Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.013
Dan Cheng
The clinical manifestations of bronchial asthma (asthma) are cough, sputum, chest tightness, and wheezing, which pathophysiological characterized by airway hyperresponsiveness and chronic eosinophilic inflammation.Airway epithelial cells are the first defensive line.Repeated injury, repair and regeneration of the airway epithelial cells caused by environmental factors and inflammation lead to histological changes and dysfunction of the airway epithelial membrane.The barrier function of airway epithelium is closely related to thymic stromal lymphopoietin, interleukin-25 (IL-25) and IL-33, and the damage of airway epithelial barrier enhances the permeability of airway epithelial mucosa, causes the activation of airway epithelial dendritic cells and type 2 innate lymphoid cells (ILC2s). Abnormal function of airway epithelial cells and activation of dendritic cells and ILC2s cells form an immunopathological unit that results in allergic airway inflammation and plays an important role in the pathogenesis of asthma. Key words: Asthma; Epithelial cells; Airway inflammation; Function
{"title":"Role of airway epithelial barrier dysfunction in bronchial asthma","authors":"Dan Cheng","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.013","url":null,"abstract":"The clinical manifestations of bronchial asthma (asthma) are cough, sputum, chest tightness, and wheezing, which pathophysiological characterized by airway hyperresponsiveness and chronic eosinophilic inflammation.Airway epithelial cells are the first defensive line.Repeated injury, repair and regeneration of the airway epithelial cells caused by environmental factors and inflammation lead to histological changes and dysfunction of the airway epithelial membrane.The barrier function of airway epithelium is closely related to thymic stromal lymphopoietin, interleukin-25 (IL-25) and IL-33, and the damage of airway epithelial barrier enhances the permeability of airway epithelial mucosa, causes the activation of airway epithelial dendritic cells and type 2 innate lymphoid cells (ILC2s). Abnormal function of airway epithelial cells and activation of dendritic cells and ILC2s cells form an immunopathological unit that results in allergic airway inflammation and plays an important role in the pathogenesis of asthma. \u0000 \u0000 \u0000Key words: \u0000Asthma; Epithelial cells; Airway inflammation; Function","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81670291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.005
Ming Wu, Qinhua Liu, Yongming Guo, Jihong Wang, Shao-Fen Liu, Yu Liu, Xin Liu, Shi Chen
Objective To investigate the epidemiological distribution characteristics and related risk factors of chronic obstructive pulmonary disease (COPD) in Fuzhou among people aged 40 years or older, and provide guidance for the prevention and treatment of COPD. Methods A random and cluster sampling method was used to survey people who older than 40 years in five districts of Fuzhou (Gulou District, Cangshan District, Jin′an District, Taijiang District and Mawei District). We designed a questionnaire for the respondents, after which, some physical examinations and lung function tests were carried out.COPD-related univariate and multivariate statistical analysis were performed on the data obtained. Results We validated 1 055 participants with available data.The overall prevalence of COPD was 10.6%(112/1 055). Male and female prevalence rates were 13.0% (70/538) and 8.1%(42/517). Age (χ2=27.051, P<0.01), gender (χ2=4.374, P<0.05), BMI (χ2=27.925, P<0.05), smoking (χ2=13.900, P<0.01), childhood cough history (χ2=80.580, P<0.01), family history (χ2=42.961, P<0.01), indoor fumes (χ2=13.603, P<0.01) and kitchen ventilation (χ2=12.111, P<0.05) were associated with the risk of COPD in the multivariate logistic regression analysis. Conclusions The total prevalence of COPD among people aged ≥40 years in Fuzhou was 10.6%.The main factors affecting COPD are male, elder, lower BMI, smoking, coughing history, family history of respiratory disease, heavy indoor fumes and poor kitchen ventilation.The risk factors related to COPD involve multiple aspects of individual, family and social life.The prevention and treatment of COPD should be carried out in a targeted manner to reduce the prevalence of COPD and improve the quality of life of COPD patients. Key words: Pulmonary disease, chronic obstructive; Epidemiology; Risk factors; Fuzhou
{"title":"An epidemiological investigation of COPD in people aged 40 years or older in Fuzhou","authors":"Ming Wu, Qinhua Liu, Yongming Guo, Jihong Wang, Shao-Fen Liu, Yu Liu, Xin Liu, Shi Chen","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.005","url":null,"abstract":"Objective \u0000To investigate the epidemiological distribution characteristics and related risk factors of chronic obstructive pulmonary disease (COPD) in Fuzhou among people aged 40 years or older, and provide guidance for the prevention and treatment of COPD. \u0000 \u0000 \u0000Methods \u0000A random and cluster sampling method was used to survey people who older than 40 years in five districts of Fuzhou (Gulou District, Cangshan District, Jin′an District, Taijiang District and Mawei District). We designed a questionnaire for the respondents, after which, some physical examinations and lung function tests were carried out.COPD-related univariate and multivariate statistical analysis were performed on the data obtained. \u0000 \u0000 \u0000Results \u0000We validated 1 055 participants with available data.The overall prevalence of COPD was 10.6%(112/1 055). Male and female prevalence rates were 13.0% (70/538) and 8.1%(42/517). Age (χ2=27.051, P<0.01), gender (χ2=4.374, P<0.05), BMI (χ2=27.925, P<0.05), smoking (χ2=13.900, P<0.01), childhood cough history (χ2=80.580, P<0.01), family history (χ2=42.961, P<0.01), indoor fumes (χ2=13.603, P<0.01) and kitchen ventilation (χ2=12.111, P<0.05) were associated with the risk of COPD in the multivariate logistic regression analysis. \u0000 \u0000 \u0000Conclusions \u0000The total prevalence of COPD among people aged ≥40 years in Fuzhou was 10.6%.The main factors affecting COPD are male, elder, lower BMI, smoking, coughing history, family history of respiratory disease, heavy indoor fumes and poor kitchen ventilation.The risk factors related to COPD involve multiple aspects of individual, family and social life.The prevention and treatment of COPD should be carried out in a targeted manner to reduce the prevalence of COPD and improve the quality of life of COPD patients. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Epidemiology; Risk factors; Fuzhou","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80565687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.002
Ling Wu, Zongan Liang
Objective To analyze and summarize the clinical characteristics of patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap Syndrome (BCOS), so as to improve the understanding of the disease and guide the clinical work. Methods The clinical data of 490 patients diagnosed as acute exacerbation of chronic obstructive pulmonary disease in the Department of Respiratory and Critical Medicine, the First People′s Hospital of Shuangliu District, Chengdu from January 2018 to December 2018 were analyzed retrospectively.The population comprised 45 subjects with BCOS diagnosed by high resolution CT were divided into BCOS group.At the same time, among the remaining patients, 45 patients with simple COPD who were admitted to the Department of Respiratory and Critical Medicine were randomly selected as the control group.The differences in general data, clinical manifestations, pulmonary function, laboratory examination, hospitalization time and cost, acute aggravation times and readmission rate within 6 months after discharge were compared between the two groups. Results There was no significant difference in age, sex, smoking index, body mass index and basic medication between the two groups.The clinical symptoms of BCOS group were more severe than those of COPD group.Laboratory examination showed that Leukocyte count and the positive rate of procalcitonin was higher, the decrease of PaO2 value and Oxygenation index was more obvious, the positive rate of sputum culture was higher, the damage of pulmonary function was more significant, the hospitalization time was longer and the hospitalization cost was higher.The number of acute aggravation was more within 6 months after discharge. Conclusions The incidence of BCOS is higher, the clinical symptoms are more severe, the pulmonary function is more obvious, and the length of stay and cost are significantly higher.More attention should be paid to this kind of patients, early diagnosis and early treatment in order to improve the prognosis of patients. Key words: Pulmonary disease, chronic obstructive; Bronchiectasis-chronic obstructive pulmonary disease overlap syndrome; Chest high resolution CT; Lung function; Sputum culture
{"title":"Clinical characteristics of bronchiectasis-chronic obstructive pulmonary disease overlap syndrome","authors":"Ling Wu, Zongan Liang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.002","url":null,"abstract":"Objective \u0000To analyze and summarize the clinical characteristics of patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap Syndrome (BCOS), so as to improve the understanding of the disease and guide the clinical work. \u0000 \u0000 \u0000Methods \u0000The clinical data of 490 patients diagnosed as acute exacerbation of chronic obstructive pulmonary disease in the Department of Respiratory and Critical Medicine, the First People′s Hospital of Shuangliu District, Chengdu from January 2018 to December 2018 were analyzed retrospectively.The population comprised 45 subjects with BCOS diagnosed by high resolution CT were divided into BCOS group.At the same time, among the remaining patients, 45 patients with simple COPD who were admitted to the Department of Respiratory and Critical Medicine were randomly selected as the control group.The differences in general data, clinical manifestations, pulmonary function, laboratory examination, hospitalization time and cost, acute aggravation times and readmission rate within 6 months after discharge were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no significant difference in age, sex, smoking index, body mass index and basic medication between the two groups.The clinical symptoms of BCOS group were more severe than those of COPD group.Laboratory examination showed that Leukocyte count and the positive rate of procalcitonin was higher, the decrease of PaO2 value and Oxygenation index was more obvious, the positive rate of sputum culture was higher, the damage of pulmonary function was more significant, the hospitalization time was longer and the hospitalization cost was higher.The number of acute aggravation was more within 6 months after discharge. \u0000 \u0000 \u0000Conclusions \u0000The incidence of BCOS is higher, the clinical symptoms are more severe, the pulmonary function is more obvious, and the length of stay and cost are significantly higher.More attention should be paid to this kind of patients, early diagnosis and early treatment in order to improve the prognosis of patients. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Bronchiectasis-chronic obstructive pulmonary disease overlap syndrome; Chest high resolution CT; Lung function; Sputum culture","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81412606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.012
LingYun Dong, Jian-an Huang
Lung cancer and chronic obstructive pulmonary disease (COPD) are two closely related diseases, which have a great impact on public health.Annual low-dose computed tomography screening of the chest can significantly reduce lung cancer mortality.COPD is associated with an increased risk of lung cancer.Epidemiological studies have found that the risk of lung cancer in COPD patients is 2 to 4 times higher than that in patients without airflow obstruction.The increased risk of COPD lung cancer appears to be due to emphysema.Emphysema has been proved to be an important risk factor for lung cancer.The screening score of COPD lung cancer to determine the high risk population of COPD lung cancer is a useful exploration of lung cancer screening in COPD population, which needs more clinical practices to prove. Key words: Pulmonary disease, chronic obstructive; Lung neoplasms; Pulmonary emphysema; Screening
{"title":"Progress in high-risk screening for lung cancer in patients of chronic obstructive pulmonary disease","authors":"LingYun Dong, Jian-an Huang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.012","url":null,"abstract":"Lung cancer and chronic obstructive pulmonary disease (COPD) are two closely related diseases, which have a great impact on public health.Annual low-dose computed tomography screening of the chest can significantly reduce lung cancer mortality.COPD is associated with an increased risk of lung cancer.Epidemiological studies have found that the risk of lung cancer in COPD patients is 2 to 4 times higher than that in patients without airflow obstruction.The increased risk of COPD lung cancer appears to be due to emphysema.Emphysema has been proved to be an important risk factor for lung cancer.The screening score of COPD lung cancer to determine the high risk population of COPD lung cancer is a useful exploration of lung cancer screening in COPD population, which needs more clinical practices to prove. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Lung neoplasms; Pulmonary emphysema; Screening","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76838846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-05DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.01.013
Jun Jiang
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) are of great significance for the treatment of patients with non-small cell lung cancer.First-generation EGFR-TKI (such as gefitinib and erlotinib) or second-generation EGFR-TKI (such as afatinib and dacomitinib) are effective in the treatment of EGFR-mutant non-small cell lung cancer, especially EGFR exon 19 deletion or exon 21 L858R mutation.However, due to acquired resistance, almost all cases will relapse after 1 to 2 years.The most common resistance mutation is the EGFR T790M secondary mutation in exon 20.Osimertinib is a third-generation EGFR-TKI targeting T790M mutation and has been shown to be highly potent against EGFR-mutant lung cancer.However, the occurrence of acquired resistance to the C797S tertiary mutation of the third generation EGFR-TKI has been observed.This article reviews these resistance mechanisms and discuss strategies for coping with EGFR-TKI resistance. Key words: Carcinoma, non-small-cell lung; Receptor, epidermal growth factor; Drug resistance, neoplasm; Epidermal growth factor receptor tyrosine kinase inhibitor
{"title":"Advances in research on EGFR-TKI resistance mechanism and therapeutic strategies in non-small cell lung cancer","authors":"Jun Jiang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.01.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.01.013","url":null,"abstract":"Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) are of great significance for the treatment of patients with non-small cell lung cancer.First-generation EGFR-TKI (such as gefitinib and erlotinib) or second-generation EGFR-TKI (such as afatinib and dacomitinib) are effective in the treatment of EGFR-mutant non-small cell lung cancer, especially EGFR exon 19 deletion or exon 21 L858R mutation.However, due to acquired resistance, almost all cases will relapse after 1 to 2 years.The most common resistance mutation is the EGFR T790M secondary mutation in exon 20.Osimertinib is a third-generation EGFR-TKI targeting T790M mutation and has been shown to be highly potent against EGFR-mutant lung cancer.However, the occurrence of acquired resistance to the C797S tertiary mutation of the third generation EGFR-TKI has been observed.This article reviews these resistance mechanisms and discuss strategies for coping with EGFR-TKI resistance. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, non-small-cell lung; Receptor, epidermal growth factor; Drug resistance, neoplasm; Epidermal growth factor receptor tyrosine kinase inhibitor","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86083388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-05DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.01.010
Weiwei Gao, Weiyi Hu, Guangchuan Dai
Exogenous lipoid pneumonia (ExLP) is a rare disease in clinical practice.Because of the lack of typical and specific clinical manifestations and auxiliary examination, further understanding and detailed history collection are very important for the diagnosis of ExLP.ExLP combined pulmonary tuberculosis is even more rare and can be easily misdiagnosed.This article reports a typical case of ExLP complicated with pulmonary tuberculosis confirmed by etiology and pathology, and literatures are reviewed in order to improve the further understanding of the disease. Key words: Pneumonia, lipid; Tuberculosis, pulmonary
{"title":"One case of exogenous lipid pneumonia complicated with pulmonary tuberculosis and literature review","authors":"Weiwei Gao, Weiyi Hu, Guangchuan Dai","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.01.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.01.010","url":null,"abstract":"Exogenous lipoid pneumonia (ExLP) is a rare disease in clinical practice.Because of the lack of typical and specific clinical manifestations and auxiliary examination, further understanding and detailed history collection are very important for the diagnosis of ExLP.ExLP combined pulmonary tuberculosis is even more rare and can be easily misdiagnosed.This article reports a typical case of ExLP complicated with pulmonary tuberculosis confirmed by etiology and pathology, and literatures are reviewed in order to improve the further understanding of the disease. \u0000 \u0000 \u0000Key words: \u0000Pneumonia, lipid; Tuberculosis, pulmonary","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79536251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-05DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.01.011
Lina Gu, Tianzhen Wang, Ju Lu, M. Cao
Growth differentiation factor 15 (GDF15) is a stress response protein, which belongs to the super family of transforming growth factor beta.GDF15 is widely expressed in tissues, such as high expression in the prostate and placenta, and weak expression in the lung.The expression of GDF15 is significantly increased in the circumstance of stress or pathology.In the lung, GDF15 is secreted by macrophages, vascular endothelial cells, alveolar and bronchial epithelial cells.Recent studies have shown that GDF15 is closely related to the development and prognosis of lung diseases.This article reviews the latest research on GDF15 in the development of lung diseases. Key words: Growth differentiation factor; Lung diseases
{"title":"The research advances of GDF15 in the pulmonary diseases","authors":"Lina Gu, Tianzhen Wang, Ju Lu, M. Cao","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.01.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.01.011","url":null,"abstract":"Growth differentiation factor 15 (GDF15) is a stress response protein, which belongs to the super family of transforming growth factor beta.GDF15 is widely expressed in tissues, such as high expression in the prostate and placenta, and weak expression in the lung.The expression of GDF15 is significantly increased in the circumstance of stress or pathology.In the lung, GDF15 is secreted by macrophages, vascular endothelial cells, alveolar and bronchial epithelial cells.Recent studies have shown that GDF15 is closely related to the development and prognosis of lung diseases.This article reviews the latest research on GDF15 in the development of lung diseases. \u0000 \u0000 \u0000Key words: \u0000Growth differentiation factor; Lung diseases","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85736646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-05DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.01.008
Yiwei Fan, Weidong Ren, Hongcan Shi, Y. Shu, Shichun Lu, Chao Sun
Objective To establish a mathematical prediction model of mediastinal lymph node metastasis in early or mid-term non-small cell lung cancer (NSCLC) with diameter ≤5 cm and improve the accuracy of preoperative staging of lung cancer. Methods A retrospective analysis of 608 patients with NSCLC meeting the inclusion criteria in the Department of Thoracic Surgery, Clinical Medical College of Yangzhou University from January 2012 to August 2017 was randomly divided into modeling and validation groups according to a 3∶1 ratio by SPSS random number generator method.Using the data of the model group, the independent risk factors of mediastinal lymph node metastasis were screened by single factor and multivariate analysis to establish the mathematical prediction model.External validation of the model was performed using validation group case data and compared with previous models. Results Multivariate tumor size, tumor location (central or peripheral), pathological type and pleural traction were independent risk factors for mediastinal lymph node metastasis.The mathematical predictive model established was P=ex/(1+ ex), x=-2.831+ (0.825×tumor diameter)+ (1.53×central type)+ (0.779×pleural traction sign)+ (1.883×pathological type)-(0.06×age). The Hosmer-Lemeshow test showed no significant difference between the predicted and observed values.The area under the curve for the receiver operating characteristic curve was 0.763(95%CI: 0.697~0.829). External verification results show that compared with the VA model and the Fudan model, the proposed model is applicable to a wider range and higher accuracy. Conclusions The mathematical model established in this study has high sensitivity and specificity for the diagnosis of mediastinal lymph node metastasis of NSCLC ≤5 cm in diameter, and its prediction ability and accuracy are higher than other similar models.This model allows for more rational clinical decisons on whether to perform further mediastinal lymph node. Key words: Carcinoma, non-small-cell lung; Lymphatic metastasis; Logistic models; Clinical verification
{"title":"Establishment of a mathematical predictive model of mediastinal lymph node metastasis in early or mid-term non-small cell lung cancer with diameter ≤5 cm","authors":"Yiwei Fan, Weidong Ren, Hongcan Shi, Y. Shu, Shichun Lu, Chao Sun","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.01.008","url":null,"abstract":"Objective \u0000To establish a mathematical prediction model of mediastinal lymph node metastasis in early or mid-term non-small cell lung cancer (NSCLC) with diameter ≤5 cm and improve the accuracy of preoperative staging of lung cancer. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis of 608 patients with NSCLC meeting the inclusion criteria in the Department of Thoracic Surgery, Clinical Medical College of Yangzhou University from January 2012 to August 2017 was randomly divided into modeling and validation groups according to a 3∶1 ratio by SPSS random number generator method.Using the data of the model group, the independent risk factors of mediastinal lymph node metastasis were screened by single factor and multivariate analysis to establish the mathematical prediction model.External validation of the model was performed using validation group case data and compared with previous models. \u0000 \u0000 \u0000Results \u0000Multivariate tumor size, tumor location (central or peripheral), pathological type and pleural traction were independent risk factors for mediastinal lymph node metastasis.The mathematical predictive model established was P=ex/(1+ ex), x=-2.831+ (0.825×tumor diameter)+ (1.53×central type)+ (0.779×pleural traction sign)+ (1.883×pathological type)-(0.06×age). The Hosmer-Lemeshow test showed no significant difference between the predicted and observed values.The area under the curve for the receiver operating characteristic curve was 0.763(95%CI: 0.697~0.829). External verification results show that compared with the VA model and the Fudan model, the proposed model is applicable to a wider range and higher accuracy. \u0000 \u0000 \u0000Conclusions \u0000The mathematical model established in this study has high sensitivity and specificity for the diagnosis of mediastinal lymph node metastasis of NSCLC ≤5 cm in diameter, and its prediction ability and accuracy are higher than other similar models.This model allows for more rational clinical decisons on whether to perform further mediastinal lymph node. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, non-small-cell lung; Lymphatic metastasis; Logistic models; Clinical verification","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88142510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-05DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.01.009
Jie Gu, Dongmei Gu, Jing‐jing Guo, Q. Su, Yanbin Chen
Synovial sarcoma is a rare and invasive malignant tumor originated from the shuttle mesophyll tissue, metastasizing most commonly to lung.Its clinical manifestations and images are not specific and are easily misdiagnosed.Related case reports are lacked at home and abroad.The two cases of pulmonary metastatic synovial sarcoma in the First Affiliated Hospital of Soochow University were analyzed and nine cases reported in literature at home and abroad in 20 years were reviewed to improve the understanding of this kind of disease. Key words: Sarcoma, synovial; Lung; Neoplasm metastasis; Retrospective analysis
{"title":"Two cases of pulmonary metastatic synovial sarcoma and literature review","authors":"Jie Gu, Dongmei Gu, Jing‐jing Guo, Q. Su, Yanbin Chen","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.01.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.01.009","url":null,"abstract":"Synovial sarcoma is a rare and invasive malignant tumor originated from the shuttle mesophyll tissue, metastasizing most commonly to lung.Its clinical manifestations and images are not specific and are easily misdiagnosed.Related case reports are lacked at home and abroad.The two cases of pulmonary metastatic synovial sarcoma in the First Affiliated Hospital of Soochow University were analyzed and nine cases reported in literature at home and abroad in 20 years were reviewed to improve the understanding of this kind of disease. \u0000 \u0000 \u0000Key words: \u0000Sarcoma, synovial; Lung; Neoplasm metastasis; Retrospective analysis","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83080900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-05DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.01.012
Yuan-yuan Liu, Zhaozhong Cheng
The scales of pulmonary embolism have played an important role in diagnosis of pulmonary embolism and producing its prognosis in early stage.The commonly used pulmonary embolism scales include: Wells score, Gevena score, pulmonary embolism severity index, pulmonary embolism rule-out criteria, etc.The article briefly reviews their clinical application. Key words: Pulmonary embolism; Diagnosis; Prognosis; Score scale
{"title":"Common pulmonary embolism score scales and their application","authors":"Yuan-yuan Liu, Zhaozhong Cheng","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.01.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.01.012","url":null,"abstract":"The scales of pulmonary embolism have played an important role in diagnosis of pulmonary embolism and producing its prognosis in early stage.The commonly used pulmonary embolism scales include: Wells score, Gevena score, pulmonary embolism severity index, pulmonary embolism rule-out criteria, etc.The article briefly reviews their clinical application. \u0000 \u0000 \u0000Key words: \u0000Pulmonary embolism; Diagnosis; Prognosis; Score scale","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76294969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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