扩展性。

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引用次数: 0

Integrated pretreatment–membrane systems for water and wastewater treatment: A critical review on fouling control and combined process efficiency 水和废水处理的集成预处理-膜系统：污染控制和组合工艺效率综述

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-24 DOI: 10.1016/j.cep.2026.110722

Shikha Jha , Aditya Tripathi, Brijesh Kumar Mishra

Membrane technologies such as microfiltration, ultrafiltration, nanofiltration, and reverse osmosis are widely used for water and wastewater treatment due to their high separation efficiency of pollutants. However, membrane fouling remains the inherent challenge, leading to reduced flux, higher energy demand, and frequent chemical cleaning. Pretreatment plays an important role in controlling fouling, improving membrane lifespan, and maintaining stable operation. This review presents a comprehensive overview of state-of-the-art pretreatment approaches, ranging from conventional methods such as coagulation–flocculation, sedimentation, and adsorption to advanced processes like electrocoagulation, oxidation, biological pretreatment, and others. Particular emphasis is given on how different pretreatment methods target specific foulants, such as suspended solids, organic and inorganic matter, colloids, and biofilm-forming microorganisms, and reduce the type of pollutants. The effectiveness of each strategy in combination with the membrane filtration process is critically discussed in enhancing pollutant removal, reducing fouling propensity, and improving overall sustainability of the system. Further, the review discusses a rationale behind choosing a pretreatment process based on types of water, environmental sustainability, cost-effectiveness, and other factors. It concludes with the future research directions aimed at developing energy-efficient, cost-effective, and environmentally sustainable pretreatment technologies for the membrane filtration process.

膜技术如微滤、超滤、纳滤、反渗透等因其对污染物的分离效率高而被广泛应用于水和废水处理。然而，膜污染仍然是固有的挑战，导致通量降低，更高的能源需求和频繁的化学清洗。预处理对控制膜污染、提高膜寿命、维持膜稳定运行具有重要作用。这篇综述全面概述了最先进的预处理方法，从传统的方法，如混凝-絮凝、沉淀和吸附，到先进的工艺，如电凝、氧化、生物预处理等。特别强调了不同的预处理方法如何针对特定的污染物，如悬浮固体、有机和无机物、胶体和形成生物膜的微生物，并减少污染物的类型。每种策略与膜过滤过程相结合的有效性在增强污染物去除，降低污染倾向和提高系统的整体可持续性方面进行了严格讨论。此外，本文还讨论了基于水的类型、环境可持续性、成本效益和其他因素选择预处理工艺的基本原理。展望了未来的研究方向，即开发高效、经济、环保的膜过滤预处理技术。

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引用次数: 0

Study on the characteristics of phenol degradation by microwave radiation over NiO/BC catalyst NiO/BC催化剂微波辐射降解苯酚的特性研究

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-23 DOI: 10.1016/j.cep.2026.110720

JIANG Xi , PANG Yunji , ZHANG Tiejun

This study prepared a biochar-supported nickel oxide (NiO/BC) catalyst for the microwave-catalyzed degradation of gaseous phenol, aiming to investigate the degradation mechanism and pathway regulation. By optimizing preparation and reaction parameters, it was found that at a Ni loading of 6 wt% and a microwave power of 480 W, the gas-phase products accounted for 98.6% of the total products, with optimal selectivity for H₂ and CO in the syngas. Characterization results indicated that NiO was in-situ reduced to metallic Ni nanoparticles during the reaction, forming the key catalytically active centers that synergistically catalyzed cracking and hydrogenation reactions. This process primarily converted phenol into syngas (H₂ + CO) and long-chain alkanes (tetradecane). The study further revealed that excessively high microwave power caused the sintering of Ni particles, resulting in catalyst deactivation. This research elucidates the dynamic evolution of the catalyst under microwave irradiation and the directed conversion mechanism of phenol, providing a scientific basis for developing efficient and stable microwave-catalyzed technologies for the resource treatment of organic pollutants.

本研究制备了一种生物炭负载的氧化镍（NiO/BC）催化剂，用于微波催化降解气态苯酚，旨在探讨其降解机理和途径调控。通过对制备工艺和反应参数的优化，发现在Ni负载为6 wt%、微波功率为480 W时，气相产物占总产物的98.6%，对合成气中的H₂和CO具有最佳的选择性。表征结果表明，NiO在反应过程中被原位还原为金属镍纳米粒子，形成了关键的催化活性中心，协同催化裂化和加氢反应。该过程主要将苯酚转化为合成气（h2 + CO）和长链烷烃（十四烷）。研究进一步发现，过高的微波功率导致Ni颗粒烧结，导致催化剂失活。本研究阐明了微波辐照下催化剂的动态演化和苯酚的定向转化机理，为开发高效、稳定的微波催化有机污染物资源化处理技术提供了科学依据。

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引用次数: 0

Recent Advances in the continuous synthesis of zeolite using tubular reactor 管式反应器连续合成沸石的研究进展

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-21 DOI: 10.1016/j.cep.2026.110719

Jialong Liu, Subing Fan, Yurong He, Junmin Lv

Zeolite has broad applications in the fields of catalysis and adsorption separation. The conventional batch synthesis process suffers from drawbacks such as low efficiency, complex operation and inconsistent product quality. Therefore, developing reliable and efficient zeolite synthesis routes has become a research hotspot in recent years. Compared to traditional batch reactors, tubular reactor offers superior heat and mass transfer performance, playing a crucial role in process intensification for zeolite synthesis. Continuous synthesis in tubular reactors is a potential effective route, as it not only significantly reduces crystallization time and improves space-time yield but also ensures consistent product quality across batches. Based on recent advances in this field, this review mainly introduces the reactor configurations for continuous zeolite synthesis in tubular systems, discusses the advantages of the synthesis process and product characteristics, clarifies the crystallization mechanisms of zeolites under continuous flow conditions, and especially emphasizes the reasons and solutions to the key problem of pipeline clogging in this process. Furthermore, perspectives on future research and industrial applications are suggested.

沸石在催化和吸附分离等领域有着广泛的应用。传统的间歇合成工艺存在效率低、操作复杂、产品质量不稳定等缺点。因此，开发可靠高效的沸石合成路线成为近年来的研究热点。与传统间歇式反应器相比，管式反应器具有优越的传热传质性能，在沸石合成过程强化中起着至关重要的作用。管式反应器连续合成是一种潜在的有效途径，它不仅显著缩短了结晶时间，提高了空时产率，而且保证了批次间产品质量的一致性。综述了近年来该领域的研究进展，主要介绍了管状系统连续合成沸石的反应器配置，讨论了合成工艺的优点和产品特性，阐明了沸石在连续流条件下的结晶机理，重点介绍了该工艺中管道堵塞的关键问题的原因和解决方法。最后，对今后的研究和工业应用提出了展望。

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引用次数: 0

Recent advances in macroalgae–plastic co-pyrolysis for high-quality fuel production 巨藻-塑料共热解制备高质量燃料的研究进展

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-20 DOI: 10.1016/j.cep.2026.110713

Apip Amrullah , Jingang Yao , Motasem Y.D. Alazaiza , Obie Farobie

The global accumulation of plastic waste and the underutilization of macroalgae pose significant environmental challenges. Co-pyrolysis, a thermochemical process, has shown promise in converting these waste streams into high-quality biofuels. This review specifically focuses on macroalgae-plastic co-pyrolysis, a distinct area which differs from broader biomass-plastic studies because of the unique chemical composition and thermal behavior of macroalgae. We explored the synergistic effects during co-pyrolysis, such as enhanced bio-oil yield (typically 10–25% compared to biomass alone), improved heating value, and reduced oxygen content, driven by mechanisms such as hydrogen donation from plastics and mineral-catalyzed cracking from macroalgae ash. Recent studies have demonstrated that co-pyrolysis of macroalgae and plastics can lead to significant improvements in bio-oil yield compared to biomass-only pyrolysis. Co-pyrolysis typically results in a 10–25% increase in bio-oil yield, enhanced heating values, and reduced oxygen content in the bio-oil. This synergistic effect arises from the interaction between the oxygen-rich volatiles from macroalgae and the hydrogen-rich radicals from plastics, which facilitates polymer degradation and improves the thermal characteristics of the pyrolysis process. Several studies have observed improvements in bio-oil quality, with some noting substantial increases in the carbon content of the oil, thus enhancing its calorific value. Unlike previous reviews that generally cover biomass-plastic co-pyrolysis, this study emphasizes the specific interactions between macroalgae and plastics, with a focus on feedstock characteristics, reaction mechanisms, and strategies for optimizing product yield and quality. Key strategies, including optimal feedstock ratios, temperature ranges, and catalyst types, are discussed in detail. The novelty of this review lies in its comprehensive synthesis of the specific mechanisms that enhance the co-pyrolysis process, offering new insights into this promising yet underexplored field. Despite the potential, challenges such as feedstock variability, catalyst deactivation, and scale-up issues remain, and future research directions to address these barriers are outlined.

塑料废物的全球积累和大型藻类的利用不足构成了重大的环境挑战。共热解是一种热化学过程，有望将这些废物转化为高质量的生物燃料。这篇综述特别关注了巨藻-塑料共热解，这是一个不同于更广泛的生物质-塑料研究的独特领域，因为巨藻的独特化学成分和热行为。我们探索了共热解过程中的协同效应，如提高生物油收率（与单独的生物质相比通常为10-25%）、提高热值和降低氧含量，这是由塑料的氢捐赠和大型藻类灰的矿物催化裂解等机制驱动的。最近的研究表明，与仅热解生物质相比，大型藻类和塑料的共热解可以显著提高生物油的产量。共热解通常会导致生物油收率提高10-25%，热值提高，生物油中的氧含量降低。这种协同效应源于大型藻类的富氧挥发物与塑料中的富氢自由基的相互作用，促进了聚合物的降解，改善了热解过程的热特性。一些研究已经观察到生物油质量的改善，其中一些注意到油的碳含量大幅增加，从而提高了其热值。与以往关于生物质-塑料共热解的综述不同，本研究强调了大型藻类与塑料之间的具体相互作用，重点关注原料特性、反应机制以及优化产品产量和质量的策略。关键策略，包括最佳进料比，温度范围和催化剂类型，详细讨论。这篇综述的新颖之处在于它全面综合了增强共热解过程的具体机制，为这一有前途但尚未开发的领域提供了新的见解。尽管具有潜力，但诸如原料可变性、催化剂失活和放大问题等挑战仍然存在，并概述了未来解决这些障碍的研究方向。

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引用次数: 0

Design, optimization and manufacturing of a novel microfluidic device for nano-andrographolide preparation 新型纳米穿心莲内酯制备微流控装置的设计、优化与制造

IF 3.9 3区工程技术 Q3 ENERGY & FUELS

Chemical Engineering and Processing - Process Intensification

Pub Date : 2026-01-20 DOI: 10.1016/j.cep.2026.110718

Yimin Wei , Chen Gong , Su Wang , Xin Yuan , Yirong Feng , Ning Zhu , Wei He , Shuangfei Zhao

Precise management of particle size and distribution is crucial for nanomedicine performance. In this study, using the anti-cancer medicine andrographolide as a typical insoluble medicine, we present a systematic approach to the design, optimization, and manufacturing of a novel microfluidic device for high-throughput and size-tunable preparation of nanomedicines. By integrating Central Composite Rotatable Design (CCRD) with computational fluid dynamics (CFD), we designed and optimized a new microfluidic structure. The optimized structure demonstrated superior mixing efficiency and low pressure drop in water-water systems, achieving a higher performance index (PI) in oil-ethanol systems compared to existing microdevices. The microfluidic field device achieves size-tunable preparation of nano-andrographolide (about 7.9 nm), which is reduced to 1.4% of the traditional method. This innovative method has the potential to advance the field of nanomedicine manufacturing.

对颗粒大小和分布的精确管理对纳米药物的性能至关重要。在本研究中，我们以抗癌药物穿心莲内酯为典型的不溶性药物，系统地设计、优化和制造了一种新型的微流控装置，用于高通量和尺寸可调的纳米药物制备。将中心复合可旋转设计（CCRD）与计算流体力学（CFD）相结合，设计并优化了一种新型微流控结构。优化后的结构在水-水系统中表现出优异的混合效率和低的压降，与现有的微装置相比，在油-乙醇系统中实现了更高的性能指数（PI）。微流控场装置实现了纳米穿心莲内酯（约7.9 nm）的尺寸可调制备，将制备工艺降低到传统方法的1.4%。这种创新的方法有可能推动纳米药物制造领域的发展。

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