Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.014
Zhuhua Liu, Jie Xu, Yi Li, Wei Guo
Objective To explore the mediating effect of interpersonal sensitivity between social adaptation and openness, as well as the moderating role of peer attachment among offenders in community. Methods Totally 155 offenders from 5 communities in Yinchuan city were investigated by symptom self-rating scale, NEO five-factor inventory(NEO-FFI), social adaptability scale and the inventory of parent and peer attachment-revised. Using the macro program PROCESS of SSPS to test the mediating effect of interpersonal sensitivity and the moderating role of peer trust. Results The scores of interpersonal sensitive subscale of the symptom checklist 90, the openness subscale of NEO five-factor inventory, the inventory of parent and peer attachment-revised were (1.52±0.48), (3.05±0.30), (0.72±0.60) and (83.40±12.17), respectively. Openness, peer attachment were positively correlated with social adaptation (r=0.25, 0.44, P<0.01), and negatively correlated with interpersonal sensitivity (r=-0.18, -0.37, P<0.05). Interpersonal sensitivity was negatively correlated with social adaptation (P<0.01). Peer trust had a significant moderating effect on openness and interpersonal sensitivity (β=0.02, SE=0.01, P<0.05). Interpersonal sensitivity played a mediating role in the relationship between openness and social adaptation (β=-0.38, SE=0.10, P<0.01). In case of high peer trust(β=-0.59, SE=0.19, P<0.001) and mid-level of peer trust(β=-0.28, SE=0.11, P<0.05), there were both significant effect between openness and social adaptation. Conclusion Openness influences the social adaptation though interpersonal sensitivity, while peer trust moderates the effect of openness on social adaptation. Key words: Openness; Interpersonal sensitivity; Community correction staff; Peer trust; Mediating effect; Moderating role
{"title":"The relationship between openness and social adaptation among offenders in community: the mediating role of interpersonal sensitivity and the moderating role of peer trust","authors":"Zhuhua Liu, Jie Xu, Yi Li, Wei Guo","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.014","url":null,"abstract":"Objective \u0000To explore the mediating effect of interpersonal sensitivity between social adaptation and openness, as well as the moderating role of peer attachment among offenders in community. \u0000 \u0000 \u0000Methods \u0000Totally 155 offenders from 5 communities in Yinchuan city were investigated by symptom self-rating scale, NEO five-factor inventory(NEO-FFI), social adaptability scale and the inventory of parent and peer attachment-revised. Using the macro program PROCESS of SSPS to test the mediating effect of interpersonal sensitivity and the moderating role of peer trust. \u0000 \u0000 \u0000Results \u0000The scores of interpersonal sensitive subscale of the symptom checklist 90, the openness subscale of NEO five-factor inventory, the inventory of parent and peer attachment-revised were (1.52±0.48), (3.05±0.30), (0.72±0.60) and (83.40±12.17), respectively. Openness, peer attachment were positively correlated with social adaptation (r=0.25, 0.44, P<0.01), and negatively correlated with interpersonal sensitivity (r=-0.18, -0.37, P<0.05). Interpersonal sensitivity was negatively correlated with social adaptation (P<0.01). Peer trust had a significant moderating effect on openness and interpersonal sensitivity (β=0.02, SE=0.01, P<0.05). Interpersonal sensitivity played a mediating role in the relationship between openness and social adaptation (β=-0.38, SE=0.10, P<0.01). In case of high peer trust(β=-0.59, SE=0.19, P<0.001) and mid-level of peer trust(β=-0.28, SE=0.11, P<0.05), there were both significant effect between openness and social adaptation. \u0000 \u0000 \u0000Conclusion \u0000Openness influences the social adaptation though interpersonal sensitivity, while peer trust moderates the effect of openness on social adaptation. \u0000 \u0000 \u0000Key words: \u0000Openness; Interpersonal sensitivity; Community correction staff; Peer trust; Mediating effect; Moderating role","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1131-1135"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44895057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the changes of brain activity in adolescents with first-episode major depressive disorder (MDD) and its significance. Methods Totally 42 first-episode MDD patients with suicidal ideation (SU group), 17 MDD patients without suicidal ideation (NSU group) and 29 healthy controls (HC group) were examined by psychological assessment and resting-state functional magnetic resonance imaging (fMRI). The differences of brain functional activities between the three groups were compared by amplitude of low frequency fluctuation(ALFF). The relationship between the difference of zALFF value in brain regions and the severity of depression, intensity of suicidal ideation were further analyzed. Results The zALFF values in the left hippocampus(MNI: x=-21, y=-33, z=0) and left Frontal_Sup_Medial(MNI: x=3, y=33, z=63) of the three groups were significantly abnormal (P 20, uncorrected). The results of Post-hoc test showed that the zALFF value of left hippocampus increased significantly (F=28.931) and decreased significantly in left Frontal_Sup_Medial(F=16.648)in SU group , compared with NSU group and HC group(P 0.05). In SU group, the zALFF values of left hippocampus and left Frontal_Sup_Medial were not correlated with total scores of HAMD-24(r=-0.214, -0.103) and suicide ideation intensity factor scores(r=0.115, -0.055)(P>0.05). Conclusion Abnormal autonomic nervous activity exists in left hippocampus and left Frontal_Sup_Medial in adolescent MDD patients with suicidal ideation, which may be the neurological basis and biological index of suicidal ideation. Key words: Major depressive disorder; Suicidal ideation; Adolescents; Amplitude of low frequency fluctuation
{"title":"The changes of amplitude of low frequency fluctuation in adolescent depression patients with suicidal ideation: a resting-state functional magnetic resonance imaging study","authors":"Hongqing Pan, Shuying Li, Yuanli Wang, Peipei Lyu, Feiyan Li, Yao Zhang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.007","url":null,"abstract":"Objective \u0000To investigate the changes of brain activity in adolescents with first-episode major depressive disorder (MDD) and its significance. \u0000 \u0000 \u0000Methods \u0000Totally 42 first-episode MDD patients with suicidal ideation (SU group), 17 MDD patients without suicidal ideation (NSU group) and 29 healthy controls (HC group) were examined by psychological assessment and resting-state functional magnetic resonance imaging (fMRI). The differences of brain functional activities between the three groups were compared by amplitude of low frequency fluctuation(ALFF). The relationship between the difference of zALFF value in brain regions and the severity of depression, intensity of suicidal ideation were further analyzed. \u0000 \u0000 \u0000Results \u0000The zALFF values in the left hippocampus(MNI: x=-21, y=-33, z=0) and left Frontal_Sup_Medial(MNI: x=3, y=33, z=63) of the three groups were significantly abnormal (P 20, uncorrected). The results of Post-hoc test showed that the zALFF value of left hippocampus increased significantly (F=28.931) and decreased significantly in left Frontal_Sup_Medial(F=16.648)in SU group , compared with NSU group and HC group(P 0.05). In SU group, the zALFF values of left hippocampus and left Frontal_Sup_Medial were not correlated with total scores of HAMD-24(r=-0.214, -0.103) and suicide ideation intensity factor scores(r=0.115, -0.055)(P>0.05). \u0000 \u0000 \u0000Conclusion \u0000Abnormal autonomic nervous activity exists in left hippocampus and left Frontal_Sup_Medial in adolescent MDD patients with suicidal ideation, which may be the neurological basis and biological index of suicidal ideation. \u0000 \u0000 \u0000Key words: \u0000Major depressive disorder; Suicidal ideation; Adolescents; Amplitude of low frequency fluctuation","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1091-1095"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45944437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.009
Yong Li, Xiaoyin Cong, Dan-jun He, Yinghui Li
Objective To evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD). Methods Totally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention. Results After 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05). Conclusion CBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function. Key words: Functional dyspepsia; Cognitive-behavior therapy; Randomized single-blind controlled trials; Emotional symptoms; Gastrointestinal symptoms
目的评价认知行为疗法(CBT)联合米氮平治疗功能性消化不良(FD)的疗效。方法收集某综合医院临床精神病学门诊符合罗马Ⅳ诊断标准的FD患者121例。随机分为联合治疗组(n=61)和单药组(n=60)。治疗期8周。所有FD患者均给予米氮平治疗。联合治疗组同时接受8次全身CBT治疗。对所有患者进行干预前和干预后8周的症状量表-90 (SCL-90)和胃肠积分量表(GIS)评估。结果干预8周后，联合治疗组SCL-90量表、躯体化、强迫、抑郁、偏执等因素总分低于单独治疗组(分别为130.26±36.18 vs 147.95±45.55、1.34±0.44 vs 1.51±0.5、1.66±0.50 vs 1.90±0.66、1.47±0.52 vs 1.69±0.63、1.48±0.49 vs 1.70±0.61、1.47±0.50 vs 1.73±0.68)，差异均有统计学意义(P<0.05)。干预8周后，联合用药组GIS量表总分(6.77±5.05 vs 9.49±5.24)、呕吐总分(0.57±0.77 vs 0.88±0.91)、痉挛性上腹痛总分(0.43±0.74 vs 0.90±1.08)、胸骨后不适总分(0.57±0.89 vs 1.05±1.19)均显著低于干预后单纯用药组(分别为6.77±5.05 vs 9.49±5.24、0.57±0.77 vs 0.88±0.91、0.43±0.74 vs 0.90±1.08、0.57±0.89 vs 1.05±1.19)。差异均有统计学意义(P<0.05)。结论CBT联合米氮平治疗FD优于单纯药物治疗。CBT联合米氮平可改善FD治疗中的情绪问题，进一步改善消化功能。关键词:功能性消化不良;将认知-行为疗法;随机单盲对照试验;情感症状;胃肠道症状
{"title":"Effect of cognitive-behavior therapy combined with mirtazapine on clinical efficacy in patients with functional dyspepsia","authors":"Yong Li, Xiaoyin Cong, Dan-jun He, Yinghui Li","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.009","url":null,"abstract":"Objective \u0000To evaluate the efficacy of cognitive-behavioral therapy (CBT) combined with mirtazapine for patients with functional dyspepsia (FD). \u0000 \u0000 \u0000Methods \u0000Totally 121 patients with FD who met Rome Ⅳ diagnostic criteria in clinic of clinical psychiatry of a general hospital were collected.They were randomly divided into combined treatment group(n=61) and single drug group(n=60). The treatment period was 8 weeks.All patients with FD were given mirtazapine.The combined treatment group received 8 times systemic CBT treatments at the same time.Symptom checklist-90 (SCL-90) and gastrointestinal integral scale (GIS) were evaluated in all patients before and after 8-week intervention. \u0000 \u0000 \u0000Results \u0000After 8 weeks of intervention, the total score of SCL-90 scale, somatization, compulsion, depression, paranoia and other factors in the combined treatment group were lower than those in the single group(130.26±36.18 vs 147.95±45.55, 1.34±0.44 vs 1.51±0.5, 1.66±0.50 vs 1.90±0.66, 1.47±0.52 vs 1.69±0.63, 1.48±0.49 vs 1.70±0.61, 1.47±0.50 vs 1.73±0.68, respectively)(all P<0.05). After 8 weeks of intervention, the total score of the GIS scale in the combined treatment group (6.77±5.05 vs 9.49±5.24), vomiting (0.57±0.77 vs 0.88±0.91), spastic upper abdominal pain (0.43±0.74 vs 0.90±1.08) and post-sternal discomfort (0.57±0.89 vs 1.05±1.19) were significantly lower than that of the simple drug group after intervention(6.77±5.05 vs 9.49±5.24, 0.57±0.77 vs 0.88 ±0.91, 0.43±0.74 vs 0.90±1.08 and 0.57±0.89 vs 1.05±1.19, respectively), and the differences were statistically significant (all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000CBT combined with mirtazapine in the treatment of FD is superior to drug therapy alone.CBT combined with mirtazapine can improve the emotional problems in the treatment of FD and further improving the digestive function. \u0000 \u0000 \u0000Key words: \u0000Functional dyspepsia; Cognitive-behavior therapy; Randomized single-blind controlled trials; Emotional symptoms; Gastrointestinal symptoms","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1102-1107"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47679825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.003
Qing Wu, Ying Wang, Haining Yu
Objective To investigate the event-based prospective memory(EBPM) and time-based prospective memory(TBPM) in patients with euthymic bipolar disorder and to explore the relationships between prospective memory and temperament. Methods Fifty patients with euthymic bipolar disorder(case group) and forty-five demographic characteristic matched healthy controls(control group) were recruited.The neuropsychological battery of tests including EBPM and TBPM tasks were used to measured the prospective memory, and all participants completed the Chinese version of short temperament evaluation of the memphis(TEMPS-A). The differences in prospective memory and temperament between the case group and control group were compared by t test.Pearson correlation analysis was used to analyze the correlation between prospective memory and temperament. Results A statistically significant in EBPM was observed between patients with euthymic bipolar disorder and health controls ((3.66±0.69) vs (4.18±0.83), t=-3.313, P<0.01) and the same result was showed in TBPM ((3.06±0.96) vs (3.89±0.75), t=-4.674, P<0.01). The total score of TEMPS-A ((18.82±4.49) vs (9.69±3.37), t=11.106, P<0.01) and the scores of all the subscales were higher in case group than those in control group.The negative correlation was showed between the scores of depression temperament and TBPM (r=-0.425, P=0.002) in the case group. Conclusion The results suggest both EBPM and TBPM have impaired, and TBPM correlates with depression temperament moderately in the patients with euthymic bipolar disorder. Key words: Bipolar disorder; Prospective memory; Temperament
{"title":"Relationship between prospective memory and temperament in patients with euthymic bipolar disorder","authors":"Qing Wu, Ying Wang, Haining Yu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.003","url":null,"abstract":"Objective \u0000To investigate the event-based prospective memory(EBPM) and time-based prospective memory(TBPM) in patients with euthymic bipolar disorder and to explore the relationships between prospective memory and temperament. \u0000 \u0000 \u0000Methods \u0000Fifty patients with euthymic bipolar disorder(case group) and forty-five demographic characteristic matched healthy controls(control group) were recruited.The neuropsychological battery of tests including EBPM and TBPM tasks were used to measured the prospective memory, and all participants completed the Chinese version of short temperament evaluation of the memphis(TEMPS-A). The differences in prospective memory and temperament between the case group and control group were compared by t test.Pearson correlation analysis was used to analyze the correlation between prospective memory and temperament. \u0000 \u0000 \u0000Results \u0000A statistically significant in EBPM was observed between patients with euthymic bipolar disorder and health controls ((3.66±0.69) vs (4.18±0.83), t=-3.313, P<0.01) and the same result was showed in TBPM ((3.06±0.96) vs (3.89±0.75), t=-4.674, P<0.01). The total score of TEMPS-A ((18.82±4.49) vs (9.69±3.37), t=11.106, P<0.01) and the scores of all the subscales were higher in case group than those in control group.The negative correlation was showed between the scores of depression temperament and TBPM (r=-0.425, P=0.002) in the case group. \u0000 \u0000 \u0000Conclusion \u0000The results suggest both EBPM and TBPM have impaired, and TBPM correlates with depression temperament moderately in the patients with euthymic bipolar disorder. \u0000 \u0000 \u0000Key words: \u0000Bipolar disorder; Prospective memory; Temperament","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1070-1074"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42746460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.017
Jun Tang, Maorong Hu, Xiong Lai, Jing Xu, Siliang Wu
Acceptance and Commitment Therapy (ACT) aims at correctly recognizing the different sides of life, accepting its inevitable pain, defining its true value and committing to action.Its ultimately aim is to improve psychological flexibility and lead a more fulfilling and meaningful life.Patients with Eating Disorders (ED) often have personality characteristics such as experiential avoidance, rigid behavior, and lack of motivation.Therefore, Acceptance and Commitment Therapy is particularly suitable for patients with Eating Disorders.This article make a brief overview of the ACT firstly, then introduces the definition, epidemiology and etiology of ED.By reviewing the relevant literatures on the use of ACT in the treatment of ED in recent years, we point out the advantages of using ACT and the possible mechanism of ACT in the treatment of ED, the future research directions and issues needing attention. Key words: Acceptance and commitment therapy; Eating disorders; Psychological flexibility; Experiential avoidance
{"title":"Application of acceptance and commitment therapy in eating disorders","authors":"Jun Tang, Maorong Hu, Xiong Lai, Jing Xu, Siliang Wu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.017","url":null,"abstract":"Acceptance and Commitment Therapy (ACT) aims at correctly recognizing the different sides of life, accepting its inevitable pain, defining its true value and committing to action.Its ultimately aim is to improve psychological flexibility and lead a more fulfilling and meaningful life.Patients with Eating Disorders (ED) often have personality characteristics such as experiential avoidance, rigid behavior, and lack of motivation.Therefore, Acceptance and Commitment Therapy is particularly suitable for patients with Eating Disorders.This article make a brief overview of the ACT firstly, then introduces the definition, epidemiology and etiology of ED.By reviewing the relevant literatures on the use of ACT in the treatment of ED in recent years, we point out the advantages of using ACT and the possible mechanism of ACT in the treatment of ED, the future research directions and issues needing attention. \u0000 \u0000 \u0000Key words: \u0000Acceptance and commitment therapy; Eating disorders; Psychological flexibility; Experiential avoidance","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1145-1148"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42923646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.001
Y. Ye, Xiaohong Li, Xinyu Shi, Zhen-Wen Zhang, Xiao‐Yin Liu, Jian Chen, Zhe Zhang, Weizhou Wu, Jing-Jing Wang, Hongxian Zhou, Yi Wang
Objective To explore the inhibitory effect of exosomes secreted by human umbilical cord mesenchymal stem cells(HUCMSC) on apoptosis of human umbilical vein endothelial cells(HUVEC) after model group(oxygen-glucose deprivation reoxygenation), and to clarify its possible mechanism. Methods Human umbilical cord mesenchymal stem cells were cultured. The collected cell supernatant was stored in a centrifugal tube. The exosomes secreted by human umbilical cord mesenchymal stem cells were extracted by ultracentrifugation and identified. Human umbilical vein endothelial cells were randomly divided into control group, model group and different concentrations of HUCMSC-EXO(20 μg/ml, 40 μg/ml, 60 μg/ml) treatment groups(adding HUCMSC-EXO into the model group) . The morphological changes of HUVEC cells in each group were observed by inverted phase contrast microscope, and the proliferation inhibition rate of HUVEC in each group was measured by CCK-8 reagent. Western blot was used to detect the expression of apoptosis-related proteins Caspase-3, Bax, Bcl-2 and hypoxia-associated protein hypoxia inducible factor 1α(HIF-1α). Inhibitor(HIF-1α inhibitor) + model group and HUCMSC-EXO + inhibitor + model group were added on the basis of the above experiments. Western blot analysis was performed to observe the effects of HUCMSC-EXO, inhibitor and both of them on HIF-1α and Bax expressions in HUVEC. Results HUCMSC-EXO was successfully extracted and identified. Compared with the control group, the volume of HUVEC in the model group and the HUCMSC-EXO group with different concentrations decreased, became round, connected and evacuated, and the growth state was poor under the inverted phase contrast microscope.CCK-8 detection showed that the cell viability in the HUCMSC-EXO group was significantly higher than that in the model group, the difference was statistically significant (t=9.23, P 0.05)and Bax protein ((0.363±0.069), (0.370±0.064); t=0.18, P>0.05). But both of them were down-regulated compared with the model group (HIF-1α protein (0.919±0.064), Bax protein (0.902±0.071)), the differences were significant( t=13.56, t=13.03, both P<0.05). Conclusion HUCMSC-EXO has a protective effect on OGD/R model of HUVEC, and its mechanism may be related to the down-regulation of HIF-1α expression. Key words: Human umbilical mesenchymal stem cells; Exosomes; Oxygen-glucose deprivation reoxygenation; Human umbilical venous endothelial cells; Apoptosis
目的探讨人脐带间充质干细胞(HUCMSC)分泌的外泌体对模型组(氧-葡萄糖剥夺再氧合)后人脐静脉内皮细胞(HUVEC)凋亡的抑制作用，并阐明其可能的机制。方法培养人脐带间充质干细胞。收集的细胞上清液储存在离心管中。对人脐带间充质干细胞分泌的外泌体进行了超离心提取和鉴定。将人脐静脉内皮细胞随机分为对照组、模型组和不同浓度的HUCMSC-EXO(20 μg/ml、40 μg/ml、60 μg/ml)处理组(模型组添加HUCMSC-EXO)。倒置相差显微镜观察各组HUVEC细胞形态变化，CCK-8试剂检测各组HUVEC细胞增殖抑制率。Western blot检测凋亡相关蛋白Caspase-3、Bax、Bcl-2及缺氧相关蛋白缺氧诱导因子1α(HIF-1α)的表达。在上述实验基础上又增加抑制剂(HIF-1α抑制剂)+模型组和HUCMSC-EXO +抑制剂+模型组。Western blot观察HUCMSC-EXO、inhibitor及两者对HUVEC中HIF-1α和Bax表达的影响。结果成功提取并鉴定了HUCMSC-EXO。与对照组比较，倒置相差显微镜下，模型组和不同浓度的HUCMSC-EXO组HUVEC体积减小，呈圆形、连通、抽真空状，生长状态较差。CCK-8检测显示，HUCMSC-EXO组细胞活力显著高于模型组，差异均有统计学意义(t=9.23, P 0.05)， Bax蛋白(0.363±0.069)、(0.370±0.064);t = 0.18, P > 0.05)。但与模型组比较，HIF-1α蛋白(0.919±0.064)、Bax蛋白(0.902±0.071)均下调，差异有统计学意义(t=13.56, t=13.03，均P<0.05)。结论humcc - exo对HUVEC OGD/R模型具有保护作用，其机制可能与下调HIF-1α表达有关。关键词:人脐带间充质干细胞;液;氧-葡萄糖剥夺再氧合;人脐静脉内皮细胞;细胞凋亡
{"title":"Inhibitory effect of exosomes secreted by human umbilical cord mesenchymal stem cells on apoptosis of oxygen-glucose deprived reoxygenation model of venous endothelial cells","authors":"Y. Ye, Xiaohong Li, Xinyu Shi, Zhen-Wen Zhang, Xiao‐Yin Liu, Jian Chen, Zhe Zhang, Weizhou Wu, Jing-Jing Wang, Hongxian Zhou, Yi Wang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.001","url":null,"abstract":"Objective \u0000To explore the inhibitory effect of exosomes secreted by human umbilical cord mesenchymal stem cells(HUCMSC) on apoptosis of human umbilical vein endothelial cells(HUVEC) after model group(oxygen-glucose deprivation reoxygenation), and to clarify its possible mechanism. \u0000 \u0000 \u0000Methods \u0000Human umbilical cord mesenchymal stem cells were cultured. The collected cell supernatant was stored in a centrifugal tube. The exosomes secreted by human umbilical cord mesenchymal stem cells were extracted by ultracentrifugation and identified. Human umbilical vein endothelial cells were randomly divided into control group, model group and different concentrations of HUCMSC-EXO(20 μg/ml, 40 μg/ml, 60 μg/ml) treatment groups(adding HUCMSC-EXO into the model group) . The morphological changes of HUVEC cells in each group were observed by inverted phase contrast microscope, and the proliferation inhibition rate of HUVEC in each group was measured by CCK-8 reagent. Western blot was used to detect the expression of apoptosis-related proteins Caspase-3, Bax, Bcl-2 and hypoxia-associated protein hypoxia inducible factor 1α(HIF-1α). Inhibitor(HIF-1α inhibitor) + model group and HUCMSC-EXO + inhibitor + model group were added on the basis of the above experiments. Western blot analysis was performed to observe the effects of HUCMSC-EXO, inhibitor and both of them on HIF-1α and Bax expressions in HUVEC. \u0000 \u0000 \u0000Results \u0000HUCMSC-EXO was successfully extracted and identified. Compared with the control group, the volume of HUVEC in the model group and the HUCMSC-EXO group with different concentrations decreased, became round, connected and evacuated, and the growth state was poor under the inverted phase contrast microscope.CCK-8 detection showed that the cell viability in the HUCMSC-EXO group was significantly higher than that in the model group, the difference was statistically significant (t=9.23, P 0.05)and Bax protein ((0.363±0.069), (0.370±0.064); t=0.18, P>0.05). But both of them were down-regulated compared with the model group (HIF-1α protein (0.919±0.064), Bax protein (0.902±0.071)), the differences were significant( t=13.56, t=13.03, both P<0.05). \u0000 \u0000 \u0000Conclusion \u0000HUCMSC-EXO has a protective effect on OGD/R model of HUVEC, and its mechanism may be related to the down-regulation of HIF-1α expression. \u0000 \u0000 \u0000Key words: \u0000Human umbilical mesenchymal stem cells; Exosomes; Oxygen-glucose deprivation reoxygenation; Human umbilical venous endothelial cells; Apoptosis","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1057-1063"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48504064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.004
Shuang-jiao Cao, Di Wu, Chen Xing, Yuqin Chen, Xiaohui Wang, D. Miao
Objective To explore the characteristics of cognitive processing over time in recognition of different emotional faces in patients with depression. Methods Totally 29 patients with depression(patient group) and 30 normal control (control group)were selected.Subjects freely viewed positive, sad, threatening and neutral facial stimuli.Eye movement data were collected during the process of watching, and the differences of attention bias in time when the two groups of subjects recognized the four emotional faces were compared.The temporal variation trend of attention between the two groups was analyzed. Results There was no significant difference in the fixation duration between the patient group and the control group in 0-2 s((10.39±1.83)ms, (9.63±1.28)ms), 2-4 s((12.61±2.34)ms, (11.21±3.00)ms), 4-6 s ((12.26±3.11)ms, (10.47±4.06)ms)(all P>0.05). Within 6-8 s((12.64±3.42)ms, (8.90±4.02)ms), 8-10 s((12.55±4.19)ms, (9.36±4.02)ms), the fixation duration in the patient group was significantly longer than that in the control group (P<0.01). The fixation time of the positive faces in the patient group in 0-2 s ((12.07±2.65)ms, (14.50±3.54)ms), 2-4 s((10.69±3.26)ms, (14.66±5.25)ms), 4-6 s((10.11±4.24)ms, (15.43±8.02)ms), 6-8 s((9.39±5.12)ms, (16.88±9.60)ms), 8-10 s ((9.45±4.94)ms, (16.63±10.15)ms) was significantly lower than that in the control group (all P<0.01). Conclusion Patients with depression tend to pay attention to negative stimuli in the later stage of cognitive processing, while the attention to positive stimuli decreases in the early stage of cognitive processing.Cognitive processing of emotional stimuli in patients with depression is manifested as increased attention duration of negative stimuli and decreased attention duration of positive stimuli. Key words: Depression; Attention bias; Face recognition; Eye movement
{"title":"Time course of attention bias in face recognition of patients with depression","authors":"Shuang-jiao Cao, Di Wu, Chen Xing, Yuqin Chen, Xiaohui Wang, D. Miao","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.004","url":null,"abstract":"Objective \u0000To explore the characteristics of cognitive processing over time in recognition of different emotional faces in patients with depression. \u0000 \u0000 \u0000Methods \u0000Totally 29 patients with depression(patient group) and 30 normal control (control group)were selected.Subjects freely viewed positive, sad, threatening and neutral facial stimuli.Eye movement data were collected during the process of watching, and the differences of attention bias in time when the two groups of subjects recognized the four emotional faces were compared.The temporal variation trend of attention between the two groups was analyzed. \u0000 \u0000 \u0000Results \u0000There was no significant difference in the fixation duration between the patient group and the control group in 0-2 s((10.39±1.83)ms, (9.63±1.28)ms), 2-4 s((12.61±2.34)ms, (11.21±3.00)ms), 4-6 s ((12.26±3.11)ms, (10.47±4.06)ms)(all P>0.05). Within 6-8 s((12.64±3.42)ms, (8.90±4.02)ms), 8-10 s((12.55±4.19)ms, (9.36±4.02)ms), the fixation duration in the patient group was significantly longer than that in the control group (P<0.01). The fixation time of the positive faces in the patient group in 0-2 s ((12.07±2.65)ms, (14.50±3.54)ms), 2-4 s((10.69±3.26)ms, (14.66±5.25)ms), 4-6 s((10.11±4.24)ms, (15.43±8.02)ms), 6-8 s((9.39±5.12)ms, (16.88±9.60)ms), 8-10 s ((9.45±4.94)ms, (16.63±10.15)ms) was significantly lower than that in the control group (all P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Patients with depression tend to pay attention to negative stimuli in the later stage of cognitive processing, while the attention to positive stimuli decreases in the early stage of cognitive processing.Cognitive processing of emotional stimuli in patients with depression is manifested as increased attention duration of negative stimuli and decreased attention duration of positive stimuli. \u0000 \u0000 \u0000Key words: \u0000Depression; Attention bias; Face recognition; Eye movement","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1075-1080"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44702635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.018
Fan Zhang, Wenpeng Cai, Xiaofei Mao, G. Deng
Negative cognitive bias is closely linked with the production and development of anxiety disorder.Recently, cognitive bias modification (CBM) has been developed to correct negative cognitive bias in anxiety.By retrieving literature researches, this paper analyzed the progress of cognitive bias modification intervention.Seventy-one literatures published in the last decade and with key words of cognitive bias and anxiety were included.Attentional bias modification and interpretation bias modification are the most useful treatment which could improve negative cognitive bias, however the controversial remains about the training effect of CBM on anxiety symptoms.Researchers have found positive results when cognitive bias modification and cognitive behavior therapy (CBT) are combined to treat anxiety disorder.Researches on the brain mechanism of cognitive bias modification provide the neurophysiological basis for the occurrence of the intervention. Cognitive bias modification help to improve negative cognitive bias in anxiety.Combination of CBM and CBT is an effective method of anxiety treatment. Key words: Anxiety; Cognitive bias; Cognitive bias modification; Attentional bias modification; Interpretational bias modification
{"title":"Antianxiety effect and mechanisms of cognitive bias modification","authors":"Fan Zhang, Wenpeng Cai, Xiaofei Mao, G. Deng","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.018","url":null,"abstract":"Negative cognitive bias is closely linked with the production and development of anxiety disorder.Recently, cognitive bias modification (CBM) has been developed to correct negative cognitive bias in anxiety.By retrieving literature researches, this paper analyzed the progress of cognitive bias modification intervention.Seventy-one literatures published in the last decade and with key words of cognitive bias and anxiety were included.Attentional bias modification and interpretation bias modification are the most useful treatment which could improve negative cognitive bias, however the controversial remains about the training effect of CBM on anxiety symptoms.Researchers have found positive results when cognitive bias modification and cognitive behavior therapy (CBT) are combined to treat anxiety disorder.Researches on the brain mechanism of cognitive bias modification provide the neurophysiological basis for the occurrence of the intervention. Cognitive bias modification help to improve negative cognitive bias in anxiety.Combination of CBM and CBT is an effective method of anxiety treatment. \u0000 \u0000 \u0000Key words: \u0000Anxiety; Cognitive bias; Cognitive bias modification; Attentional bias modification; Interpretational bias modification","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1149-1152"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43238229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.008
Q. Ding, Xiaoyan Tang, Lina Huang, Qin Li, Q. Dong, Hongqiang Zhang, Z. Qian, Xiaowei Yin, P. Liang
Objective To explore the characteristics of the default memory network (DMN) and working memory network (WMN) at resting state brain functional network of exercise addiction people. Methods Twenty-nine sports addicts and 26 non-sports addicts matched by sex, age, average education level and sports dependence were screened by the exercise addiction index (EAI). Resting status brain scanning was performed with 3.0T magnetic resonance scanner.Sparse approximation coefficients independent component analysis (SACICA) model was used to analyze the independent components of brain networks. Results Compared with the DMN template, four features were extracted, including " basic conformity" , " less frontal lobe" , " more frontal lobe" and " less occipitoparietal lobe" . Compared with the parameters of " basic conformity" , the proportion of exercise addiction group (33.3%, 9/27) was higher than that of control group (18.2%, 4/22). In the other three parameters, the proportion of exercise addiction group (37.0%, 10/27; 3.7%, 1/27; 22.2%, 6/27) was lower than those of control group (45.5%, 10/22; 22.7%, 5/22; 27.3%, 6/22). But Chi-square test showed that there was no significant difference between the two groups(all P>0.05). Compared with the WMN template, six features were extracted, including " basic conformity" , " more frontal and parietal lobes" , " more parietal lobes" , " more frontal lobes" , " less frontal lobes" and " less parietal lobes" . The percentages of the first three features in exercise addiction group (22.2%, 6/27; 7.4%, 2/27; 7.4%, 2/27) were less than those in the control group (45.5%, 10/22; 22.7%, 5/22; 9.1%, 2/22), while the percentages of the last three features in the exercise addiction group (7.4%, 2/27; 37.0%, 10/27; 14.8%, 4/27) were higher than those in the control group (4.5%, 1/22; 13.6%, 3/22; 0, 0). Chi-square test showed that there was no significant difference in all features between the two groups was statistically(P>0.05). Conclusion No significant characteristic changes are found in DMN and WMN networks of exercise addiction population. Key words: Sports addiction; Resting state; Sparse approximation coefficients independent component analysis; Default memory network; Working memory network
{"title":"Default memory network and working memory network in exercise addicts","authors":"Q. Ding, Xiaoyan Tang, Lina Huang, Qin Li, Q. Dong, Hongqiang Zhang, Z. Qian, Xiaowei Yin, P. Liang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.008","url":null,"abstract":"Objective \u0000To explore the characteristics of the default memory network (DMN) and working memory network (WMN) at resting state brain functional network of exercise addiction people. \u0000 \u0000 \u0000Methods \u0000Twenty-nine sports addicts and 26 non-sports addicts matched by sex, age, average education level and sports dependence were screened by the exercise addiction index (EAI). Resting status brain scanning was performed with 3.0T magnetic resonance scanner.Sparse approximation coefficients independent component analysis (SACICA) model was used to analyze the independent components of brain networks. \u0000 \u0000 \u0000Results \u0000Compared with the DMN template, four features were extracted, including \" basic conformity\" , \" less frontal lobe\" , \" more frontal lobe\" and \" less occipitoparietal lobe\" . Compared with the parameters of \" basic conformity\" , the proportion of exercise addiction group (33.3%, 9/27) was higher than that of control group (18.2%, 4/22). In the other three parameters, the proportion of exercise addiction group (37.0%, 10/27; 3.7%, 1/27; 22.2%, 6/27) was lower than those of control group (45.5%, 10/22; 22.7%, 5/22; 27.3%, 6/22). But Chi-square test showed that there was no significant difference between the two groups(all P>0.05). Compared with the WMN template, six features were extracted, including \" basic conformity\" , \" more frontal and parietal lobes\" , \" more parietal lobes\" , \" more frontal lobes\" , \" less frontal lobes\" and \" less parietal lobes\" . The percentages of the first three features in exercise addiction group (22.2%, 6/27; 7.4%, 2/27; 7.4%, 2/27) were less than those in the control group (45.5%, 10/22; 22.7%, 5/22; 9.1%, 2/22), while the percentages of the last three features in the exercise addiction group (7.4%, 2/27; 37.0%, 10/27; 14.8%, 4/27) were higher than those in the control group (4.5%, 1/22; 13.6%, 3/22; 0, 0). Chi-square test showed that there was no significant difference in all features between the two groups was statistically(P>0.05). \u0000 \u0000 \u0000Conclusion \u0000No significant characteristic changes are found in DMN and WMN networks of exercise addiction population. \u0000 \u0000 \u0000Key words: \u0000Sports addiction; Resting state; Sparse approximation coefficients independent component analysis; Default memory network; Working memory network","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1096-1101"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48043537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1674-6554.2019.12.015
Zhenya Zhu, Xueyan Ouyang, Chao Yang, Ruihua Yu, Gang Ding, Yonghua Ji, Feng Jiang
Objective To establish a novel stress-induced depression model by changing the lighting conditions and continuously damping cushion (L-D). Methods The L-D stress depression animal model was established in C57BL / 6 mice with body weight of 18-22 g. Seventy-five mice with the horizontal and vertical scores higher than 30 and less than 120 in open field test were employed.In the research of model construction, mice were randomly divided into three groups: control group (n=9), chronic unpredictable mild stress(CUMS) model group (n=10) and L-D model group (n=9). In the drug intervention experiments, mice were randomly divided into five groups: control group (n=9), chronic unpredictable mild stress(CUMS) model group (n=10), L-D model group (n=9), CUMS+ fluoxetine group (n=10) and L-D model+ fluoxetine group (n=9). Open field test, forced swimming test and sucrose preference test were used to evaluate the degree of depression in animals. Results (1) In the open field test, the horizontal score of CUMS model group (67.20±5.81) and the L-D model group (52.56±19.05) were significantly lower than that of the control group (76.44±9.22) (t=2.645, t=3.387, both P 0.05). Conclusion Changing the lighting conditions and continuously damping cushion is a new method to establish mice model with depression behavior.Shorter modeling duration and simple operation are the main advantages of this model. Key words: Stress-induced depression animal model; Damp cushion; Lighting conditions; Mice
{"title":"Establishment and evaluation of a stress depression model induced by light and dampness on mice","authors":"Zhenya Zhu, Xueyan Ouyang, Chao Yang, Ruihua Yu, Gang Ding, Yonghua Ji, Feng Jiang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.015","url":null,"abstract":"Objective \u0000To establish a novel stress-induced depression model by changing the lighting conditions and continuously damping cushion (L-D). \u0000 \u0000 \u0000Methods \u0000The L-D stress depression animal model was established in C57BL / 6 mice with body weight of 18-22 g. Seventy-five mice with the horizontal and vertical scores higher than 30 and less than 120 in open field test were employed.In the research of model construction, mice were randomly divided into three groups: control group (n=9), chronic unpredictable mild stress(CUMS) model group (n=10) and L-D model group (n=9). In the drug intervention experiments, mice were randomly divided into five groups: control group (n=9), chronic unpredictable mild stress(CUMS) model group (n=10), L-D model group (n=9), CUMS+ fluoxetine group (n=10) and L-D model+ fluoxetine group (n=9). Open field test, forced swimming test and sucrose preference test were used to evaluate the degree of depression in animals. \u0000 \u0000 \u0000Results \u0000(1) In the open field test, the horizontal score of CUMS model group (67.20±5.81) and the L-D model group (52.56±19.05) were significantly lower than that of the control group (76.44±9.22) (t=2.645, t=3.387, both P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Changing the lighting conditions and continuously damping cushion is a new method to establish mice model with depression behavior.Shorter modeling duration and simple operation are the main advantages of this model. \u0000 \u0000 \u0000Key words: \u0000Stress-induced depression animal model; Damp cushion; Lighting conditions; Mice","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1136-1140"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46357311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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