Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.014
Tong-Zeng Li
Pneumocystis pneumonia (PCP) is a pulmonary disease that occurs frequently in immunocompromised and acquired human immunodeficiency virus infected patients.Severe patients can be life-threatening.Trimethoprim-sulfamethoxazole is the first choice for first-line treatment, but it has potential drug resistance.Most mild patients have good prognosis after using compound sulfamethoxazole and active treatment of primary diseases.However, for severe patients, due to lack of specific diagnostic methods in the early stage, the course of disease progresses rapidly, and glucocorticoid therapy can be combined to reduce the mortality of PCP.This article reviews the progress of treatment of PCP. Key words: Pneumonia; Homones; Sulfamethoxazole; Spores
{"title":"Progress in the treatment of Pneumocystis pneumonia","authors":"Tong-Zeng Li","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.014","url":null,"abstract":"Pneumocystis pneumonia (PCP) is a pulmonary disease that occurs frequently in immunocompromised and acquired human immunodeficiency virus infected patients.Severe patients can be life-threatening.Trimethoprim-sulfamethoxazole is the first choice for first-line treatment, but it has potential drug resistance.Most mild patients have good prognosis after using compound sulfamethoxazole and active treatment of primary diseases.However, for severe patients, due to lack of specific diagnostic methods in the early stage, the course of disease progresses rapidly, and glucocorticoid therapy can be combined to reduce the mortality of PCP.This article reviews the progress of treatment of PCP. \u0000 \u0000 \u0000Key words: \u0000Pneumonia; Homones; Sulfamethoxazole; Spores","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81698631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.003
Xi Wang, Ping Li, B. Zhuan, Qun Yuan, Jun Xie, Zhao Yang
Objective To explore the significance of immunohistochemical expression of Ryanodine receptor 2 (RYR2), FK506-binding protein 12.6 (FKBP12.6) and Calcium/ calmodulin dependent protein kinaseⅡ (CaMK-Ⅱ) in lung tissues from patients with chronic obstructive pulmonary disease (COPD). Methods A retrospective analysis from November 2012 to April 2017 in People′s Hospital of Ningxia Hui Autonomous Regin, lung tissue of 30 patients after lung cancer surgery, according to the results of pulmonary function test and Cardio-Uhrasonography, the patients were divided into three groups: COPD with pulmonary hypertension (PH)(group A) and COPD group (group B), non-COPD, non-PH patients with pulmonary tumor as the negative control group (group C). Take lung tissue about 5 cm from the cancerous area was removed after surgery.The Circum-ferential area of pulmonary valve of the three groups has been observed.To observe RYR2, FKBP12.6 and CaMK-Ⅱby immunohistochemical method respectively, then make correlation analysis. Results (1)Compared with group C, wall area% (WA%), pulmonary artery systolic pressure (PASP) were higher in group A and group B (F=24.115, 9.421, both P<0.05), and WA%, PASP were higher in group A than group B. (2)Compared with group C, the immunohistochemical expressions of RYR2, FKBP12.6 and CaMK-Ⅱ in group A and group B were all increased (F=9.219, 6.143, 11.337, all P<0.05), and the immunohistochemical expressions of RYR2, FKBP12.6 and CaMK-Ⅱ in group A was higher than group B. (3)Correlation analysis indicated that the immunohistochemical expressions of RYR2 in group A and B was positively correlated with WA% (r=0.547, 0.771, both P<0.01), while the immunohistochemical expressions of RYR2 in group A was positively correlated with PASP (r=0.773, P<0.01). Histochemical expressions of FKBP12.6 in group A were positively correlated with WA% (r=0.796, 0.810, both P<0.01), and the immunohistochemical expressions of FKBP12.6 in group A was positively correlated with PASP (r=0.729, P<0.01). The immunohistochemical expressions of CaMK-Ⅱ in group A and B were positively correlated with WA% (r=0.879, 0.504, both P<0.01), and the immunohistochemical expressions of CaMK-Ⅱ in group A was positively correlated with PASP (r=0.748, P<0.01). Conclusions FKBP12.6 and CaMK-Ⅱ may play a role in COPD-related pulmonary artery proliferation. Key words: Pulmonary disease, chronic obstructive; Hypertension, pulmonary; Ryanodine receptor calcium release channel; Calcium-calmodulin-dependent protein kinase type 2; FK506-binding protein 12.6
{"title":"Study on expression of RYR2, FKBP12.6 and CaMK-II in lung tissue of patients with chronic obstructive pulmonary disease","authors":"Xi Wang, Ping Li, B. Zhuan, Qun Yuan, Jun Xie, Zhao Yang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.003","url":null,"abstract":"Objective \u0000To explore the significance of immunohistochemical expression of Ryanodine receptor 2 (RYR2), FK506-binding protein 12.6 (FKBP12.6) and Calcium/ calmodulin dependent protein kinaseⅡ (CaMK-Ⅱ) in lung tissues from patients with chronic obstructive pulmonary disease (COPD). \u0000 \u0000 \u0000Methods \u0000A retrospective analysis from November 2012 to April 2017 in People′s Hospital of Ningxia Hui Autonomous Regin, lung tissue of 30 patients after lung cancer surgery, according to the results of pulmonary function test and Cardio-Uhrasonography, the patients were divided into three groups: COPD with pulmonary hypertension (PH)(group A) and COPD group (group B), non-COPD, non-PH patients with pulmonary tumor as the negative control group (group C). Take lung tissue about 5 cm from the cancerous area was removed after surgery.The Circum-ferential area of pulmonary valve of the three groups has been observed.To observe RYR2, FKBP12.6 and CaMK-Ⅱby immunohistochemical method respectively, then make correlation analysis. \u0000 \u0000 \u0000Results \u0000(1)Compared with group C, wall area% (WA%), pulmonary artery systolic pressure (PASP) were higher in group A and group B (F=24.115, 9.421, both P<0.05), and WA%, PASP were higher in group A than group B. (2)Compared with group C, the immunohistochemical expressions of RYR2, FKBP12.6 and CaMK-Ⅱ in group A and group B were all increased (F=9.219, 6.143, 11.337, all P<0.05), and the immunohistochemical expressions of RYR2, FKBP12.6 and CaMK-Ⅱ in group A was higher than group B. (3)Correlation analysis indicated that the immunohistochemical expressions of RYR2 in group A and B was positively correlated with WA% (r=0.547, 0.771, both P<0.01), while the immunohistochemical expressions of RYR2 in group A was positively correlated with PASP (r=0.773, P<0.01). Histochemical expressions of FKBP12.6 in group A were positively correlated with WA% (r=0.796, 0.810, both P<0.01), and the immunohistochemical expressions of FKBP12.6 in group A was positively correlated with PASP (r=0.729, P<0.01). The immunohistochemical expressions of CaMK-Ⅱ in group A and B were positively correlated with WA% (r=0.879, 0.504, both P<0.01), and the immunohistochemical expressions of CaMK-Ⅱ in group A was positively correlated with PASP (r=0.748, P<0.01). \u0000 \u0000 \u0000Conclusions \u0000FKBP12.6 and CaMK-Ⅱ may play a role in COPD-related pulmonary artery proliferation. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Hypertension, pulmonary; Ryanodine receptor calcium release channel; Calcium-calmodulin-dependent protein kinase type 2; FK506-binding protein 12.6","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85090468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.011
Lin Chen
Chronic obstructive pulmonary disease (COPD) is a common and preventable disease.However, due to its high number of patients and high mortality, it is still highly valued.Although the research on the occurrence and development of COPD has gradually deepened in recent years, it still can not fully reveal the nature of its disease.Therefore, it is urgent to explore from a new perspective to develop new treatment methods.With the development of molecular biology, people gradually recognize the concept of pulmonary micro-ecology, and related research is further explored.Future research on pulmonary micro-ecology will provide new and effective treatments for the prevention and treatment of COPD. Key words: Pulmonary disease, chronic obstructive; Pathogenesis; Pulmonary micro-ecology
{"title":"Advances in research of pulmonary micro-ecology in chronic obstructive pulmonary disease","authors":"Lin Chen","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.011","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a common and preventable disease.However, due to its high number of patients and high mortality, it is still highly valued.Although the research on the occurrence and development of COPD has gradually deepened in recent years, it still can not fully reveal the nature of its disease.Therefore, it is urgent to explore from a new perspective to develop new treatment methods.With the development of molecular biology, people gradually recognize the concept of pulmonary micro-ecology, and related research is further explored.Future research on pulmonary micro-ecology will provide new and effective treatments for the prevention and treatment of COPD. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Pathogenesis; Pulmonary micro-ecology","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87477100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.015
Jiejun Shi, G. Qian, N. Yang
Voriconazole (C16H14N5OF3) is a novel triazole antifungal drug with broad spectrum, strong potency, good tolerance and high safety.It is a derivative of fluconazole, but it has a broader antibacterial spectrum and stronger bactericidal action than fluconazole.It can highly selectively inhibit the biosynthesis of ergosterol in various fungal cell membranes.Voriconazole has high permeability to the blood-brain barrier and blood-eye barrier, thus it can reach multiple sites of cryptococcal infection with effective drug concentration.In addition, it has a certain effect on drug-resistant fungi.What′s more, voriconazole can regulate immunity to accelerate the clearance of fungi in the lesion.Therefore, voriconazole is widely used in clinical practice.This article reviews the pharmacological effects, basic research of voriconazole and its application in cryptococcal infection. Key words: Cryptococcosis; Voriconazole
{"title":"Research progress of voriconazole in the treatment of cryptococcal infection","authors":"Jiejun Shi, G. Qian, N. Yang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.015","url":null,"abstract":"Voriconazole (C16H14N5OF3) is a novel triazole antifungal drug with broad spectrum, strong potency, good tolerance and high safety.It is a derivative of fluconazole, but it has a broader antibacterial spectrum and stronger bactericidal action than fluconazole.It can highly selectively inhibit the biosynthesis of ergosterol in various fungal cell membranes.Voriconazole has high permeability to the blood-brain barrier and blood-eye barrier, thus it can reach multiple sites of cryptococcal infection with effective drug concentration.In addition, it has a certain effect on drug-resistant fungi.What′s more, voriconazole can regulate immunity to accelerate the clearance of fungi in the lesion.Therefore, voriconazole is widely used in clinical practice.This article reviews the pharmacological effects, basic research of voriconazole and its application in cryptococcal infection. \u0000 \u0000 \u0000Key words: \u0000Cryptococcosis; Voriconazole","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85875365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.009
Tingting Zhao, Dongyan Li
As one of the common extrapulmonary effects of chronic obstructive pulmonary disease, skeletal muscle dysfunction seriously affects patients′ exercise endurance, quality of life and prognosis.The mechanism may be that under the action of multifactorial etiology, some biological events occur in skeletal muscle, such as structural abnormality, oxidative stress, muscle protein metabolism disorder (increased proteolysis/decreased protein synthesis), autophagy, epigenetic regulation, cell apoptosis, endoplasmic reticulum stress, etc.At present, exercise training, neuromuscular electrical stimulation, nutritional support and other pulmonary rehabilitation interventions have been proved to be suitable for the prevention and treatment of skeletal muscle dysfunction. Key words: Pulmonary disease, chronic obstructive; Skeletal muscle dysfunction; Biological mechanisms; Pulmonary rehabilitation
{"title":"Research progress of skeletal muscle dysfunction and related pulmonary rehabilitation in chronic obstructive pulmonary disease","authors":"Tingting Zhao, Dongyan Li","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.009","url":null,"abstract":"As one of the common extrapulmonary effects of chronic obstructive pulmonary disease, skeletal muscle dysfunction seriously affects patients′ exercise endurance, quality of life and prognosis.The mechanism may be that under the action of multifactorial etiology, some biological events occur in skeletal muscle, such as structural abnormality, oxidative stress, muscle protein metabolism disorder (increased proteolysis/decreased protein synthesis), autophagy, epigenetic regulation, cell apoptosis, endoplasmic reticulum stress, etc.At present, exercise training, neuromuscular electrical stimulation, nutritional support and other pulmonary rehabilitation interventions have been proved to be suitable for the prevention and treatment of skeletal muscle dysfunction. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Skeletal muscle dysfunction; Biological mechanisms; Pulmonary rehabilitation","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87225712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.006
Xian-kang Zhu, Chunyan Xu, Shu-zhen Guo
Objective To identify the factors related to prolonged stay in those patients admitted with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) to hospital. Methods Anumber of 661 patients were selected, all the patients admitted with AECOPD to Shanghai Pudong Hospital, either in the internal medical unit or pneumology department, from 2017 to 2018.The baseline characteristics, AECOPD characteristics and comorbidities were recorded. Results A number of 661 patients were assessed, 76.6% were male, and the mean age were 74.5 years.The mean stay were 11.9 days.24% of all patients required prolonged stay, 2.57% of all patients needed admission to intensive care unit (ICU), 14.67% of all patients were treated with noninvasive mechanical ventilation (NIV). The following factors were significantly associated with length of stay: age, lower hemoglobin count, chronic kidney disease, inpatient department, AECOPD characteristics, need for admission to ICU and the need for NIV, the differences were statistically significant (all P<0.05). Conclusions Prolonged stay in AECOPD primarily related to the unit patients are admitted to, and the need for ICU and NIV. Key words: Length of stay; Intensive care units; Acute exacerbation of chronic obstructive pulmonary disease; Noninvasive mechanical ventilation
{"title":"Prolonged stay predictors in patients admitted with chronic obstructive pulmonary disease acute exacerbation","authors":"Xian-kang Zhu, Chunyan Xu, Shu-zhen Guo","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.006","url":null,"abstract":"Objective \u0000To identify the factors related to prolonged stay in those patients admitted with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) to hospital. \u0000 \u0000 \u0000Methods \u0000Anumber of 661 patients were selected, all the patients admitted with AECOPD to Shanghai Pudong Hospital, either in the internal medical unit or pneumology department, from 2017 to 2018.The baseline characteristics, AECOPD characteristics and comorbidities were recorded. \u0000 \u0000 \u0000Results \u0000A number of 661 patients were assessed, 76.6% were male, and the mean age were 74.5 years.The mean stay were 11.9 days.24% of all patients required prolonged stay, 2.57% of all patients needed admission to intensive care unit (ICU), 14.67% of all patients were treated with noninvasive mechanical ventilation (NIV). The following factors were significantly associated with length of stay: age, lower hemoglobin count, chronic kidney disease, inpatient department, AECOPD characteristics, need for admission to ICU and the need for NIV, the differences were statistically significant (all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Prolonged stay in AECOPD primarily related to the unit patients are admitted to, and the need for ICU and NIV. \u0000 \u0000 \u0000Key words: \u0000Length of stay; Intensive care units; Acute exacerbation of chronic obstructive pulmonary disease; Noninvasive mechanical ventilation","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77717738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.008
He Hao, A. Meng
Endoplasmic reticulum stress (ERS) is an important self-defense mechanism of cells, and strong persistent ERS can induce apoptosis.Unfolded protein reaction is an important signal pathway of ERS.There are many kinds of cell types with high protein synthesis and secretion in lung.It is easy to appear ERS.At present, it is believed that ERS is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). This review focus on the relationship between ERS and COPD, to provide a new direction for the treatment of COPD. Key words: Pulmonary disease, chronic obstructive; Unfolded protein response; Endoplasmic reticulum stress
{"title":"Progress of endoplasmic reticulum stress in chronic obstructive pulmonary disease","authors":"He Hao, A. Meng","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.008","url":null,"abstract":"Endoplasmic reticulum stress (ERS) is an important self-defense mechanism of cells, and strong persistent ERS can induce apoptosis.Unfolded protein reaction is an important signal pathway of ERS.There are many kinds of cell types with high protein synthesis and secretion in lung.It is easy to appear ERS.At present, it is believed that ERS is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). This review focus on the relationship between ERS and COPD, to provide a new direction for the treatment of COPD. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Unfolded protein response; Endoplasmic reticulum stress","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90185084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.007
Weixia Li, Jiaqiang Zhang
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable respiratory disease characterized by persistent airflow limitation.Its mechanism has not yet been fully clarified.In recent years, many studies have shown that oxidative stress and gene polymorphism play a very important role in its development.Heme oxygenase-1 (HO-1) is an important oxygen reductase in the body and is closely related to COPD.This article reviews the relationship between the occurrence, development, treatment and prognosis of HO-1 and COPD, in order to provide new ideas for the diagnosis, treatment and management of COPD. Key words: Pulmonary disease, chronic obstructive; Genes, duplicate; Heme oxygenase-1
{"title":"Research progress of heme oxygenase-1 and chronic obstructive pulmonary disease","authors":"Weixia Li, Jiaqiang Zhang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.007","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a preventable and treatable respiratory disease characterized by persistent airflow limitation.Its mechanism has not yet been fully clarified.In recent years, many studies have shown that oxidative stress and gene polymorphism play a very important role in its development.Heme oxygenase-1 (HO-1) is an important oxygen reductase in the body and is closely related to COPD.This article reviews the relationship between the occurrence, development, treatment and prognosis of HO-1 and COPD, in order to provide new ideas for the diagnosis, treatment and management of COPD. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Genes, duplicate; Heme oxygenase-1","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77403723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.004
Lillian Du, Liang Chen, Yue Zhuo, Bi-ying Wang
Objective To analyze the expression of Foxp3-mRNA and the regulation of Th1/Th2 immune response in patients with chronic obstructive pulmonary disease (COPD), and to provide a theoretical basis for the monitoring of immune status and its related mechanisms in patients with COPD. Methods A group sampling method was used to select 95 cases of patients with COPD who received a follow-up treatment in a third-grade hospital in the same hospital and 85 controls were conducted at the same time, from March 2016 to December 2017.The Foxp3-mRNA fragment was amplified by PCR and the expression of Foxp3-mRNA in serum was detected by Western blot.The expression of Th1/Th2 immune response system expression assay (including IFN-γ, IL-2, IL-4, IL-10), the obtained data were entered into SPSS 16.0 for statistical analysis. Results The level of IFN-γ, IL-2, IL-4, IL-10 in COPD group were higher than those of in the control group and there were statistical differences(t=7.282, 5.996, 7.380, 4.835, all P<0.05). In the case group, patients of different ages in IFN-γ, IL-2, IL-4, IL-10, were statistically different (t=22.237, 16.943, 45.386, 31.831, all P<0.05). In the case group, patients of different disease durations in IFN-γ, IL-2, IL-4, IL-10 were statistically different (F=33.226, 30.096, 29.353, 34.300, all P<0.05). In the case group, clear bands were seen at about 592 bp (group 1 to group 5), while the control group (group 6) and the DNA marker group (group 7) had no bands.The levels of IL-2, IL-4 and IL-10 were positively correlated and the correlation coefficients were statistically significant (r=0.614, 0.493, 0.529, 0.501, all P<0.05). Conclusions The theoretical basis for the specific expression of Foxp3-mRNA in patients with COPD is established.There is a statistically positive correlation between the expression of Foxp3-mRNA and the characteristics of Th1/Th2 immune response, but considering the epidemic of COPD in China.Characteristics, this conclusion also needs to be combined with the environmental epidemiological factors of patients with COPD to further verify the relationship between Foxp3-mRNA expression characteristics and Th1/Th2 immune response characteristics at the mechanism level. Key words: Pulmonary disease, chronic obstructive; Foxp3-mRNA; Immune response
{"title":"Regulation of Foxp3-mRNA expression and Th1/Th2 immune response in patients with chronic obstructive pulmonary disease","authors":"Lillian Du, Liang Chen, Yue Zhuo, Bi-ying Wang","doi":"10.3760/CMA.J.ISSN.1673-436X.2020.02.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-436X.2020.02.004","url":null,"abstract":"Objective \u0000To analyze the expression of Foxp3-mRNA and the regulation of Th1/Th2 immune response in patients with chronic obstructive pulmonary disease (COPD), and to provide a theoretical basis for the monitoring of immune status and its related mechanisms in patients with COPD. \u0000 \u0000 \u0000Methods \u0000A group sampling method was used to select 95 cases of patients with COPD who received a follow-up treatment in a third-grade hospital in the same hospital and 85 controls were conducted at the same time, from March 2016 to December 2017.The Foxp3-mRNA fragment was amplified by PCR and the expression of Foxp3-mRNA in serum was detected by Western blot.The expression of Th1/Th2 immune response system expression assay (including IFN-γ, IL-2, IL-4, IL-10), the obtained data were entered into SPSS 16.0 for statistical analysis. \u0000 \u0000 \u0000Results \u0000The level of IFN-γ, IL-2, IL-4, IL-10 in COPD group were higher than those of in the control group and there were statistical differences(t=7.282, 5.996, 7.380, 4.835, all P<0.05). In the case group, patients of different ages in IFN-γ, IL-2, IL-4, IL-10, were statistically different (t=22.237, 16.943, 45.386, 31.831, all P<0.05). In the case group, patients of different disease durations in IFN-γ, IL-2, IL-4, IL-10 were statistically different (F=33.226, 30.096, 29.353, 34.300, all P<0.05). In the case group, clear bands were seen at about 592 bp (group 1 to group 5), while the control group (group 6) and the DNA marker group (group 7) had no bands.The levels of IL-2, IL-4 and IL-10 were positively correlated and the correlation coefficients were statistically significant (r=0.614, 0.493, 0.529, 0.501, all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The theoretical basis for the specific expression of Foxp3-mRNA in patients with COPD is established.There is a statistically positive correlation between the expression of Foxp3-mRNA and the characteristics of Th1/Th2 immune response, but considering the epidemic of COPD in China.Characteristics, this conclusion also needs to be combined with the environmental epidemiological factors of patients with COPD to further verify the relationship between Foxp3-mRNA expression characteristics and Th1/Th2 immune response characteristics at the mechanism level. \u0000 \u0000 \u0000Key words: \u0000Pulmonary disease, chronic obstructive; Foxp3-mRNA; Immune response","PeriodicalId":10004,"journal":{"name":"Chinese Journal of Asthma","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76713197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-436X.2020.02.010
Jing-yun Fan
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the respiratory tract.It is one of the diseases with high morbidity and mortality in the world.Acute exacerbation of COPD(AECOPD) is an important event in the process of COPD, which often leads to the decline of patients′ quality of life and the increase of mortality.Respiratory virus infection is closely related to AECOPD.Viral infection in patients with AECOPD is characterized by diversity, seasonality and locality.Respiratory virus infection can aggravate COPD by activating inflammatory mediators and participating in immune response.The effects and mechanisms of various viral infections on AECOPD may be different and require further study. Key words: Pulmonary disease, chronic obstructive; Viruses
慢性阻塞性肺病(COPD)是一种常见的呼吸道炎症性疾病。它是世界上发病率和死亡率最高的疾病之一。慢性阻塞性肺病急性加重(Acute exacerbation of COPD, AECOPD)是慢性阻塞性肺病病程中的重要事件，常导致患者生活质量下降，死亡率升高。呼吸道病毒感染与AECOPD密切相关。AECOPD患者的病毒感染具有多样性、季节性和地域性的特点。呼吸道病毒感染可通过激活炎症介质和参与免疫应答而加重COPD。各种病毒感染对AECOPD的作用和机制可能不同，需要进一步研究。关键词:肺部疾病;慢性阻塞性肺疾病;病毒
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